公开(公告)号：US06526984B1

公开(公告)日：2003-03-04

申请号：US09673815

申请日：2000-10-20

申请人： Kenth Nilsson ,  Johan Lidman ,  Karin Ljungstrom ,  Charlotte Kjellman

发明人： Kenth Nilsson ,  Johan Lidman ,  Karin Ljungstrom ,  Charlotte Kjellman

IPC分类号： A61B1900

CPC分类号： A61L31/028 ,  A61N1/0565 ,  C04B35/495

摘要： A biocompatible medical implant has at least one part thereof composed of ceramic material with the formula NaxKyNbO3, wherein 0≦x≦0.8, 0.2≦y≦1, and x+y=1. The ceramic material can be polarized to give the implant spatially varying piezoelectric properties. Signals can be measured from the respective piezoelectric regions of the selectively polarized ceramic material to provide an indication of the degree of fixation of the implant to surrounding tissue.

摘要翻译： 生物相容性医用植入体至少有一部分由具有式NaxKyNbO3的陶瓷材料构成，其中0≤x≤0.8,0.2≤y≤1且x + y = 1。 陶瓷材料可以被极化以给予植入物空间上变化的压电性质。 可以从选择性极化的陶瓷材料的各个压电区域测量信号，以提供植入物到周围组织的固定程度的指示。

公开(公告)号：US20090177049A1

公开(公告)日：2009-07-09

申请号：US11920380

申请日：2005-05-31

申请人： Tom Eriksson ,  Kenth Nilsson ,  Anna-Karin Johansson ,  Karin Ljungstrom ,  Koroush Lashgari ,  Annika Pohl ,  Gunnar Westin

发明人： Tom Eriksson ,  Kenth Nilsson ,  Anna-Karin Johansson ,  Karin Ljungstrom ,  Koroush Lashgari ,  Annika Pohl ,  Gunnar Westin

IPC分类号： A61B5/00 ,  C04B35/495 ,  B05D3/02 ,  B32B9/00

CPC分类号： C04B35/495 ,  A61N1/056 ,  A61N1/0565 ,  A61N1/36542 ,  A61N1/36564 ,  C01G33/00 ,  C01G33/006 ,  C01P2002/72 ,  C01P2002/77 ,  C01P2002/82 ,  C01P2002/88 ,  C01P2004/03 ,  C04B35/624 ,  C04B35/62645 ,  C04B35/62675 ,  C04B2235/3201 ,  C04B2235/3251 ,  C04B2235/3255 ,  C04B2235/441 ,  C04B2235/6562 ,  C04B2235/768 ,  C04B2235/80 ,  C23C18/1216 ,  C23C18/1225 ,  C23C18/1254 ,  C23C18/1283 ,  H01L41/1873 ,  H01L41/318

摘要： A method for producing a biocompatible material of the formula NaxKyNbO3, 0≦x≦0.8, 0.2≦y≦1, x+y=1 includes the steps of a) providing a Na-precursor and a K-precursor for NaxKyNbO3, b) mixing the precursors in solution wherein said precursors first react to form a sol and thereafter a gel, c) heat treating the gel to obtain an oxide of the material NaxKyNbO3, 0≦x≦0.8, 0.2≦y≦1, x+y=1. The material can be produced as a film, and the material or film can be provided on the exterior surface of a medical implant that will come into contact with body tissue and/or body fluids upon implantation thereof.

摘要翻译： 一种制备式NaxKyNbO3,0 <= x <= 0.8,0.2 <= y <= 1，x + y = 1的生物相容性材料的方法包括以下步骤：a）提供Na-前体和K-前体， NaxKyNbO3，b）在溶液中混合前体，其中所述前体首先反应形成溶胶，然后凝胶，c）热处理该凝胶以获得材料NaxKyNbO3的氧化物，0≤x≤0.8,0.2≤y <= 1，x + y = 1。 该材料可以作为膜制造，并且材料或膜可以设置在将在其植入时将与身体组织和/或体液接触的医用植入物的外表面上。

公开(公告)号：US20070100249A1

公开(公告)日：2007-05-03

申请号：US10562302

申请日：2004-05-06

申请人： Maria Torpo ,  Malin Ohlander ,  Anders Bjorling ,  Karin Ljungstrom

发明人： Maria Torpo ,  Malin Ohlander ,  Anders Bjorling ,  Karin Ljungstrom

IPC分类号： A61B5/02

CPC分类号： A61N1/3627 ,  A61B8/06 ,  A61B8/13

摘要： An implantable medical apparatus for detecting diastolic heart failure, DHF, has a DHF determining device for determining at least one DHF parameter for detecting a DHF state of the heart of a patient. The DHF includes circuitry for determining, as the DHF parameter, the time duration of a predetermined phase of diastole. A pacemaker has such an apparatus and a control unit that optimizes pacing therapy and pacemaker settings depending on the determined time duration. A corresponding method of detecting diastolic heart failure, DHF, includes determining at least one DHF parameter for detecting a DHF state of the heart of a patient. As the DHF parameter, the time duration of a predetermined phase of diastole is determined.

摘要翻译： 用于检测舒张性心力衰竭的可植入医疗装置DHF具有DHF确定装置，用于确定用于检测患者心脏的DHF状态的至少一个DHF参数。 DHF包括用于确定舒张期的预定阶段的持续时间作为DHF参数的电路。 起搏器具有这样的装置和控制单元，其根据确定的持续时间优化起搏治疗和起搏器设置。 检测舒张性心力衰竭DHF的相应方法包括确定用于检测患者心脏的DHF状态的至少一个DHF参数。 作为DHF参数，确定舒张期的预定相位的持续时间。

公开(公告)号：US20110257696A1

公开(公告)日：2011-10-20

申请号：US13140119

申请日：2008-12-17

申请人： Nils Holmstrom ,  Karin Ljungstrom ,  Michael Broome ,  Cecilia Emanuelsson

发明人： Nils Holmstrom ,  Karin Ljungstrom ,  Michael Broome ,  Cecilia Emanuelsson

IPC分类号： A61N1/365

CPC分类号： A61N1/3627 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/0816 ,  A61B5/11 ,  A61B5/7239 ,  A61B5/7289 ,  A61N1/36521 ,  A61N1/36578 ,  A61N1/3684 ,  A61N1/3686

摘要： In an implantable medical device and a method for monitoring ventricular synchronicity of a heart, impedance signals are measured that reflect septal wall movements and impedance amplitude peaks in the impedance signal are detected. A synchronicity index indicating a degree of synchronicity is determined based on detected impedance peaks, with at least two impedance peaks detected within a predetermined time window including a cardiac cycle or a part of a cardiac cycle indicating an increased dyssynchronicity in the ventricular contractions.

摘要翻译： 在可植入医疗装置和用于监测心脏心室同步性的方法中，测量阻抗信号，其反映了隔膜壁运动，并且检测阻抗信号中的阻抗幅度峰值。 基于检测到的阻抗峰值确定表示同步度的同步性指标，其中在包括心动周期的预定时间窗口或心跳周期的一部分中检测到至少两个阻抗峰值，指示心室收缩中的不同步性增加。

公开(公告)号：US20080269822A1

公开(公告)日：2008-10-30

申请号：US11666960

申请日：2004-11-02

申请人： Karin Ljungstrom ,  Anders Bjorling ,  Hans Strandberg

发明人： Karin Ljungstrom ,  Anders Bjorling ,  Hans Strandberg

IPC分类号： A61N1/368

CPC分类号： A61N1/372 ,  A61B5/029 ,  A61B5/0452 ,  A61N1/08

摘要： In a device and method for evaluating positions of a medical lead during an implantation procedure, an IEGM signal and a signal indicative of heart pumping activity are obtained for each of a number of different lead positions, and those signals are stored dependent on the different lead positions. A processor automatically determines a lead position, from among the stored lead positions, that results in most favorable hemodynamics of the heart, based on the IEGM signal and the pumping activity signal.

摘要翻译： 在用于评估植入程序期间医疗引线位置的装置和方法中，针对多个不同引导位置的每一个获得指示心脏泵送活动的IEGM信号和信号，并且这些信号取决于不同的引线 职位 基于IEGM信号和泵送活动信号，处理器根据存储的引导位置自动确定导致心脏最有利的血液动力学的引导位置。

公开(公告)号：US20050125042A1

公开(公告)日：2005-06-09

申请号：US10499253

申请日：2002-10-04

申请人： Kjell Noren ,  Karin Ljungstrom ,  Sven Kalling ,  Lars Mandal ,  Anders Bjorling

发明人： Kjell Noren ,  Karin Ljungstrom ,  Sven Kalling ,  Lars Mandal ,  Anders Bjorling

IPC分类号： A61N1/362 ,  A61N1/365 ,  A61N1/368

CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/3682 ,  A61N1/3684

摘要： In an implantable heart stimulating device, system and method, electrical stimulation pulses are delivered to first and second ventricles of a heart with a variable time interval therebetween, and signals are sensed at two different positions in the heart, from which an impedance value is derived. A minimum value and a maximum value of the impedance value are determined during a heart cycle, and a relationship between the minimum and maximum values also is determined. The time interval is varied and the relationship is monitored over a number of heart cycles. The time interval is set so that the relationship satisfies a predetermined requirement.

摘要翻译： 在可植入心脏刺激装置，系统和方法中，将电刺激脉冲以其间具有可变时间间隔输送到心脏的第一和第二心室，并且在心脏中的两个不同位置处感测信号，从其中导出阻抗值 。 在心脏周期期间确定阻抗值的最小值和最大值，并且还确定最小值与最大值之间的关系。 时间间隔变化，并且在许多心脏周期上监测关系。 设定时间间隔使得该关系满足预定的要求。

公开(公告)号：US20060235325A1

公开(公告)日：2006-10-19

申请号：US10524196

申请日：2003-06-23

申请人： Nils Holmstrom ,  Martin Obel ,  Anna Norlin ,  Kenneth Dahlberg ,  Anders Bjorling ,  Sven Kalling ,  Karin Ljungstrom ,  Kjell Noren

发明人： Nils Holmstrom ,  Martin Obel ,  Anna Norlin ,  Kenneth Dahlberg ,  Anders Bjorling ,  Sven Kalling ,  Karin Ljungstrom ,  Kjell Noren

IPC分类号： A61B5/05 ,  A61B5/02

CPC分类号： A61B5/0538 ,  A61B5/053 ,  A61N1/3627

摘要： A congestive heart failure monitor has an impedance measuring unit that measures the impedance between at least two electrodes implanted in a patient, to use a detected change of the measured impedance as an indication of a change in the left atrium volume. Any analyzing unit analyzes the measured impedance and detects insipient congestive heart failure dependent on a quotient of a maximum value of the measured impedance and a minimum value of the measured impedance during a cardiac cycle.

摘要翻译： 充血性心力衰竭监测器具有阻抗测量单元，其测量植入患者中的至少两个电极之间的阻抗，以使用检测到的测量阻抗的变化作为左心房体积变化的指示。 任何分析单元分析所测量的阻抗，并根据所测量的阻抗的最大值和心动周期内所测量的阻抗的最小值来检测不利的充血性心力衰竭。

公开(公告)号：US20060149327A1

公开(公告)日：2006-07-06

申请号：US10562109

申请日：2004-04-26

申请人： Sven-erik Hedberg ,  Anders Bjorling ,  Maria Torpo ,  Karin Ljungstrom

发明人： Sven-erik Hedberg ,  Anders Bjorling ,  Maria Torpo ,  Karin Ljungstrom

IPC分类号： A61N1/368

CPC分类号： A61B5/021 ,  A61B5/02154 ,  A61N1/3627 ,  A61N1/36564 ,  A61N1/3702 ,  G06F19/00

摘要： An implantable medical apparatus for detecting diastolic heart failure, DHF, has a DHF determining device for determining at least one blood pressure parameter for detecting a DHF state of the heart of a patient. The DHF determining device includes a pressure measuring unit for measuring pulse pressure in a cardiac cycle for a predetermined workload situation of the patient as the blood pressure parameter, and a comparator compares the measured pulse pressure with a predetermined reference value. A pacemaker includes such an apparatus and a control unit that optimizes pacing therapy depending on the result of the comparison of the measured pulse pressures with the predetermined reference values. A corresponding method of detecting diastolic heart failure, DHF, includes the step of determining at least one blood pressure parameter for detecting a DHF state of the heart of a patient by determining, as said blood pressure parameter, the pulse pressure in a cardiac cycle for a predetermined workload situation of the patient, and the determined pulse pressure is compared with a predetermined reference value.