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公开(公告)号：US20100291536A1
公开(公告)日：2010-11-18
申请号：US12780345
申请日：2010-05-14
CPC分类号： A61B10/0096 , A61B10/0051 , A61B90/98 , B01L3/505 , B01L2200/0689 , B01L2300/021 , B01L2300/0864 , G01N2001/005
摘要： The present invention provides a method and device for collecting treating and analysis of biological or chemical material by introducing a source material into a specimen container, transferring the source material to a processing device and thermally, chemically and/or mechanically treating the source material to alter at least one constitutive characteristic of the source material and to release or create a target material from the source material.
摘要翻译： 本发明提供了一种通过将源材料引入到样本容器中来收集生物或化学材料的处理和分析的方法和装置，将源材料转移到处理装置，并且热，化学和/或机械地处理源材料以改变 源材料的至少一个构成特征并且从源材料释放或产生靶材料。
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公开(公告)号：US20100288059A1
公开(公告)日：2010-11-18
申请号：US12780508
申请日：2010-05-14
CPC分类号： A61B10/0096 , A61B10/0051 , A61B90/98 , B01L3/505 , B01L2200/0689 , B01L2300/021 , B01L2300/0864 , G01N2001/005
摘要： This invention relates to the collection and handling of biological or chemical specimens. The invention provides a device and a method for collecting and preparing patient samples, such as sputum, to be used in downstream diagnostics tests. The invention reduces the handling and exposure of healthcare workers to the sample by the use of a bag in which hermetic seals are utilized to separate sample aliquots.
摘要翻译： 本发明涉及生物或化学样品的收集和处理。 本发明提供了用于收集和制备用于下游诊断测试中的患者样品（例如痰液）的装置和方法。 本发明通过使用其中使用气密封来分离样品等分试样的袋子来减少医护人员对样品的处理和暴露。
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公开(公告)号：US09034635B2
公开(公告)日：2015-05-19
申请号：US12918594
申请日：2009-02-19
CPC分类号： B01L7/52 , B01L3/505 , B01L2300/043 , B01L2300/0627 , B01L2300/0838 , B01L2300/18 , B01L2300/1822 , B01L2300/1844
摘要： A thermocycler apparatus and method for rapidly performing the PCR process employs at least two thermoelectric modules which are in substantial spatial opposition with an interior space present between opposing modules. One or multiple sample vessels are placed in between the modules such that the vessels are subjected to temperature cycling by the modules. The sample vessels have a minimal internal dimension that is substantially perpendicular to the modules that facilitates rapid temperature cycling. In embodiments of the invention the sample vessels may be deformable between: a) a shape having a wide mouth to facilitate filling and removing of sample fluids from the vessel, and b) a shape which is thinner for conforming to the sample cavity or interior space between the thermoelectric modules of the thermocycler for more rapid heat transfer.
摘要翻译： 用于快速执行PCR过程的热循环仪装置和方法采用至少两个热电模块，其与存在于相对模块之间的内部空间实质上空间相对。 将一个或多个样品容器放置在模块之间，使得容器经过模块的温度循环。 样品容器具有基本垂直于促进快速温度循环的模块的最小内部尺寸。 在本发明的实施例中，样品容器可以在以下之间变形：a）具有宽口的形状，以便于从容器中填充和除去样品流体，以及b）更薄的形状，以符合样品腔或内部空间 在热循环器的热电模块之间用于更快速的热传递。
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公开(公告)号：US08889086B2
公开(公告)日：2014-11-18
申请号：US13452419
申请日：2012-04-20
CPC分类号： B01L3/50825 , B01L7/52 , B01L2300/022 , B01L2300/043 , B01L2300/123 , B01L2300/168
摘要： An improved tube including a closure portion, a strap integrally connected to the closure portion and being configured for defining a living hinge, a body portion having a longitudinal axis and an outer wall generally circumscribing the longitudinal axis, and being integrally and hingedly connected with the closure portion by way of the strap. The body portion including a sample portion being generally elongated along the longitudinal axis and being configured for elastic deformation along a portion of its length, including in a direction that is generally transverse to the longitudinal axis so that at least a portion of the wall structure compressively and resiliently deforms and engages a wall defining an opening in a sample block of a polymerase chain reaction amplification device, and the first outer wall dimension of the sample portion reduces to a smaller second outer wall dimension.
摘要翻译： 一种改进的管，其包括封闭部分，整体地连接到所述封闭部分并且构造成用于限定活动铰链的带，具有纵向轴线的主体部分和通常围绕所述纵向轴线的外壁，并且与所述主体部分整体地和铰接地连接 通过带子的封闭部分。 主体部分包括沿着纵向轴线大致细长的样本部分，并且构造成沿其长度的一部分弹性变形，包括沿大致横向于纵向轴线的方向弹性变形，使得壁结构的至少一部分被压缩 并且弹性变形并且接合限定聚合酶链式反应扩增装置的样品块中的开口的壁，并且样品部分的第一外壁尺寸减小到更小的第二外壁尺寸。
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公开(公告)号：US20120269703A1
公开(公告)日：2012-10-25
申请号：US13452419
申请日：2012-04-20
IPC分类号： B01L3/14
CPC分类号： B01L3/50825 , B01L7/52 , B01L2300/022 , B01L2300/043 , B01L2300/123 , B01L2300/168
摘要： An improved tube including a closure portion, a strap integrally connected to the closure portion and being configured for defining a living hinge, a body portion having a longitudinal axis and an outer wall generally circumscribing the longitudinal axis, and being integrally and hingedly connected with the closure portion by way of the strap. The body portion including a sample portion being generally elongated along the longitudinal axis and being configured for elastic deformation along a portion of its length, including in a direction that is generally transverse to the longitudinal axis so that at least a portion of the wall structure compressively and resiliently deforms and engages a wall defining an opening in a sample block of a polymerase chain reaction amplification device, and the first outer wall dimension of the sample portion reduces to a smaller second outer wall dimension.
摘要翻译： 一种改进的管，其包括封闭部分，整体地连接到所述封闭部分并且构造成用于限定活动铰链的带，具有纵向轴线的主体部分和通常围绕所述纵向轴线的外壁，并且与所述主体部分整体地和铰接地连接 通过带子的封闭部分。 主体部分包括沿着纵向轴线大致细长的样本部分，并且构造成沿其长度的一部分弹性变形，包括沿大致横向于纵向轴线的方向弹性变形，使得壁结构的至少一部分被压缩 并且弹性变形并且接合限定聚合酶链式反应扩增装置的样品块中的开口的壁，并且样品部分的第一外壁尺寸减小到更小的第二外壁尺寸。
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公开(公告)号：US20110039305A1
公开(公告)日：2011-02-17
申请号：US12918594
申请日：2009-02-19
CPC分类号： B01L7/52 , B01L3/505 , B01L2300/043 , B01L2300/0627 , B01L2300/0838 , B01L2300/18 , B01L2300/1822 , B01L2300/1844
摘要： A thermocycler apparatus and method for rapidly performing the PCR process employs at least two thermoelectric modules which are in substantial spatial opposition with an interior space present between opposing modules. One or multiple sample vessels are placed in between the modules such that the vessels are subjected to temperature cycling by the modules. The sample vessels have a minimal internal dimension that is substantially perpendicular to the modules that facilitates rapid temperature cycling. In embodiments of the invention the sample vessels may be deformable between: a) a shape having a wide mouth to facilitate filling and removing of sample fluids from the vessel, and b) a shape which is thinner for conforming to the sample cavity or interior space between the thermoelectric modules of the thermocycler for more rapid heat transfer.
摘要翻译： 用于快速执行PCR过程的热循环仪装置和方法采用至少两个热电模块，其与存在于相对模块之间的内部空间实质上空间相对。 将一个或多个样品容器放置在模块之间，使得容器经过模块的温度循环。 样品容器具有基本垂直于促进快速温度循环的模块的最小内部尺寸。 在本发明的实施例中，样品容器可以在以下之间变形：a）具有宽口的形状，以便于从容器中填充和除去样品流体，以及b）更薄的形状，以符合样品腔或内部空间 在热循环器的热电模块之间用于更快速的热传递。
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公开(公告)号：US20130078641A1
公开(公告)日：2013-03-28
申请号：US13700817
申请日：2011-06-01
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , B01L3/5023 , B01L3/5029 , B01L3/505 , B01L2300/0825
摘要： The present invention provides a method and device for treating and analyzing a biological specimen. The biological specimen is introduced into a processing device and treated thermally, mechanically, chemically or any combination thereof within the processing device to alter at least one constitutive characteristic of the biological specimen and to release or create one or more biological indicators from the biological specimen. The biological specimen is further contacted with a treated polymeric material so that at least a portion of the polymeric material binds to the one or more biological indicators.
摘要翻译： 本发明提供一种用于处理和分析生物样本的方法和装置。 将生物样品引入处理装置中并在加工装置内热处理，机械地，化学地或其任何组合进行处理，以改变生物样本的至少一个构成特征并从生物样品中释放或产生一个或多个生物指示剂。 生物样品进一步与经处理的聚合物材料接触，使得至少一部分聚合物材料与一种或多种生物指示剂结合。
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公开(公告)号：US09737891B2
公开(公告)日：2017-08-22
申请号：US13484963
申请日：2012-05-31
CPC分类号： B01L7/52 , B01L2200/14 , B01L2300/0627 , B01L2300/0858 , B01L2300/1805 , B01L2300/1822 , C12Q1/6844 , G01N2035/00366
摘要： A thermocycling device and method of operating a thermocycler instrument, the instrument including a sample holder, at least one thermal cycling element, and at least one first and second temperature sensors, for causing the sample holder containing the at least one sample to undergo polymerase chain reaction amplification by repeated cycling between at least a denaturation heating stage and an annealing cooling stage. The first temperature corresponding with the temperature of the sample holder is monitored using the at least one first temperature sensor, and a second temperature corresponding with the temperature external of the sample holder is monitored using the at least one second temperature sensor. Based upon the first temperature and the second temperature, the power that is delivered to the at least one thermal cycling element of the instrument is dynamically controlled.
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9.发明申请Rapid Thermocycler System for Rapid Amplification of Nucleic Acids and Related Methods 有权用于快速扩增核酸的快速热循环仪系统及相关方法公开(公告)号：US20120308990A1
公开(公告)日：2012-12-06
申请号：US13484963
申请日：2012-05-31
IPC分类号： C12Q3/00
CPC分类号： B01L7/52 , B01L2200/14 , B01L2300/0627 , B01L2300/0858 , B01L2300/1805 , B01L2300/1822 , C12Q1/6844 , G01N2035/00366
摘要： A thermocycling device and method of operating a thermocycler instrument, the instrument including a sample holder, at least one thermal cycling element, and at least one first and second temperature sensors, for causing the sample holder containing the at least one sample to undergo polymerase chain reaction amplification by repeated cycling between at least a denaturation heating stage and an annealing cooling stage. The first temperature corresponding with the temperature of the sample holder is monitored using the at least one first temperature sensor, and a second temperature corresponding with the temperature external of the sample holder is monitored using the at least one second temperature sensor. Based upon the first temperature and the second temperature, the power that is delivered to the at least one thermal cycling element of the instrument is dynamically controlled.
摘要翻译： 一种热循环装置和操作热循环仪器的方法，所述仪器包括样品保持器，至少一个热循环元件和至少一个第一和第二温度传感器，用于使含有至少一个样品的样品架进行聚合酶链 在至少变性加热阶段和退火冷却阶段之间重复循环的反应扩增。 使用至少一个第一温度传感器监测与样品保持器的温度相对应的第一温度，并且使用至少一个第二温度传感器监测与样品保持器外部的温度相对应的第二温度。 基于第一温度和第二温度，动态地控制输送到仪器的至少一个热循环元件的功率。
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公开(公告)号：US6057628A
公开(公告)日：2000-05-02
申请号：US110286
申请日：1998-07-06
IPC分类号： H01L41/047 , H01L41/18 , H01L41/04
CPC分类号： H01L41/0477 , H01L41/18
摘要： Disclosed is a piezoelectric system which demonstrates piezoelectric properties over a large temperature range of from room temperature to approximately 1360 degrees centigrade. The piezoelectric system is sequentially comprised of a first electrically conductive layer, a layer of (Ta.sub.2 O.sub.5) in other than a monoclinic phase, (preferably orthorhombic demonstrating small x-ray crystalographic and peaks), and a second electrically conductive layer. A preferred method of fabrication involves sputter deposition of both said layer of (Ta.sub.2 O.sub.5) and said second electrically conductive layer.
摘要翻译： 公开了一种在室温至约1360摄氏度的大温度范围内显示压电性能的压电体系。 压电体系依次包括第一导电层，除单斜晶相以外的（Ta 2 O 5）层（优选为正交的，表示小的x射线结晶图和1101峰），以及 第二导电层。 优选的制造方法包括溅射沉积所述（Ta 2 O 5）层和所述第二导电层。
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