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    Recombinant methods for production of serine protease inhibitors and DNA sequences useful for same
    6.
    发明授权
    Recombinant methods for production of serine protease inhibitors and DNA sequences useful for same 失效
    用于生产丝氨酸蛋白酶抑制剂和可用于其的DNA序列的重组方法

    公开(公告)号：US6132990A

    公开(公告)日：2000-10-17

    申请号：US712354

    申请日：1991-06-07

    申请人： Pradip K. Bandyopadhyay ,  Stephen P. Eisenberg ,  Gary L. Stetler ,  Robert C. Thompson

    发明人： Pradip K. Bandyopadhyay ,  Stephen P. Eisenberg ,  Gary L. Stetler ,  Robert C. Thompson

    IPC分类号： A61K38/00 ,  C07K14/81 ,  C12N15/15 ,  C12N15/70 ,  A61K37/64 ,  C12N15/11 ,  C12N15/79

    CPC分类号： C07K14/811 ,  C12N15/70 ,  A61K38/00 ,  C07K2319/02

    摘要： A synthetic DNA sequence and its genetic equivalents are disclosed which sequences are capable, when used in a recombinant DNA method, of directing production of a serine protease inibitor protein. Recombinant DNA methods for the production of serine protease inhibitor proteins are also disclosed. These methods incorporate either the synthetic DNA sequence of the present invention or natural DNA sequences isolated from human cDNA or genomic libraries.In addition, a single polypeptide chain protein is disclosed which is capable of inhibiting chymotrypsin and elastase but not trypsin. In one embodiment, this protein is a shortened from (single domain) of the protein produced by the method described herein.

    摘要翻译： 公开了合成DNA序列及其遗传等同物，当在重组DNA方法中使用时，能够引导产生丝氨酸蛋白酶内含蛋白的序列。 还公开了用于产生丝氨酸蛋白酶抑制蛋白的重组DNA方法。 这些方法包括本发明的合成DNA序列或从人cDNA或基因组文库分离的天然DNA序列。 此外，公开了能够抑制糜蛋白酶和弹性蛋白酶而不是胰蛋白酶的单个多肽链蛋白。 在一个实施方案中，该蛋白质是从通过本文所述的方法产生的蛋白质的（单结构域）缩短。

    Serine protease inhibitor analogs
    7.
    发明授权
    Serine protease inhibitor analogs 失效
    丝氨酸蛋白酶抑制剂类似物

    公开(公告)号：US5900400A

    公开(公告)日：1999-05-04

    申请号：US283477

    申请日：1994-07-29

    申请人： Robert C. Thompson ,  Kjell Ohlsson

    发明人： Robert C. Thompson ,  Kjell Ohlsson

    IPC分类号： A61K38/00 ,  A61P1/14 ,  A61P31/04 ,  C07K14/81 ,  C12N15/15 ,  A61K38/55

    CPC分类号： C07K14/811 ,  A61K38/00 ,  Y10S530/854

    摘要： Analogs of the serine protease inhibitors in which the amino acid sequence is varied slightly are disclosed, which analogs variously show improved properties including improved resistance to oxidative inactivation, improved ability to inhibit pancreatic elastase, improved ability to inhibit cathepsin G, and improved ability to inhibit trypsin.

    摘要翻译： 公开了其中氨基酸序列略微变化的丝氨酸蛋白酶抑制剂的类似物，其各种显示出改善的性质，包括改善的抗氧化失活性，改善的抑制胰腺弹性蛋白酶的能力，改进的抑制组织蛋白酶G的能力和改善的抑制能力 胰蛋白酶。

    Confidential electronic election system
    9.
    发明授权
    Confidential electronic election system 有权
    机密电子选举制度

    公开(公告)号：US07597258B2

    公开(公告)日：2009-10-06

    申请号：US11739039

    申请日：2007-04-23

    申请人： Gerald B. Feldkamp ,  G. Scott Scholler ,  Michael J. Baum ,  Robert C. Thompson

    发明人： Gerald B. Feldkamp ,  G. Scott Scholler ,  Michael J. Baum ,  Robert C. Thompson

    IPC分类号： G07C13/00

    CPC分类号： G07C13/00

    摘要： A system is provided for improved elections which may separate the identity of the voter from the content of the vote she casts. The system may be implemented using electronic or other communication methods. Separate entities may be used to implement the system, with one entity acting as a member services system, and another entity acting as an election services system. The member services system may control voter information for all members of a group eligible to vote in a specific election. The election services system may control the voting process, including receiving votes from members, without having access to the voter information controlled by the member services system. The two entities might be configured so that no single person or organization may connect the voter information to a particular vote. This separation of voter information from information in the members' votes may comply with various government regulations relating to elections.

    摘要翻译： 提供了一个改进选举的制度，可以将选民的身份与投票的内容分开。 该系统可以使用电子或其他通信方法来实现。 可以使用单独的实体来实施系统，一个实体充当成员服务系统，另一个实体作为选举服务系统。 会员服务制度可以控制有资格在特定选举中投票的团体的所有成员的选民信息。 选举服务制度可以控制投票过程，包括收到成员投票，无需访问由会员服务系统控制的选民信息。 这两个实体可能被配置为使得没有一个人或组织可以将选民信息连接到特定的投票。 将选民信息与成员投票中的资料分开可能符合有关选举的各种政府规定。