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38 条记录 (耗时 0.029 秒)

    Amyloid β(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof
    2.
    发明授权
    Amyloid β(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof 有权
    淀粉样蛋白（1-42）寡聚体，其衍生物和抗体，其制备方法和用途

    公开(公告)号：US07902328B2

    公开(公告)日：2011-03-08

    申请号：US10543841

    申请日：2004-02-02

    申请人： Heinz Hillen ,  Andreas Striebinger

    发明人： Heinz Hillen ,  Andreas Striebinger

    IPC分类号： A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  C07K16/00 ,  C07K17/00

    CPC分类号： C07K14/4711 ,  A61K38/1709 ,  A61K39/0007 ,  A61K2039/57 ,  C07K16/005 ,  C07K16/18 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  G01N33/6896 ,  G01N2333/4709

    摘要： The invention relates to neuromodulatory oligomers of the amyloid-β(1-42) protein, a particular production method, by means of which the oligomer can be obtained in a reproducible manner at high yield, the use of the oligomers as diagnostic and therapeutics agents, for the generation of oligomer-specific antibodies and for the discovery of substances which can interact with the oligomers and in the formation thereof. Corresponding methods for the production of the antibodies and for discovery of the substances are also disclosed as are the antibodies themselves and the use of the antibodies or substances as diagnostic and therapeutic agents. The invention further relates to derivatives of the oligomers and oligomers based on abbreviated forms of the amyloid-β(1-42) proteins, the production and use thereof.

    摘要翻译： 本发明涉及淀粉样蛋白（1-42）蛋白的神经调节性低聚物，一种特定的制备方法，通过该方法可以以高产率以可重复的方式获得寡聚体，使用低聚物作为诊断和治疗 用于产生寡聚体特异性抗体以及用于发现可与低聚物相互作用并在其形成中的物质。 还公开了生产抗体和发现物质的相应方法，抗体本身以及抗体或物质作为诊断和治疗剂的用途也是如此。 本发明还涉及基于淀粉样蛋白（1-42）蛋白质的缩写形式的寡聚物和低聚物的衍生物，其生产和用途。

    Aß(X - 38 .. 43) oligomers, and processes, compositions, and uses thereof
    6.
    发明申请
    Aß(X - 38 .. 43) oligomers, and processes, compositions, and uses thereof 审中-公开
    Aß（X-38.43）低聚物及其工艺，组合物和用途

    公开(公告)号：US20100173828A1

    公开(公告)日：2010-07-08

    申请号：US12509315

    申请日：2009-07-24

    申请人： Heinz Hillen ,  Andreas Striebinger ,  Simone Giaisi ,  Stefan Barghorn ,  Gerald Gellermann ,  Ulrich Ebert ,  Joerg Moelleken

    发明人： Heinz Hillen ,  Andreas Striebinger ,  Simone Giaisi ,  Stefan Barghorn ,  Gerald Gellermann ,  Ulrich Ebert ,  Joerg Moelleken

    IPC分类号： A61K38/17 ,  C07K14/435 ,  A61P25/28 ,  C40B30/04 ,  G01N33/53

    CPC分类号： C07K14/4711 ,  A61K39/0007 ,  A61K2039/55566 ,  C07K16/18 ,  G01N33/6896 ,  G01N2800/2821

    摘要： The present invention relates to an Aβ(X-38 . . . 43) oligomer having a high molecular weight, or a derivative thereof, a process for preparing the oligomer or derivative, compositions comprising the oligomer or derivative, and uses of the oligomer or derivative such as its use for treating or preventing an amyloidosis (e.g. by active immunization), for diagnosing an amyloidosis, and for providing agents that are capable of binding to the Aβ(X-38 . . . 43) oligomer or derivative. The subject invention also describes agents that are capable of binding to the Aβ(X-38 . . . 43) oligomer or derivative, e.g. antibodies, compositions comprising the agents, and uses of the agents such as their use for treating or preventing an amyloidosis (e.g. by passive immunization) and for diagnosing an amyloidosis.

    摘要翻译： 本发明涉及具有高分子量的A（b）（X-38.43）低聚物或其衍生物，制备低聚物或衍生物的方法，包含低聚物或衍生物的组合物，以及低聚物 或其衍生物，例如其用于治疗或预防淀粉样变性（例如通过主动免疫）用于诊断淀粉样变性的用途，以及用于提供能够与Aβ结合的试剂（X-38.43）寡聚体或衍生物。 本发明还描述了能够结合A和B（X-38.43）低聚物或衍生物的试剂。 抗体，包含该试剂的组合物，以及该药剂的用途，例如其用于治疗或预防淀粉样变性（例如通过被动免疫）和用于诊断淀粉样变性的用途。