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    Heterocyclic compounds and their therapeutic use
    2.
    发明授权
    Heterocyclic compounds and their therapeutic use 失效
    杂环化合物及其治疗用途

    公开(公告)号：US06455561B1

    公开(公告)日：2002-09-24

    申请号：US09976811

    申请日：2001-10-12

    申请人： Hazel Joan Dyke ,  Christopher Lowe ,  John Gary Montana

    发明人： Hazel Joan Dyke ,  Christopher Lowe ,  John Gary Montana

    IPC分类号： A61K3142

    CPC分类号： C07D405/12 ,  C07D413/12

    摘要： The present invention pertains to compositions and methods for treating disease states which are capable of being modulated by inhibition of phosphodiesterase IV or Tumour Necrosis Factor, or that is a pathological condition associated with a function of phosphodiesterase IV, eosinophil accumulation or a function of the eosinophil, said method comprising administering to a person or animal in need of such treatment an effective amount of the compound of a formula wherein R1 is C1-3 alkyl optionally substituted with one or more fluorines; R2 is CH2OCH3 or 2 or 3-tetrahydrofuranyl; R3 is a pyrazole, imidazole or isoxazole group of partial formula (A), (B) or (C) R4 is C 1-3 alkyl; and R5 and R6, which may be the same or different, each represents C1-3 alkyl, halogen, CF3 or CN; or a pharmaceutically-acceptable salt thereof

    摘要翻译： 本发明涉及用于治疗能够通过抑制磷酸二酯酶IV或肿瘤坏死因子调节的疾病状态的组合物和方法，或者是与磷酸二酯酶IV，嗜酸性粒细胞积累或嗜酸性粒细胞的功能相关的病理状况 所述方法包括向需要这种治疗的人或动物施用有效量的化学式R 1是任选被一个或多个氟取代的C 1-3烷基; R 2是CH 2 OCH 3或2或3-四氢呋喃基; R 3是 部分式（A），（B）或（C）R 4的吡唑，咪唑或异恶唑基是C 1-3烷基; 和R 5和R 6可以相同或不同，各自表示C 1-3烷基，卤素，CF 3或CN;或其药学上可接受的盐

    Heterocyclic compounds and their therapeutic use
    5.
    发明授权
    Heterocyclic compounds and their therapeutic use 失效
    杂环化合物及其治疗用途

    公开(公告)号：US06331556B2

    公开(公告)日：2001-12-18

    申请号：US09780657

    申请日：2001-02-09

    申请人： Hazel Joan Dyke ,  Christopher Lowe ,  John Gary Montana

    发明人： Hazel Joan Dyke ,  Christopher Lowe ,  John Gary Montana

    IPC分类号： A61K31422

    CPC分类号： C07D405/12 ,  C07D413/12

    摘要： A compound of the formula wherein R1 is C1-3 alkyl optionally substituted with one or more fluorines; R2 is CH2OCH3 or 2 or 3-tetrahydrofuranyl; R3 is a pyrazole, imidazole or isoxazole group of partial formula (A), (B) or (C)  R4 is C1-3 alkyl; and R5 and R6, which may be the same or different, each represents C1-3 alkyl, halogen, CF3 or CN; or a pharmaceutically-acceptable salt thereof.

    摘要翻译： 式R 1的化合物是任选被一个或多个氟取代的C 1-3烷基; R 2是CH 2 OCH 3或2或3-四氢呋喃基; R 3是部分式（A），（B）或（B）的吡唑，咪唑或异恶唑基， C）R 4是C 1-3烷基; 和R 5和R 6可以相同或不同，各自表示C 1-3烷基，卤素，CF 3或CN;或其药学上可接受的盐。

    Heterocyclic compounds and their therapeutic use
    10.
    发明授权
    Heterocyclic compounds and their therapeutic use 失效
    杂环化合物及其治疗用途

    公开(公告)号：US06262070B1

    公开(公告)日：2001-07-17

    申请号：US09433274

    申请日：1999-11-03

    申请人： Hazel Joan Dyke ,  John Gary Montana

    发明人： Hazel Joan Dyke ,  John Gary Montana

    IPC分类号： C07D40112

    CPC分类号： C07D401/12 ,  Y10S514/912

    摘要： N-oxides of formula (i) wherein R1 is CH3, CH2F, CHF2 or CF3; R2 is CH3 or CF3; R3 is F, Cl, Br, CN or CH3; and R4 is H, F, Cl, Br, CN or CH3; and pharmaceutically-acceptable salts thereof, are useful as therapeutic agents, e.g. for the treatment of inflammatory diseases.

    摘要翻译： 式（ⅰ）的N-氧化物，其中R 1是CH 3，CH 2 F，CHF 2或CF 3; R 2是CH 3或CF 3; R 3是F，Cl，Br，CN或CH 3; 和R 4是H，F，Cl，Br，CN或CH 3;及其药学上可接受的盐，可用作治疗剂。 用于治疗炎性疾病。