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公开(公告)号：US5861377A
公开(公告)日：1999-01-19
申请号：US369829
申请日：1995-01-06
申请人： Hans Fritz , Christian Sommerhoff , Jutta Heim
发明人： Hans Fritz , Christian Sommerhoff , Jutta Heim
IPC分类号： C12N15/09 , A61K38/55 , A61P7/02 , A61P35/00 , A61P43/00 , C07H21/04 , C07K1/16 , C07K14/81 , C07K14/815 , C12N1/19 , C12N1/21 , C12P21/02 , C12R1/19 , C12R1/865 , A61K38/57
CPC分类号： C07K14/815 , C07K2319/02
摘要： The present invention relates to novel inhibitors belonging to the family of antistasin-type serine proteinase inhibitors, to their isolation from the medical leech Hirudo medicinalis, to DNA sequences encoding the novel inhibitors, to variants obtained by recombinant DNA technology or peptide synthesis, pharmaceutical compositions containing the inhibitors, and to their use in diagnosis and therapy.
摘要翻译： 本发明涉及属于抗静脉蛋白型丝氨酸蛋白酶抑制剂家族的新型抑制剂，其分离自医药水蛭水蛭素，编码新型抑制剂的DNA序列，通过重组DNA技术或肽合成获得的变体，药物组合物 含有抑制剂，并用于诊断和治疗。
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公开(公告)号：US06410272B1
公开(公告)日：2002-06-25
申请号：US07488513
申请日：1990-02-27
申请人： Bernd Meyhack , Walter Märki , Jutta Heim
发明人： Bernd Meyhack , Walter Märki , Jutta Heim
IPC分类号： C12P2104
CPC分类号： C07K14/815 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C07K2319/33 , C12N9/16 , C12N9/2408 , C12N15/70 , C12N15/81 , C12N15/90
摘要： A method for the production and secretion of proteins with hirudin activity in an eukaryotic host organism is provided. There are also provided hybrid vectors comprising a DNA sequence encoding a signal peptide upstream of and in reading frame with the structural gene for desulphatohirudin, and eukaryotic host organisms transformed with said hybrid vectors.
摘要翻译： 提供了在真核宿主生物体中产生和分泌具有水蛭素活性的蛋白质的方法。 还提供了包含编码上游和读框中的信号肽与脱硫水蛭素的结构基因的DNA序列的混合载体和用所述杂交载体转化的真核宿主生物。
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公开(公告)号：US5922569A
公开(公告)日：1999-07-13
申请号：US453051
申请日：1995-05-26
申请人： Jutta Heim , Thomas Hottiger , Gabriele Pohlig , Peter Furst
发明人： Jutta Heim , Thomas Hottiger , Gabriele Pohlig , Peter Furst
IPC分类号： C12N1/19 , C07K14/00 , C07K14/815 , C12N15/09 , C12N15/15 , C12N15/81 , C12P21/02 , C12R1/865
CPC分类号： C07K14/815 , C12N15/81 , C07K2319/02
摘要： The invention concerns a method for the production of a polypeptide with the aid of genetically engineered yeast cells which contain not more than one functional CUP1 gene in the genome and carry a plasmid comprising a gene coding for said polypeptide and a functional CUP1 gene; and said yeast cells and said plasmids.
摘要翻译： 本发明涉及一种在遗传工程化的酵母细胞的帮助下生产多肽的方法，所述酵母细胞在基因组中含有不超过一个功能性CUP1基因并携带包含编码所述多肽和功能性CUP1基因的基因的质粒; 并说酵母细胞和所述质粒。
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4.发明授权Process for the production of urokinase using Saccharomyes cerevisiae 失效使用SACCHAROMYES CERUISIAE生产尿素酶的方法
公开(公告)号：US5175105A
公开(公告)日：1992-12-29
申请号：US179345
申请日：1988-04-08
申请人： Bernd Meyhack , Jutta Heim , Rolf Burgi
发明人： Bernd Meyhack , Jutta Heim , Rolf Burgi
IPC分类号： A61K38/46 , A61P7/02 , C07K20060101 , C07K1/20 , C07K1/22 , C07K14/00 , C07K14/745 , C12N20060101 , C12N1/16 , C12N1/19 , C12N9/16 , C12N9/26 , C12N9/72 , C12N15/00 , C12N15/09 , C12N15/12 , C12N15/58 , C12N15/76 , C12N15/81 , C12P20060101 , C12P21/00 , C12P21/02 , C12R1/865
CPC分类号： C12N9/2408 , C12N15/81 , C12N9/16 , C12N9/6462 , C12Y304/21073 , C07K2319/02
摘要： Novel human plasminogen activators of the urokinase type are produced by yeast cells transformed with a hybrid vector comprising a DNA sequence coding for said human plasminogen activator. Novel hybrid vectors, yeast hosts transformed with such hybrid vectors and processes for the production thereof are also provided. 77
摘要翻译： 尿素激酶类型的新型人类纤溶酶原激活剂是由用包含编码所述人纤溶酶原激活物的DNA序列的杂交载体转化的酵母细胞产生的。 还提供了新的杂交载体，用这种杂交载体转化的酵母宿主及其制备方法。
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5.发明授权Pharmaceutical compositions comprising modified and unmodified plasminogen activators 失效包含修饰和未修饰的纤溶酶原激活剂的药物组合物
公开(公告)号：US5409700A
公开(公告)日：1995-04-25
申请号：US44563
申请日：1993-04-07
IPC分类号： C12N9/64 , A61K38/46 , A61K38/49 , A61P7/02 , C12N9/72 , C12N15/09 , C12P21/02 , C12R1/865 , C12R1/92 , A61K37/54 , C12N9/48 , A61K37/547
CPC分类号： A61K38/49
摘要： The present invention relates to pharmaceutical compositions comprising a combination of two different plasminogen activators which are used for the prophylaxis and therapie of thrombosis.
摘要翻译： 本发明涉及包含用于预防和治疗血栓形成的两种不同纤溶酶原激活物的组合的药物组合物。
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公开(公告)号：US08962842B2
公开(公告)日：2015-02-24
申请号：US13821250
申请日：2011-09-16
申请人： Patrick Roussel , Jutta Heim , Peter Schneider , Christian Bartels , Yaoquan Liu , Glen Dale , Daniel Milligan
发明人： Patrick Roussel , Jutta Heim , Peter Schneider , Christian Bartels , Yaoquan Liu , Glen Dale , Daniel Milligan
IPC分类号： C07D455/02 , A61K31/4375
CPC分类号： A61K31/496 , A61K31/4375 , A61K31/444 , A61K31/4709 , C07D455/02 , Y02A50/475
摘要： Described are a series of 2-pyridone compounds as a potent and selective new class of type II topoisomerase inhibitors with broad-spectrum antimicrobial activity having the general formula (I); where R1, R2, X, and Y are defined herein Such compounds can be used in methods for treating an infection caused by a gram-positive pathogen, a gram-negative pathogen, or a drug-resistant strains thereof.
摘要翻译： 描述了一系列2-吡啶酮化合物，作为具有广谱抗微生物活性的具有通式（I）的有效和选择性新型II型拓扑异构酶抑制剂; 其中R1，R2，X和Y如本文所定义。这些化合物可用于治疗由革兰氏阳性病原体，革兰氏阴性病原体或其耐药菌株引起的感染的方法。
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公开(公告)号：US20130245035A1
公开(公告)日：2013-09-19
申请号：US13821250
申请日：2011-09-16
申请人： Patrick Roussel , Jutta Heim , Peter Schneider , Christian Bartels , Yaoquan Liu , Glen Dale , Daniel Milligan
发明人： Patrick Roussel , Jutta Heim , Peter Schneider , Christian Bartels , Yaoquan Liu , Glen Dale , Daniel Milligan
IPC分类号： C07D455/02
CPC分类号： A61K31/496 , A61K31/4375 , A61K31/444 , A61K31/4709 , C07D455/02 , Y02A50/475
摘要： Described are a series of 2-pyridone compounds as a potent and selective new class of type II topoisomerase inhibitors with broad-spectrum antimicrobial activity having the general formula (I); where R1, R2, X, and Y are defined herein Such compounds can be used in methods for treating an infection caused by a gram-positive pathogen, a gram-negative pathogen, or a drug-resistant strains thereof.
摘要翻译： 描述了一系列2-吡啶酮化合物，作为具有广谱抗微生物活性的具有通式（I）的有效和选择性新型II型拓扑异构酶抑制剂; 其中R1，R2，X和Y如本文所定义。这些化合物可用于治疗由革兰氏阳性病原体，革兰氏阴性病原体或其耐药菌株引起的感染的方法。
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公开(公告)号：US5726043A
公开(公告)日：1998-03-10
申请号：US715252
申请日：1996-09-16
申请人： Jutta Heim , Peter Furst , Thomas Hottiger , Jochen Kuhla , Gabriele Pohlig
发明人： Jutta Heim , Peter Furst , Thomas Hottiger , Jochen Kuhla , Gabriele Pohlig
IPC分类号： C12N1/16 , C07K20060101 , C07K14/815 , C12N20060101 , C12N1/15 , C12N1/19 , C12N15/09 , C12N15/15 , C12N15/81 , C12P20060101 , C12P21/00 , C12P21/02 , C12R20060101 , C12R1/865 , C12P21/06
CPC分类号： C07K14/815 , C12N15/81
摘要： A novel process for the production of recombinant desulphatohirudin by transformed yeast strains is provided. The process makes use of an expression cassette comprising the yeast CUP1 promoter. The invention concerns also said transformed yeast strains, novel expression vectors and methods for the production thereof.
摘要翻译： 提供了一种通过转化酵母菌株生产重组脱硫水蛭素的新方法。 该方法利用包含酵母CUP1启动子的表达盒。 本发明还涉及转化酵母菌株，新型表达载体及其生产方法。
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公开(公告)号：US20130252882A1
公开(公告)日：2013-09-26
申请号：US13823187
申请日：2012-01-31
申请人： Jutta Heim , Peter Schneider , Patrick Roussel , Daniel Milligan , Christian Bartels , Glenn Dale
发明人： Jutta Heim , Peter Schneider , Patrick Roussel , Daniel Milligan , Christian Bartels , Glenn Dale
IPC分类号： C07D455/02 , A61K31/506 , A61K31/496 , A61K38/12 , A61K31/4375
CPC分类号： A61K38/12 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , C07D455/02 , Y02A50/402 , Y02A50/475 , Y02A50/478 , Y02A50/479 , Y02A50/481 , A61K2300/00
摘要： This invention provides novel 4-oxoquinolizine compounds and their uses for a series of broad-spectrum antibiotics having no cross-resistance to existing or emerging classes of antibiotics. In addition the novel 4-oxoquinolizine compounds are useful against CDC Category A and B pathogens The invention also provides pharmaceutical compositions comprising certain 4-oxoquinolizines in combination with subinhibitory concentrations of polymyxin B against clinical isolates which are resistant to quinolones, carbapenems and other antimicrobial agents.
摘要翻译： 本发明提供新的4-氧喹诺嗪化合物及其用于一系列对现有或新兴类型的抗生素没有交叉抗性的广谱抗生素的用途。 此外，新的4-氧代喹嗪化合物可用于抗CDC类A和B病原体本发明还提供药物组合物，其包含某些4-氧代喹诺嗪与亚抑菌浓度的多粘菌素B对抗喹诺酮类，碳青霉烯类和其他抗微生物剂的临床分离物 。
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10.发明授权
公开(公告)号：US6103515A
公开(公告)日：2000-08-15
申请号：US895581
申请日：1992-06-08
IPC分类号： C07K14/815 , C12N1/16 , C12N1/19 , C12N15/81 , C12N15/00
CPC分类号： C07K14/815 , C12N15/81 , C12R1/685 , C07K2319/036
摘要： A novel process for the production of heterologous proteins including the use of certain transformed protease deficient yeast strains is provided. The invention concerns also said transformed yeast strains and methods for the production thereof.
摘要翻译： 提供了用于产生异源蛋白质的新方法，包括使用某些转化的蛋白酶缺陷型酵母菌株。 本发明还涉及转化的酵母菌株及其生产方法。
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