公开(公告)号：US6162631A

公开(公告)日：2000-12-19

申请号：US989493

申请日：1997-12-12

申请人： Hans-Peter Hauser ,  Stefan Knapp ,  Stefan Brust ,  Lutz G. Gurtler ,  Josef Eberle ,  Lazare Kaptue ,  Leopold Achengui Zekeng

发明人： Hans-Peter Hauser ,  Stefan Knapp ,  Stefan Brust ,  Lutz G. Gurtler ,  Josef Eberle ,  Lazare Kaptue ,  Leopold Achengui Zekeng

IPC分类号： G01N33/569 ,  A61K39/00 ,  A61K39/21 ,  A61P31/12 ,  A61P31/18 ,  C07K14/155 ,  C07K14/16 ,  C12N7/00 ,  C12N15/00 ,  C12N15/09 ,  C12N15/49 ,  C12Q1/68 ,  C12Q1/70 ,  C12R1/92 ,  G09B19/00

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N2740/16021 ,  C12N2740/16022 ,  C12N2740/16122 ,  Y10S435/974 ,  Y10S435/975 ,  Y10S436/828 ,  Y10S530/812

摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-2901/94 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 95012601. The characteristic antigens which can be obtained from the virus and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the partial DNA and amino acid sequences of the virus.

摘要翻译： 公开了具有命名为MVP-2901/94的新型免疫缺陷病毒，其已经在欧洲动物细胞培养物库（ECACC）V 95012601下保藏。可以从病毒获得的特征性抗原 用于检测与免疫缺陷病相关的逆转录病毒的抗体也被公开，病毒的部分DNA和氨基酸序列也被公开。

公开(公告)号：US5798205A

公开(公告)日：1998-08-25

申请号：US602713

申请日：1996-02-16

申请人： Hans-Peter Hauser ,  Stefan Knapp ,  Stefan Brust ,  Lutz G. Gurtler ,  Josef Eberle ,  Lazare Kaptue ,  Leopold Achenqui Zekeng

发明人： Hans-Peter Hauser ,  Stefan Knapp ,  Stefan Brust ,  Lutz G. Gurtler ,  Josef Eberle ,  Lazare Kaptue ,  Leopold Achenqui Zekeng

IPC分类号： G01N33/569 ,  A61K39/00 ,  A61K39/21 ,  A61P31/12 ,  A61P31/18 ,  C07K14/155 ,  C07K14/16 ,  C12N7/00 ,  C12N15/00 ,  C12N15/09 ,  C12N15/49 ,  C12Q1/68 ,  C12Q1/70 ,  C12R1/92

CPC分类号： C07K14/005 ,  C12N7/00 ,  A61K39/00 ,  C12N2740/16021 ,  C12N2740/16022 ,  C12N2740/16122 ,  Y10S435/974 ,  Y10S435/975 ,  Y10S436/828 ,  Y10S530/812

摘要： A novel HIV type O immunodeficiency virus is disclosed which has the designation MVP-2901/94 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 95012601. The characteristic antigens which can be obtained from the virus and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the partial DNA and amino acid sequences of the virus.

摘要翻译： 公开了一种新型的HIV型O免疫缺陷病毒，其命名为MVP-2901/94，并且已经在欧洲动物细胞培养物收集库（ECACC）V 95012601中保藏。可以从病毒获得的特征性抗原 并且还可以用于检测与免疫缺陷病相关的抗逆转录病毒的抗体，以及病毒的部分DNA和氨基酸序列。

公开(公告)号：US06548635B1

公开(公告)日：2003-04-15

申请号：US09610271

申请日：2000-07-06

申请人： Hans-Peter Hauser ,  Stefan Knapp ,  Stefan Brust ,  Lutz G. Gürtler ,  Josef Eberle ,  Lazare Kaptue ,  Léopold Achengui Zekeng

发明人： Hans-Peter Hauser ,  Stefan Knapp ,  Stefan Brust ,  Lutz G. Gürtler ,  Josef Eberle ,  Lazare Kaptue ,  Léopold Achengui Zekeng

IPC分类号： A61K3804

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N2740/16021 ,  C12N2740/16022 ,  C12N2740/16122 ,  Y10S435/974 ,  Y10S435/975 ,  Y10S530/812

摘要： A novel HIV type O immunodeficiency virus is disclosed which has the designation MVP-2901/94 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 950121601. The characteristic antigens which can be obtained from the virus and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the partial DNA and amino acid sequences of the virus.

摘要翻译： 公开了一种新型HIV型O免疫缺陷病毒，其命名为MVP-2901/94，并已经在欧洲动物细胞培养物保藏中心（ECACC）VAL 950121601中保藏。可以从病毒获得的特征性抗原 并且还可以用于检测与免疫缺陷病相关的抗逆转录病毒的抗体，以及病毒的部分DNA和氨基酸序列。

公开(公告)号：US06974866B2

公开(公告)日：2005-12-13

申请号：US10357400

申请日：2003-02-04

申请人： Hans-Peter Hauser ,  Stefan Knapp ,  Stefan Brust ,  Lutz G. Gürtler ,  Josef Eberle ,  Lazare Kaptue ,  Léopold Achenqui Zekeng

发明人： Hans-Peter Hauser ,  Stefan Knapp ,  Stefan Brust ,  Lutz G. Gürtler ,  Josef Eberle ,  Lazare Kaptue ,  Léopold Achenqui Zekeng

IPC分类号： A61K39/00 ,  C07K14/16 ,  C12N7/00 ,  C07H21/04

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N2740/16021 ,  C12N2740/16022 ,  C12N2740/16122 ,  Y10S435/974 ,  Y10S435/975 ,  Y10S530/812

摘要： A novel HIV type O immunodeficiency virus is disclosed which has the designation MVP-2901/94 and which has been deposited with the European collection of animal Cell Cultures (ECACC) under No. V 950121601. The characteristic antigens which can be obtained from the virus and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the partial DNA and amino acid sequences of the virus.

摘要翻译： 公开了一种新型的HIV型O免疫缺陷病毒，其命名为MVP-2901/94，并且已经在欧洲的动物细胞培养物集合（ECACC）V 950121601中保藏。可从病毒获得的特征性抗原 并且还可以用于检测与免疫缺陷病相关的抗逆转录病毒的抗体，以及病毒的部分DNA和氨基酸序列。

公开(公告)号：US6120990A

公开(公告)日：2000-09-19

申请号：US90190

申请日：1998-06-04

申请人： Stefan Brust ,  Hans-Peter Hauser ,  Stefan Knapp ,  Helmut Peters

发明人： Stefan Brust ,  Hans-Peter Hauser ,  Stefan Knapp ,  Helmut Peters

IPC分类号： G01N33/53 ,  G01N33/531 ,  G01N33/543 ,  G01N33/68 ,  C12Q1/70 ,  C12Q1/04

CPC分类号： G01N33/6854 ,  G01N33/53 ,  G01N33/531 ,  G01N33/54306

摘要： The present invention is directed to an immunochemical method for qualitatively or quantitatively detecting an analyte in which a first and a second binding component are contacted with the analyte, followed by detection of the binding of the binding components to the analyte. According to the invention, both of the binding components are prepared recombinantly in the same host using different vectors (V1 and V2) for expressing fusion proteins, with the first binding component being expressed as a fusion protein F1 in vector V1 and the second binding component being expressed as a fusion protein F2 in vector V2. The novel method, which can also be employed for simultaneously determining several analytes, is more sensitive and specific than prior known methods.

摘要翻译： 本发明涉及用于定性或定量检测其中第一和第二结合组分与分析物接触的分析物的免疫化学方法，然后检测结合组分与分析物的结合。 根据本发明，使用不同的载体（V1和V2）在同一宿主中重组制备两种结合成分，用于表达融合蛋白，其中第一结合成分在载体V1中表达为融合蛋白F1，第二结合成分 在载体V2中表达为融合蛋白F2。 也可以用于同时测定多种分析物的新方法比现有已知的方法更敏感和特异。

公开(公告)号：US20070105219A1

公开(公告)日：2007-05-10

申请号：US11634254

申请日：2006-12-06

申请人： Lutz Guertler ,  Josef Eberle ,  Albrecht Brunn ,  Stefan Knapp ,  Hans-Peter Hauser

发明人： Lutz Guertler ,  Josef Eberle ,  Albrecht Brunn ,  Stefan Knapp ,  Hans-Peter Hauser

IPC分类号： C12Q1/68 ,  C12N5/06 ,  C12N5/16

CPC分类号： G01N33/56988 ,  A61K39/00 ,  C07K14/005 ,  C12N2740/16021 ,  C12N2740/16022 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12Q1/703

摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.

公开(公告)号：US20070264627A1

公开(公告)日：2007-11-15

申请号：US11634155

申请日：2006-12-06

申请人： Lutz Guertler ,  Josef Eberle ,  Albrecht Brunn ,  Stefan Knapp ,  Hans-Peter Hauser

发明人： Lutz Guertler ,  Josef Eberle ,  Albrecht Brunn ,  Stefan Knapp ,  Hans-Peter Hauser

IPC分类号： C12Q1/70 ,  C12N7/00

CPC分类号： G01N33/56988 ,  A61K39/00 ,  C07K14/005 ,  C12N2740/16021 ,  C12N2740/16022 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12Q1/703

摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.

摘要翻译： 公开了一种新型免疫缺陷病毒，其名称为MVP-5180/91，并且已经在欧洲动物细胞培养物收集库（ECACC）V 920 52 318下保藏。可从其中获得的特征性抗原，其中 可以用于检测与免疫缺陷病相关的逆转录病毒的抗体，以及病毒的DNA和氨基酸序列也被公开。

公开(公告)号：US20050053920A1

公开(公告)日：2005-03-10

申请号：US10829442

申请日：2004-04-22

申请人： Lutz Guertler ,  Josef Eberle ,  Albrecht Brunn ,  Stefan Knapp ,  Hans-Peter Hauser

发明人： Lutz Guertler ,  Josef Eberle ,  Albrecht Brunn ,  Stefan Knapp ,  Hans-Peter Hauser

IPC分类号： A61K39/21 ,  A61K39/00 ,  A61P31/12 ,  A61P31/18 ,  C07K14/00 ,  C07K14/155 ,  C07K14/16 ,  C12N5/02 ,  C12N7/00 ,  C12N7/01 ,  C12N15/09 ,  C12N15/48 ,  C12P21/02 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/53 ,  G01N33/569 ,  G01N33/68

CPC分类号： G01N33/56988 ,  A61K39/00 ,  C07K14/005 ,  C12N2740/16021 ,  C12N2740/16022 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12Q1/703

摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.

摘要翻译： 公开了一种新型免疫缺陷病毒，其名称为MVP-5180/91，并且已经在欧洲动物细胞培养物收集库（ECACC）V 920 52 318下保藏。可从其中获得的特征性抗原，其中 可以用于检测与免疫缺陷病相关的逆转录病毒的抗体，以及病毒的DNA和氨基酸序列也被公开。

公开(公告)号：US06531587B2

公开(公告)日：2003-03-11

申请号：US09886150

申请日：2001-06-22

申请人： Lutz G. Guertler ,  Josef Eberle ,  Albrecht V. Brunn ,  Stefan Knapp ,  Hans-Peter Hauser

发明人： Lutz G. Guertler ,  Josef Eberle ,  Albrecht V. Brunn ,  Stefan Knapp ,  Hans-Peter Hauser

IPC分类号： C07H2104

CPC分类号： G01N33/56988 ,  A61K39/00 ,  C07K14/005 ,  C12N2740/16021 ,  C12N2740/16022 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12Q1/703

摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.

公开(公告)号：US06528626B2

公开(公告)日：2003-03-04

申请号：US09886156

申请日：2001-06-22

申请人： Lutz G. Guertler ,  Josef Eberle ,  Albrecht v. Brunn ,  Stefan Knapp ,  Hans-Peter Hauser

发明人： Lutz G. Guertler ,  Josef Eberle ,  Albrecht v. Brunn ,  Stefan Knapp ,  Hans-Peter Hauser

IPC分类号： C07K1600

CPC分类号： G01N33/56988 ,  A61K39/00 ,  C07K14/005 ,  C12N2740/16021 ,  C12N2740/16022 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12Q1/703

摘要： A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318. The characteristic antigens which can be obtained from it and which can be employed for detecting antibodies against retroviruses which are associated with immunodeficiency diseases are also disclosed, as are the DNA and amino acid sequences of the virus.