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1.发明申请Self-Assembled Combinatorial Encoding Nanoarrays for Multiplexed Biosensing 审中-公开用于复用生物传感的自组装组合编码纳米阵列公开(公告)号：US20100009868A1
公开(公告)日：2010-01-14
申请号：US12374259
申请日：2007-09-11
申请人： Hao Yan , Chenxiang Lin , Evaldas Katilius , Yan Liu
发明人： Hao Yan , Chenxiang Lin , Evaldas Katilius , Yan Liu
CPC分类号： C12N15/10 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00599 , B01J2219/00605 , B01J2219/00626 , B01J2219/00659 , B01J2219/00677 , B01J2219/00709 , B01J2219/00722 , B82Y30/00 , C40B50/14 , C40B50/16
摘要： The present invention provides combinatorial encoding nucleic acid tiling arrays and methods for their use and synthesis.
摘要翻译： 本发明提供组合编码核酸贴片阵列及其使用和合成方法。
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公开(公告)号：US08895241B2
公开(公告)日：2014-11-25
申请号：US13417035
申请日：2012-03-09
申请人： Urs Ochsner , Evaldas Katilius , Nebojsa Janjic
发明人： Urs Ochsner , Evaldas Katilius , Nebojsa Janjic
IPC分类号： C12Q1/68 , C12N15/115 , C07H21/02 , C07H21/04
CPC分类号： G01N33/573 , C12N15/115 , C12N2310/16 , G01N2333/91102
摘要： The present disclosure relates generally to the field of nucleic acids and, more particularly, to aptamers capable of binding to toxins produced by Clostridium difficile; diagnostic kits and methods comprising such aptamers; and methods of making and using such aptamers.
摘要翻译： 本公开一般涉及核酸领域，更具体地涉及能够结合艰难梭菌产生的毒素的适体; 包括这种适体的诊断试剂盒和方法; 以及制造和使用这些适体的方法。
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公开(公告)号：US08703416B2
公开(公告)日：2014-04-22
申请号：US13525271
申请日：2012-06-15
申请人： Glenn Sanders , Evaldas Katilius , Larry Gold
发明人： Glenn Sanders , Evaldas Katilius , Larry Gold
CPC分类号： C12N15/115 , C12N5/061 , C12N2310/16 , C12N2320/10 , C12N2330/00
摘要： The present disclosure describes the isolation, identification and purification of aptamers having sufficiently high affinity and specificity to capture and immobilize intact sperm cells in the presence of female epithelial cells and other non-sperm semen components. The present disclosure also describes affinity-based methods for the detection of sperm cells in samples, including from forensic sample surrogates consisting of swab eluates containing a mixture of HeLa cells and sperm cells. The present disclosure describes methods for eluting sperm cell samples from swabs; methods for purifying sperm cells and methods for amplification and analysis of male DNA. The affinity-based system described herein is inexpensive, simple to use and easily implemented in forensic laboratories.
摘要翻译： 本公开描述了具有足够高的亲和性和特异性的适体的分离，鉴定和纯化，以在存在雌性上皮细胞和其它非精液精液组分的情况下捕获和固定完整精子细胞。 本公开还描述了用于检测样品中精子细胞的基于亲和性的方法，包括由包含HeLa细胞和精子细胞的混合物的拭子洗脱液组成的法医样品替代物。 本公开描述了从拭子洗脱精子细胞样品的方法; 纯化精子细胞的方法和扩增和分析雄性DNA的方法。 本文描述的基于亲和性的系统是廉价的，易于使用并且容易地在法医实验室中实施。
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公开(公告)号：US20120264117A1
公开(公告)日：2012-10-18
申请号：US13525271
申请日：2012-06-15
申请人： Glenn Sanders , Evaldas Katilius , Larry Gold
发明人： Glenn Sanders , Evaldas Katilius , Larry Gold
CPC分类号： C12N15/115 , C12N5/061 , C12N2310/16 , C12N2320/10 , C12N2330/00
摘要： The present disclosure describes the isolation, identification and purification of aptamers having sufficiently high affinity and specificity to capture and immobilize intact sperm cells in the presence of female epithelial cells and other non-sperm semen components. The present disclosure also describes affinity-based methods for the detection of sperm cells in samples, including from forensic sample surrogates consisting of swab eluates containing a mixture of HeLa cells and sperm cells. The present disclosure describes methods for eluting sperm cell samples from swabs; methods for purifying sperm cells and methods for amplification and analysis of male DNA. The affinity-based system described herein is inexpensive, simple to use and easily implemented in forensic laboratories.
摘要翻译： 本公开描述了具有足够高的亲和性和特异性的适体的分离，鉴定和纯化，以在存在雌性上皮细胞和其它非精液精液组分的情况下捕获和固定完整精子细胞。 本公开还描述了用于检测样品中精子细胞的基于亲和性的方法，包括由包含HeLa细胞和精子细胞的混合物的拭子洗脱液组成的法医样品替代物。 本公开描述了从拭子洗脱精子细胞样品的方法; 纯化精子细胞的方法和扩增和分析雄性DNA的方法。 本文描述的基于亲和性的系统是廉价的，易于使用并且容易地在法医实验室中实施。
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5.发明申请Methods to create fluorescent biosensors using aptamers with fluorescent base analogs 审中-公开使用具有荧光基础类似物的适体产生荧光生物传感器的方法公开(公告)号：US20090054250A1
公开(公告)日：2009-02-26
申请号：US11664914
申请日：2005-11-02
CPC分类号： C12N15/115 , C07H21/00 , C12N2310/16 , C12N2310/33
摘要： The present invention provides improved methods for generating fluorescent aptamer polynucleotides, novel polynucleotides, and methods for use thereof.
摘要翻译： 本发明提供了用于产生荧光适体多核苷酸的改进方法，新的多核苷酸及其使用方法。
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公开(公告)号：US20120231467A1
公开(公告)日：2012-09-13
申请号：US13417035
申请日：2012-03-09
申请人： Urs Ochsner , Evaldas Katilius , Nebojsa Janjic
发明人： Urs Ochsner , Evaldas Katilius , Nebojsa Janjic
CPC分类号： G01N33/573 , C12N15/115 , C12N2310/16 , G01N2333/91102
摘要： The present disclosure relates generally to the field of nucleic acids and, more particularly, to aptamers capable of binding to toxins produced by Clostridium difficile; diagnostic kits and methods comprising such aptamers; and methods of making and using such aptamers.
摘要翻译： 本公开一般涉及核酸领域，更具体地涉及能够结合艰难梭菌产生的毒素的适体; 包括这种适体的诊断试剂盒和方法; 以及制备和使用这些适体的方法。
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