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公开(公告)号：US20080050377A1
公开(公告)日：2008-02-28
申请号：US10553491
申请日：2004-04-16
申请人： Heidi Ackerly , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Marsters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
发明人： Heidi Ackerly , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Marsters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00 , C12N1/00 , C12N15/63 , G01N33/574 , G01N33/53 , C12N15/13 , C07K14/435 , C07K16/18
CPC分类号： C07K16/32 , C07K16/22 , C07K16/4283 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present invention provides novel polypeptides, antibodies, antagonists, agonists, potentiators, nucleic acid molecules, compositions and methods relating to the STOP-1 polypeptide that are useful for treating and preventing diseases and for medical diagnosis and research. The present invention also provides consensus sequences and specific sequences for antibodies that specifically bind to STOP-1 that are useful in the methods described herein.
摘要翻译： 本发明提供了可用于治疗和预防疾病和医学诊断和研究的新型多肽，抗体，拮抗剂，激动剂，增效剂，核酸分子，与STOP-1多肽相关的组合物和方法。 本发明还提供了与本文所述方法有用的特异性结合STOP-1的抗体的共有序列和特异性序列。
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公开(公告)号：US20110112279A1
公开(公告)日：2011-05-12
申请号：US12845470
申请日：2010-07-28
申请人： HEIDI ACKERLY , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Marsters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
发明人： HEIDI ACKERLY , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Marsters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
IPC分类号： C07K16/18
CPC分类号： C07K16/32 , C07K16/22 , C07K16/4283 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present invention provides novel polypeptides, antibodies, antagonists, agonists, potentiators, nucleic acid molecules, compositions and methods relating to the STOP-1 polypeptide that are useful for treating and preventing diseases and for medical diagnosis and research. The present invention also provides consensus sequences and specific sequences for antibodies that specifically bind to STOP-1 that are useful in the methods described herein.
摘要翻译： 本发明提供了可用于治疗和预防疾病和医学诊断和研究的新型多肽，抗体，拮抗剂，激动剂，增效剂，核酸分子，与STOP-1多肽相关的组合物和方法。 本发明还提供了与本文所述方法有用的特异性结合STOP-1的抗体的共有序列和特异性序列。
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公开(公告)号：US07799899B2
公开(公告)日：2010-09-21
申请号：US10553491
申请日：2004-04-16
申请人： Heidi Ackerly , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Masters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
发明人： Heidi Ackerly , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Masters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
IPC分类号： C07K16/00
CPC分类号： C07K16/32 , C07K16/22 , C07K16/4283 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present invention provides novel polypeptides, antibodies, antagonists, agonists, potentiators, nucleic acid molecules, compositions and methods relating to the STOP-1 polypeptide that are useful for treating and preventing diseases and for medical diagnosis and research. The present invention also provides consensus sequences and specific sequences for antibodies that specifically bind to STOP-1 that are useful in the methods described herein.
摘要翻译： 本发明提供了可用于治疗和预防疾病和医学诊断和研究的新型多肽，抗体，拮抗剂，激动剂，增效剂，核酸分子，与STOP-1多肽相关的组合物和方法。 本发明还提供了与本文所述方法有用的特异性结合STOP-1的抗体的共有序列和特异性序列。
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公开(公告)号：US20080280856A1
公开(公告)日：2008-11-13
申请号：US12133148
申请日：2008-06-04
IPC分类号： A61K31/69 , C07F5/02 , C07D213/02 , A61P9/00 , A61P17/00 , A61P37/00 , A61P29/00 , A61P25/00 , A61P35/00 , C07D207/00
CPC分类号： C07F5/025
摘要： Amino terminus-blocked peptide boronate compounds of Formulas I and II are useful for inhibiting Fibroblast Activation Protein (FAP) and other proteases, and for treating disorders mediated by FAP. Methods of using the amino terminus blocked peptide boronate compounds, and stereoisomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译： 式I和II的氨基末端封闭的肽硼酸酯化合物可用于抑制成纤维细胞激活蛋白（FAP）和其它蛋白酶，以及用于治疗由FAP介导的病症。 使用氨基末端阻断肽硼酸酯化合物及其立体异构体，互变异构体，溶剂化物和其药学上可接受的盐的方法用于体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理学病症中的这种病症。 披露
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公开(公告)号：US07399869B2
公开(公告)日：2008-07-15
申请号：US11437182
申请日：2006-05-18
IPC分类号： C07D207/00 , A01N43/36
CPC分类号： C07F5/025
摘要： Amino terminus-blocked peptide boronate compounds of Formulas I and II are useful for inhibiting Fibroblast Activation Protein (FAP) and other proteases, and for treating disorders mediated by FAP. Methods of using the amino terminus blocked peptide boronate compounds, and stereoisomers, tautomers, solvates and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
摘要翻译： 式I和II的氨基末端封闭的肽硼酸酯化合物可用于抑制成纤维细胞激活蛋白（FAP）和其它蛋白酶，以及用于治疗由FAP介导的病症。 使用氨基末端阻断肽硼酸酯化合物及其立体异构体，互变异构体，溶剂化物和其药学上可接受的盐的方法用于体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这些疾病。 披露
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