公开(公告)号：US6134472A

公开(公告)日：2000-10-17

申请号：US269347

申请日：1999-11-26

Applicant: Hans Strandberg ,  Johan Lidman ,  Kjell Noren

Inventor： Hans Strandberg ,  Johan Lidman ,  Kjell Noren

IPC: A61N1/362 ,  A61N1/365

CPC classification number: A61N1/36521 ,  A61N1/3627

Abstract: In the determination of an optimal rate for the delivery of stimulation pulses to a heart, the stroke volume (SV) of a heart ventricle is measured as a function of heart rate (HR), e.g. by determination of impedance in individual heart cycles whose duration is varied from the duration corresponding to the prevailing rate or the basic rate regarded as optimal for stimulation. The optimal rate should lie at the knee of this function. A corresponding knee is also found in the curve for cardiac output (CO). This rate is determined by calculation of an auxiliary function, e.g. HF=HR.times.CO, which displays a peak at the heart rate at which the knee is located, and the heart rate is determined which yields this maximum. The heart rate determined in this manner is subsequently employed as a basic rate.

Abstract translation: PCT No.PCT / SE97 / 01590 Sec。 371日期1999年11月26日 102（e）1999年11月26日PCT PCT 1997年9月22日PCT公布。 公开号WO98 / 14240 日期1998年4月9日在确定将心脏刺激脉冲递送到最佳速率时，测量心室的搏动体积（SV）作为心率（HR）的函数，例如心率。 通过确定其持续时间从对应于当前速率或被认为是刺激最佳的基本速率的持续时间变化的各个心脏周期中的阻抗的确定。 最佳速率应该在这个功能的膝盖上。 在心输出量（CO）曲线中也发现了相应的膝盖。 该速率通过辅助功能的计算来确定，例如， HF = HRxCO，其以膝盖所处的心率显示峰值，并且确定产生该最大值的心率。 以这种方式确定的心率随后用作基本速率。

公开(公告)号：US06937902B2

公开(公告)日：2005-08-30

申请号：US10258645

申请日：2001-04-23

Applicant: Johan Lidman ,  Nils Holmström ,  Kjell Norén

Inventor： Johan Lidman ,  Nils Holmström ,  Kjell Norén

IPC: A61N1/362 ,  A61N1/368 ,  A61N1/37 ,  A61N1/365

CPC classification number: A61N1/368 ,  A61N1/3627 ,  A61N1/3682 ,  A61N1/3702

Abstract: A cardiac pacemaker has a pulse generator for delivering stimulation pulses to a patient's heart and a control unit for controlling the delivery of the stimulation pulses from the pulse generator. The control unit includes an altering unit for altering the AV-delay value from a predetermined first AV-delay value to a predetermined second AV-delay value, and back to the first AV-delay value. A sensor measures a parameter related to cardiac output of the patient, the sensor measuring this parameter in a time window within a time of operation with the first AV-delay value, and in a time window within the time of operation with said second AV-delay value, and in a time window within the time of operation after the return back to the first AV-delay value. A calculation unit calculates respective average values of the parameter during each of the time windows, and a determining unit determines from these average values which of the AV-delay values results in a higher cardiac output.

Abstract translation: 心脏起搏器具有用于将刺激脉冲传送到患者心脏的脉冲发生器和用于控制来自脉冲发生器的刺激脉冲的传送的控制单元。 控制单元包括改变单元，用于将AV延迟值从预定的第一AV延迟值改变到预定的第二AV延迟值，并且返回到第一AV延迟值。 传感器测量与患者的心输出量相关的参数，所述传感器在具有第一AV延迟值的操作时间内的时间窗中测量该参数，并且在所述第二AV-延迟值的操作时间内的时间窗中， 延迟值，并且在返回到第一AV延迟值之后的操作时间内的时间窗中。 计算单元计算每个时间窗口期间的参数的各个平均值，并且确定单元从这些平均值确定哪个AV延迟值导致更高的心输出量。

公开(公告)号：US07088868B1

公开(公告)日：2006-08-08

申请号：US10070701

申请日：2000-09-07

Applicant: Johan Lidman

Inventor： Johan Lidman

IPC: G06K9/46

CPC classification number: H03M7/30

Abstract: In a compression and decompression coding method, arrangement and computer program product, a data signal containing a number of symbols is converted into a series of codewords. A set of codewords is established and the data signal is monitored to determine the most frequently occurring symbols therein and/or sequences of symbols therein containing at least two symbols. A codeword is then allocated to each of the most frequently occurring of the symbols and/or symbol sequences. At least one codeword is reserved for indicating uncompressed data. When compressing a signal, the incoming symbols are first checked to determine if they correspond to a codeword. If a symbol corresponds to more than one codeword, further symbols are read until a symbol occurs which corresponds to one codeword only. That codeword is then transmitted. Any symbol that does not correspond to a codeword is supplemented with a codeword indicative of no compression and is then transmitted.

Abstract translation: 在压缩和解压缩编码方法，布置和计算机程序产品中，包含多个符号的数据信号被转换成一系列码字。 建立一组代码字，并监视数据信号以确定其中最频繁出现的符号和/或其中包含至少两个符号的符号序列。 然后将码字分配给最常出现的符号和/或符号序列中的每一个。 至少一个码字被保留用于指示未压缩的数据。 当压缩信号时，首先检查输入符号以确定它们是否对应于码字。 如果符号对应于多于一个码字，则读出其它符号，直到发生仅对应于一个码字的符号。 然后发送该码字。 不对应于码字的任何符号用指示不压缩的码字补充，然后被发送。

公开(公告)号：US06571130B1

公开(公告)日：2003-05-27

申请号：US09673747

申请日：2000-10-20

Applicant: Karin Ljungström ,  Kenth Nilsson ,  Johan Lidman ,  Charlotte Kjellman

Inventor： Karin Ljungström ,  Kenth Nilsson ,  Johan Lidman ,  Charlotte Kjellman

IPC: A61N105

CPC classification number: C04B35/495 ,  A61L31/028 ,  A61N1/0565

Abstract: A medical implant has an element with at least a part thereof which is composed of piezoelectric material. The piezoelectric material is suitable for contact with body tissue and/or body fluids, and has the formula NaxKyNbO3, with 0≦x≦0.8, 0.2≦y≦1, and x+y=1.

Abstract translation: 医疗植入物具有至少一部分由压电材料构成的元件。 压电材料适于与身体组织和/或体液接触，并且具有公式NaxKyNbO3，其中0 <= x <= 0.8,0.2 <= y <= 1，x + y = 1。

公开(公告)号：US06886411B2

公开(公告)日：2005-05-03

申请号：US10399813

申请日：2001-10-24

Applicant: Charlotte Kjellman ,  Johan Lidman ,  Karin Ljungström ,  Kenth Nilsson

Inventor： Charlotte Kjellman ,  Johan Lidman ,  Karin Ljungström ,  Kenth Nilsson

IPC: A61B5/0215 ,  A61B19/00 ,  G01L9/06 ,  G01L9/08 ,  G01L7/00

CPC classification number: G01L9/08 ,  A61B5/0215 ,  A61B2090/064 ,  A61B2562/0247 ,  A61M2025/0002 ,  G01L9/06

Abstract: A fluid pressure sensor for a lead or catheter intended for placement in a living organism, such as a human heart, includes a rigid annular or tubular supporting structure and a piezoelectric element disposed on at least a portion of the outer surface thereof. The piezoelectric element delivers an electrical signal when subjected to a pressure variation, and exhibits circumferential sensitivity. The rigidity of the sensor is defined to satisfy predetermined criteria to ensure that the sensor, when sensing pressure transferred to the sensor through an on-growth of tissue on the sensor, which is at least 90% of the signal which the sensor would emit without the on-growth.

Abstract translation: 用于放置在诸如人心脏的生物体中的用于引导或导管的流体压力传感器包括刚性环形或管状支撑结构和设置在其外表面的至少一部分上的压电元件。 当经受压力变化时，压电元件传递电信号，并且具有周向灵敏度。 传感器的刚度被定义为满足预定的标准，以确保传感器在通过传感器上的组织的增长传感到传感器的压力时，其传感器将不会发射的信号的至少90％ 增长。

公开(公告)号：US6064910A

公开(公告)日：2000-05-16

申请号：US978366

申请日：1997-11-25

Applicant: Jonas Andersson ,  Johan Lidman ,  Carolina Bigert

Inventor： Jonas Andersson ,  Johan Lidman ,  Carolina Bigert

IPC: G01N33/49 ,  A61B5/00 ,  A61B5/0205 ,  A61B5/0245 ,  A61B5/025 ,  A61B5/08 ,  A61B5/11 ,  A61N1/365

CPC classification number: A61B7/003 ,  A61B5/02455 ,  A61B5/0816 ,  A61B5/7232

Abstract: A device for determining the respiration rate and/or respiration depth of a patient includes a sensor for sensing heart sounds and an analyzer for analyzing the variation of the amplitude of the sensed heart sounds to determine the respiration rate and/or respiration depth from this amplitude variation. An apparatus for monitoring the respiration of a patient includes such a device and the analyzer is arranged to determine an anomaly in the amplitude variation of the sensed heart sounds as an indication of a respiration anomaly.

Abstract translation: 用于确定患者的呼吸速率和/或呼吸深度的装置包括用于感测心脏声音的传感器和用于分析感测到的心脏声音的振幅的变化的分析器，以从该幅度确定呼吸速率和/或呼吸深度 变异。 用于监测患者的呼吸的装置包括这样的装置，并且分析器布置成确定感测到的心音的振幅变化中的异常，作为呼吸异常的指示。

公开(公告)号：US5694952A

公开(公告)日：1997-12-09

申请号：US771151

申请日：1996-12-20

Applicant: Johan Lidman ,  Kenth Nilsson

Inventor： Johan Lidman ,  Kenth Nilsson

IPC: A61N1/362 ,  A61N1/37 ,  A61N1/372 ,  G01R33/02 ,  A61B5/05

CPC classification number: A61N1/37223 ,  A61N1/37 ,  G01R33/02 ,  A61N1/3718

Abstract: In a magnetic field detector as well as in a combined telemetry and magnetic field detector unit in a medical implant, a magnetic field sensor with a coil and a diode are employed for determining the presence of a magnetic field. For making such a determination, the coil is charged by a source of voltage for a defined period of time, the time for the discharge of the coil through the diode depending on whether a magnetic field is present. A detection signal indicating the presence of a magnetic field is generated if the discharge time is less than a defined time threshold value.

Abstract translation: 在磁场检测器以及医用植入物中的组合遥测和磁场检测器单元中，使用具有线圈和二极管的磁场传感器来确定磁场的存在。 为了进行这样的确定，线圈由电压源充电一定时间，根据磁场是否存在，通过二极管放电线圈的时间。 如果放电时间小于规定的时间阈值，则产生指示存在磁场的检测信号。

公开(公告)号：US06526984B1

公开(公告)日：2003-03-04

申请号：US09673815

申请日：2000-10-20

Applicant: Kenth Nilsson ,  Johan Lidman ,  Karin Ljungstrom ,  Charlotte Kjellman

Inventor： Kenth Nilsson ,  Johan Lidman ,  Karin Ljungstrom ,  Charlotte Kjellman

IPC: A61B1900

CPC classification number: A61L31/028 ,  A61N1/0565 ,  C04B35/495

Abstract: A biocompatible medical implant has at least one part thereof composed of ceramic material with the formula NaxKyNbO3, wherein 0≦x≦0.8, 0.2≦y≦1, and x+y=1. The ceramic material can be polarized to give the implant spatially varying piezoelectric properties. Signals can be measured from the respective piezoelectric regions of the selectively polarized ceramic material to provide an indication of the degree of fixation of the implant to surrounding tissue.

Abstract translation: 生物相容性医用植入体至少有一部分由具有式NaxKyNbO3的陶瓷材料构成，其中0≤x≤0.8,0.2≤y≤1且x + y = 1。 陶瓷材料可以被极化以给予植入物空间上变化的压电性质。 可以从选择性极化的陶瓷材料的各个压电区域测量信号，以提供植入物到周围组织的固定程度的指示。

公开(公告)号：US5662694A

公开(公告)日：1997-09-02

申请号：US572068

申请日：1995-12-14

Applicant: Johan Lidman ,  Kenth Nilsson

Inventor： Johan Lidman ,  Kenth Nilsson

IPC: A61N1/362 ,  A61N1/37 ,  A61N1/372 ,  G01R33/02 ,  A61N1/02

CPC classification number: A61N1/37223 ,  A61N1/37 ,  G01R33/02 ,  A61N1/3718

Abstract: In a magnetic field detector as well as in a combined telemetry and magnetic field detector unit in a medical implant, a magnetic field sensor with a coil and a diode are employed for determining the presence of a magnetic field. For making such a determination, the coil is charged by a source of voltage for a defined period of time, the time for the discharge of the coil through the diode depending on whether a magnetic field is present. A detection signal indicating the presence of a magnetic field is generated if the discharge time is less than a defined time threshold value.

公开(公告)号：US06829507B1

公开(公告)日：2004-12-07

申请号：US09787735

申请日：2001-10-15

Applicant: Johan Lidman ,  Lars Landelius ,  Charlotte Kjellman ,  Kenth Nilsson

Inventor： Johan Lidman ,  Lars Landelius ,  Charlotte Kjellman ,  Kenth Nilsson

IPC: A61N108

CPC classification number: A61N1/36542 ,  A61N1/36535 ,  G01P13/00 ,  G01P15/09 ,  Y10S128/901

Abstract: In an apparatus for determining the actual status of a piezoelectric sensor in a medical implant, electrical charges generated in the sensor, in response to changes in acceleration and/or gravitational force or other loads acting on the sensor, are continuously detected and the charges are then removed from the sensor, thereby maintaining the voltage across the sensor at a substantial constant zero level. The detected charges, both negative and positive, are integrated, thereby providing a resulting integrated signal representing the actual status of the sensor. The integrated signal is then evaluated for determining the physical activity and/or the posture of a patient in whom the medical implant is implanted.

Abstract translation: 在用于确定医用植入物中的压电传感器的实际状态的装置中，响应于加速度和/或重力作用在传感器上的其它负载的变化而在传感器中产生的电荷被连续地检测到，并且电荷是 然后从传感器中取出，从而将传感器两端的电压保持在基本恒定的零电平。 检测到的负和负的电荷被积分，从而提供表示传感器的实际状态的结果集成信号。 然后评估积分信号以确定植入医用植入物的患者的身体活动和/或姿势。