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公开(公告)号：US20080050377A1
公开(公告)日：2008-02-28
申请号：US10553491
申请日：2004-04-16
申请人： Heidi Ackerly , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Marsters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
发明人： Heidi Ackerly , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Marsters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
IPC分类号： C07K16/30 , A61K39/395 , A61P35/00 , C12N1/00 , C12N15/63 , G01N33/574 , G01N33/53 , C12N15/13 , C07K14/435 , C07K16/18
CPC分类号： C07K16/32 , C07K16/22 , C07K16/4283 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present invention provides novel polypeptides, antibodies, antagonists, agonists, potentiators, nucleic acid molecules, compositions and methods relating to the STOP-1 polypeptide that are useful for treating and preventing diseases and for medical diagnosis and research. The present invention also provides consensus sequences and specific sequences for antibodies that specifically bind to STOP-1 that are useful in the methods described herein.
摘要翻译： 本发明提供了可用于治疗和预防疾病和医学诊断和研究的新型多肽，抗体，拮抗剂，激动剂，增效剂，核酸分子，与STOP-1多肽相关的组合物和方法。 本发明还提供了与本文所述方法有用的特异性结合STOP-1的抗体的共有序列和特异性序列。
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公开(公告)号：US20110112279A1
公开(公告)日：2011-05-12
申请号：US12845470
申请日：2010-07-28
申请人： HEIDI ACKERLY , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Marsters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
发明人： HEIDI ACKERLY , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Marsters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
IPC分类号： C07K16/18
CPC分类号： C07K16/32 , C07K16/22 , C07K16/4283 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present invention provides novel polypeptides, antibodies, antagonists, agonists, potentiators, nucleic acid molecules, compositions and methods relating to the STOP-1 polypeptide that are useful for treating and preventing diseases and for medical diagnosis and research. The present invention also provides consensus sequences and specific sequences for antibodies that specifically bind to STOP-1 that are useful in the methods described herein.
摘要翻译： 本发明提供了可用于治疗和预防疾病和医学诊断和研究的新型多肽，抗体，拮抗剂，激动剂，增效剂，核酸分子，与STOP-1多肽相关的组合物和方法。 本发明还提供了与本文所述方法有用的特异性结合STOP-1的抗体的共有序列和特异性序列。
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公开(公告)号：US07799899B2
公开(公告)日：2010-09-21
申请号：US10553491
申请日：2004-04-16
申请人： Heidi Ackerly , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Masters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
发明人： Heidi Ackerly , Avi Ashkenazi , David Eberhard , Gretchen Frantz , Dorothy French , Germaine G. Fuh , Jo-Anne S. Hongo , Chingwei V. Lee , Scot A. Masters , Helga A. Raab , Evgeny Varfolomeev , Beni B. Wolf , Robert Maurice Pitti , Liliana Soroceanu
IPC分类号： C07K16/00
CPC分类号： C07K16/32 , C07K16/22 , C07K16/4283 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622
摘要： The present invention provides novel polypeptides, antibodies, antagonists, agonists, potentiators, nucleic acid molecules, compositions and methods relating to the STOP-1 polypeptide that are useful for treating and preventing diseases and for medical diagnosis and research. The present invention also provides consensus sequences and specific sequences for antibodies that specifically bind to STOP-1 that are useful in the methods described herein.
摘要翻译： 本发明提供了可用于治疗和预防疾病和医学诊断和研究的新型多肽，抗体，拮抗剂，激动剂，增效剂，核酸分子，与STOP-1多肽相关的组合物和方法。 本发明还提供了与本文所述方法有用的特异性结合STOP-1的抗体的共有序列和特异性序列。
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公开(公告)号：US07910098B2
公开(公告)日：2011-03-22
申请号：US12315220
申请日：2008-12-01
申请人： Germaine Fuh , Chingwei V. Lee
发明人： Germaine Fuh , Chingwei V. Lee
IPC分类号： A61K39/395 , G01N33/53 , C12P21/08 , C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92 , G01N33/6893 , G01N2333/475
摘要： The invention herein provides isolated antibodies that bind to VEGF. The invention further provides methods of making anti-VEGF antibodies, and polynucleotides encoding anti-VEGF antibodies.
摘要翻译： 本发明提供了结合VEGF的分离的抗体。 本发明还提供了制备抗VEGF抗体的方法，以及编码抗VEGF抗体的多核苷酸。
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公开(公告)号：US08921537B2
公开(公告)日：2014-12-30
申请号：US13039881
申请日：2011-03-03
申请人： Germaine Fuh , Chingwei V. Lee
发明人： Germaine Fuh , Chingwei V. Lee
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92 , G01N33/6893 , G01N2333/475
摘要： The invention herein provides isolated antibodies that bind to VEGF. The invention further provides methods of making anti-VEGF antibodies, and polynucleotides encoding anti-VEGF antibodies.
摘要翻译： 本发明提供了结合VEGF的分离的抗体。 本发明还提供了制备抗VEGF抗体的方法，以及编码抗VEGF抗体的多核苷酸。
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公开(公告)号：US20100166741A1
公开(公告)日：2010-07-01
申请号：US12373662
申请日：2007-07-12
申请人： Robert F. Kelley , Amy Yijuan Shen , Dorothea Reilly , Mark S. Dennis , Germaine Fuh , Chingwei V. Lee , Christine M. Ambrose , Jeffrey S. Thompson
发明人： Robert F. Kelley , Amy Yijuan Shen , Dorothea Reilly , Mark S. Dennis , Germaine Fuh , Chingwei V. Lee , Christine M. Ambrose , Jeffrey S. Thompson
IPC分类号： A61K39/395 , C12N5/00 , C12N5/02 , C12N5/10 , C12N1/19 , C12N15/63 , C07K16/00 , C07H21/04 , A61P35/04
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/52 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76
摘要： The present invention relates to novel BR3 binding antibodies having altered Fc effector function and/or having a mature core carbohydrate structure in the Fc region which lacks fiicose. The present invention also relates to the use of those BR3 binding antibodies and polypeptides in, e.g., methods of treatment, screening methods, diagnostic methods, assays and protein purification methods.
摘要翻译： 本发明涉及具有改变的Fc效应子功能和/或在Fc区中具有成熟核心碳水化合物结构的新颖BR3结合抗体，其缺少微胶囊。 本发明还涉及这些BR3结合抗体和多肽在例如治疗方法，筛选方法，诊断方法，测定和蛋白质纯化方法中的用途。
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公开(公告)号：US20090142343A1
公开(公告)日：2009-06-04
申请号：US12315220
申请日：2008-12-01
申请人： Germaine Fuh , Chingwei V. Lee
发明人： Germaine Fuh , Chingwei V. Lee
IPC分类号： A61K39/395 , C07K16/18 , C12N15/11 , C12N15/00 , C12N1/21 , C12N5/06 , C12P21/04 , G01N33/566
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/92 , G01N33/6893 , G01N2333/475
摘要： The invention herein provides isolated antibodies that bind to VEGF. The invention further provides methods of making anti-VEGF antibodies, and polynucleotides encoding anti-VEGF antibodies.
摘要翻译： 本发明提供了结合VEGF的分离的抗体。 本发明还提供了制备抗VEGF抗体的方法，以及编码抗VEGF抗体的多核苷酸。
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公开(公告)号：US08486397B2
公开(公告)日：2013-07-16
申请号：US12882330
申请日：2010-09-15
申请人： Anil D. Bagri , Germaine Fuh , Chingwei V. Lee
发明人： Anil D. Bagri , Germaine Fuh , Chingwei V. Lee
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32 , A61K2300/00
摘要： The invention provides VEGF-C antagonists, such as anti-VEGF-C antibodies, and their use in the prevention and treatment of tumor progression.
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公开(公告)号：US20120052566A9
公开(公告)日：2012-03-01
申请号：US12882330
申请日：2010-09-15
申请人： Anil D. Bagri , Germaine Fuh , Chingwei V. Lee
发明人： Anil D. Bagri , Germaine Fuh , Chingwei V. Lee
CPC分类号： C07K16/22 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32 , A61K2300/00
摘要： The invention provides VEGF-C antagonists, such as anti-VEGF-C antibodies, and their use in the prevention and treatment of tumor progression.
摘要翻译： 本发明提供VEGF-C拮抗剂，例如抗VEGF-C抗体，以及它们在预防和治疗肿瘤进展中的用途。
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公开(公告)号：US20110143428A1
公开(公告)日：2011-06-16
申请号：US12882330
申请日：2010-09-15
申请人： Anil D. Bagri , Germaine Fuh , Chingwei V. Lee
发明人： Anil D. Bagri , Germaine Fuh , Chingwei V. Lee
CPC分类号： C07K16/22 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/32 , A61K2300/00
摘要： The invention provides VEGF-C antagonists, such as anti-VEGF-C antibodies, and their use in the prevention and treatment of tumor progression.
摘要翻译： 本发明提供VEGF-C拮抗剂，例如抗VEGF-C抗体，以及它们在预防和治疗肿瘤进展中的用途。
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