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    Benzopyran derivatives and an anti-allergic agent possessing the same as the active ingredient
    5.
    发明授权
    Benzopyran derivatives and an anti-allergic agent possessing the same as the active ingredient 失效
    苯并吡喃衍生物和具有与活性成分相同的抗过敏剂

    公开(公告)号：US5428059A

    公开(公告)日：1995-06-27

    申请号：US938132

    申请日：1992-11-20

    申请人： Hidetsugu Takagaki ,  Mitsuru Sakai ,  Hiromu Takahashi ,  Kazuhiko Inazawa ,  Masayoshi Abe ,  Nobuyuki Kimura

    发明人： Hidetsugu Takagaki ,  Mitsuru Sakai ,  Hiromu Takahashi ,  Kazuhiko Inazawa ,  Masayoshi Abe ,  Nobuyuki Kimura

    IPC分类号： C07D311/56 ,  A61K31/35

    CPC分类号： C07D311/56

    摘要： The present invention relates to an extremely effective anti-allergic agent with a low toxicity, which possesses as its active ingredient a benzopyran derivative described by the general formula below (in the formula, R.sup.1 and R.sup.2 are each respectively a hydrogen atom, an acyl group, an alkyl group having 1.about.12 carbon atoms, or an alkenyl group having 2.about.10 carbon atoms; and R.sup.3 is a hydroxyl group, an acyloxy group, an alkoxy group having 1.about.10 carbon atoms, or an alkenyloxy group having 2.about.10 carbon atoms).General Formula ##STR1##

    摘要翻译： PCT No.PCT / JP92 / 00095 Sec。 371日期：1992年11月20日 102（e）1992年11月20日PCT PCT 1992年1月31日PCT公布。 第WO92 / 13852号公报 本发明涉及一种毒性低的极有效的抗过敏剂，它具有下列通式所示的苯并吡喃衍生物作为其活性成分（式中，R1和R2各自分别为 氢原子，酰基，具有1个碳原子的烷基或具有2个碳原子的烯基; R3是羟基，酰氧基，具有1-10个碳原子的烷氧基， 或具有2个碳原子的烯氧基）。 通用公式

    Quinolinone derivative, method for preparing the same, and anti-allergic agent
    6.
    发明授权
    Quinolinone derivative, method for preparing the same, and anti-allergic agent 有权
    喹啉酮衍生物，其制备方法和抗过敏剂

    公开(公告)号：US6136822A

    公开(公告)日：2000-10-24

    申请号：US201662

    申请日：1998-12-01

    申请人： Hidetsugu Takagaki ,  Shinobu Yamaguchi ,  Masayoshi Abe ,  Mitsuru Sakai ,  Osamu Misumi

    发明人： Hidetsugu Takagaki ,  Shinobu Yamaguchi ,  Masayoshi Abe ,  Mitsuru Sakai ,  Osamu Misumi

    IPC分类号： C07D215/22 ,  A61K31/00 ,  A61K31/47 ,  A61K31/4704 ,  A61P37/00 ,  A61P37/08 ,  C07C235/16 ,  C07D215/38 ,  C07D215/40 ,  C07D215/48 ,  C07D401/12 ,  C07D405/04 ,  C07D405/06 ,  C07D215/16 ,  C07D215/20 ,  C07D215/36

    CPC分类号： C07D215/22 ,  C07C235/16 ,  C07D215/38 ,  C07D215/40 ,  C07D215/48 ,  C07D401/12 ,  C07D405/04 ,  C07D405/06

    摘要： The present invention relates to a simple method for preparing a quinolinone derivative, which is effective as a medicine, e.g., as an agent for treating allergic diseases and the like; novel amide derivatives effective as an intermediate in the method; novel quinolinone derivatives obtained according to the method; and an anti-allergic agent containing a quinolinone derivative and/or physiological salt of the same as the active ingredients. The quinolinone derivative is expressed by the following general formula (II); and the method is characterized in that an amide derivative, expressed by the following formula (I), is reacted with a basic agent, followed by intramolecular ring formation: ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group, an alkyl group containing a hydroxyl group an alkenyl group, or an aryl group; R.sub.2 represents an alkyl group, an alkenyl group, an aryl group, or an aralkyl group; R.sub.3 represents a reactive carboxyl group; and R.sub.4 to R.sub.7 represent, respectively and independently, a hydrogen atom; a hydroxyl group; an alkyl group; an alkoxy group; an alkenyl group; an alkenyloxy group; an aryl group; an aryloxy group; an aralkyloxy group; a R.sub.8 R.sub.9 N group wherein R.sub.8 and R.sub.9 represent, respectively and independently, a hydrogen atom, an alkyl group, an alkenyl group an aralkyl group, or an acyl group; a nitro group; or a R.sub.10 OOC group wherein R.sub.10 represents a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group; ##STR2## wherein R.sub.1, R.sub.2 and R.sub.4 to R.sub.7 represent, respectively, the same constituents as described in formula (I).

    摘要翻译： 本发明涉及一种制备喹啉酮衍生物的简单方法，其作为药物是有效的，例如用作治疗过敏性疾病等的药剂; 在该方法中作为中间体有效的新型酰胺衍生物; 按照该方法得到的新型喹啉酮衍生物; 以及含有与活性成分相同的喹啉酮衍生物和/或其生理盐的抗过敏剂。 喹啉酮衍生物由以下通式（II）表示; 该方法的特征在于将由下式（I）表示的酰胺衍生物与碱性试剂反应，然后分子内环形成：其中R 1表示氢原子，烷基，含有羟基的烷基 烯基或芳基; R2表示烷基，烯基，芳基或芳烷基; R3代表活性羧基; 和R 4至R 7分别独立地表示氢原子; 羟基; 烷基; 烷氧基 烯基; 烯氧基; 芳基; 芳氧基; 芳烷氧基; R8R9N基，其中R8和R9分别独立地表示氢原子，烷基，烯基，芳烷基或酰基; 硝基; 或R10OOC基，其中R10表示氢原子，烷基，烯基，芳基或芳烷基; 其中R1，R2和R4至R7分别表示与式（I）中所述相同的组分。

    Quinolinone derivative, method for preparing the same, and anti-allergic agent
    7.
    发明授权
    Quinolinone derivative, method for preparing the same, and anti-allergic agent 有权
    喹啉酮衍生物，其制备方法和抗过敏剂

    公开(公告)号：US06271416B1

    公开(公告)日：2001-08-07

    申请号：US09595909

    申请日：2000-06-20

    申请人： Hidetsugu Takagaki ,  Shinobu Yamaguchi ,  Masayoshi Abe ,  Mitsuru Sakai ,  Osamu Misumi

    发明人： Hidetsugu Takagaki ,  Shinobu Yamaguchi ,  Masayoshi Abe ,  Mitsuru Sakai ,  Osamu Misumi

    IPC分类号： C07C22900

    CPC分类号： C07D215/22 ,  C07C235/16 ,  C07D215/38 ,  C07D215/40 ,  C07D215/48 ,  C07D401/12 ,  C07D405/04 ,  C07D405/06

    摘要： The present invention relates to a simple method for preparing a quinolinone derivative, which is effective as a medicine, e.g., as an agent for treating allergic diseases and the like; novel amide derivatives effective as an intermediate in the method, novel quinolinone derivatives obtained according to the method; and an anti-allergic agent containing a quinolinone derivative and/or physiological salt of the same as the active ingredients. The quinolinone derivative is expressed by the following general formula (II); and the method is characterized in that an amide derivative, expressed by the following general formula (I), is reacted with a basic agent, followed by intramolecular ring formation: General Formula (I) [wherein, R1 represents a hydrogen atom, an alkyl group, an alkyl group containing a hydroxyl group, an alkenyl group, or an aryl group; R2 represents an alkyl group, an alkenyl group, an aryl group, or an aralkyl group; R3 represents a reactive carboxyl group; and R4 to R7 represent, respectively and independently, a hydrogen atom, a hydroxyl group, an alkyl group, an alkoxy group, an alkenyl group, an alkenyloxy group, an aryl group, an aryloxy group, an aralkyloxy group, a R8R9N group (wherein, R8 and R9 represent, respectively and independently, a hydrogen atom, an alkyl group, an alkenyl group, an aralkyl group, or an acyl group), a nitro group, or a R10OOC group (wherein, R10 represents a hydrogen atom, an alkyl group, an alkenyl group, an aryl group, or an aralkyl group)]. General Formula (II) [wherein, R1, R2 and R4 to R7 represent, respectively, the same constituents as described in general formula (I)].

    摘要翻译： 本发明涉及一种制备喹啉酮衍生物的简单方法，其作为药物是有效的，例如用作治疗过敏性疾病等的药剂; 该方法中作为中间体有效的新型酰胺衍生物，按照该方法得到的新型喹啉酮衍生物; 以及含有与活性成分相同的喹啉酮衍生物和/或其生理盐的抗过敏剂。 喹啉酮衍生物由以下通式（II）表示; 该方法的特征在于将由以下通式（I）表示的酰胺衍生物与碱性试剂反应，然后分子内环形成：通式（I）[其中，R 1表示氢原子，烷基 基团，含有羟基，烯基或芳基的烷基; R2表示烷基，烯基，芳基或芳烷基; R3代表活性羧基; R 4〜R 7分别独立地表示氢原子，羟基，烷基，烷氧基，烯基，烯氧基，芳基，芳氧基，芳烷氧基，R8R9N基（ 其中，R8和R9分别独立地表示氢原子，烷基，烯基，芳烷基或酰基），硝基或R10OOC基（其中，R10表示氢原子， 烷基，烯基，芳基或芳烷基）]通式（II）[其中，R1，R2和R4至R7分别表示与通式（I）中所述相同的组分] 。

    Optical disc recording/reproducing apparatus
    10.
    发明授权
    Optical disc recording/reproducing apparatus 有权
    光盘记录/重放装置

    公开(公告)号：US08000213B2

    公开(公告)日：2011-08-16

    申请号：US12667092

    申请日：2008-06-27

    申请人： Dai Ichiryu ,  Mitsuru Sakai

    发明人： Dai Ichiryu ,  Mitsuru Sakai

    IPC分类号： G11B7/00

    CPC分类号： G11B7/00745 ,  G11B7/0053 ,  G11B7/00718

    摘要： There is provided an optical disc recording/reproducing apparatus which can reduce the chip size using the high-miniaturization process and can enhance the detection accuracy. A signal which is obtained by amplitude-adjusting a header region in a reproduced signal detected by an optical pickup (1) is digitized, and peak detection or bottom detection from the reproduced signal in each of a first section and a second section in the header region is performed by detection circuits (9) to (12), respectively. Then, amplitude data in the first section and the second section are obtained by subtracters (13) and (14) from the detected values in the respective detection circuits. A difference in amplitude between the first section and the second section in the header region is obtained by a subtracter (15) based on the amplitude data, and the amplitude difference is outputted as an off-track error signal. The respective detection circuits (9) to (12) perform detection operations in the first and second sections, and hold the detection operations in the sections other than the first and second sections.

    摘要翻译： 提供了一种光盘记录/再现装置，其可以使用高度小型化处理来减小芯片尺寸，并且可以提高检测精度。 通过对由光学拾取器（1）检测到的再现信号中的标题区进行幅度调整而获得的信号被数字化，并且在标题中的第一部分和第二部分中的每一个中的再现信号中进行峰值检测或底部检测 区域由检测电路（9）〜（12）分别进行。 然后，通过减法器（13）和（14）从各个检测电路中的检测值获得第一部分和第二部分中的幅度数据。 通过基于幅度数据的减法器（15）获得标题区域中的第一部分和第二部分之间的幅度差异，并且将幅度差作为偏离磁道误差信号输出。 各检测电路（9）至（12）执行第一和第二部分的检测操作，并且将检测操作保持在除第一和第二部分之外的部分中。