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48 条记录 (耗时 0.04 秒)

    Welding method and welding device
    1.
    发明授权
    Welding method and welding device 失效
    焊接方法和焊接装置

    公开(公告)号：US5446257A

    公开(公告)日：1995-08-29

    申请号：US218630

    申请日：1994-03-28

    申请人： Hiroki Sakamoto ,  Kimihiro Shibata ,  Kiyokazu Mori

    发明人： Hiroki Sakamoto ,  Kimihiro Shibata ,  Kiyokazu Mori

    IPC分类号： B23K26/00 ,  B23K26/04 ,  B23K26/20 ,  G01J1/42 ,  G01N21/84 ,  G01N21/88 ,  B23K26/02

    CPC分类号： B23K26/04

    摘要： During melting and jointing members 2, 3 to weld the members by applying a laser beam 5 to the members while supplying a filler wire 13 to the locally heated portion of the members, welding plasma intensities are measured by sensors 8, 9 from both sides of the locally heated portion with reference to an advancing direction of welding. When the welding plasma intensities measured from both sides of the locally heated portion are largely different from each other, the relative deviation between the laser beam 5 and the filler wire 13 is large, so that a good welding may be difficult to be carried out. Based on this recognitions, the relative position between the laser beam 5 and the filler wire 13 is corrected during welding to prevent occurrence of weld inferiority, so that the occurrence of weld inferiority due to the relative deviation between the the laser beam 5 and the filler wire 13 can be effectively prevented, thereby scrapped inferior members can be decreased providing a reduction of costs of materials and an improvement of weld efficiency.

    摘要翻译： 在熔融和接合构件2,3中，通过在构件的局部加热部分供给填充金属丝13的同时施加激光束5来焊接构件，焊接等离子体强度由传感器8,9从两侧 相对于焊接的前进方向的局部加热部。 当从局部加热部分的两侧测量的焊接等离子体强度大大不同时，激光束5和填充焊丝13之间的相对偏差较大，因此可能难以进行良好的焊接。 基于该识别，在焊接期间校正激光束5和填充焊丝13之间的相对位置，以防止焊接劣化的发生，从而由于激光束5和填充物之间的相对偏离而导致焊接劣化的发生 可以有效地防止钢丝13，从而降低材料成本和提高焊接效率，从而可以减少报废的下部件。

    Method of laser quenching
    2.
    发明授权
    Method of laser quenching 失效
    激光淬火方法

    公开(公告)号：US5182433A

    公开(公告)日：1993-01-26

    申请号：US780500

    申请日：1991-10-22

    申请人： Hiroki Sakamoto ,  Hidenobu Matsuyama ,  Kimihiro Shibata

    发明人： Hiroki Sakamoto ,  Hidenobu Matsuyama ,  Kimihiro Shibata

    IPC分类号： C21D1/09

    CPC分类号： C21D1/09

    摘要： A method of laser transformation hardening adapted to irradiate a laser beam in a sense of P polarization on a work piece at an angle of incidence to a surface of the work piece of 60.degree. or more which comprises steps of: forming a plurality of triangular ridges on a horizontal plane adjacent to a surface of the work piece, having a first plurality of inclined surfaces inclined at a first angle to the horizontal plane and a second plurality of inclined surfaces inclined at a second angle to the horizontal plane, the first angle being smaller than the second angle; and irradiating the laser on the work piece at the angle of incidence to the surface of the work piece of 65.degree. to 70.degree. from a direction on the side of the second plurality of inclined surface.

    摘要翻译： 一种激光变换硬化的方法，其适用于以与60度以上的工件的表面成角度的方式在工件上照射P极化的激光束，该方法包括以下步骤：形成多个三角形脊 在与所述工件的表面相邻的水平面上具有与所述水平面倾斜成第一角度的第一多个倾斜面和与所述水平面倾斜第二角度的第二多个倾斜面，所述第一角度为 小于第二角度; 以及从第二多个倾斜面的一侧的方向以与工件表面65°〜70°的角度的入射角将激光照射在工件上。

    Laser processing arrangement
    3.
    发明授权
    Laser processing arrangement 失效
    激光加工布置

    公开(公告)号：US5196672A

    公开(公告)日：1993-03-23

    申请号：US840545

    申请日：1992-02-25

    申请人： Hidenobu Matsuyama ,  Kimihiro Shibata ,  Hiroki Sakamoto

    发明人： Hidenobu Matsuyama ,  Kimihiro Shibata ,  Hiroki Sakamoto

    IPC分类号： B23K26/00 ,  B23K26/03 ,  C21D1/09 ,  G01K11/12

    CPC分类号： B23K26/034 ,  B23K26/064

    摘要： A laser processing arrangement includes a laser oscillator which outputs a laser beam. The laser beam path is established such that the beam reflects from a flat surfaced mirror to a concave mirror and then to a second concave mirror before irradiating a work piece under processing. The arrangement further includes a temperature sensor associated with a temperature detecting means. The temperature detecting means is connected to a control unit which controls moving means connected to movable axes of a processing surface in order to move the work piece relative the laser beam. The control unit is further effective to control the laser oscillator according to a desired temperature range for processing. The temperature sensor is preferably positioned within 45.degree. of the laser beam and the angle of incidence of the laser beam is selected so as to be smaller than a brewster angle of the material of the work piece.

    摘要翻译： 激光加工装置包括输出激光束的激光振荡器。 建立激光束路径，使得光束从平坦的表面反射镜反射到凹面镜，然后在照射处理的工件之前到第二凹面镜。 该装置还包括与温度检测装置相关联的温度传感器。 温度检测装置连接到控制单元，该控制单元控制连接到处理表面的可移动轴的移动装置，以便相对于激光束移动工件。 控制单元进一步有效地根据期望的温度范围控制激光振荡器进行处理。 温度传感器优选位于激光束的45°内，并且激光束的入射角被选择为小于工件材料的布鲁斯特角。

    Laser hardening device
    4.
    发明授权
    Laser hardening device 失效
    激光淬火装置

    公开(公告)号：US5313042A

    公开(公告)日：1994-05-17

    申请号：US892886

    申请日：1992-06-03

    申请人： Hidenobu Matsuyama ,  Kimihiro Shibata ,  Hiroki Sakamoto

    发明人： Hidenobu Matsuyama ,  Kimihiro Shibata ,  Hiroki Sakamoto

    IPC分类号： B23K26/06 ,  B23K26/14 ,  C21D1/09 ,  B23K26/00

    CPC分类号： B23K26/0643 ,  B23K26/1438 ,  B23K26/147 ,  C21D1/09

    摘要： A laser hardening device for forming a hardened layer on the surface of an object irradiated by a laser beam is so arranged as to emit a laser beam which is linearly polarized in the incidence plane containing the normal to the surface and the optic axis of the laser beam irradiating the surface. The device comprises a first concave mirror for condensing the laser beam the incidence plane, and a second concave mirror for condensing the laser beam in a perpendicular plane to the incidence plane, the first concave mirror being disposed closer than the second concave mirror to the laser oscillator in the path of the laser beam. Laser beam is therefore absorbed at a high absorption rate by the object, and a hardened layer is formed without coating a laser absorption agent onto the object. The incidence angle of the laser is preferably no less than 60 degrees, and by arranging that the laser beam is parallel on the irradiated surface, a uniform, hardened layer is obtained. Moreover, by blowing shield gas on the irradiated surface from a gas nozzle provided with a smoothing mechanism such as metal mesh, oxidation of the hardened layer or surface melting due to oxidation is prevented and a more desirable hardened surface is obtained.

    摘要翻译： 用于在被激光束照射的物体的表面上形成硬化层的激光淬火装置被布置成发射在包含激光的表面和光轴的法线的入射平面中线性偏振的激光束 光束照射表面。 该装置包括用于将激光束聚焦入射平面的第一凹面镜和用于将激光束在与入射平面垂直的平面中聚光的第二凹面镜，第一凹面镜被设置成比第二凹面镜更靠近激光 振荡器在激光束的路径中。 因此，激光束以物体的高吸收率被吸收，并且形成硬化层而不在激光吸收剂上涂覆物体。 激光的入射角优选为60度以上，通过将激光束平行配置在照射面上，得到均匀的硬化层。 此外，通过从设置有金属网的平滑机构的气体喷嘴在被照射的表面上吹扫保护气体，防止了由于氧化而导致的硬化层的氧化或表面熔融，并且获得了更理想的硬化面。

    Method of Diagnosing Pancreatic Cancer with the Use of N-Binding Type Sugar Chains
    7.
    发明申请
    Method of Diagnosing Pancreatic Cancer with the Use of N-Binding Type Sugar Chains 失效
    使用N-结合型糖链诊断胰腺癌的方法

    公开(公告)号：US20110065141A1

    公开(公告)日：2011-03-17

    申请号：US12991340

    申请日：2009-05-08

    申请人： Tokuzo Arao ,  Kazuko Matsumoto ,  Kazuto Nishio ,  Hiroki Sakamoto ,  Masayuki Kitano ,  Masatoshi Kudo

    发明人： Tokuzo Arao ,  Kazuko Matsumoto ,  Kazuto Nishio ,  Hiroki Sakamoto ,  Masayuki Kitano ,  Masatoshi Kudo

    IPC分类号： C12Q1/37 ,  C12Q1/34

    CPC分类号： G01N33/57438 ,  Y10T436/24

    摘要： The present invention is to provide a novel marker for diagnosing pancreatic cancer, a method for determining if a subject has pancreatic cancer utilizing the marker, etc. The present inventors collected blood from patients of 78 cases in total including patients of 24 cases with pancreaticobiliary-duct benign disorder (16 gallstone cases and 8 pancreatitis cases) and patients of 54 cases with pancreatic cancer, and mass spectrometry was performed on N-linked sugar chains in plasma. From the 74 mass-spectrometric peaks detected, 65 sugar chains were extracted based on the results of PAM analysis. These extracted sugar chains were then used to predict pancreatic cancer or pancreaticobiliary-duct benign disorder, to correctly diagnose 74% cases. Further, a T-test was performed between the two groups, the group of pancreaticobiliary-duct benign disorder and the group of pancreatic cancer, which identified two sugar chains, the sugar chain of m/z 3031 and the sugar chain of m/z 2362, as sugar chains demonstrating significant difference (p

    摘要翻译： 本发明提供一种用于诊断胰腺癌的新型标记物，用于确定受试者是否使用标记物的胰腺癌的方法等。本发明人从78例患者中收集了总共包括24例胰腺胆管癌患者的血液， 膀胱良性疾病（16例胆囊病例和8例胰腺炎病例）和54例胰腺癌患者，并对血浆中的N链糖链进行质谱分析。 根据PAM分析结果，从检测到的74个质谱峰中提取出65个糖链。 然后将这些提取的糖链用于预测胰腺癌或胰胆管良性疾病，以正确诊断74％的病例。 此外，在两组之间进行T检验，即胰胆管良性病变组和胰腺癌组，鉴定了两条糖链，m / z 3031的糖链和m / z的糖链 2362，由于糖链显示出显着性差异（p <0.05），并且两组之间的表达水平呈现2倍或更大的差异。 使用这些糖链的正确检测率用六个分类器计算，所有这些分类器都得到约70％的正确检测结果。

    HETEROMONOCYCLIC COMPOUND AND USE THEREOF
    9.
    发明申请
    HETEROMONOCYCLIC COMPOUND AND USE THEREOF 审中-公开
    异环化合物及其用途

    公开(公告)号：US20080207654A1

    公开(公告)日：2008-08-28

    申请号：US11943910

    申请日：2007-11-21

    申请人： Takanobu Kuroita ,  Hiroki Sakamoto ,  Hideyuki Igawa ,  Minoru Sasaki ,  Kouhei Asano ,  Tsuyoshi Maekawa

    发明人： Takanobu Kuroita ,  Hiroki Sakamoto ,  Hideyuki Igawa ,  Minoru Sasaki ,  Kouhei Asano ,  Tsuyoshi Maekawa

    IPC分类号： A61K31/506 ,  C07D239/22 ,  A61P3/10 ,  A61P3/04

    CPC分类号： C07D413/14 ,  C07D413/10 ,  C07D417/14

    摘要： A compound represented by the formula (I): wherein R1 is an oxo group, ═N—R or the like; a group represented by the formula: is a group represented by the formula: R2 is a group represented by the formula: R3 and R4 are each H, or C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 alkylamino, di(C1-C6)alkylamino or C1-C6 alkylthio, each of which is optionally substituted; and R5 is H, or C1-C6 alkyl, C2-C6 alkenyl, cyclic group, each of which is optionally substituted, —CO—R8 or —O—R8′, or a salt thereof. The compound of the present invention is useful as a drug for the prophylaxis or treatment of circulatory diseases, metabolic diseases and/or central nervous system diseases.

    摘要翻译： 由式（I）表示的化合物：其中R1是氧代基，-N-R等; 由下式表示的基团是由下式表示的基团：R 2是由下式表示的基团：R 3和R 4各自为H或C 1 -C 6烷基，C 3 -C 6环烷基，C 1 -C 6烷氧基，C 1 -C 6 烷基氨基，二（C 1 -C 6）烷基氨基或C 1 -C 6烷硫基，其各自任选被取代; 和R 5为H或C 1 -C 6烷基，C 2 -C 6烯基，环状基团，各自为任选取代的-CO-R 8或-O-R 8'或其盐。 本发明的化合物可用作预防或治疗循环系统疾病，代谢疾病和/或中枢神经系统疾病的药物。

    Thiazoline derivative and use of the same
    10.
    发明申请
    Thiazoline derivative and use of the same 失效
    噻唑啉衍生物和使用相同

    公开(公告)号：US20070010528A1

    公开(公告)日：2007-01-11

    申请号：US10574048

    申请日：2004-09-29

    申请人： Keiji Kubo ,  Takanobu Kuroita ,  Masaki Kawamura ,  Hiroki Sakamoto

    发明人： Keiji Kubo ,  Takanobu Kuroita ,  Masaki Kawamura ,  Hiroki Sakamoto

    IPC分类号： A61K31/496 ,  A61K31/454 ,  A61K31/426 ,  C07D417/02

    CPC分类号： C07D417/06 ,  C07D277/42 ,  C07D417/04 ,  C07D417/12

    摘要： A thiazoline derivative represented by Formula (I): wherein R is a cyclic hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; X is a bond or a divalent chain hydrocarbon group which may be substituted; X′ is a bond or —N(R5)—; Y is a divalent hydrocarbon group which may be substituted; Y′ is a bond or —C(═O)—; ring A is a nitrogen-containing heterocycle which may be substituted; Z1 and Z3 are each independently a bond or a divalent chain hydrocarbon group which may be substituted; Z2 is a bond or —N(R6)—; and B is a group represented by the formula: which is useful as a therapeutic drug for thrombosis, is provided.

    摘要翻译： 由式（I）表示的噻唑啉衍生物：其中R是可被取代的环状烃基或可被取代的杂环基; X是可以被取代的键或二价链烃基; X'是键或-N（R 5） - ; Y是可以被取代的二价烃基; Y'是键或-C（-O） - ; 环A是可以被取代的含氮杂环; Z 1和Z 3各自独立地为可以被取代的键或二价链烃基; Z 2是键或-N（R 6） - ; 并且B是由下式表示的基团：其可用作血栓形成的治疗药物。