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45 条记录 (耗时 0.022 秒)

    CARDIAC DYSFUNCTION-AMELIORATING AGENT OR CARDIAC FUNCTION-MAINTAINING AGENT
    1.
    发明申请
    CARDIAC DYSFUNCTION-AMELIORATING AGENT OR CARDIAC FUNCTION-MAINTAINING AGENT 审中-公开
    心脏功能改善剂或心脏功能维持剂

    公开(公告)号：US20090246185A1

    公开(公告)日：2009-10-01

    申请号：US12282448

    申请日：2007-03-09

    申请人： Hideyuki Kishida ,  Kenji Fujii ,  Hiroshi Kubo ,  Kazunori Hosoe

    发明人： Hideyuki Kishida ,  Kenji Fujii ,  Hiroshi Kubo ,  Kazunori Hosoe

    IPC分类号： A61K31/122 ,  C07C43/23 ,  A61P9/00

    CPC分类号： A61K31/122 ,  A23K20/111 ,  A23K20/174 ,  A23L33/10 ,  A23L33/15 ,  A23V2002/00 ,  A61K45/06 ,  A23V2200/326 ,  A23V2250/314

    摘要： An object of the present invention is to provide a highly safe oral composition superior in a cardiac dysfunction-ameliorating or cardiac function-maintaining action. The present inventors have conducted intensive studies in an attempt to solve the aforementioned problems and found that use of, particularly, reduced coenzyme Q10 from among highly safe coenzyme Q affords a composition useful for amelioration of cardiac dysfunction and maintenance of cardiac function. Accordingly, the present invention provides a cardiac dysfunction-ameliorating agent or cardiac function-maintaining agent containing reduced coenzyme Q as an active ingredient, and a pharmaceutical product, a food, an animal drug, a feed and the like, which contain the agent.

    摘要翻译： 本发明的目的是提供在心脏功能障碍改善或心脏功能保持作用方面优异的高度安全的口服组合物。 本发明人为了解决上述问题进行了深入研究，发现特别是来自高度安全性的辅酶Q中的还原型辅酶Q10的使用提供了用于改善心脏功能障碍和维持心脏功能的组合物。 因此，本发明提供含有还原型辅酶Q作为活性成分的心脏功能障碍改善剂或心脏功能维持剂，以及含有该药剂的药物，食品，动物药物，饲料等。

    AGENT FOR IMPROVING NERVOUS SYSTEM CELL FUNCTIONS
    2.
    发明申请
    AGENT FOR IMPROVING NERVOUS SYSTEM CELL FUNCTIONS 审中-公开
    改善神经系统细胞功能的代理

    公开(公告)号：US20090246186A1

    公开(公告)日：2009-10-01

    申请号：US12295258

    申请日：2007-03-29

    申请人： Yoshiyuki Shinagawa ,  Hideyuki Kishida ,  Taizo Kawabe ,  Hirokazu Sakamoto ,  Hiroshi Kubo ,  Kazunori Hosoe

    发明人： Yoshiyuki Shinagawa ,  Hideyuki Kishida ,  Taizo Kawabe ,  Hirokazu Sakamoto ,  Hiroshi Kubo ,  Kazunori Hosoe

    IPC分类号： A61K31/122 ,  A61P25/00

    CPC分类号： A61K31/09 ,  A61K31/122

    摘要： The present invention aims to activate neural cells in brain, and further provide a useful composition having an action to protect intracerebral neural cells from external and internal stresses.An agent for improving a neural cell function containing reduced coenzyme Q as an active ingredient, more specifically, an agent for activating neural cells and an agent for protecting neural cells, is useful, and can be used for the improvement or prophylaxis of central neurological diseases or neuropathy symptoms derived from or associated with a neurodegenerative disease, promotion of cognitive function or improvement of learning and memory disorders.

    摘要翻译： 本发明旨在激活脑中的神经细胞，并进一步提供一种有用的组合物，其具有保护脑内神经细胞免受外部和内部应激的作用。 用于改善包含还原型辅酶Q作为活性成分的神经细胞功能的药剂，更具体地，用于激活神经细胞的药剂和用于保护神经细胞的药剂是有用的，并且可用于改善或预防中枢神经系统疾病 或由神经退行性疾病引起或与之相关的神经病症状，促进认知功能或改善学习和记忆障碍。

    Whitening composition containing reduced coenzyme Q
    3.
    发明申请
    Whitening composition containing reduced coenzyme Q 审中-公开
    含有还原型辅酶Q的美白组合物

    公开(公告)号：US20070196349A1

    公开(公告)日：2007-08-23

    申请号：US11653974

    申请日：2007-01-17

    申请人： Shiro Kitamura ,  Takahiro Ueda ,  Yasuyoshi Ueda ,  Hideyuki Kishida ,  Kenji Fujii ,  Kazunori Hosoe

    发明人： Shiro Kitamura ,  Takahiro Ueda ,  Yasuyoshi Ueda ,  Hideyuki Kishida ,  Kenji Fujii ,  Kazunori Hosoe

    IPC分类号： A61K8/18

    CPC分类号： A61Q19/02 ,  A23L33/10 ,  A23V2002/00 ,  A61K8/355 ,  A23V2200/318 ,  A23V2250/314

    摘要： The present invention provides a cosmetic or food composition which is excellent in a skincare effect, particularly an effect of whitening the skin browned due to ultraviolet radiation or aging, and which can be safely used for many mammals. The present invention provides a whitening composition comprising reduced coenzyme Q represented by formula (1) as an effective component: wherein n represents an integer of 1 to 12. The present invention also provides a whitening composition further comprising oxidized coenzyme Q represented by formula (2) as an effective component: wherein n represents an integer of 1 to 12. The present invention also provides a method for whitening the skin of a mammal, the method comprising administering the mammal with the composition.

    摘要翻译： 本发明提供一种护肤效果优异的化妆品或食品组合物，特别是由于紫外线照射或老化而使皮肤变白而变白的效果，可以安全地用于许多哺乳动物。 本发明提供一种美白组合物，其包含由式（1）表示的还原型辅酶Q作为有效成分：其中n表示1〜12的整数。本发明还提供了还含有由式（2）表示的氧化型辅酶Q ）作为有效成分：其中n表示1至12的整数。本发明还提供了一种使哺乳动物的皮肤变白的方法，所述方法包括给哺乳动物施用该组合物。

    Anti-Fatigue Composition
    4.
    发明申请
    Anti-Fatigue Composition 审中-公开
    抗疲劳成分

    公开(公告)号：US20070293572A1

    公开(公告)日：2007-12-20

    申请号：US11596059

    申请日：2005-05-09

    申请人： Hideyuki Kishida ,  Taizo Kawabe ,  Kazunori Hosoe ,  Kenji Fujii

    发明人： Hideyuki Kishida ,  Taizo Kawabe ,  Kazunori Hosoe ,  Kenji Fujii

    IPC分类号： A61K31/05 ,  A61K31/205 ,  A61P25/26

    CPC分类号： A61K31/205 ,  A23L33/10 ,  A23V2002/00 ,  A61K31/09 ,  A61K31/122 ,  A61K45/06 ,  A61K2300/00 ,  A23V2200/31 ,  A23V2250/314 ,  A23V2250/0612

    摘要： Fatigue is significantly involved in the lifestyle of people today. Although many anti-fatigue products are on market, those with definite and reliable effects are still few. Under such circumstances, the inventors of the present invention have conducted studies aiming at providing a composition which exhibits a distinctive anti-fatigue effect, and consequently accomplished the present invention. The present invention provides an anti-fatigue composition containing reduced coenzyme Q and a carnitine derivative. By administering the anti-fatigue composition of the present invention to a mammal, anti-fatigue effects can be synergistically seen even at doses which are not effective when the components are individually used. According to the present invention, an anti-fatigue composition having a reliable effect can be provided.

    摘要翻译： 疲劳显着地涉及到今天人们的生活方式。 虽然许多抗疲劳产品在市场上，但具有确定和可靠影响的产品仍然很少。 在这种情况下，本发明的发明人进行了旨在提供具有显着抗疲劳效果的组合物的研究，从而完成了本发明。 本发明提供含有还原型辅酶Q和肉碱衍生物的抗疲劳组合物。 通过将本发明的抗疲劳组合物施用于哺乳动物，即使在单独使用组分时没有效果的剂量，也可以协同地看到抗疲劳作用。 根据本发明，可以提供具有可靠效果的抗疲劳组合物。

    Composition having liver function protecting effect
    5.
    发明申请
    Composition having liver function protecting effect 审中-公开
    具有肝功能保护作用的组合物

    公开(公告)号：US20070122400A1

    公开(公告)日：2007-05-31

    申请号：US10580403

    申请日：2004-10-29

    申请人： Hiroshi Kubo ,  Kenji Fujii ,  Kazunori Hosoe

    发明人： Hiroshi Kubo ,  Kenji Fujii ,  Kazunori Hosoe

    IPC分类号： A61K38/43 ,  A61K31/075

    CPC分类号： A61K9/1623 ,  A23K20/111 ,  A23K20/30 ,  A23L33/10 ,  A23L33/16 ,  A23V2002/00 ,  A61K9/146 ,  A61K9/1652 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/075 ,  A61K31/09 ,  A23V2200/32 ,  A23V2250/314

    摘要： The present invention provides a highly safe composition which is effective for protecting liver functions and preventing liver dysfunctions in the case where liver dysfunctions rise by various causes. The present inventors found that oxidized coenzyme Q is effective for protecting liver functions in the absence of selenium and that reduced coenzyme Q has a higher efficacy for protecting liver functions. The composition containing, as the main components, oxidized coenzyme Q and less than 0.01 percent by weight of selenium, or reduced coenzyme Q can be used to protect liver functions. The present invention can provide a highly safe composition which is highly effective for maintaining health.

    摘要翻译： 本发明提供了一种高度安全的组合物，其在肝功能障碍由各种原因升高的情况下对于保护肝功能和预防肝功能障碍是有效的。 本发明人发现，氧化型辅酶Q在不存在硒的情况下对肝功能的保护有效，还原型辅酶Q具有较高的肝功能保护功能。 作为主要成分的含有氧化型辅酶Q和小于0.01重量％的硒或还原型辅酶Q的组合物可用于保护肝功能。 本发明可以提供高度安全的用于维持健康的组合物。

    Composition For Increasing Anti-Oxidation Activity In Blood
    6.
    发明申请
    Composition For Increasing Anti-Oxidation Activity In Blood 审中-公开
    用于增加血液中抗氧化活性的组合物

    公开(公告)号：US20080254016A1

    公开(公告)日：2008-10-16

    申请号：US11909966

    申请日：2006-03-28

    申请人： Hiroshi Kubo ,  Kenji Fujii ,  Kazunori Hosoe

    发明人： Hiroshi Kubo ,  Kenji Fujii ,  Kazunori Hosoe

    IPC分类号： A61K31/122 ,  A61P7/00

    CPC分类号： A61K31/09 ,  A61K31/122

    摘要： The present invention provides a composition capable of maintaining antioxidative activity in blood high by keeping the reduced coenzyme Q10 ratio in blood high after taking coenzyme Q10 even in aged mammals.The present invention relates to a composition which comprises reduced coenzyme Q10 as an active component and enhances the antioxidative activity in blood of aged mammals.

    摘要翻译： 本发明提供了即使在老化的哺乳动物中，在服用辅酶Q 10之后，通过将血液中的还原型辅酶Q 10比例保持在较低水平，能够维持血液中的抗氧化活性。 本发明涉及一种组合物，其包含还原型辅酶Q 10作为活性组分并增强老年哺乳动物血液中的抗氧化活性。

    COMPOSITION FOR PREVENTION OR TREATMENT OF DIABETES
    7.
    发明申请
    COMPOSITION FOR PREVENTION OR TREATMENT OF DIABETES 审中-公开
    用于预防或治疗糖尿病的组合物

    公开(公告)号：US20100028319A1

    公开(公告)日：2010-02-04

    申请号：US12525446

    申请日：2008-01-31

    申请人： Hirokazu Sakamoto ,  Hideyuki Kishida ,  Kazunori Hosoe

    发明人： Hirokazu Sakamoto ,  Hideyuki Kishida ,  Kazunori Hosoe

    IPC分类号： A61K38/43 ,  C07H19/20 ,  A61P7/12

    CPC分类号： A61K31/7076 ,  A23K20/10 ,  A23K20/105 ,  A23K20/116 ,  A23K20/121 ,  A23K20/137 ,  A23K20/174 ,  A23K50/40 ,  A23L33/10 ,  A23V2002/00 ,  A23V2200/328 ,  A23V2250/30

    摘要： The present invention aims to provide a composition which has an extremely broad range of applications, has an excellent safety, and can be used for preventing, ameliorating, or therapeutically-treating diabetes.The present invention provides an agent for preventing, ameliorating, or therapeutically-treating diabetes or a diabetic complication, a glycemic control agent, and an insulin secretion-promoting agent, each of which contains reduced coenzyme A as an active ingredient. The present invention also provides a method for preventing, ameliorating, or therapeutically-treating diabetes or a diabetic complication, which includes administration of the aforementioned agent.

    摘要翻译： 本发明旨在提供一种应用范围非常广泛，安全性优异的组合物，可用于预防，改善或治疗糖尿病。 本发明提供了用于预防，改善或治疗糖尿病或糖尿病并发症的药剂，血糖控制剂和胰岛素分泌促进剂，其各自含有还原型辅酶A作为活性成分。 本发明还提供了预防，改善或治疗性治疗糖尿病或糖尿病并发症的方法，其包括给药前述药剂。

    COMPOSITION FOR LIFE EXTENSION AND METHOD OF EXTENDING THE LIFE
    8.
    发明申请
    COMPOSITION FOR LIFE EXTENSION AND METHOD OF EXTENDING THE LIFE 审中-公开
    生命延长的组成和延长生命的方法

    公开(公告)号：US20090148426A1

    公开(公告)日：2009-06-11

    申请号：US12067783

    申请日：2006-09-21

    申请人： Hideyuki Kishida ,  Taizuo Kawabe ,  Kazunori Hosoe

    发明人： Hideyuki Kishida ,  Taizuo Kawabe ,  Kazunori Hosoe

    IPC分类号： A61K38/43 ,  C07C43/205 ,  A61K31/09 ,  A61K31/122

    CPC分类号： A61K31/05 ,  A61K31/122

    摘要： The present invention relates to a composition for life extension, comprising reduced coenzyme Q10 as an active ingredient, as well as relates to a method of extending a life span using the composition comprising reduced coenzyme Q10 as an active ingredient. In the present invention, it has been found that long-term ingestion of feed that contains reduced coenzyme Q10 enables the life span of senescence-accelerated model mice to be extended. No sign indicating toxicity is observed in the senescence-accelerated model mice that have been fed with reduced coenzyme Q10 over a long period. Based on these findings, it was found that the composition containing reduce coenzyme Q10 as an active ingredient has potential to be a composition for life extension with high safety, capable of being taken for a long period. The present invention provides a composition, which can extend the life span of humans or animals, enables them to spend active and healthy senectitudes and shows high safety during the ingestion over a long period.

    摘要翻译： 本发明涉及一种延长寿命的组合物，其包含还原型辅酶Q10作为活性成分，以及涉及使用包含还原型辅酶Q10作为活性成分的组合物延长使用寿命的方法。 在本发明中，已经发现，含有还原型辅酶Q10的饲料的长期摄入使得能够延长衰老加速模型小鼠的寿命。 没有迹象表明，在衰老加速模型小鼠中观察到毒性，这些老鼠在长时间内补充还原型辅酶Q10。 基于这些发现，发现含有还原型辅酶Q10作为活性成分的组合物具有潜在的延长寿命的组合物，其安全性高，能够长时间服用。 本发明提供一种能够延长人类或动物寿命的组合物，使其能够在长时间摄取过程中花费积极和健康的感觉并显示高安全性。