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17 条记录 (耗时 0.024 秒)

    Tryptase inhibitor
    2.
    发明授权
    Tryptase inhibitor 失效
    胰蛋白酶抑制剂

    公开(公告)号：US5972698A

    公开(公告)日：1999-10-26

    申请号：US586676

    申请日：1996-01-25

    申请人： Hans Fritz ,  Christian Sommerhoff

    发明人： Hans Fritz ,  Christian Sommerhoff

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K38/55 ,  A61P1/02 ,  A61P7/02 ,  A61P11/00 ,  A61P29/00 ,  A61P43/00 ,  C07H21/04 ,  C07K14/81 ,  C07K14/815 ,  C12N9/99 ,  C12N15/81 ,  C12P21/02 ,  C12R1/865 ,  A61K38/58 ,  C12N15/11

    CPC分类号： C07K14/811 ,  C12N15/81 ,  A61K38/00

    摘要： The present invention relates to novel inhibitors of human tryptase, to their isolation from leeches, to nucleotide sequences encoding the novel inhibtor molecules or fragments thereof, to vectors containing the coding sequence thereof, to host cells transformed with such vectors, to the recombinant production of the inibitors, to pharmaceutical compositions containing the novel inhibitor molecules, and to their use in diagnosis and therapy.

    摘要翻译： PCT No.PCT / EP94 / 02445 Sec。 371日期：1996年1月25日 102（e）日期1996年1月25日PCT 1994年7月25日PCT公布。 公开号WO95 / 03333 日期1995年2月2日本发明涉及新型的类胰蛋白酶抑制剂，其从水蛭分离到编码新型抑制剂分子或其片段的核苷酸序列，涉及含有其编码序列的载体，宿主用这些载体转化的细胞， 涉及重组生产的内含子，含有新型抑制剂分子的药物组合物及其在诊断和治疗中的应用。

    Method and Apparatus for Longitudinal and Lateral Guiding Assistance of Driver of a Vehicle
    3.
    发明申请
    Method and Apparatus for Longitudinal and Lateral Guiding Assistance of Driver of a Vehicle 审中-公开
    车辆驾驶员纵向和横向辅助的方法和装置

    公开(公告)号：US20100324797A1

    公开(公告)日：2010-12-23

    申请号：US12866673

    申请日：2009-01-15

    申请人： Hans Fritz

    发明人： Hans Fritz

    IPC分类号： B60W30/16

    CPC分类号： B60W10/06 ,  B60T2201/08 ,  B60T2201/081 ,  B60T2201/089 ,  B60W10/184 ,  B60W30/165 ,  B60W2550/306 ,  B62D15/026

    摘要： In a method and apparatus for the longitudinal and lateral guidance assistance to the driver of a vehicle, longitudinal guidance assistance is performed as distance regulation for regulating the distance between the vehicle and a preceding guide vehicle. Lateral guidance assistance is optionally carried out as an object tracking regulation for guiding the vehicle according to a displacement lane of a preceding guide vehicle, as a lane tracking regulation for guiding the vehicle along a marked driving lane, or as combined lane object tracking regulation. The lateral guidance assistance is then available only when the distance regulation is active and when the distance between the vehicle and the guide vehicle is smaller than a predefined distance limit and/or when a shaft angle as a viewing angle from the vehicle to the guide vehicle is smaller than a predefined angle limit.

    摘要翻译： 在用于向车辆的驾驶员的纵向和横向引导辅助的方法和装置中，作为用于调节车辆与前一引导车辆之间的距离的距离调节件执行纵向引导辅助。 侧向引导辅助可选地作为用于根据前导向车辆的位移车道引导车辆的对象跟踪规则，作为用于沿着标记的行驶车道引导车辆的车道跟踪规则，或者作为组合车道对象跟踪调节。 只有当距离调节有效时和当车辆和导向车辆之间的距离小于预定义的距离限制时和/或当从车辆到引导车辆的视角的轴角度时，横向引导辅助 小于预定义的角度限制。

    Method for isolating anionic organic substances from aqueous systems using cationic polymer nanoparticles
    5.
    发明授权
    Method for isolating anionic organic substances from aqueous systems using cationic polymer nanoparticles 失效
    使用阳离子聚合物纳米颗粒从水性体系中分离阴离子有机物质的方法

    公开(公告)号：US06447764B1

    公开(公告)日：2002-09-10

    申请号：US09505963

    申请日：2000-02-17

    申请人： Ernst Bayer ,  Hans Fritz ,  Martin Maier ,  Jens Schewitz ,  Michael Gerster

    发明人： Ernst Bayer ,  Hans Fritz ,  Martin Maier ,  Jens Schewitz ,  Michael Gerster

    IPC分类号： A61K3174

    CPC分类号： B01J41/04 ,  C12N15/1006 ,  C12Q1/6806 ,  Y10S977/906

    摘要： The invention relates to a method for isolating anionic organic substances from aqueous systems using polymer nanoparticles with cationic pH-sensitive surface groups. Extraction can be carried out directly from diluted solutions, biological media (blood plasma, serum, urine, etc.) and complex buffer systems (e.g. PCR preparations contain detergents) without prior derivatization of the samples or addition of binding buffers. After separation from the surrounding medium the conjugates of the corresponding substances and polymer nanoparticles obtained in this manner can be purified through additional washing steps and effectively desalinated. Owing to the pH-sensitivity of the basic surface groups, the bound substances can be released in a targeted manner after separation by modification of the pH of the medium. By using volatile bases contamination of the released samples with ionic residues can be avoided. By adding small quantities of SDS and acetonitrile during the separation stage, the sensitivity of the method can be raised further, especially when the substance to be isolated are present in low concentrations (

    摘要翻译： 本发明涉及使用具有阳离子pH敏感表面基团的聚合物纳米颗粒从水性体系中分离阴离子有机物质的方法。 提取可以直接从稀释溶液，生物培养基（血浆，血清，尿液等）和复合缓冲液系统（例如PCR制剂含有洗涤剂）进行，而无需样品的先前衍生或添加结合缓冲液。 在与周围介质分离后，可以通过另外的洗涤步骤纯化相应物质和以这种方式获得的聚合物纳米颗粒的共轭物，并有效脱盐。 由于碱性表面基团的pH敏感性，可以通过改变介质的pH进行分离后以目标方式释放结合物质。 通过使用挥发性碱可以避免释放的样品与离子残留物的污染。 通过在分离阶段添加少量的SDS和乙腈，可以进一步提高该方法的灵敏度，特别是当待分离的物质以低浓度（<1mumol / L）存在时。 该方法是通用应用的一种提取方法，适用于低分子阴离子化合物以及肽，核酸和核酸衍生物。 恢复率高达100％。

    Adsorbing material comprised of porous functional solid incorporated in a polymer matrix
    7.
    发明申请
    Adsorbing material comprised of porous functional solid incorporated in a polymer matrix 审中-公开
    吸收材料由多孔功能固体掺入聚合物基质中组成

    公开(公告)号：US20060105158A1

    公开(公告)日：2006-05-18

    申请号：US10500349

    申请日：2002-12-20

    申请人： Hans Fritz ,  Hans Hofer ,  Jochen Hammer

    发明人： Hans Fritz ,  Hans Hofer ,  Jochen Hammer

    IPC分类号： B32B5/22

    CPC分类号： B01J20/28026 ,  B01D53/02 ,  B01D2253/202 ,  B01J20/183 ,  B01J20/26 ,  B01J20/28042 ,  B01J20/28045 ,  B01J20/28069 ,  C02F1/42 ,  Y02C10/08 ,  Y10T428/249955 ,  Y10T428/249958 ,  Y10T428/249969 ,  Y10T428/249986

    摘要： The present invention relates to an adsorbing material which comprises at least one porous functional solid, e.g. a zeolite, incorporated in a polymer matrix. The adsorbing material contains the porous functional solid in an amount of 45 to 80 wt. %. The polymer matrix comprises at least one organic polymer, particularly selected from thermoplastics, and has a secondary pore volume in addition to the primary pore volume of the porous functional solid. Further, the present invention is directed to a shaped article, which comprises or consists of the afore-mentioned adsorbing material, to a method for its preparation and to its use. The present invention is finally conerned with the use of specific rheological additives, in particular waxy components, which function as pore-forming agents in the preparation of shaped articles.

    摘要翻译： 本发明涉及一种吸附材料，其包含至少一种多孔功能固体，例如， 掺入聚合物基质中的沸石。 吸附材料含有45〜80重量％的多孔功能性固体。 ％。 聚合物基质包含至少一种有机聚合物，特别是选自热塑性塑料，除了多孔功能固体的主孔体积之外，还具有二次孔体积。 此外，本发明涉及一种成形制品，其包含或由上述吸附材料组成，涉及其制备方法及其用途。 本发明最终结合使用特定的流变添加剂，特别是在成型制品的制备中用作成孔剂的蜡质组分。