利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

40 条记录 (耗时 0.044 秒)

    BAGLIKE CONTAINER FOR CENTRIFUGATION AND METHOD OF GENE TRANSFER USING THE SAME
    4.
    发明申请
    BAGLIKE CONTAINER FOR CENTRIFUGATION AND METHOD OF GENE TRANSFER USING THE SAME 失效
    用于离心的巴格莱集装箱和使用该方法的基因转移方法

    公开(公告)号：US20100136680A1

    公开(公告)日：2010-06-03

    申请号：US12377234

    申请日：2006-08-23

    申请人： Hideto Chono ,  Junichi Mineno ,  Kazutoh Takesako ,  Takao Yoshida ,  Takashi Morimura ,  Kenji Sakai ,  Shin-ichi Yamada ,  Noritsugu Yabe ,  Yuko Taguchi

    发明人： Hideto Chono ,  Junichi Mineno ,  Kazutoh Takesako ,  Takao Yoshida ,  Takashi Morimura ,  Kenji Sakai ,  Shin-ichi Yamada ,  Noritsugu Yabe ,  Yuko Taguchi

    IPC分类号： C12N5/10 ,  B04B7/12

    CPC分类号： A61J1/10 ,  B01L3/5021 ,  B01L3/505 ,  C12M23/14 ,  C12M35/04 ,  C12N15/87

    摘要： Baglike container (1) that is fitted in a centrifuge to thereby allow centrifugation of any dispersion liquid placed therein. The baglike container for centrifugation is one comprising a main frame constituted of first container wall (3) with recess portion (6) formed so as to allow fitting in a centrifuge and with flange portion (7) provided on an open face border of the recess portion (6) and constituted of flexible second container wall (4) having its peripheral portion sealed mutually with the flange portion (7) of the first container wall (3) so as to define storing space (6′) for dispersion liquid in cooperation with the recess portion (6) and further comprising port (5) fitted to the main frame in a fashion allowing communication with the storing space (6′), wherein the recess portion (6) defining the storing space (6′) can be set in the centrifuge so that centrifugal force perpendicular to the bottom plane of the recess portion (6) applies. Moreover, there is disclosed a method of gene introduction using this baglike container.

    摘要翻译： 袋状容器（1），其装配在离心机中，从而允许离心分离任何分散液体。 用于离心的袋状容器是包括由具有凹部（6）的第一容器壁（3）构成的主框架，所述第一容器壁（3）形成为能够安装在离心机中，并且具有设置在凹部的开放面边界上的凸缘部（7） 部分（6），并且由具有与第一容器壁（3）的凸缘部分（7）相互密封的周边部分的柔性第二容器壁（4）构成，以便在合作中限定用于分散液体的储存空间（6'） 与所述凹部（6）相连并且还包括以允许与所述存放空间（6'）连通的方式装配到所述主框架的端口（5），其中限定所述存储空间（6'）的所述凹部（6）可以 设置在离心机中，使得垂直于凹部（6）的底面的离心力适用。 此外，公开了使用该袋状容器的基因导入方法。

    Physiologically active substances TKR2449, process for producing the same, and microorganism
    5.
    发明授权
    Physiologically active substances TKR2449, process for producing the same, and microorganism 失效
    生理活性物质TKR2449，其生产方法和微生物

    公开(公告)号：US06303350B1

    公开(公告)日：2001-10-16

    申请号：US09445543

    申请日：2000-03-07

    申请人： Kazutoh Takesako ,  Mitsuhiro Ueno ,  Naoyuki Awazu ,  Yoko Uno ,  Ikunoshin Kato

    发明人： Kazutoh Takesako ,  Mitsuhiro Ueno ,  Naoyuki Awazu ,  Yoko Uno ,  Ikunoshin Kato

    IPC分类号： C12P1302

    CPC分类号： C07C235/76 ,  C12P13/02 ,  Y10S435/911

    摘要： The present invention has for its object to provide novel biologically active substances which is of value as a therapeutic agent for fungal infections and immune disorders. This invention is related to a biologically active substance TKR2449 analog(s) which is represented by the following general formula (A); (In the formula, R1, R2 and R3 are the same or differ each other, and each represents hydrogen or an alkyl group of carbon number of 1 to 4. R4 is a linear or branched alkyl or alkenyl group of carbon number of 1 to 8.).

    摘要翻译： 本发明的目的是提供新的生物活性物质，其作为真菌感染和免疫疾病的治疗剂是有价值的。 本发明涉及由以下通式（A）表示的生物活性物质TKR2449类似物：（式中，R 1，R 2和R 3相同或不同，各自表示氢或 碳数为1〜4的烷基.R 4为碳原子数为1〜8的直链或支链烷基或烯基。

    Sphingosine analogues
    7.
    发明授权
    Sphingosine analogues 失效
    鞘氨醇类似物

    公开(公告)号：US06235912B1

    公开(公告)日：2001-05-22

    申请号：US09380647

    申请日：1999-10-15

    申请人： Kazutoh Takesako ,  Toru Kurome ,  Naoyuki Awazu ,  Ikunoshin Kato

    发明人： Kazutoh Takesako ,  Toru Kurome ,  Naoyuki Awazu ,  Ikunoshin Kato

    IPC分类号： C07C23100

    CPC分类号： C07D307/33 ,  C07C215/10 ,  C07C215/24 ,  C07C229/22 ,  C07C229/30 ,  C07C237/08 ,  C07C237/22 ,  C07C251/08 ,  C07C271/22 ,  C07D263/06 ,  Y02P20/55

    摘要： The present invention aims to provide a novel sphingosine analogue, which is useful as an intermediate for syntheses of novel lipid derivatives such as sphingolipid derivatives and the like that can regulate the effects of sphingolipid. The present invention relates to a sphingosine analogue represented by the general formula (I) described below. In the formula, as for Q1, Q2 and Q3, Q1 and Q2, which are the same or different each other, are hydrogen, alkyl groups having 1-4 of carbon atoms, acyl groups having 2-5 of carbon atoms, or protecting groups of the amino group, and Q3 is a hydrogen or a protecting group of the hydroxyl group; or Q2 and Q3 make up an isopropylidene group and Q1 is a hydrogen or a protecting group of the amino group. Q4 and Q5, which are the same or different each other, are hydroxyl groups, acyl groups having 2-5 of carbon atoms, —O—Q6, or hydrogen; or Q4 and Q5 make up a covalent bond. Q6 is a protecting group of the hydroxyl group. X1 is —COOH, —CONH2, —CO—Q7, —CH2OH, or —CH2O—Q8. Q7 is a protecting group of the carboxyl group, and Q8 is a protecting group of the hydroxyl group.

    摘要翻译： 本发明的目的在于提供一种新颖的鞘氨醇类似物，其可用作合成新型脂质衍生物的中间体，例如可以调节鞘脂的作用的鞘脂衍生物等。本发明涉及一般的鞘氨醇类似物 在该式中，对于Q1，Q2和Q3，Q1和Q2彼此相同或不同，为氢，具有1-4个碳原子的烷基，酰基具有2- 5个碳原子或氨基的保护基，Q3为氢或羟基的保护基; 或Q2和Q3构成异亚丙基，Q 1为氢或氨基的保护基。 Q4和Q5彼此相同或不同，是羟基，具有2-5个碳原子的酰基，-O-Q6或氢; 或Q4和Q5构成共价键。 Q6是羟基的保护基。 X 1是-COOH，-CONH 2，-CO-Q 7，-CH 2 OH或-CH 2 O-Q 8。 Q7是羧基的保护基，Q8是羟基的保护基。