公开(公告)号：US08241561B2

公开(公告)日：2012-08-14

申请号：US12676271

申请日：2010-03-03

申请人： Fumihiko Gejima ,  Hiroki Sakamoto ,  Mamoru Sayashi

发明人： Fumihiko Gejima ,  Hiroki Sakamoto ,  Mamoru Sayashi

IPC分类号： C22C21/00

CPC分类号： C22C21/00 ,  B22F2998/10 ,  C22C1/0416 ,  C22C1/0491 ,  C22F1/04 ,  C22F1/053 ,  B22F9/082 ,  B22F3/20

摘要： Inventors of the present invention have found that, by manufacturing a stress-buffering material with a Ca-containing aluminum alloy including 0.1 to 12 at % of Ca, the stress-buffering material at low cost, capable of expanding its use in various fields, and having low Young's modulus that is beyond a conventional level, can be obtain.

摘要翻译： 本发明的发明人已经发现，通过使用包含0.1〜12at％的Ca的含Ca的铝合金制造应力缓冲材料，能够以各种领域扩大其应用的低成本的应力缓冲材料， 并且可以获得超过常规水平的低杨氏模量。

公开(公告)号：US20100172792A1

公开(公告)日：2010-07-08

申请号：US12676271

申请日：2008-09-11

申请人： Fumihiko Gejima ,  Hiroki Sakamoto ,  Mamoru Sayashi

发明人： Fumihiko Gejima ,  Hiroki Sakamoto ,  Mamoru Sayashi

IPC分类号： C22C21/00 ,  C22C21/10

CPC分类号： C22C21/00 ,  B22F2998/10 ,  C22C1/0416 ,  C22C1/0491 ,  C22F1/04 ,  C22F1/053 ,  B22F9/082 ,  B22F3/20

摘要： Inventors of the present invention have found that, by manufacturing a stress-buffering material with a Ca-containing aluminum alloy including 0.1 to 12 at % of Ca, the stress-buffering material at low cost, capable of expanding its use in various fields, and having low Young's modulus that is beyond a conventional level, can be obtain.

摘要翻译： 本发明的发明人已经发现，通过使用包含0.1〜12at％的Ca的含Ca的铝合金制造应力缓冲材料，能够以各种领域扩大其应用的低成本的应力缓冲材料， 并且可以获得超过常规水平的低杨氏模量。

公开(公告)号：US20110309512A1

公开(公告)日：2011-12-22

申请号：US12673082

申请日：2008-09-08

申请人： Fumihiko Gejima ,  Hiroki Sakamoto

发明人： Fumihiko Gejima ,  Hiroki Sakamoto

IPC分类号： H01L23/48

CPC分类号： H01L23/3735 ,  H01L23/053 ,  H01L23/147 ,  H01L23/49894 ,  H01L23/562 ,  H01L24/29 ,  H01L24/32 ,  H01L24/48 ,  H01L24/49 ,  H01L24/73 ,  H01L24/83 ,  H01L2224/29 ,  H01L2224/29101 ,  H01L2224/29111 ,  H01L2224/29298 ,  H01L2224/32225 ,  H01L2224/32507 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/4911 ,  H01L2224/73265 ,  H01L2224/838 ,  H01L2224/85424 ,  H01L2224/92 ,  H01L2224/92247 ,  H01L2924/0001 ,  H01L2924/00013 ,  H01L2924/00014 ,  H01L2924/01004 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01012 ,  H01L2924/01014 ,  H01L2924/01019 ,  H01L2924/0102 ,  H01L2924/01028 ,  H01L2924/01029 ,  H01L2924/0103 ,  H01L2924/01033 ,  H01L2924/01038 ,  H01L2924/01047 ,  H01L2924/0105 ,  H01L2924/01051 ,  H01L2924/01056 ,  H01L2924/01074 ,  H01L2924/01082 ,  H01L2924/0132 ,  H01L2924/01322 ,  H01L2924/01327 ,  H01L2924/0133 ,  H01L2924/014 ,  H01L2924/12042 ,  H01L2924/15787 ,  H01L2924/1579 ,  H01L2924/16195 ,  H01L2924/19107 ,  H01L2924/351 ,  H01L2924/00 ,  H01L2224/45099 ,  H01L2924/00012 ,  H01L2924/01013 ,  H01L2924/3512 ,  H01L2924/00015 ,  H01L2224/29099 ,  H01L2224/29199 ,  H01L2224/29299 ,  H01L2224/2929

摘要： Embodiments of the invention provide a semiconductor device having high reliability as they ease the thermal stress or a heat distortion or strain occurring during the manufacturing process or during operation, and the embodiments function with stability for a long time. A semiconductor device has a semiconductor substrate, an insulating ceramic plate on which the semiconductor substrate is mounted and stress buffer 40 that eases a thermal stress. The stress buffer is provided between the semiconductor substrate and the insulating ceramic plate and can be provided on a surface of the insulating ceramic plate that is opposite to a surface on which the semiconductor substrate is mounted. The stress buffer is formed from a structure including at least Al and a second phase. The second phase is Al4X where X is at least one element of alkaline earth metal elements.

摘要翻译： 本发明的实施例提供了一种具有高可靠性的半导体器件，因为它们易于在制造过程中或在操作期间发生热应力或热变形或应变，并且该实施例长时间稳定地起作用。 半导体器件具有半导体衬底，其上安装有半导体衬底的绝缘陶瓷板和缓解热应力的应力缓冲器40。 应力缓冲器设置在半导体衬底和绝缘陶瓷板之间，并且可以设置在与安装半导体衬底的表面相对的绝缘陶瓷板的表面上。 应力缓冲器由至少包括Al和第二相的结构形成。 第二相是Al4X，其中X是至少一种碱土金属元素元素。

公开(公告)号：US08125088B2

公开(公告)日：2012-02-28

申请号：US12673082

申请日：2008-09-08

申请人： Fumihiko Gejima ,  Hiroki Sakamoto

发明人： Fumihiko Gejima ,  Hiroki Sakamoto

IPC分类号： H01L23/48

CPC分类号： H01L23/3735 ,  H01L23/053 ,  H01L23/147 ,  H01L23/49894 ,  H01L23/562 ,  H01L24/29 ,  H01L24/32 ,  H01L24/48 ,  H01L24/49 ,  H01L24/73 ,  H01L24/83 ,  H01L2224/29 ,  H01L2224/29101 ,  H01L2224/29111 ,  H01L2224/29298 ,  H01L2224/32225 ,  H01L2224/32507 ,  H01L2224/48091 ,  H01L2224/48227 ,  H01L2224/4911 ,  H01L2224/73265 ,  H01L2224/838 ,  H01L2224/85424 ,  H01L2224/92 ,  H01L2224/92247 ,  H01L2924/0001 ,  H01L2924/00013 ,  H01L2924/00014 ,  H01L2924/01004 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01012 ,  H01L2924/01014 ,  H01L2924/01019 ,  H01L2924/0102 ,  H01L2924/01028 ,  H01L2924/01029 ,  H01L2924/0103 ,  H01L2924/01033 ,  H01L2924/01038 ,  H01L2924/01047 ,  H01L2924/0105 ,  H01L2924/01051 ,  H01L2924/01056 ,  H01L2924/01074 ,  H01L2924/01082 ,  H01L2924/0132 ,  H01L2924/01322 ,  H01L2924/01327 ,  H01L2924/0133 ,  H01L2924/014 ,  H01L2924/12042 ,  H01L2924/15787 ,  H01L2924/1579 ,  H01L2924/16195 ,  H01L2924/19107 ,  H01L2924/351 ,  H01L2924/00 ,  H01L2224/45099 ,  H01L2924/00012 ,  H01L2924/01013 ,  H01L2924/3512 ,  H01L2924/00015 ,  H01L2224/29099 ,  H01L2224/29199 ,  H01L2224/29299 ,  H01L2224/2929

摘要： Embodiments of the invention provide a semiconductor device having high reliability as they ease the thermal stress or a heat distortion or strain occurring during the manufacturing process or during operation, and the embodiments function with stability for a long time. A semiconductor device has a semiconductor substrate, an insulating ceramic plate on which the semiconductor substrate is mounted and stress buffer 40 that eases a thermal stress. The stress buffer is provided between the semiconductor substrate and the insulating ceramic plate and can be provided on a surface of the insulating ceramic plate that is opposite to a surface on which the semiconductor substrate is mounted. The stress buffer is formed from a structure including at least Al and a second phase. The second phase is Al4X where X is at least one element of alkaline earth metal elements.

摘要翻译： 本发明的实施例提供了一种具有高可靠性的半导体器件，因为它们易于在制造过程中或在操作期间发生热应力或热变形或应变，并且该实施例长时间稳定地起作用。 半导体器件具有半导体衬底，其上安装有半导体衬底的绝缘陶瓷板和缓解热应力的应力缓冲器40。 应力缓冲器设置在半导体衬底和绝缘陶瓷板之间，并且可以设置在与安装半导体衬底的表面相对的绝缘陶瓷板的表面上。 应力缓冲器由至少包括Al和第二相的结构形成。 第二相是Al4X，其中X是至少一种碱土金属元素元素。

公开(公告)号：US08163863B2

公开(公告)日：2012-04-24

申请号：US12096050

申请日：2006-12-01

申请人： Hiroki Sakamoto ,  Hiroaki Murase ,  Tsuyoshi Fujiki ,  Shingo Osawa ,  Yoshiyuki Morita ,  Tetsuya Hosomi ,  Nobuaki Aoki

发明人： Hiroki Sakamoto ,  Hiroaki Murase ,  Tsuyoshi Fujiki ,  Shingo Osawa ,  Yoshiyuki Morita ,  Tetsuya Hosomi ,  Nobuaki Aoki

IPC分类号： C08G77/48 ,  C08G77/60

CPC分类号： C08G77/60 ,  C08L83/16 ,  C09D183/16

摘要： A polysilane having excellent functionalities (e.g., solubility in a solvent and reactivity) is obtained by introducing a structural unit of the following formula (1) to a polysilane through a reaction of a dihalosilane having a Si—H bond and adding a hydrosilylatable compound (e.g., a compound having a carbon-carbon unsaturated bond) to the Si—H bond, wherein R1 represents a hydrogen atom, an organic group, or a silyl group; and “n” denotes an integer of not less than 1.

摘要翻译： 通过将具有Si-H键的二卤代硅烷和加入可氢化可硅烷化合物（通过使用可氢化的化合物）反应，将具有下列通式（1）的结构单元引入聚硅烷中，获得具有优异官能度的聚硅烷（例如溶剂中的溶解性和反应性） 例如具有碳 - 碳不饱和键的化合物）与Si-H键，其中R1表示氢原子，有机基团或甲硅烷基基团; “n”表示不小于1的整数。

公开(公告)号：US20110065141A1

公开(公告)日：2011-03-17

申请号：US12991340

申请日：2009-05-08

申请人： Tokuzo Arao ,  Kazuko Matsumoto ,  Kazuto Nishio ,  Hiroki Sakamoto ,  Masayuki Kitano ,  Masatoshi Kudo

发明人： Tokuzo Arao ,  Kazuko Matsumoto ,  Kazuto Nishio ,  Hiroki Sakamoto ,  Masayuki Kitano ,  Masatoshi Kudo

IPC分类号： C12Q1/37 ,  C12Q1/34

CPC分类号： G01N33/57438 ,  Y10T436/24

摘要： The present invention is to provide a novel marker for diagnosing pancreatic cancer, a method for determining if a subject has pancreatic cancer utilizing the marker, etc. The present inventors collected blood from patients of 78 cases in total including patients of 24 cases with pancreaticobiliary-duct benign disorder (16 gallstone cases and 8 pancreatitis cases) and patients of 54 cases with pancreatic cancer, and mass spectrometry was performed on N-linked sugar chains in plasma. From the 74 mass-spectrometric peaks detected, 65 sugar chains were extracted based on the results of PAM analysis. These extracted sugar chains were then used to predict pancreatic cancer or pancreaticobiliary-duct benign disorder, to correctly diagnose 74% cases. Further, a T-test was performed between the two groups, the group of pancreaticobiliary-duct benign disorder and the group of pancreatic cancer, which identified two sugar chains, the sugar chain of m/z 3031 and the sugar chain of m/z 2362, as sugar chains demonstrating significant difference (p

摘要翻译： 本发明提供一种用于诊断胰腺癌的新型标记物，用于确定受试者是否使用标记物的胰腺癌的方法等。本发明人从78例患者中收集了总共包括24例胰腺胆管癌患者的血液， 膀胱良性疾病（16例胆囊病例和8例胰腺炎病例）和54例胰腺癌患者，并对血浆中的N链糖链进行质谱分析。 根据PAM分析结果，从检测到的74个质谱峰中提取出65个糖链。 然后将这些提取的糖链用于预测胰腺癌或胰胆管良性疾病，以正确诊断74％的病例。 此外，在两组之间进行T检验，即胰胆管良性病变组和胰腺癌组，鉴定了两条糖链，m / z 3031的糖链和m / z的糖链 2362，由于糖链显示出显着性差异（p <0.05），并且两组之间的表达水平呈现2倍或更大的差异。 使用这些糖链的正确检测率用六个分类器计算，所有这些分类器都得到约70％的正确检测结果。

公开(公告)号：US20080207654A1

公开(公告)日：2008-08-28

申请号：US11943910

申请日：2007-11-21

申请人： Takanobu Kuroita ,  Hiroki Sakamoto ,  Hideyuki Igawa ,  Minoru Sasaki ,  Kouhei Asano ,  Tsuyoshi Maekawa

发明人： Takanobu Kuroita ,  Hiroki Sakamoto ,  Hideyuki Igawa ,  Minoru Sasaki ,  Kouhei Asano ,  Tsuyoshi Maekawa

IPC分类号： A61K31/506 ,  C07D239/22 ,  A61P3/10 ,  A61P3/04

CPC分类号： C07D413/14 ,  C07D413/10 ,  C07D417/14

摘要： A compound represented by the formula (I): wherein R1 is an oxo group, ═N—R or the like; a group represented by the formula: is a group represented by the formula: R2 is a group represented by the formula: R3 and R4 are each H, or C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 alkylamino, di(C1-C6)alkylamino or C1-C6 alkylthio, each of which is optionally substituted; and R5 is H, or C1-C6 alkyl, C2-C6 alkenyl, cyclic group, each of which is optionally substituted, —CO—R8 or —O—R8′, or a salt thereof. The compound of the present invention is useful as a drug for the prophylaxis or treatment of circulatory diseases, metabolic diseases and/or central nervous system diseases.

摘要翻译： 由式（I）表示的化合物：其中R1是氧代基，-N-R等; 由下式表示的基团是由下式表示的基团：R 2是由下式表示的基团：R 3和R 4各自为H或C 1 -C 6烷基，C 3 -C 6环烷基，C 1 -C 6烷氧基，C 1 -C 6 烷基氨基，二（C 1 -C 6）烷基氨基或C 1 -C 6烷硫基，其各自任选被取代; 和R 5为H或C 1 -C 6烷基，C 2 -C 6烯基，环状基团，各自为任选取代的-CO-R 8或-O-R 8'或其盐。 本发明的化合物可用作预防或治疗循环系统疾病，代谢疾病和/或中枢神经系统疾病的药物。

公开(公告)号：US20070010528A1

公开(公告)日：2007-01-11

申请号：US10574048

申请日：2004-09-29

申请人： Keiji Kubo ,  Takanobu Kuroita ,  Masaki Kawamura ,  Hiroki Sakamoto

发明人： Keiji Kubo ,  Takanobu Kuroita ,  Masaki Kawamura ,  Hiroki Sakamoto

IPC分类号： A61K31/496 ,  A61K31/454 ,  A61K31/426 ,  C07D417/02

CPC分类号： C07D417/06 ,  C07D277/42 ,  C07D417/04 ,  C07D417/12

摘要： A thiazoline derivative represented by Formula (I): wherein R is a cyclic hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; X is a bond or a divalent chain hydrocarbon group which may be substituted; X′ is a bond or —N(R5)—; Y is a divalent hydrocarbon group which may be substituted; Y′ is a bond or —C(═O)—; ring A is a nitrogen-containing heterocycle which may be substituted; Z1 and Z3 are each independently a bond or a divalent chain hydrocarbon group which may be substituted; Z2 is a bond or —N(R6)—; and B is a group represented by the formula: which is useful as a therapeutic drug for thrombosis, is provided.

摘要翻译： 由式（I）表示的噻唑啉衍生物：其中R是可被取代的环状烃基或可被取代的杂环基; X是可以被取代的键或二价链烃基; X'是键或-N（R 5） - ; Y是可以被取代的二价烃基; Y'是键或-C（-O） - ; 环A是可以被取代的含氮杂环; Z 1和Z 3各自独立地为可以被取代的键或二价链烃基; Z 2是键或-N（R 6） - ; 并且B是由下式表示的基团：其可用作血栓形成的治疗药物。

公开(公告)号：US20060281795A1

公开(公告)日：2006-12-14

申请号：US11466633

申请日：2006-08-23

申请人： Takanobu Kuroita ,  Hiroki Sakamoto ,  Mami Ojima

发明人： Takanobu Kuroita ,  Hiroki Sakamoto ,  Mami Ojima

IPC分类号： A61K31/4245 ,  C07D413/02 ,  C07D413/14

CPC分类号： C07D413/14

摘要： The present invention relates to a compound represented by the formula (I) wherein R1 is a group represented by the formula wherein R2, R3, R4, R5, R6, R7 and R8 are each independently a hydrogen atom or a C1-6 alkyl, or a salt thereof. The compound of the present invention is useful as an agent for the prophylaxis or treatment of circulatory diseases such as hypertension and the like and metabolic diseases such as diabetes and the like.

摘要翻译： 本发明涉及由式（I）表示的化合物，其中R 1为由下式表示的基团：其中R 2，R 3， R 4，R 5，R 6，R 7和R 8，R 8， >各自独立地为氢原子或C 1-6烷基，或其盐。 本发明的化合物可用作预防或治疗诸如高血压等循环系统疾病和糖尿病等代谢疾病的药剂。

公开(公告)号：US5182433A

公开(公告)日：1993-01-26

申请号：US780500

申请日：1991-10-22

申请人： Hiroki Sakamoto ,  Hidenobu Matsuyama ,  Kimihiro Shibata

发明人： Hiroki Sakamoto ,  Hidenobu Matsuyama ,  Kimihiro Shibata

IPC分类号： C21D1/09

CPC分类号： C21D1/09

摘要： A method of laser transformation hardening adapted to irradiate a laser beam in a sense of P polarization on a work piece at an angle of incidence to a surface of the work piece of 60.degree. or more which comprises steps of: forming a plurality of triangular ridges on a horizontal plane adjacent to a surface of the work piece, having a first plurality of inclined surfaces inclined at a first angle to the horizontal plane and a second plurality of inclined surfaces inclined at a second angle to the horizontal plane, the first angle being smaller than the second angle; and irradiating the laser on the work piece at the angle of incidence to the surface of the work piece of 65.degree. to 70.degree. from a direction on the side of the second plurality of inclined surface.

摘要翻译： 一种激光变换硬化的方法，其适用于以与60度以上的工件的表面成角度的方式在工件上照射P极化的激光束，该方法包括以下步骤：形成多个三角形脊 在与所述工件的表面相邻的水平面上具有与所述水平面倾斜成第一角度的第一多个倾斜面和与所述水平面倾斜第二角度的第二多个倾斜面，所述第一角度为 小于第二角度; 以及从第二多个倾斜面的一侧的方向以与工件表面65°〜70°的角度的入射角将激光照射在工件上。