Cholesterol-lowering agents
    4.
    发明授权
    Cholesterol-lowering agents 失效
    降胆固醇剂

    公开(公告)号:US5178854A

    公开(公告)日:1993-01-12

    申请号:US684318

    申请日:1991-04-12

    IPC分类号: A61K31/785

    CPC分类号: A61K31/785

    摘要: A method for lowering serum total cholesterol in an animal by administering to the aminal an anion-exchange resin having the monomer units respectively represented by the below-given structural formulas (I), (II), (III) and (IV) in a content of 60-95 molar % of the monomer unit (I), 0-25 molar % of the monomer unit (II), 0--30 molar % of the monomer unit (III) and 1-6 molar % of themonomer unit (IV). ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 which may be the same or different respectively are hydrogen atom, a lower alkyl group or benzyl group, R.sup.4 is hydrogen atom, a lower alkyl group or hydroxy-methyl group and X is a halogen atom. The above-mentioned agents specifically bind with bile acid in the intestinal tract even in the presence of other acids.

    摘要翻译: 一种降低动物体内血清总胆固醇的方法,其中通过向所述阿米尔给予具有分别由下述结构式(I),(II),(III)和(IV)表示的单体单元的阴离子交换树脂) 单体单元(I)的60-95摩尔%,单体单元(II)的0-25摩尔%,单体单元(III)的0-30摩尔%和单体单元(I)的1-6摩尔% IV)。 (IV)其中可以相同或不同的R 1,R 2和R 3分别是氢原子,低级烷基或苄基的化合物(II) R4是氢原子,低级烷基或羟基甲基,X是卤素原子。 上述药剂即使在其它酸的存在下也与胆汁酸在肠道中特异性结合。

    Process for producing 2-nitrocycloalkanones
    7.
    发明授权
    Process for producing 2-nitrocycloalkanones 失效
    2-硝基环烷酮的制备方法

    公开(公告)号:US3959380A

    公开(公告)日:1976-05-25

    申请号:US559795

    申请日:1975-03-19

    IPC分类号: C07C45/04

    摘要: 2-Nitrocycloalkanone, and its derivatives are prepared by reacting in a single step a cycloalkene with nitrogen dioxide and an oxygen containing gas in the presence of an aromatic hydrocarbon solvent having 6 - 10 carbon atoms, and a dimethylsulfoxide catalyst.

    摘要翻译: 2-硝基环烷酮及其衍生物通过在具有6-10个碳原子的芳族烃溶剂和二甲基亚砜催化剂的存在下,在一个步骤中使环烯烃与二氧化氮和含氧气体反应来制备。