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    GENE EXPRESSION INHIBITOR SELECTIVE FOR MATRIX METALLOPROTEINASE-9 GENE
    2.
    发明申请
    GENE EXPRESSION INHIBITOR SELECTIVE FOR MATRIX METALLOPROTEINASE-9 GENE 审中-公开
    基因表达抑制剂选择性基因金属蛋白酶-9基因

    公开(公告)号：US20110046070A1

    公开(公告)日：2011-02-24

    申请号：US12988163

    申请日：2009-04-17

    申请人： Hiroki Nagase ,  Xiaofei Wang

    发明人： Hiroki Nagase ,  Xiaofei Wang

    IPC分类号： A61K38/10 ,  C07K7/08 ,  A61P35/00 ,  C12N5/00

    CPC分类号： C07D403/14 ,  A61K31/787

    摘要： Disclosed are: an inhibitor of the expression of matrix metalloproteinase-9 gene; a therapeutic agent for a disease associated with matrix metalloproteinase-9; and a carcinostatic agent. Each of the agents comprises a pyrrole-imidazole polyamide having an N-methylpyrrole unit, an N-methylimidazole unit and a γ-aminobutyric acid unit. The pyrrole-imidazole polyamide can be folded at the site of the γ-aminobutyric acid unit to form a U-shaped conformation in a minor groove of a double-stranded domain comprising a part or the whole of a specific nucleotide sequence (SEQ ID NO:2, SEQ ID NO:4) included in a human matrix metalloproteinase-9 gene promoter and a strand complementary to the part or the whole of the specific nucleotide sequence. In the U-shaped conformation, a Py-Im pair, an Im/Py pair and a Py/Py pair in the pyrrole-imidazole polyamide target a C-G base pair, a G-C base pair, and both of an A-T base pair and a T-A base pair in the minor groove, respectively.

    摘要翻译： 公开了：基质金属蛋白酶-9基因表达的抑制剂; 用于与基质金属蛋白酶-9相关的疾病的治疗剂; 和制癌剂。 每种试剂包括具有N-甲基吡咯单元，N-甲基咪唑单元和γ-氨基丁酸单元的吡咯 - 咪唑聚酰胺。 吡咯 - 咪唑聚酰胺可以在γ-氨基丁酸单元的位置处折叠以在双链结构域的小沟中形成U形构象，其包含部分或全部特定核苷酸序列（SEQ ID NO ：2，SEQ ID NO：4），以及与该特定核苷酸序列的一部分或全部互补的链。 在U形构象中，吡咯 - 咪唑聚酰胺靶中的Py-Im对，Im / Py对和Py / Py对为CG碱基对，GC碱基对，AT碱基对和 分别在小槽中的TA碱基对。

    PROLIFERATIVE DISEASE DETECTION METHOD
    3.
    发明申请
    PROLIFERATIVE DISEASE DETECTION METHOD 失效
    增殖性疾病检测方法

    公开(公告)号：US20110033864A1

    公开(公告)日：2011-02-10

    申请号：US12937407

    申请日：2009-04-14

    申请人： Hiroki Nagase ,  Yui Shinojima ,  Tadashi Terui

    发明人： Hiroki Nagase ,  Yui Shinojima ,  Tadashi Terui

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/156

    摘要： In the present invention, the methylation of the genomic DNA a Zar1 gene specifically found in proliferative disease is used as a marker. Specifically, the present invention provides a method for detecting proliferative disease, which comprises detecting the methylation of the genomic DNA of a Zar1 gene in a biological sample. There is thereby provided a method for detecting proliferative disease, using a marker having a high detection rate and a low false positive rate.

    摘要翻译： 在本发明中，使用在增殖性疾病中特异性发现的Zar1基因的基因组DNA的甲基化作为标记。 具体地，本发明提供了检测增殖性疾病的方法，其包括检测生物样品中Zar1基因的基因组DNA的甲基化。 由此提供了使用具有高检测率和低假阳性率的标记物来检测增殖性疾病的方法。

    Proliferative disease detection method
    4.
    发明授权
    Proliferative disease detection method 失效
    增生病检测方法

    公开(公告)号：US08372587B2

    公开(公告)日：2013-02-12

    申请号：US12937407

    申请日：2009-04-14

    申请人： Hiroki Nagase ,  Yui Shinojima ,  Tadashi Terui

    发明人： Hiroki Nagase ,  Yui Shinojima ,  Tadashi Terui

    IPC分类号： C12Q1/68 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/156

    摘要： In the present invention, the methylation of the genomic DNA a Zar1 gene specifically found in proliferative disease is used as a marker. Specifically, the present invention provides a method for detecting proliferative disease, which comprises detecting the methylation of the genomic DNA of a Zar1 gene in a biological sample. There is thereby provided a method for detecting proliferative disease, using a marker having a high detection rate and a low false positive rate.

    摘要翻译： 在本发明中，使用在增殖性疾病中特异性发现的Zar1基因的基因组DNA的甲基化作为标记。 具体地，本发明提供了检测增殖性疾病的方法，其包括检测生物样品中Zar1基因的基因组DNA的甲基化。 由此提供了使用具有高检测率和低假阳性率的标记物来检测增殖性疾病的方法。

    Small engine and engine work machine including the same
    6.
    发明授权
    Small engine and engine work machine including the same 有权
    小发动机和发动机工作机器包括相同

    公开(公告)号：US08869774B2

    公开(公告)日：2014-10-28

    申请号：US13155294

    申请日：2011-06-07

    申请人： Toshihide Sasaki ,  Shigetoshi Ishida ,  Hiroki Nagase

    发明人： Toshihide Sasaki ,  Shigetoshi Ishida ,  Hiroki Nagase

    IPC分类号： F02D11/10 ,  F02M35/10 ,  F02B27/00 ,  F02D35/00 ,  F02B63/02 ,  F02B75/02

    CPC分类号： F02M35/10275 ,  F02B27/003 ,  F02B63/02 ,  F02B2075/025 ,  F02D11/10 ,  F02D35/0053 ,  F02D2400/04 ,  F02D2400/06 ,  Y02T10/146

    摘要： An engine includes: a carburetor configured to supply an air-fuel mixture of fuel and air; a crank case defining a crank chamber; a cylinder block which includes: a cylinder bore in which a reciprocable piston is disposed; and an intake port which supplies the air-fuel mixture supplied from the carburetor to the crank chamber; a control valve configured to open and close the intake port; and a controller configured to control the control valve. The controller controls the number of times that the control valve closes the intake port with respect to the number of times that the piston moves up to thereby reduce pressure of the crank chamber.

    摘要翻译： 发动机包括：化油器，其构造成供应燃料和空气的空气燃料混合物; 限定曲柄室的曲轴箱; 气缸体，其包括：气缸孔，其中布置有往复活塞; 以及将从所述化油器供给的所述空气燃料混合物供给到所述曲柄室的进气口; 构造成打开和关闭进气口的控制阀; 以及配置成控制所述控制阀的控制器。 控制器控制控制阀相对于活塞向上移动的次数关闭进气口的次数，从而减小曲柄室的压力。