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46 条记录 (耗时 0.019 秒)

    2'-(Orthochlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and use as medicaments
    5.
    发明授权
    2'-(Orthochlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and use as medicaments 失效
    2' - （邻氯苯甲酰基）-4'-氯草酰酰苯胺及其组合物，并用作药物

    公开(公告)号：US4382930A

    公开(公告)日：1983-05-10

    申请号：US220514

    申请日：1980-12-29

    申请人： Gilbert Mouzin ,  Henri Cousse ,  Antoine Stenger

    发明人： Gilbert Mouzin ,  Henri Cousse ,  Antoine Stenger

    IPC分类号： A61K31/165 ,  A61K31/535 ,  A61P21/02 ,  A61P25/18 ,  A61P25/20 ,  C07C231/12 ,  C07C237/04 ,  C07C237/06 ,  C07C275/38 ,  C07D295/15 ,  C07D295/14

    CPC分类号： C07D295/15 ,  Y10S514/96 ,  Y10S514/962 ,  Y10S514/966

    摘要： The present invention relates to 2'-(ortho-chlorobenzoyl)-4'-chloroglycylanilides, compositions thereof, and their use as medicaments, e.g., as anxiolytic agents.The compounds of the invention have the general formula I ##STR1## in which R represents hydrogen or alkyl,R.sub.1 and R.sub.2 may be identical or different and are selected from hydrogen, alkyl, hydroxyalkyl, alkenyl, and alkynyl, possibly substituted by alkyl, and cycloalkyl having three to six members, possibly substituted by alkyl, with the proviso that, when one of R.sub.1 and R.sub.2 represents hydrogen, the other is not lower alkyl or hydroxyalkyl; and with the further proviso that R.sub.1 and R.sub.2 may not simultaneously represent either hydrogen or lower-alkyl. R.sub.1 and R.sub.2 may furthermore form, with the nitrogen atom to which they are connected, a nitrogen heterocycle possibly containing a second heteroatom selected from oxygen and nitrogen.

    摘要翻译： 本发明涉及2' - （邻氯苯甲酰基）-4'-氯草酰苯胺，其组合物及其作为药物的用途，例如作为抗焦虑剂。 本发明的化合物具有通式I（I）其中R表示氢或烷基，R 1和R 2可以相同或不同，并且选自氢，烷基，羟基烷基，烯基和炔基，可能被 烷基和具有3至6个成员的环烷基，可能被烷基取代，条件是当R 1和R 2之一表示氢时，另一个不是低级烷基或羟烷基; 并且进一步的条件是R 1和R 2可以不同时表示氢或低级烷基。 R1和R2可以与它们所连接的氮原子形成可能含有选自氧和氮的第二杂原子的氮杂环。

    .beta.-Nicotinamido-ethyl anthranilate
    6.
    发明授权
    .beta.-Nicotinamido-ethyl anthranilate 失效
    乙酰氨基苯甲酸乙酯

    公开(公告)号：US4152521A

    公开(公告)日：1979-05-01

    申请号：US931488

    申请日：1978-08-07

    申请人： Henri Cousse ,  Gilbert Mouzin

    发明人： Henri Cousse ,  Gilbert Mouzin

    IPC分类号： C07D213/82 ,  C07D213/56

    CPC分类号： C07D213/82

    摘要： The invention concerns new chemical compounds which can be used as medicaments, their preparation, and pharmaceutical compositions, and method of treating therewith.The new chemical compounds have the general formula ##STR1## in which X, which is in 7 position, represents a halogen atom or a trifluoromethyl group.The medicaments containing these active principles may be used in the treatment of various pains, i.e., as analgesics.

    摘要翻译： 本发明涉及可用作药物的新化合物，其制备方法和药物组合物及其处理方法。

    2-alkoxycarbonylalkyl-3-oxo-5,6-diaryl-as-triazines having utility as therapeutics
    9.
    发明授权
    2-alkoxycarbonylalkyl-3-oxo-5,6-diaryl-as-triazines having utility as therapeutics 失效
    具有作为治疗用途的2-烷氧基羰基烷基-3-氧代-5,6-二芳基 - 三嗪嗪

    公开(公告)号：US4677105A

    公开(公告)日：1987-06-30

    申请号：US823342

    申请日：1986-01-28

    申请人： Pitet Guy ,  Henri Cousse ,  Gilbert Mouzin

    发明人： Pitet Guy ,  Henri Cousse ,  Gilbert Mouzin

    IPC分类号： A61K31/53 ,  A61P25/04 ,  C07D253/06 ,  C07D253/07

    CPC分类号： C07D253/065 ,  C07D253/07

    摘要： 2-Alkoxycarbonylalkyl-3-oxo-5,6-diaryl-as-Triazines of the formula I ##STR1## wherein R and R.sub.1, which may be identical or different, represent hydrogen, alkyl, alkoxy, hydroxy, dialkylamino, or halogen,R.sub.2 represents hydrogen or alkyl, andR.sub.3 represents alkyl, the method of preparation thereof, pharmaceutical compositions thereof, and a method of treating therewith, are all disclosed.The compounds are useful as essentially non-antiinflammatory analgesics.

    摘要翻译： 式I的2-烷氧基羰基烷基-3-氧代-5,6-二芳基 - 三嗪，其中R和R 1可以相同或不同，代表氢，烷基，烷氧基，羟基，二烷基氨基或卤素 R2表示氢或烷基，R3表示烷基，其制备方法，药物组合物及其处理方法。 该化合物可用作基本上非抗炎止痛剂。