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公开(公告)号：US20080050377A1
公开(公告)日：2008-02-28
申请号：US10553491
申请日：2004-04-16
申请人： Heidi Ackerly , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Marsters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
发明人： Heidi Ackerly , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Marsters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00 , C12N1/00 , C12N15/63 , G01N33/574 , G01N33/53 , C12N15/13 , C07K14/435 , C07K16/18
CPC分类号： C07K16/32 , C07K16/22 , C07K16/4283 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present invention provides novel polypeptides, antibodies, antagonists, agonists, potentiators, nucleic acid molecules, compositions and methods relating to the STOP-1 polypeptide that are useful for treating and preventing diseases and for medical diagnosis and research. The present invention also provides consensus sequences and specific sequences for antibodies that specifically bind to STOP-1 that are useful in the methods described herein.
摘要翻译： 本发明提供了可用于治疗和预防疾病和医学诊断和研究的新型多肽，抗体，拮抗剂，激动剂，增效剂，核酸分子，与STOP-1多肽相关的组合物和方法。 本发明还提供了与本文所述方法有用的特异性结合STOP-1的抗体的共有序列和特异性序列。
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公开(公告)号：US20110112279A1
公开(公告)日：2011-05-12
申请号：US12845470
申请日：2010-07-28
申请人： HEIDI ACKERLY , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Marsters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
发明人： HEIDI ACKERLY , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Marsters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
IPC分类号： C07K16/18
CPC分类号： C07K16/32 , C07K16/22 , C07K16/4283 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present invention provides novel polypeptides, antibodies, antagonists, agonists, potentiators, nucleic acid molecules, compositions and methods relating to the STOP-1 polypeptide that are useful for treating and preventing diseases and for medical diagnosis and research. The present invention also provides consensus sequences and specific sequences for antibodies that specifically bind to STOP-1 that are useful in the methods described herein.
摘要翻译： 本发明提供了可用于治疗和预防疾病和医学诊断和研究的新型多肽，抗体，拮抗剂，激动剂，增效剂，核酸分子，与STOP-1多肽相关的组合物和方法。 本发明还提供了与本文所述方法有用的特异性结合STOP-1的抗体的共有序列和特异性序列。
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公开(公告)号：US07799899B2
公开(公告)日：2010-09-21
申请号：US10553491
申请日：2004-04-16
申请人： Heidi Ackerly , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Masters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
发明人： Heidi Ackerly , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Masters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
IPC分类号： C07K16/00
CPC分类号： C07K16/32 , C07K16/22 , C07K16/4283 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present invention provides novel polypeptides, antibodies, antagonists, agonists, potentiators, nucleic acid molecules, compositions and methods relating to the STOP-1 polypeptide that are useful for treating and preventing diseases and for medical diagnosis and research. The present invention also provides consensus sequences and specific sequences for antibodies that specifically bind to STOP-1 that are useful in the methods described herein.
摘要翻译： 本发明提供了可用于治疗和预防疾病和医学诊断和研究的新型多肽，抗体，拮抗剂，激动剂，增效剂，核酸分子，与STOP-1多肽相关的组合物和方法。 本发明还提供了与本文所述方法有用的特异性结合STOP-1的抗体的共有序列和特异性序列。
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公开(公告)号：US20050170368A1
公开(公告)日：2005-08-04
申请号：US10884070
申请日：2004-07-02
申请人： Avi Ashkenazi , Belinda Caims , Patrick Dowd , Gretchen Frantz , Dorothy French , Lino Gonzalez , Paul Polakis , Victoria Smith , Beni Wolf , Thomas Wu , Zemin Zhang
发明人： Avi Ashkenazi , Belinda Caims , Patrick Dowd , Gretchen Frantz , Dorothy French , Lino Gonzalez , Paul Polakis , Victoria Smith , Beni Wolf , Thomas Wu , Zemin Zhang
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20070212735A1
公开(公告)日：2007-09-13
申请号：US11534850
申请日：2006-09-25
申请人： Avi Ashkenazi , Belinda Caims , Patrick Dowd , Gretchen Frantz , Dorothy French , Lino Gonzalez , Paul Polakis , Victoria Smith , Beni Wolf , Thomas Wu , Zemin Zhang
发明人： Avi Ashkenazi , Belinda Caims , Patrick Dowd , Gretchen Frantz , Dorothy French , Lino Gonzalez , Paul Polakis , Victoria Smith , Beni Wolf , Thomas Wu , Zemin Zhang
IPC分类号： G01N33/574 , C07K16/30 , C07K14/82
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6809 , A61K47/6843 , A61K47/6851 , A61K2039/505
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20070143871A1
公开(公告)日：2007-06-21
申请号：US11556803
申请日：2006-11-06
IPC分类号： A01K67/027 , C12N5/06
CPC分类号： G01N33/57438 , C07K14/50 , G01N2500/04
摘要： The invention relates to the field of non-human, transgenic animal models for hepatocellular carcinoma.
摘要翻译： 本发明涉及用于肝细胞癌的非人类，转基因动物模型的领域。
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公开(公告)号：US20050166274A1
公开(公告)日：2005-07-28
申请号：US10516868
申请日：2003-06-04
IPC分类号： A01K67/027 , A61K31/7088 , A61K35/12 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P1/00 , A61P1/16 , A61P1/18 , A61P11/00 , A61P13/10 , A61P15/00 , A61P17/00 , A61P25/00 , A61P35/00 , A61P35/02 , C07K14/00 , C07K14/47 , C07K14/50 , C07K16/18 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/50 , G01N33/574 , C12N5/06
CPC分类号： G01N33/57438 , C07K14/50 , G01N2500/04
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20150064186A1
公开(公告)日：2015-03-05
申请号：US14349005
申请日：2012-04-06
IPC分类号： C07K16/28
CPC分类号： C07K16/28 , A61K39/395 , A61K39/3955 , A61K2039/505 , C07K14/705 , C07K14/71 , C07K14/715 , C07K16/2863 , C07K16/2866 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/76
摘要： Methods and compositions for the treatment of liver conditions are provided, such methods and compositions comprising Notch2 antagonists, e.g., anti-Notch2 antibodies. Liver conditions include, but are not limited to, chronic liver disease.
摘要翻译： 提供了用于治疗肝脏病症的方法和组合物，所述方法和组合物包含Notch2拮抗剂，例如抗Notch2抗体。 肝病包括但不限于慢性肝病。
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公开(公告)号：US08409579B2
公开(公告)日：2013-04-02
申请号：US13539151
申请日：2012-06-29
申请人： Mark Dennis , Luc Desnoyers , Dorothy French
发明人： Mark Dennis , Luc Desnoyers , Dorothy French
IPC分类号： A61K39/395 , C07K16/22 , C07K14/50
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention concerns antagonists of the FGF19/FGFR4 pathways, and the uses of same.
摘要翻译： 本发明涉及FGF19 / FGFR4途径的拮抗剂及其用途。
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公开(公告)号：US20120263717A1
公开(公告)日：2012-10-18
申请号：US13539151
申请日：2012-06-29
申请人： Mark Dennis , Luc Desnoyers , Dorothy French
发明人： Mark Dennis , Luc Desnoyers , Dorothy French
IPC分类号： A61K39/395 , A61P35/04
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention concerns antagonists of the FGF19/FGFR4 pathways, and the uses of same.
摘要翻译： 本发明涉及FGF19 / FGFR4途径的拮抗剂及其用途。
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