公开(公告)号：US5039490A

公开(公告)日：1991-08-13

申请号：US40163

申请日：1987-04-17

申请人： Hermann Marsoner ,  Herbert Kroneis ,  Hellfried Karpf ,  Otto S. Wolfbeis ,  Helmut List ,  Alfred Leitner

发明人： Hermann Marsoner ,  Herbert Kroneis ,  Hellfried Karpf ,  Otto S. Wolfbeis ,  Helmut List ,  Alfred Leitner

IPC分类号： G01N21/64 ,  G01N21/25 ,  G01N21/27 ,  G01N21/77 ,  G01N21/81

CPC分类号： G01N21/77 ,  G01N21/255 ,  G01N2021/174 ,  G01N2021/7786 ,  G01N21/6428 ,  G01N21/81 ,  G01N2201/0621 ,  G01N2201/0622

摘要： Due to the size of the devices used for the excitation and measuring of light, conventional sensor elements for optically determining the concentrations of substances contained in gaseous and liquid samples, featuring an indicator layer with one or more indicator substances, are not well suited for use with microanalysis equipment, nor are they easy to mass-produce. These disadvantages are eliminated by using a unitary sensor element having a carrier layer, at least one photosensitive element with electric contact leads in contact with the carrier layer, and an indicator layer containing an indicator substance.

摘要翻译： 由于用于激发和测量光的装置的尺寸，用于光学确定气态和液体样品中所含物质浓度的常规传感器元件，其特征在于具有一个或多个指示剂物质的指示剂层，不太适用于 使用微量分析设备，也不易于批量生产。 这些缺点通过使用具有载体层的单一传感器元件，至少一个具有电接触引线与载体层接触的感光元件以及含有指示物质的指示剂层来消除。

公开(公告)号：US5193545A

公开(公告)日：1993-03-16

申请号：US476360

申请日：1990-02-07

申请人： Hermann Marsoner ,  Falko Skrabal ,  Helmut List

发明人： Hermann Marsoner ,  Falko Skrabal ,  Helmut List

IPC分类号： A61B5/00

CPC分类号： A61B5/14542 ,  A61B5/14528 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/686 ,  Y10S128/13

摘要： A device designed for determining one or more medical variables in living organisms, comprises a part to be inserted into the tissue of the organism, which has an exchange channel with openings into the tissue. The device comprising a delivery unit connected with the exchange channel for the delivery of a perfusion fluid and its drainage after partial equilibration with the medical variable or quantity to be measured, i.e., preferably glucose concentration, and comparatively constant endogenous or exogenous marker variables. The device further comprising an analyzing unit for measuring the medical variable and one marker variable, and an evaluation unit for determining the actual concentration of the medical variable with the use of the marker variables. The proposal is put forward that the part to be inserted into the tissue is configured as a flexible plastic cannula, and that this cannula is provided with a puncturing needle on one end, and that the two ends of the cannula are connected to feeder and drainage tubes of the delivery unit both on the pressure and suction side.

摘要翻译： 设计用于确定活生物体中的一个或多个医学变量的装置包括要插入生物体的组织的部分，其具有与组织中的开口的交换通道。 该装置包括与用于输送灌注流体的交换通道连接的递送单元，以及在与待测量的医学变量或待测量的部分平衡之后的排水，即优选葡萄糖浓度，以及相对恒定的内源或外源标记变量。 该装置还包括用于测量医疗变量和一个标记变量的分析单元，以及用于使用标记变量来确定医疗变量的实际浓度的评估单元。 提出的是，要插入组织的部分被配置为柔性塑料插管，并且该套管在一端设有穿刺针，套管的两端连接到给料器和排水管 输送单元的管在压力和吸力侧。

公开(公告)号：US4704893A

公开(公告)日：1987-11-10

申请号：US903199

申请日：1986-09-03

申请人： Hermann Marsoner ,  Gerald Kirchmayer ,  Helmut List

发明人： Hermann Marsoner ,  Gerald Kirchmayer ,  Helmut List

IPC分类号： G01N33/483 ,  G01N1/22

CPC分类号： G01N33/4925 ,  Y10T436/25

摘要： A device for equilibrating small quantities of a liquid reagent or a test solution with a gas-containing liquid or a gas in which at least part of the passage of the reagent leads through a hollow space that is separated by a permeable wall from a gas chamber which is closed, except for an inlet and an outlet opening, and which may be charged with the gas or gas-containing liquid. In order to ensure good mixing of the test liquid during equilibration, the hollow space carrying the liquid is configured as a tube or hose with one or more helical sections inside the gas chamber whose walls are permeable to the gas.

摘要翻译： 一种用于使含有气体的液体或气体平衡少量液体试剂或测试溶液的装置，其中试剂的至少一部分通道穿过由透气壁与气室隔开的中空空间 除了入口和出口之外，其是封闭的，并且可以装入气体或含气体的液体。 为了在平衡期间确保测试液体的良好混合，承载液体的中空空间被配置为具有一个或多个螺旋部分的管或软管，其内部的气体可渗透气体室内。

公开(公告)号：US5157262A

公开(公告)日：1992-10-20

申请号：US706004

申请日：1991-05-28

申请人： Hermann Marsoner ,  Herbert Kroneis ,  Hellfried Karpf ,  Otto S. Wolfbeis ,  Helmut List ,  Alfred Leitner

发明人： Hermann Marsoner ,  Herbert Kroneis ,  Hellfried Karpf ,  Otto S. Wolfbeis ,  Helmut List ,  Alfred Leitner

IPC分类号： G01N21/64 ,  G01N21/25 ,  G01N21/27 ,  G01N21/77 ,  G01N21/81

CPC分类号： G01N21/77 ,  G01N21/255 ,  G01N2021/174 ,  G01N2021/7786 ,  G01N21/6428 ,  G01N21/81 ,  G01N2201/0621 ,  G01N2201/0622

摘要： Due to the size of the devices used for the excitation and measuring of light, conventional sensor elements for optically determining the concentrations of substances contained in gaseous and liquid samples, featuring an indicator layer with one or more indicator substances, are not well suited for use with microanalysis equipment, nor are they easy to mass-produce. These disadvantages are eliminated by integrating on the carrier layer (1) at least one photosensitive element (3) and its electric contact leads in planar arrangement, and by establishing optical contact between the indicator substance (7, 7') of the indicator layer (6) stimulated by the excitation radiation (11), and the photosensitive elements (3).

公开(公告)号：US5080865A

公开(公告)日：1992-01-14

申请号：US390754

申请日：1989-08-08

申请人： Marco J. Leiner ,  Karl Harnoncourt ,  Gerald Kirchmayer ,  Erich Kleinhappl ,  Helmut List ,  Hermann Marsoner ,  Otto S. Wolfbeis ,  Werner E. Ziegler

发明人： Marco J. Leiner ,  Karl Harnoncourt ,  Gerald Kirchmayer ,  Erich Kleinhappl ,  Helmut List ,  Hermann Marsoner ,  Otto S. Wolfbeis ,  Werner E. Ziegler

IPC分类号： G01N33/48 ,  G01N1/00 ,  G01N1/28 ,  G01N21/77 ,  G01N33/483 ,  G01N33/487 ,  G01N33/49

CPC分类号： G01N1/28 ,  G01N21/7703 ,  G01N2201/1288 ,  G01N33/487

摘要： In order to improve a one-way measuring element, which may be inserted into an analyzer for analyzing gaseous or liquid samples and which comprises a measuring channel with a measuring zone and one or more sensors located therein, the proposal is put forward that the one-way measuring element be provided with a sensor part whose measuring channel has seals on both ends, and with a sample-taking part, and that a coupling element be placed at the inlet end of the measuring channel for direct coupling of the sample-taking part containing the gaseous or liquid sample, and that the measuring channel be filled with a calibrating and storage medium prior to the measuring process, and that the calibrating and storage medium contained in the measuring channel be displaced by the sample flowing in after the sample-taking part has been coupled to the sensor part. The one-way measuring elements obtained in this way are characterized by great simplicity of design and ease of handling.

摘要翻译： 为了改进可以插入用于分析气体或液体样品的分析器中的单向测量元件，并且包括具有测量区域的测量通道和位于其中的一个或多个传感器，提出了一种方案 测量元件设有传感器部分，测量通道在两端都有密封，并具有采样部分，耦合元件放置在测量通道的入口端，用于直接耦合采样 包含气体或液体样品的部分，并且测量通道在测量过程之前用校准和存储介质填充，并且测量通道中包含的校准和存储介质被样品流动后的样品置换， 参与传感器部件。 以这种方式获得的单向测量元件的特征在于设计的简单性和易于操作。

公开(公告)号：US4351798A

公开(公告)日：1982-09-28

申请号：US233574

申请日：1981-02-11

申请人： Hermann Marsoner ,  Helmut List ,  Erich Kleinhappl

发明人： Hermann Marsoner ,  Helmut List ,  Erich Kleinhappl

IPC分类号： G01N1/00 ,  G01N1/14 ,  G01N35/06

CPC分类号： G01N35/1097

摘要： An analyzing apparatus for measuring samples of a liquid has feeding means for feeding the samples contained in sample containers to a subsequent sample conduit, the feeding means having a substantially funnel shaped filling mouth serving for fastening sample containers of very different shapes, such as syringes, pipettes or capillary tubes, and the dimensions of the outlet opening thereof varying within wide limits. A cleaning device can be used, which has a washing body which during the cleaning operation, together with the funnel shaped filling mouth, defines an annular gap adapted to match the form of the filling mouth and is providable with a cleaning medium.To ascertain the presence and opening diameter category of a sample container and to automatically adjust the appropriate operating condition of the analyzing device, at a distance before the sample feeding inlet, an oscillation emitter and, with respect to the center of the sample feeding inlet, diametrically opposite the emitter and at a distance from the center of the sample feeding inlet, at least two identical detectors for the emitter oscillations are arranged, whereby according to the respective number of detectors which, after insertion of a certain sample container in the sample feeding inlet, will receive a signal or not, depending on the dimensions of the sample container present between emitter and detector, the adequate operating condition of the analyzing device is automatically adjustable.

摘要翻译： 用于测量液体样品的分析装置具有用于将包含在样品容器中的样品供给到随后的样品导管的进料装置，所述进料装置具有大致漏斗形填充口，用于紧固非常不同形状的样品容器，例如注射器， 移液器或毛细管，并且其出口开口的尺寸在宽范围内变化。 可以使用清洁装置，其具有洗涤体，其在清洁操作期间与漏斗形填充口一起限定适于与填充口的形状匹配的环形间隙，并且可用清洁介质提供。 为了确定样品容器的存在和开口直径类别并且在样品供给入口之前的距离处自动调节分析装置的适当操作条件，振荡发射器和相对于样品供给入口的中心， 与发射体直径相对并且距离样品供给入口的中心一定距离处，布置了用于发射体振荡的至少两个相同的检测器，由此根据相应数量的检测器，在将样品容器插入样品进料之后 入口，将会收到一个信号，根据发射器和探测器之间存在的样品容器的尺寸，分析装置的适当工作状态可自动调节。

公开(公告)号：US5074157A

公开(公告)日：1991-12-24

申请号：US488532

申请日：1990-02-28

申请人： Hermann Marsoner ,  Helmut List

发明人： Hermann Marsoner ,  Helmut List

IPC分类号： G01N27/403 ,  G01N33/487

CPC分类号： G01N33/48707

摘要： An analyzing apparatus primarily designed for the analysis of body fluids, includes a feeding device, a measuring unit formed by a string of measuring cells linked by a channel, and a waste disposal unit for removal of the samples analyzed. Such an analyzing apparatus may be tailored to suit specific purposes by providing the measuring unit, or at least parts thereof, as modular units, which can directly be coupled to the feeding device and the waste disposal unit via a separate control block.

摘要翻译： 主要设计用于体液分析的分析装置包括供给装置，由通过通道连接的一串测量单元形成的测量单元和用于移除分析的样品的废物处理单元。 可以通过将测量单元或其至少部分作为模块单元来定制这样的分析装置以适合特定目的，该模块单元可以通过单独的控制块直接耦合到进给装置和废物处理单元。

公开(公告)号：US4501296A

公开(公告)日：1985-02-26

申请号：US547589

申请日：1983-11-01

申请人： Hermann Marsoner ,  Karl Harnoncourt ,  Helmut List

发明人： Hermann Marsoner ,  Karl Harnoncourt ,  Helmut List

IPC分类号： G01N1/00 ,  G01N27/28 ,  G01N33/487 ,  G01N33/49 ,  F16K11/02

CPC分类号： G01N35/1097 ,  G01N33/4925 ,  Y10T137/86405 ,  Y10T137/86823

摘要： An electrochemical measuring apparatus may be charged with an option of several media by providing a feeder part with the respective media connections, and by guiding a piece of pipe in a bore, which is sealed off and is movable relative to this feeder part. On its end facing away from a measuring chamber in the apparatus, the piece of pipe has a connection for additional media. Besides, it carries at least one circumferential bore which may be brought to coincide with at least one of the input openings into the bore connecting to the feed lines, by means of a relative motion - preferably controlled via a stepping motor - between the pipe piece and the above bore.

摘要翻译： 电化学测量装置可以通过提供具有各个介质连接的给料部分并且通过引导密封的孔中的管件并相对于该进料器部件可移动来对带有多种介质的选项进行充电。 在其远离设备中的测量室的端部，该管道具有用于附加介质的连接。 此外，它携带至少一个周向孔，其可以通过相对运动（优选地通过步进电机控制）与至少一个输入开口重合到连接到进料管的孔中，该相对运动在管件 和上述孔。

公开(公告)号：US5130009A

公开(公告)日：1992-07-14

申请号：US469214

申请日：1990-01-24

申请人： Hermann Marsoner ,  Helmut List ,  Heinz Kontschieder ,  Falko Skrabal

发明人： Hermann Marsoner ,  Helmut List ,  Heinz Kontschieder ,  Falko Skrabal

IPC分类号： C12Q1/00 ,  G01N27/08 ,  G01N27/28 ,  G01N27/404 ,  G01N27/416

CPC分类号： C12Q1/006 ,  G01N27/3272 ,  Y10S435/817 ,  Y10S436/806

摘要： In order to produce a small-volume flow measuring cell with good flow characteristics in a sensor device for determining the concentration of a substrate in a sample medium, comprising an enzyme electrode which is covered by a membrane and a reference electrode, both of which are in contact with the measuring cell, the proposal is put forward that the reference electrode be located outside of the membrane cover of the enzyme electrode and that the maximum extension of the flow measuring cell normal to the flow direction of the sample medium essentially be the same as the diameter of the sensitive layer of the enzyme electrode.

摘要翻译： 为了在用于确定样品介质中的基底浓度的传感器装置中产生具有良好流动特性的小体积流量测量单元，包括由膜和参比电极覆盖的酶电极，它们均为 提出了将参考电极定位在酶电极的膜覆盖层外侧的方案，并且流动测量元件的垂直于样品介质的流动方向的最大延伸基本上是相同的 作为酶电极敏感层的直径。

公开(公告)号：US4587101A

公开(公告)日：1986-05-06

申请号：US553386

申请日：1983-11-18

申请人： Hermann Marsoner ,  Herbert Kroneis

发明人： Hermann Marsoner ,  Herbert Kroneis

IPC分类号： G01N21/76 ,  C09K11/02 ,  C09K11/06 ,  G01N21/64 ,  G01N21/78 ,  G01N31/00 ,  G01N31/22

CPC分类号： G01N21/643 ,  C09K11/02 ,  C09K11/025 ,  C09K11/06 ,  G01N21/6428

摘要： In a sensor element for determining the O.sub.2 content of a sample, comprising a fluorescent indicator substance which is embedded in a polymer carrier and with which the sample may be brought into contact, a fluorescence extinction sufficiently high for yielding useful measurement results is achieved by the use of plasticizer-compatible polymers as carrier materials which contain plasticizers in addition to the indicator molecules.

摘要翻译： 在用于确定样品的O 2含量的传感器元件中，包括嵌入在聚合物载体中并与样品接触的荧光指示物质，足够高的荧光消光以产生有用的测量结果，由 使用与增塑剂相容的聚合物作为载体材料，除了指示剂分子之外还含有增塑剂。