Piperazine derivatives, pharmaceutical compositions containing these
compounds, their use and processes for preparing them
    7.
    发明授权
    Piperazine derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them 失效
    哌嗪衍生物,含有这些化合物的药物组合物,其用途和制备方法

    公开(公告)号:US5700801A

    公开(公告)日:1997-12-23

    申请号:US572256

    申请日:1995-12-13

    摘要: Piperazine derivatives useful in the treatment or prevention of inflammation, bone degradation, thrombosis and tumor metastasis. Exemplary species are: (a) �4-trans-�3-�4-(4-Pyridyl)-piperazin-1-yl!propionyl!amino!-cyclohexanecarboxylic acid, (b) 3-�4-trans-�4-(4-Pyridyl)-piperazin-1-yl!carbonylamino!-cyclohexylpropionic acid, (c) 3-�4-trans-�4-(4-Pyridyl)-piperazin-1-yl!malonylamino!cyclohexylcarboxylic acid, (d) Methyl �4-trans-�3-�4-(4-pyridyl)-piperazin-1-yl!-propionyl!-amino!cyclohexane carboxylate, (e) Methyl 3-�4-trans-�4-(4-pyridyl)-piperazin-1-yl!-carbonylamino!cyclohexyl propionate, (f) Methyl �4-trans-�4-(4-pyridyl)-piperazin-1-yl!-malonylamino!-cyclohexyl carboxylate, (g) Cyclohexyl �4-trans-��4-(4-pyridyl)-piperazin-1-yl!-acetyl!-amino!-cyclohexane carboxylate, and (h) Isobutyl �4-trans-��4-(4-pyridyl)-piperazin-1-yl!-acetyl!-amino!-cyclohexane carboxylate.

    摘要翻译: 哌嗪衍生物可用于治疗或预防炎症,骨退化,血栓形成和肿瘤转移。 示例性物质是:(a)[4-反式 - [3- [4-(4-吡啶基) - 哌嗪-1-基]丙酰基]氨基] - 环己烷甲酸,(b)3- [4-反式 - [4 - (4-吡啶基) - 哌嗪-1-基]羰基氨基] - 环己基丙酸,(c)3- [4-反式 - [4-(4-吡啶基) - 哌嗪-1-基]丙二酰氨基]环己基羧酸, d)[4-反式 - [3- [4-(4-吡啶基) - 哌嗪-1-基] - 丙酰基] - 氨基]环己烷羧酸甲酯,(e)3- [4-反式 - [4- 4-吡啶基) - 哌嗪-1-基] - 羰基氨基]环己基丙酸酯,(f)[4-反式 - [4-(4-吡啶基) - 哌嗪-1-基] - 丙酰基氨基] )[4-反式 - [[4-(4-吡啶基) - 哌嗪-1-基] - 乙酰基] - 氨基] - 环己烷羧酸环己酯和(h)[4-反式 - [[4- 吡啶基) - 哌嗪-1-基] - 乙酰基] - 氨基] - 环己烷羧酸酯。