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    Polypeptide DNA thereof and use of the same
    3.
    发明授权
    Polypeptide DNA thereof and use of the same 失效
    其多肽DNA及其用途

    公开(公告)号：US07323541B2

    公开(公告)日：2008-01-29

    申请号：US10489537

    申请日：2002-09-13

    申请人： Masaaki Mori ,  Kozo Hayashi ,  Hiroyuki Miya ,  Shuji Sato ,  Chieko Kitada ,  Hirokazu Matsumoto ,  Toshimi Nagi ,  Yukio Shimomura

    发明人： Masaaki Mori ,  Kozo Hayashi ,  Hiroyuki Miya ,  Shuji Sato ,  Chieko Kitada ,  Hirokazu Matsumoto ,  Toshimi Nagi ,  Yukio Shimomura

    IPC分类号： A61K38/04

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： The present invention aims at providing a novel polypeptide, a receptor, a DNA thereof, and the like. Specifically, the present invention provides a polypeptide having a binding ability to the protein represented by SEQ ID NO: 1 or SEQ ID NO: 3, or its amide, its ester or its salt, a polynucleotide encoding the polypeptide, an antisense polynucleotide or an antibody to the polypeptide, a screening of agent for prevention and/or treatment of cancer, obesity, etc., which comprises using the above, and the like.The polypeptide, receptor, polynucleotide, antisense polynucleotide, antibody and the like are useful for an agent of prevention and/or treatment of cancer, obesity and the like. Further, they are useful for a screening of an agent for prevention and/or treatment of cancer, obesity and the like.

    摘要翻译： 本发明的目的在于提供新的多肽，受体及其DNA等。 具体地说，本发明提供了具有与SEQ ID NO：1或SEQ ID NO：3所代表的蛋白结合能力的多肽或其酰胺，其酯或其盐，编码多肽的多核苷酸，反义多核苷酸或 对多肽的抗体，筛选用于预防和/或治疗癌症，肥胖症等的药剂，其包括使用上述方法等。 多肽，受体，多核苷酸，反义多核苷酸，抗体等可用于预防和/或治疗癌症，肥胖症等。 此外，它们可用于筛选用于预防和/或治疗癌症，肥胖症等的药剂。

    Novel polypeptide dna thereof and use of the same
    4.
    发明申请
    Novel polypeptide dna thereof and use of the same 失效
    新型多肽dna及其用途

    公开(公告)号：US20050048605A1

    公开(公告)日：2005-03-03

    申请号：US10489537

    申请日：2002-09-13

    申请人： Masaaki Mori ,  Kozo Hayashi ,  Hiroyuki Miya ,  Shuji Sato ,  Chieko Kitada ,  Hirokazu Matsumoto ,  Toshimi Nagi ,  Yukio Shimomura

    发明人： Masaaki Mori ,  Kozo Hayashi ,  Hiroyuki Miya ,  Shuji Sato ,  Chieko Kitada ,  Hirokazu Matsumoto ,  Toshimi Nagi ,  Yukio Shimomura

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/705 ,  C12N15/12 ,  C12P21/08 ,  C07H21/04 ,  C07K14/47

    CPC分类号： C07K14/705 ,  A61K38/00 ,  A61K48/00

    摘要： The present invention aims at providing a novel polypeptide, a receptor, a DNA thereof, and the like. Specifically, the present invention provides a polypeptide having a binding ability to the protein represented by SEQ ID NO: 1 or SEQ ID NO: 3, or its amide, its ester or its salt, a polynucleotide encoding the polypeptide, an antisense polynucleotide or an antibody to the polypeptide, a screening of agent for prevention and/or treatment of cancer, obesity, etc., which comprises using the above, and the like. The polypeptide, receptor, polynucleotide, antisense polynucleotide, antibody and the like are useful for an agent of prevention and/or treatment of cancer, obesity and the like. Further, they are useful for a screening of an agent for prevention and/or treatment of cancer, obesity and the like.

    摘要翻译： 本发明的目的在于提供新的多肽，受体及其DNA等。 具体地说，本发明提供了具有与SEQ ID NO：1或SEQ ID NO：3所代表的蛋白结合能力的多肽或其酰胺，其酯或其盐，编码多肽的多核苷酸，反义多核苷酸或 对多肽的抗体，筛选用于预防和/或治疗癌症，肥胖症等的药剂，其包括使用上述方法等。 多肽，受体，多核苷酸，反义多核苷酸，抗体等可用于预防和/或治疗癌症，肥胖症等。 此外，它们可用于筛选用于预防和/或治疗癌症，肥胖症等的药剂。

    Antibodies and utilization thereof
    5.
    发明授权
    Antibodies and utilization thereof 失效
    抗体及其利用

    公开(公告)号：US07067268B1

    公开(公告)日：2006-06-27

    申请号：US09700643

    申请日：1999-05-20

    申请人： Hirokazu Matsumoto ,  Chieko Kitada ,  Shuji Hinuma

    发明人： Hirokazu Matsumoto ,  Chieko Kitada ,  Shuji Hinuma

    IPC分类号： G01N33/53

    CPC分类号： G01N33/74 ,  C07K16/18 ,  C07K16/26 ,  G01N33/6854

    摘要： The anti-19P2 ligand monoclonal antibodies of the invention (in particular P2L-1Ca) have very high binding ability and can neutralize the arachidonic acid metabolite releasing activity of the 19P2 ligand. Therefore, they can be used, among others, as diagnostic, prophylactic and/or therapeutic agents for various diseases caused by some or other abnormality in the pituitary function modulating activity (e.g. prolactin secretion promoting activity), central nervous system modulating activity and pancreatic function modulating activity, among others, supposedly possessed by the 19P2 ligand.The immunoassay method using the monoclonal antibodies of the invention by the sandwich technique (in particular the sandwich technique using the monoclonal antibody and an antibody recognizing an intermediate portion of the 19P2 ligand) can assay the 19P2 ligand or a derivative thereof specifically and with high sensitivity. This assay method can be used in elucidating the physiological functions of the 19P2 ligand or a derivative thereof.

    摘要翻译： 本发明的抗-19P2配体单克隆抗体（特别是P2L-1Ca）具有非常高的结合能力，可中和19P2配体的花生四烯酸代谢物释放活性。 因此，它们可以用作垂体功能调节活性（例如催乳素分泌促进活性），中枢神经系统调节活性和胰腺功能的一些或其他异常引起的各种疾病的诊断，预防和/或治疗剂 19P2配体据称具有调节活性。 使用本发明的单克隆抗体通过夹心技术（特别是使用单克隆抗体的夹心技术和识别19P2配体的中间部分的抗体）的免疫测定方法可以特异性且高灵敏度地测定19P2配体或其衍生物 。 该测定方法可用于阐明19P2配体或其衍生物的生理功能。

    Antibody and use thereof
    6.
    发明申请
    Antibody and use thereof 失效
    抗体及其用途

    公开(公告)号：US20050158795A1

    公开(公告)日：2005-07-21

    申请号：US11004336

    申请日：2004-12-03

    申请人： Hirokazu Matsumoto ,  Chieko Kitada ,  Shuji Hinuma

    发明人： Hirokazu Matsumoto ,  Chieko Kitada ,  Shuji Hinuma

    IPC分类号： C07K16/18 ,  C07K16/26 ,  C12P21/08 ,  G01N33/68 ,  G01N33/74 ,  G01N33/53

    CPC分类号： G01N33/74 ,  C07K16/18 ,  C07K16/26 ,  G01N33/6854

    摘要： The anti-19P2 ligand monoclonal antibodies of the invention (in particular P2L-1Ca) have very high binding ability and can neutralize the arachidonic acid metabolite releasing activity of the 19P2 ligand. Therefore, they can be used, among others, as diagnostic, prophylactic and/or therapeutic agents for various diseases caused by some or other abnormality in the pituitary function modulating activity (e.g. prolactin secretion promoting activity), central nervous system modulating activity and pancreatic function modulating activity, among others, supposedly possessed by the 19P2 ligand. The immunoassay method using the monoclonal antibodies of the invention by the sandwich technique (in particular the sandwich technique using the monoclonal antibody and an antibody recognizing an intermediate portion of the 19P2 ligand) can assay the 19P2 ligand or a derivative thereof specifically and with high sensitivity. This assay method can be used in elucidating the physiological functions of the 19P2 ligand or a derivative thereof.

    摘要翻译： 本发明的抗-19P2配体单克隆抗体（特别是P2L-1Ca）具有非常高的结合能力，可中和19P2配体的花生四烯酸代谢物释放活性。 因此，它们可以用作垂体功能调节活性（例如催乳素分泌促进活性），中枢神经系统调节活性和胰腺功能的一些或其他异常引起的各种疾病的诊断，预防和/或治疗剂 19P2配体据称具有调节活性。 使用本发明的单克隆抗体通过夹心技术（特别是使用单克隆抗体的夹心技术和识别19P2配体的中间部分的抗体）的免疫测定方法可以特异性且高灵敏度地测定19P2配体或其衍生物 。 该测定方法可用于阐明19P2配体或其衍生物的生理功能。

    Use of peptides
    8.
    发明申请
    Use of peptides 审中-公开
    使用肽

    公开(公告)号：US20050209151A1

    公开(公告)日：2005-09-22

    申请号：US11116727

    申请日：2005-04-28

    申请人： Chieko Kitada ,  Hirokazu Matsumoto ,  Shuji Hinuma

    发明人： Chieko Kitada ,  Hirokazu Matsumoto ,  Shuji Hinuma

    IPC分类号： A61K38/17 ,  A61P3/04 ,  A61P5/40 ,  A61K38/22

    CPC分类号： A61K38/1709

    摘要： The ligand polypeptides of the present invention have activity to regulate CRH secretion, and thus are useful as CRH secretion regulators for the relief, prevention or treatment of various diseases related to CRH secretion, such as hypoaldosteronism, hypocortisolemia, secondary and chronic adrenocorticism, Addison's disease (weakness, nausea, pigmentation, hypogonadism, alopecia, hypotension), adrenal dysfunction, and obesity, and also as analgesics.

    摘要翻译： 本发明的配体多肽具有调节CRH分泌的活性，因此可用作CRH分泌调节剂用于缓解，预防或治疗与CRH分泌有关的各种疾病，例如醛糖醛酸降低症，低皮质醇血症，继发性和慢性肾上腺皮质激素，艾迪生病 （虚弱，恶心，色素沉着，性腺机能减退，脱发，低血压），肾上腺功能障碍和肥胖，以及止痛药。

    Antibody and use thereof
    10.
    发明授权
    Antibody and use thereof 失效
    抗体及其用途

    公开(公告)号：US07598351B2

    公开(公告)日：2009-10-06

    申请号：US11004336

    申请日：2004-12-03

    申请人： Hirokazu Matsumoto ,  Chieko Kitada ,  Shuji Hinuma

    发明人： Hirokazu Matsumoto ,  Chieko Kitada ,  Shuji Hinuma

    IPC分类号： C12P21/08

    CPC分类号： G01N33/74 ,  C07K16/18 ,  C07K16/26 ,  G01N33/6854

    摘要： The anti-19P2 ligand monoclonal antibodies of the invention (in particular P2L-1Ca) have very high binding ability and can neutralize the arachidonic acid metabolite releasing activity of the 19P2 ligand. Therefore, they can be used, among others, as diagnostic, prophylactic and/or therapeutic agents for various diseases caused by some or other abnormality in the pituitary function modulating activity (e.g. prolactin secretion promoting activity), central nervous system modulating activity and pancreatic function modulating activity, among others, supposedly possessed by the 19P2 ligand.

    摘要翻译： 本发明的抗-19P2配体单克隆抗体（特别是P2L-1Ca）具有非常高的结合能力，可中和19P2配体的花生四烯酸代谢物释放活性。 因此，它们可以用作垂体功能调节活性（例如催乳素分泌促进活性），中枢神经系统调节活性和胰腺功能的一些或其他异常引起的各种疾病的诊断，预防和/或治疗剂 19P2配体据称具有调节活性。