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1.发明申请CULTURE METHOD OF EMBRYOID BODIES AND/OR NEURAL STEM CELLS DERIVED FROM HUMAN DIFFERENTIATED CELL-DERIVED PLURIPOTENT STEM CELLS 审中-公开从人类分化细胞衍生的PLUIPOTETI STEM细胞获得的胚状体和/或神经干细胞的培养方法公开(公告)号：US20120009157A1
公开(公告)日：2012-01-12
申请号：US13147558
申请日：2010-02-03
申请人： Hideyuki Okano , Yohei Okada , Masaya Nakamura
发明人： Hideyuki Okano , Yohei Okada , Masaya Nakamura
CPC分类号： C12N5/0618 , A61K35/12 , C12N2501/115 , C12N2501/235 , C12N2506/45
摘要： A method for differentiating a human differentiated cell-derived pluripotent stem cell into a neural stem cell is provided, which includes the steps of: making an embryoid body from the human differentiated cell-derived pluripotent stem cell; and culturing the embryoid body in a medium containing LIF to differentiate into a neural stem cell, so that, when the neural stem cell is allowed to differentiate in vitro after multiple subculturing of the neural stem cell, it differentiate mainly into neurons but substantially not into glial cells.
摘要翻译： 提供了将人分化细胞衍生的多能干细胞分化为神经干细胞的方法，其包括以下步骤：从人分化的细胞衍生的多能干细胞制备胚状体; 并在含有LIF的培养基中培养胚状体以分化为神经干细胞，使得当神经干细胞在神经干细胞的多次传代培养后允许体外分化时，其主要分化为神经元但基本上不进入 胶质细胞。
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公开(公告)号：US10041040B2
公开(公告)日：2018-08-07
申请号：US13147558
申请日：2010-02-03
申请人： Hideyuki Okano , Yohei Okada , Masaya Nakamura
发明人： Hideyuki Okano , Yohei Okada , Masaya Nakamura
摘要： A method for differentiating a human differentiated cell-derived pluripotent stem cell into a neural stem cell is provided, which includes the steps of: making an embryoid body from the human differentiated cell-derived pluripotent stem cell; and culturing the embryoid body in a medium containing LIF to differentiate into a neural stem cell, so that, when the neural stem cell is allowed to differentiate in vitro after multiple subculturing of the neural stem cell, it differentiate mainly into neurons but substantially not into glial cells.
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公开(公告)号：US08518880B2
公开(公告)日：2013-08-27
申请号：US12548881
申请日：2009-08-27
申请人： Hideyuki Okano , Yoshiaki Toyama , Masaya Nakamura , Akio Iwanami , Kazuya Kitamura , Toshikazu Nakamura , Hiroshi Funakoshi , Keigo Hanada
发明人： Hideyuki Okano , Yoshiaki Toyama , Masaya Nakamura , Akio Iwanami , Kazuya Kitamura , Toshikazu Nakamura , Hiroshi Funakoshi , Keigo Hanada
IPC分类号： A61K38/18
CPC分类号： A61K38/1833 , A61K9/0004 , A61K9/0024 , A61K9/0085 , A61K9/146 , A61K9/2063 , A61K9/5026 , A61K9/5031
摘要： Disclosed is a therapeutic agent effective for the fundamental treatment of a spinal cord injury and a demyelinating disease. Specifically disclosed are a therapeutic agent for a spinal cord injury and a therapeutic agent for a demyelinating disease, each of which comprises an HGF protein as an active ingredient.
摘要翻译： 公开了一种有效治疗脊髓损伤和脱髓鞘疾病的治疗剂。 具体公开了用于脊髓损伤的治疗剂和脱髓鞘疾病的治疗剂，其各自包含HGF蛋白作为活性成分。
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4.发明申请METHOD FOR SELECTING SECONDARY NEUROSPHERE DERIVED FROM DIFFERENTIATED CELL-DERIVED PLURIPOTENT STEM CELL, CLONE SELECTED BY THE METHOD AND USE OF THE CLONE 审中-公开选择从分化细胞衍生的细胞干细胞中获得的二次神经元的方法和方法选择的克隆和使用克隆公开(公告)号：US20110183350A1
公开(公告)日：2011-07-28
申请号：US13057710
申请日：2009-08-05
申请人： Hideyuki Okano , Osahiko Tsuji , Masaya Nakamura , Shinya Yamanaka , Kyoko Miura
发明人： Hideyuki Okano , Osahiko Tsuji , Masaya Nakamura , Shinya Yamanaka , Kyoko Miura
CPC分类号： C12N5/0618 , A61K35/12 , C12N2501/385 , C12N2501/60 , C12N2506/45 , C12N2510/00 , C12Q1/6886 , C12Q2600/158
摘要： In order to provide a therapeutic agent for nerve injury which contains iPS-derived neural stem cells and has low or no risk of side effects, as well as a method for treating a nerve injury using the iPS cells, by efficiently establishing in vivo the iPS-derived neural stem having low or no risk of tumor formation, neurospheres are formed following formation of embryoid bodies from the iPS cells, and a clone whose ratio of cells in which the promoter of Nanog gene is activated is 0.01% or less is selected, and the clone is administered to a patient suffering from the nerve injury.
摘要翻译： 为了提供包含iPS衍生的神经干细胞的神经损伤治疗剂，并且具有低或没有副作用的风险，以及使用iPS细胞治疗神经损伤的方法，通过在体内有效建立iPS 衍生自具有低或没有肿瘤形成风险的神经干细胞，在形成来自iPS细胞的胚状体之后形成神经球，并且选择其中Nanog基因的启动子的活化比例为0.01％以下的克隆， 并将克隆施用于患有神经损伤的患者。
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公开(公告)号：US20130142848A1
公开(公告)日：2013-06-06
申请号：US13814341
申请日：2011-08-04
申请人： Miho Maeda , Akiyoshi Kishino , Akihiko Sano , Hideyuki Okano , Masaya Nakamura , Liang Zhang
发明人： Miho Maeda , Akiyoshi Kishino , Akihiko Sano , Hideyuki Okano , Masaya Nakamura , Liang Zhang
IPC分类号： A61K9/00
CPC分类号： A61K9/0024 , A61K9/0085 , A61K9/7007 , A61K31/352 , A61K47/02 , A61K47/28 , A61K47/34 , A61K47/38
摘要： The present invention is a solid sustained-release formulation comprising an agent for inhibiting semaphorin 3A as an active ingredient, which comprises an agent for inhibiting semaphorin 3A and pharmaceutically acceptable hardly water-soluble solid substance, in which the carrier is silicone.
摘要翻译： 本发明是一种固体缓释制剂，其包含用于抑制信号素3A作为活性成分的试剂，其包含用于抑制信号素3A和药学上可接受的几乎不溶于水的固体物质的试剂，其中载体是硅氧烷。
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6.发明申请公开(公告)号：US20050186545A1
公开(公告)日：2005-08-25
申请号：US10496993
申请日：2002-11-26
申请人： Hideyuki Okano , Yoshiaki Toyama , Masaya Nakamura , Tatsuji Nomura , Yoshikuni Tanioka , Kiyoshi Ando , Yonehiro Kanemura
发明人： Hideyuki Okano , Yoshiaki Toyama , Masaya Nakamura , Tatsuji Nomura , Yoshikuni Tanioka , Kiyoshi Ando , Yonehiro Kanemura
IPC分类号： A01K67/027 , A61P25/00 , C12N15/85 , G09B23/28
CPC分类号： A01K67/027 , A01K2227/106 , A01K2267/03 , A01K2267/0356
摘要： A method for creating a monkey model of spinal cord injury, which includes exposing the dura mater of the cervical cord of a monkey and applying a load on the dura mater; the thus-created monkey model of spinal cord injury; and a method for evaluating a therapeutic drug for spinal cord injury by use of this model. According to the present invention, it is possible to create a monkey which is close to the human and thus useful as a model of human spinal cord injury. This model enables proper evaluation of therapeutic effects of various drugs on spinal cord injury. Through use of this model, it has been confirmed for the first time that transplantation therapy of human neural stem cells is efficacious against spinal cord injury.
摘要翻译： 一种创建脊髓损伤猴模型的方法，其包括暴露猴子的颈椎硬脑膜并在硬脑膜上施加负荷; 由此造成的脊髓损伤猴模型; 以及使用该模型评价脊髓损伤治疗药物的方法。 根据本发明，可以产生靠近人类的猴，因此可用作人脊髓损伤的模型。 该模型能够适当评估各种药物对脊髓损伤的治疗效果。 通过使用该模型，人类神经干细胞的移植治疗首次对脊髓损伤有效。
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公开(公告)号：US09040062B2
公开(公告)日：2015-05-26
申请号：US13814341
申请日：2011-08-04
申请人： Miho Maeda , Akiyoshi Kishino , Akihiko Sano , Hideyuki Okano , Masaya Nakamura , Liang Zhang
发明人： Miho Maeda , Akiyoshi Kishino , Akihiko Sano , Hideyuki Okano , Masaya Nakamura , Liang Zhang
IPC分类号： A61K9/00 , A61K9/70 , A61K47/34 , A61K31/352 , A61K47/28 , A61K47/02 , A61K47/38 , A61P25/00 , A61P43/00
CPC分类号： A61K9/0024 , A61K9/0085 , A61K9/7007 , A61K31/352 , A61K47/02 , A61K47/28 , A61K47/34 , A61K47/38
摘要： The present invention is a solid sustained-release formulation comprising an agent for inhibiting semaphorin 3A as an active ingredient, which comprises an agent for inhibiting semaphorin 3A and pharmaceutically acceptable hardly water-soluble solid substance, in which the carrier is silicone.
摘要翻译： 本发明是一种固体缓释制剂，其包含用于抑制信号素3A作为活性成分的试剂，其包含用于抑制信号素3A和药学上可接受的几乎不溶于水的固体物质的试剂，其中载体是硅氧烷。
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8.发明授权公开(公告)号：US07753054B2
公开(公告)日：2010-07-13
申请号：US10496993
申请日：2002-11-26
申请人： Hideyuki Okano , Yoshiaki Toyama , Masaya Nakamura , Tatsuji Nomura , Yoshikuni Tanioka , Kiyoshi Ando , Yonehiro Kanemura
发明人： Hideyuki Okano , Yoshiaki Toyama , Masaya Nakamura , Tatsuji Nomura , Yoshikuni Tanioka , Kiyoshi Ando , Yonehiro Kanemura
IPC分类号： A61B19/00
CPC分类号： A01K67/027 , A01K2227/106 , A01K2267/03 , A01K2267/0356
摘要： A method for creating a monkey model of spinal cord injury, which includes exposing the dura mater of the cervical cord of a monkey and applying a load on the dura mater; the thus-created monkey model of spinal cord injury; and a method for evaluating a therapeutic drug for spinal cord injury by use of this model.According to the present invention, it is possible to create a monkey which is close to the human and thus useful as a model of human spinal cord injury. This model enables proper evaluation of therapeutic effects of various drugs on spinal cord injury. Through use of this model, it has been confirmed for the first time that transplantation therapy of human neural stem cells is efficacious against spinal cord injury.
摘要翻译： 一种创建脊髓损伤猴模型的方法，其包括暴露猴子的颈椎硬脑膜并在硬脑膜上施加负荷; 由此造成的脊髓损伤猴模型; 以及使用该模型评价脊髓损伤治疗药物的方法。 根据本发明，可以产生靠近人类的猴，因此可用作人脊髓损伤的模型。 该模型能够适当评估各种药物对脊髓损伤的治疗效果。 通过使用该模型，人类神经干细胞的移植治疗首次对脊髓损伤有效。
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公开(公告)号：US20060165696A1
公开(公告)日：2006-07-27
申请号：US10546149
申请日：2004-02-24
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , A61K38/00 , A61K2039/505 , C07K16/248
摘要： A therapeutic agent for spinal cord injury, a modulator of differentiation of neural stem cells and an inhibitor of differentiation into glia cells comprising an interleukin-6 antagonist as an active ingredient.
摘要翻译： 用于脊髓损伤的治疗剂，神经干细胞分化的调节剂和分化成胶质细胞的抑制剂，其包含白细胞介素-6拮抗剂作为活性成分。
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公开(公告)号：US20090208465A1
公开(公告)日：2009-08-20
申请号：US12164827
申请日：2008-06-30
申请人： Hideyuki Okano , Masaya Nakamura , Osahiko Tsuji , Shinya Yamanaka , Kyoko Miura
发明人： Hideyuki Okano , Masaya Nakamura , Osahiko Tsuji , Shinya Yamanaka , Kyoko Miura
IPC分类号： A61K35/12
CPC分类号： C12N5/0696 , A61K35/12 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2510/00
摘要： The present invention provides a therapeutic agent for a nerve injury and a method for treating a nerve injury. One aspect of the invention is the method for treating a nerve injury by administering to a patient with a nerve injury a therapeutic agent for a nerve injury containing a differentiated cell-derived pluripotent cell obtained by forced expression of reprogramming genes such as a combination of the Oct3/4 gene, Sox2 gene, Klf4, and c-myc gene. in a differentiated cell; or cells obtained by inducing the aforementioned differentiated cell-derived pluripotent cells to differentiate into an embryoid body or a neurosphere.
摘要翻译： 本发明提供神经损伤治疗剂和神经损伤治疗方法。 本发明的一个方面是通过向患有神经损伤的患者施用神经损伤治疗剂来治疗神经损伤的方法，所述治疗剂含有通过强制表达重编程基因获得的分化的细胞衍生的多能细胞，所述重编程基因如 Oct3 / 4基因，Sox2基因，Klf4和c-myc基因。 在分化细胞中 或通过诱导上述分化的细胞衍生的多能细胞分化成胚状体或神经球获得的细胞。
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