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    RNA virus expression and replication, methods and uses therefor
    2.
    发明申请
    RNA virus expression and replication, methods and uses therefor 审中-公开
    RNA病毒表达和复制，其方法和用途

    公开(公告)号：US20060003957A1

    公开(公告)日：2006-01-05

    申请号：US11122944

    申请日：2005-05-05

    申请人： Herbert Virgin ,  Christiane Wobus ,  Stephanie Karst

    发明人： Herbert Virgin ,  Christiane Wobus ,  Stephanie Karst

    IPC分类号： A61K48/00 ,  C07H21/02

    CPC分类号： C12N7/00 ,  C07K14/005 ,  C07K16/10 ,  C07K2317/76 ,  C12N15/1131 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/52 ,  C12N2770/16022 ,  C12N2770/16051 ,  C12N2310/3521

    摘要： A norovirus-permissive cell culture infected with a norovirus, and methods of culturing a norovirus, are disclosed. Norovirus-permissive cells include dendritic cell-lineage cells, and macrophage-lineage cells, such as dendritic cells, and macrophages having a deficiency in a cellular anti-viral pathway such as a STAT-1-dependent pathway, an interferon receptor-dependent pathway, or a PKR-dependent pathway. Also disclosed are methods of screening anti-viral compounds against norovirus-permissive cells infected with norovirus, and norovirus adapted to grow in fibroblasts as well as macrophages that are not deficient in a cellular anti-viral pathway. Methods of making a norovirus vaccine are also disclosed. A replicative form of norovirus as well as its use in the development of an anti-viral agent and a polypeptide expression system are also described.

    摘要翻译： 公开了用诺如病毒感染的诺如病毒允许细胞培养物，以及培养诺如病毒的方法。 诺如病毒允许细胞包括树突状细胞谱系细胞和巨噬细胞谱系细胞，例如树突细胞和在细胞抗病毒途径中缺乏的巨噬细胞，例如STAT-1-依赖性途径，干扰素受体依赖性途径 ，或PKR依赖性途径。 还公开了筛选针对诺如病毒感染的诺如病毒允许细胞的抗病毒化合物的方法，以及适于在成纤维细胞以及细胞抗病毒途径中不缺陷的巨噬细胞生长的诺如病毒。 还公开了制备诺如病毒疫苗的方法。 还描述了诺如病毒的复制形式及其在开发抗病毒剂和多肽表达系统中的用途。

    RNA virus expression and replication, methods and uses therefor
    6.
    发明申请
    RNA virus expression and replication, methods and uses therefor 有权
    RNA病毒表达和复制，其方法和用途

    公开(公告)号：US20050255480A1

    公开(公告)日：2005-11-17

    申请号：US10839211

    申请日：2004-05-05

    申请人： Herbert Virgin ,  Christiane Wobus ,  Stephanie Karst

    发明人： Herbert Virgin ,  Christiane Wobus ,  Stephanie Karst

    IPC分类号： A01N43/36 ,  A61K31/40 ,  C07K14/08 ,  C12N5/00 ,  C12N5/02 ,  C12N7/00 ,  C12N7/01 ,  C12N15/00 ,  C12N15/09 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74 ,  C12Q1/68 ,  C12Q1/70

    CPC分类号： C07K14/005 ,  A61K2039/5254 ,  C12N7/00 ,  C12N2770/30021 ,  C12N2770/30022

    摘要： A norovirus-permissive cell culture infected with a norovirus, and methods of culturing a norovirus, are disclosed. Norovirus-permissive cells include dendritic cell-lineage cells, and macrophage-lineage cells, such as dendritic cells, and macrophages having a deficiency in a cellular anti-viral pathway such as a STAT-1-dependent pathway, an interferon receptor-dependent pathway, or a PKR-dependent pathway. Also disclosed are methods of screening anti-viral compounds against norovirus-permissive cells infected with norovirus, and norovirus adapted to grow in fibroblasts as well as macrophages that are not deficient in a cellular anti-viral pathway. Methods of making a norovirus vaccine are also disclosed.

    摘要翻译： 公开了用诺如病毒感染的诺如病毒允许细胞培养物，以及培养诺如病毒的方法。 诺如病毒允许细胞包括树突状细胞谱系细胞和巨噬细胞谱系细胞，例如树突细胞和在细胞抗病毒途径中缺乏的巨噬细胞，例如STAT-1-依赖性途径，干扰素受体依赖性途径 ，或PKR依赖性途径。 还公开了筛选针对诺如病毒感染的诺如病毒允许细胞的抗病毒化合物的方法，以及适于在成纤维细胞以及细胞抗病毒途径中不缺陷的巨噬细胞生长的诺如病毒。 还公开了制备诺如病毒疫苗的方法。