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    Method and preparation for administration to the mucosa of the oral or nasal cavity
    1.
    发明授权
    Method and preparation for administration to the mucosa of the oral or nasal cavity 失效
    用于口腔或鼻腔粘膜的方法和制剂

    公开(公告)号：US4250163A

    公开(公告)日：1981-02-10

    申请号：US103558

    申请日：1979-12-13

    申请人： Tsuneji Nagai ,  Yoshiharu Machida ,  Yoshiki Suzuki ,  Hiroshi Ikura

    发明人： Tsuneji Nagai ,  Yoshiharu Machida ,  Yoshiki Suzuki ,  Hiroshi Ikura

    IPC分类号： A61K9/14 ,  A61K9/00 ,  A61K45/08 ,  A61K47/30 ,  A61K47/32 ,  A61K47/38 ,  A61K31/74 ,  A61K31/78

    CPC分类号： A61K9/0043 ,  A61K9/006 ,  A61K47/32 ,  A61K47/38 ,  Y10S514/96

    摘要： A method for administering a medicament which comprises adhering to the mucosa of the oral or nasal cavity a pharmaceutical preparation comprising(a) a water-swellable and mucosa-adhesive polymeric matrix comprising about 50 to about 95% by weight of a cellulose ether and about 50 to about 5% by weight of a homo- or copolymer of acrylic acid or a pharmaceutically acceptable salt thereof, and(b) dispersed therein, a pharmaceutically effective amount of the medicament,said preparation releasing continuously the medicament at a controlled rate; and causing the released medicament to be absorbed through the mucosa or enterally; said mucosa-adhesive preparation; and process for said preparation.

    摘要翻译： 一种用于施用药物的方法，其包括将口腔或鼻腔的粘膜粘附到药物制剂中，所述药物制剂包含（a）水溶胀性和粘膜粘合性聚合物基质，其包含约50至约95重量％的纤维素醚和约 50至约5重量％的丙烯酸或其药学上可接受的盐的均聚物或共聚物，和（b）其中分散有药物有效量的药物，所述制剂以受控的速率连续释放药物; 并使释放的药物通过粘膜或肠内吸收; 所述粘膜粘合剂制剂; 和所述制备方法。

    Oral sustained release pharmaceutical preparation
    2.
    发明授权
    Oral sustained release pharmaceutical preparation 失效
    口服持续释放药物制剂

    公开(公告)号：US4777033A

    公开(公告)日：1988-10-11

    申请号：US872996

    申请日：1986-06-11

    申请人： Hiroshi Ikura ,  Yoshiki Suzuki ,  Tsuneji Nagai ,  Yoshiharu Machida

    发明人： Hiroshi Ikura ,  Yoshiki Suzuki ,  Tsuneji Nagai ,  Yoshiharu Machida

    IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K9/22 ,  A61K9/46 ,  A61K9/26

    CPC分类号： A61K9/0065 ,  A61K9/2027 ,  A61K9/2054

    摘要： This invention is concerned with an oral sustained release pharmaceutical preparation which is prepared as a pharmaceutical preparation comprising lower alkyl ether of cellulose, polyacrylic acid or its pharmaceutically acceptable salt, and active drugs, or a pharmaceutical preparation comprising lower alkyl ether of cellulose, polyacrylic acid or its pharmaceutically acceptable salt, and active drugs together with a foaming agent, so that it may release the active drugs by such slow degrees in the stomach or the intestinal tract as to make it possible to provide an adequate supply of active drugs in enough concentration to display their therapeutic value for many hours.

    摘要翻译： 本发明涉及作为包含纤维素的低级烷基醚，聚丙烯酸或其药学上可接受的盐的药物制剂和活性药物制备的口服持续释放药物制剂，或包含纤维素的低级烷基醚，聚丙烯酸的药物制剂 或其药学上可接受的盐和活性药物与发泡剂一起释放，使得其可以在胃或肠道中以如此缓慢的程度释放活性药物，使得可以提供足够浓度的活性药物的足够供应 显示其治疗价值多小时。

    Method and preparation for administration to the mucosa of the oral or nasal cavity
    3.
    发明授权
    Method and preparation for administration to the mucosa of the oral or nasal cavity 失效
    用于口腔或鼻腔粘膜的方法和制剂

    公开(公告)号：US4226848A

    公开(公告)日：1980-10-07

    申请号：US17059

    申请日：1979-03-02

    申请人： Tsuneji Nagai ,  Yoshiharu Machida ,  Yoshiki Suzuki ,  Hiroshi Ikura

    发明人： Tsuneji Nagai ,  Yoshiharu Machida ,  Yoshiki Suzuki ,  Hiroshi Ikura

    IPC分类号： A61K9/14 ,  A61K9/00 ,  A61K45/08 ,  A61K47/30 ,  A61K47/32 ,  A61K47/38 ,  A61K9/02 ,  A61K9/22

    CPC分类号： A61K9/0043 ,  A61K9/006 ,  A61K47/32 ,  A61K47/38 ,  Y10S514/96

    摘要： A method for administering a medicament which comprises adhering to the mucosa of the oral or nasal cavity a pharmaceutical preparation comprising(a) a water-swellable and mucosa-adhesive polymeric matrix comprising about 50 to about 95% by weight of a cellulose ether and about 50 to about 5% by weight of a homo- or copolymer of acrylic acid or a pharmaceutically acceptable salt thereof, and(b) dispersed therein, pharmaceutically effective amount of the medicament,said preparation releasing continuously the medicament at a controlled rate; and causing the released medicament to be absorbed through the mucosa or enterally; said mucosa-adhesive preparation; and process for said preparation.

    摘要翻译： 一种用于施用药物的方法，其包括将口腔或鼻腔的粘膜粘附于药物制剂中，所述药物制剂包含（a）水溶胀性和粘膜粘合性聚合物基质，其包含约50至约95重量％的纤维素醚和约 50至约5重量％的丙烯酸或其药学上可接受的盐的均聚物或共聚物，和（b）分散在其中的药学上有效量的药物，所述制剂以受控的速率连续释放药物; 并使释放的药物通过粘膜或肠内吸收; 所述粘膜粘合剂制剂; 和所述制备方法。

    Powdery pharmaceutical composition and powdery preparation for application to the nasal mucosa, and method for administration thereof
    4.
    发明授权
    Powdery pharmaceutical composition and powdery preparation for application to the nasal mucosa, and method for administration thereof 失效
    用于鼻粘膜的粉末状药物组合物和粉末制剂及其施用方法

    公开(公告)号：US4294829A

    公开(公告)日：1981-10-13

    申请号：US173906

    申请日：1980-07-30

    申请人： Yoshiki Suzuki ,  Hiroshi Ikura ,  Gentaro Yamashita ,  Tsuneji Nagai

    发明人： Yoshiki Suzuki ,  Hiroshi Ikura ,  Gentaro Yamashita ,  Tsuneji Nagai

    IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K47/38 ,  A61K31/58 ,  A01N43/36 ,  A61K31/56

    CPC分类号： A61K9/0043 ,  Y10S514/951

    摘要： A powdery pharmaceutical composition and a powdery preparation in unit dosage form for application to the mucosa of the nasal cavity, at least about 90% of which consists of particles having an effective particle diameter of about 20 to about 250 microns, said composition comprising a lower alkyl ether of cellulose having a viscosity, determined at about 37.degree. C. for a 2% aqueous solution thereof, of at least about 5 centipoises and a pharmaceutically effective amount of a drug; and a method for treating or preventing a human nasal disease, which comprises administering a powdery preparation in unit dosage form to the nasal cavity of a human being requiring treatment or prevention of a nasal disease through his nostrils.

    摘要翻译： 一种粉末状药物组合物和单位剂量形式的粉末制剂，其用于鼻腔粘膜，其至少约90％由具有约20至约250微米的有效粒径的颗粒组成，所述组合物包含较低的 在约37℃下测定其2％水溶液的粘度为至少约5厘泊和药物有效量的药物的纤维素的烷基醚; 以及用于治疗或预防人鼻疾病的方法，其包括将单位剂型的粉末制剂施用于需要通过鼻孔治疗或预防鼻部疾病的人的鼻腔。

    Powdery pharmaceutical composition suitable for application to mucosa of oral or nasal cavity
    6.
    发明授权
    Powdery pharmaceutical composition suitable for application to mucosa of oral or nasal cavity 失效
    适用于口腔或鼻腔粘膜的粉状药物组合物

    公开(公告)号：US4835142A

    公开(公告)日：1989-05-30

    申请号：US153527

    申请日：1988-02-04

    申请人： Yoshiki Suzuki ,  Hiroshi Ikura

    发明人： Yoshiki Suzuki ,  Hiroshi Ikura

    IPC分类号： A61K31/19 ,  A61K9/00 ,  A61K9/14 ,  A61K31/195 ,  A61K31/56 ,  A61K31/57 ,  A61K31/715 ,  A61K47/12 ,  A61K47/38 ,  A61P27/16

    CPC分类号： A61K47/12 ,  A61K47/38 ,  A61K9/0043 ,  A61K9/006

    摘要： A powdery pharmaceutical composition for application to the mucosa of the oral or nasal cavity including: (a) a base selected from the group consisting of lower alkyl ethers of cellulose; (b) a pharmaceutically effective amount of a drug selected from the group consisting of steroid or glycyrrhizic acid type anti-inflammatory agents; and (c) a stabilizer for the drug composed of at least one low irritant solid organic acid selected from the group consisting of saturated higher aliphatic monocarboxylic acids having 12 or more carbon atoms, aliphatic polycarboxylic acid, hydroxy aliphatic polycarboxylic acids, aromatic carboxylic acids, unsaturated lower aliphatic monocarboxylic acids having six or less carbon atoms, and cellulose derivatives having carboxyl group.This powdery pharmaceutical composition has extremely excellent stability in the steroid or glycyrrhizic acid type anti-inflammatory agent contained therein, low irritation of the mucosa of the oral or nasal cavity, and sustained release of the drug over an extended period of time.

    摘要翻译： 一种用于口腔或鼻腔粘膜的粉末状药物组合物，包括：（a）选自纤维素的低级烷基醚的碱; （b）药学有效量的选自类固醇或甘草酸类抗炎剂的药物; 和（c）由至少一种选自具有12个或更多个碳原子的饱和高级脂肪族单羧酸，脂肪族多元羧酸，羟基脂肪族多元羧酸，芳香族羧酸等低刺激性固体有机酸组成的药物稳定剂， 具有6个以下碳原子的不饱和低级脂族一元羧酸和具有羧基的纤维素衍生物。 该粉末状药物组合物在其中含有的类固醇或甘草酸类抗炎剂中具有非常优异的稳定性，对口腔或鼻腔粘膜的低刺激性以及长时间的药物持续释放。

    Slow-releasing medical preparation to be administered by adhering to a wet mucous surface
    8.
    发明授权
    Slow-releasing medical preparation to be administered by adhering to a wet mucous surface 失效
    慢性释放的药物制剂通过粘附在湿的粘液表面进行施用

    公开(公告)号：US4292299A

    公开(公告)日：1981-09-29

    申请号：US202384

    申请日：1980-07-07

    申请人： Yoshiki Suzuki ,  Hiroshi Ikura ,  Gentaro Yamashita

    发明人： Yoshiki Suzuki ,  Hiroshi Ikura ,  Gentaro Yamashita

    IPC分类号： A61K9/02 ,  A61K9/00 ,  A61K9/22 ,  A61K9/24 ,  A61K9/70 ,  A61L15/03

    CPC分类号： A61K9/209 ,  A61K9/006 ,  A61K9/70

    摘要： PCT No. PCT/JP79/00284 Sec. 371 Date Nov. 6, 1979 Sec. 102(e) Date July 7, 1980 PCT Filed July 7, 1980 PCT Pub. No. WO80/00916 PCT Pub. Date May 15, 1980A medical preparation composed of an adhesive layer comprising polymers which have adhesiveness to a wet mucous surface and swellability upon moistening and a nonadhesive layer which has no adhesiveness to a wet mucous surface and is water soluble or water disintegrable, with at least one of the layers made to contain a medicament. The medical preparation is administered by adhering to a wet mucous surface of the mucous membrane and skin of men or animals, whereby exhibiting a property to release the medicament slowly extending over a long period of time to cure or prevent general or local diseases.

    摘要翻译： PCT No.PCT / JP79 / 00284 Sec。 371日期1979年11月6日 102（e）日期1980年7月7日PCT提交1980年7月7日PCT公布。 出版物WO80 / 0091600 日期1980年5月15日由包含对湿粘性表面具有粘附性和润湿时的溶胀性的聚合物的粘合层组成的药物制剂和与湿粘性表面无粘合性并且具有水溶性或水分解性的非粘附层， 制成含有药物的层中的至少一层。 医疗制剂通过粘附在粘膜和湿性粘膜表面上而施用，其粘膜表面与男性或动物的皮肤呈现特性，从而显示出缓慢延长药物的性能，以缓解长期的时间，以治愈或预防一般或局部疾病。

    Air conditioning systems for vehicles, comprising such air conditioning systems, and methods for driving hybrid compressors of such air conditioning systems
    10.
    发明授权
    Air conditioning systems for vehicles, comprising such air conditioning systems, and methods for driving hybrid compressors of such air conditioning systems 失效
    包括这种空调系统的用于车辆的空调系统以及用于驱动这种空调系统的混合压缩机的方法

    公开(公告)号：US06952929B2

    公开(公告)日：2005-10-11

    申请号：US10934695

    申请日：2004-09-07

    申请人： Atsuo Inoue ,  Masato Tsuboi ,  Hiromitsu Adachi ,  Masamichi Kubota ,  Hiroshi Ikura ,  Hideki Watanabe

    发明人： Atsuo Inoue ,  Masato Tsuboi ,  Hiromitsu Adachi ,  Masamichi Kubota ,  Hiroshi Ikura ,  Hideki Watanabe

    IPC分类号： B60H1/00 ,  B60H1/32 ,  F25B1/00

    CPC分类号： B60H1/3208 ,  B60H2001/3294

    摘要： An air conditioning system for a vehicle includes a compressor. The vehicle includes a first drive source and the compressor includes a second drive source. The compressor is driven by the first drive source or the second drive source, or a combination thereof, and the second drive source includes an electrical power supply. The air conditioning system also includes a controller for selecting between the first drive source and the second drive source, such that when the compressor is active, the first drive source drives the compressor except when the vehicle is operating in a predetermined mode, a voltage of the electrical power supply is greater than or equal to a minimum electrical power supply voltage, and an amount of electric power consumed by the second drive source is less than a maximum electric power. For example, the predetermined mode may be an idle-stop mode.

    摘要翻译： 一种用于车辆的空调系统包括压缩机。 车辆包括第一驱动源，压缩机包括第二驱动源。 压缩机由第一驱动源或第二驱动源或其组合驱动，并且第二驱动源包括电源。 所述空调系统还包括用于在所述第一驱动源和所述第二驱动源之间进行选择的控制器，使得当所述压缩机处于活动状态时，所述第一驱动源驱动所述压缩机，除非所述车辆以预定模式操作， 电源大于或等于最小电源电压，并且由第二驱动源消耗的电力量小于最大电力。 例如，预定模式可以是怠速停止模式。