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公开(公告)号：US20080050377A1
公开(公告)日：2008-02-28
申请号：US10553491
申请日：2004-04-16
申请人： Heidi Ackerly , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Marsters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
发明人： Heidi Ackerly , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Marsters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00 , C12N1/00 , C12N15/63 , G01N33/574 , G01N33/53 , C12N15/13 , C07K14/435 , C07K16/18
CPC分类号： C07K16/32 , C07K16/22 , C07K16/4283 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present invention provides novel polypeptides, antibodies, antagonists, agonists, potentiators, nucleic acid molecules, compositions and methods relating to the STOP-1 polypeptide that are useful for treating and preventing diseases and for medical diagnosis and research. The present invention also provides consensus sequences and specific sequences for antibodies that specifically bind to STOP-1 that are useful in the methods described herein.
摘要翻译： 本发明提供了可用于治疗和预防疾病和医学诊断和研究的新型多肽，抗体，拮抗剂，激动剂，增效剂，核酸分子，与STOP-1多肽相关的组合物和方法。 本发明还提供了与本文所述方法有用的特异性结合STOP-1的抗体的共有序列和特异性序列。
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公开(公告)号：US20110112279A1
公开(公告)日：2011-05-12
申请号：US12845470
申请日：2010-07-28
申请人： HEIDI ACKERLY , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Marsters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
发明人： HEIDI ACKERLY , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Marsters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
IPC分类号： C07K16/18
CPC分类号： C07K16/32 , C07K16/22 , C07K16/4283 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present invention provides novel polypeptides, antibodies, antagonists, agonists, potentiators, nucleic acid molecules, compositions and methods relating to the STOP-1 polypeptide that are useful for treating and preventing diseases and for medical diagnosis and research. The present invention also provides consensus sequences and specific sequences for antibodies that specifically bind to STOP-1 that are useful in the methods described herein.
摘要翻译： 本发明提供了可用于治疗和预防疾病和医学诊断和研究的新型多肽，抗体，拮抗剂，激动剂，增效剂，核酸分子，与STOP-1多肽相关的组合物和方法。 本发明还提供了与本文所述方法有用的特异性结合STOP-1的抗体的共有序列和特异性序列。
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公开(公告)号：US07799899B2
公开(公告)日：2010-09-21
申请号：US10553491
申请日：2004-04-16
申请人： Heidi Ackerly , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Masters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
发明人： Heidi Ackerly , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Masters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
IPC分类号： C07K16/00
CPC分类号： C07K16/32 , C07K16/22 , C07K16/4283 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present invention provides novel polypeptides, antibodies, antagonists, agonists, potentiators, nucleic acid molecules, compositions and methods relating to the STOP-1 polypeptide that are useful for treating and preventing diseases and for medical diagnosis and research. The present invention also provides consensus sequences and specific sequences for antibodies that specifically bind to STOP-1 that are useful in the methods described herein.
摘要翻译： 本发明提供了可用于治疗和预防疾病和医学诊断和研究的新型多肽，抗体，拮抗剂，激动剂，增效剂，核酸分子，与STOP-1多肽相关的组合物和方法。 本发明还提供了与本文所述方法有用的特异性结合STOP-1的抗体的共有序列和特异性序列。
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公开(公告)号：US20070212735A1
公开(公告)日：2007-09-13
申请号：US11534850
申请日：2006-09-25
申请人： Avi Ashkenazi , Belinda Caims , Patrick Dowd , Gretchen Frantz , Dorothy French , Lino Gonzalez , Paul Polakis , Victoria Smith , Beni Wolf , Thomas Wu , Zemin Zhang
发明人： Avi Ashkenazi , Belinda Caims , Patrick Dowd , Gretchen Frantz , Dorothy French , Lino Gonzalez , Paul Polakis , Victoria Smith , Beni Wolf , Thomas Wu , Zemin Zhang
IPC分类号： G01N33/574 , C07K16/30 , C07K14/82
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20050170368A1
公开(公告)日：2005-08-04
申请号：US10884070
申请日：2004-07-02
申请人： Avi Ashkenazi , Belinda Caims , Patrick Dowd , Gretchen Frantz , Dorothy French , Lino Gonzalez , Paul Polakis , Victoria Smith , Beni Wolf , Thomas Wu , Zemin Zhang
发明人： Avi Ashkenazi , Belinda Caims , Patrick Dowd , Gretchen Frantz , Dorothy French , Lino Gonzalez , Paul Polakis , Victoria Smith , Beni Wolf , Thomas Wu , Zemin Zhang
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20050123925A1
公开(公告)日：2005-06-09
申请号：US10712892
申请日：2003-11-12
申请人： Avi Ashkenazi , Gretchen Frantz , Audrey Goddard , Lino Gonzalez , Austin Gurney , Paul Polakis , Andrew Polson , William Wood , Thomas Wu , Zemin Zhang
发明人： Avi Ashkenazi , Gretchen Frantz , Audrey Goddard , Lino Gonzalez , Austin Gurney , Paul Polakis , Andrew Polson , William Wood , Thomas Wu , Zemin Zhang
IPC分类号： A61K20060101 , A61K38/16 , A61K39/395 , C07K16/18 , C07K16/30 , C12N15/13 , C12P21/02 , C12Q1/68 , G01N33/574
CPC分类号： C07K16/30 , A61K2039/505
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20070054361A1
公开(公告)日：2007-03-08
申请号：US11486298
申请日：2006-07-13
申请人： Avi Ashkenazi , Gretchen Frantz , Audrey Goddard , Lino Gonzalez , Austin Gurney , Paul Polakis , Andrew Polson , William Wood , Thomas Wu , Zemin Zhang
发明人： Avi Ashkenazi , Gretchen Frantz , Audrey Goddard , Lino Gonzalez , Austin Gurney , Paul Polakis , Andrew Polson , William Wood , Thomas Wu , Zemin Zhang
CPC分类号： C07K16/30 , A61K2039/505
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译： 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。
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公开(公告)号：US20070143871A1
公开(公告)日：2007-06-21
申请号：US11556803
申请日：2006-11-06
IPC分类号： A01K67/027 , C12N5/06
CPC分类号： G01N33/57438 , C07K14/50 , G01N2500/04
摘要： The invention relates to the field of non-human, transgenic animal models for hepatocellular carcinoma.
摘要翻译： 本发明涉及用于肝细胞癌的非人类，转基因动物模型的领域。
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公开(公告)号：US20050166274A1
公开(公告)日：2005-07-28
申请号：US10516868
申请日：2003-06-04
IPC分类号： A01K67/027 , A61K31/7088 , A61K35/12 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/00 , A61P1/16 , A61P1/18 , A61P11/00 , A61P13/10 , A61P15/00 , A61P17/00 , A61P25/00 , A61P35/00 , A61P35/02 , C07K14/00 , C07K14/47 , C07K14/50 , C07K16/18 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/574 , C12N5/06
CPC分类号： G01N33/57438 , C07K14/50 , G01N2500/04
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US08410250B2
公开(公告)日：2013-04-02
申请号：US12731100
申请日：2010-03-24
申请人： Avi Ashkenazi , Jing Qing , Christian Wiesmann , Yan Wu
发明人： Avi Ashkenazi , Jing Qing , Christian Wiesmann , Yan Wu
CPC分类号： C07K16/2863 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K2039/505 , C07K16/3038 , C07K16/3061 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30
摘要： The invention provides FGFR3 antibodies, and compositions comprising and methods of using these antibodies.
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