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公开(公告)号：US07485769B2
公开(公告)日：2009-02-03
申请号：US10362429
申请日：2001-08-27
IPC分类号： A01K67/027 , C12N15/00
CPC分类号： A01K67/0275 , A01K67/0271 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2227/108 , A01K2267/02 , A01K2267/025 , A01K2267/03 , C07K14/70596 , C12N9/1048 , C12N9/1051 , C12N15/8509
摘要： This invention provides a nonhuman transgenic mammal carrying transgene comprising the regulatory genes capable of functioning in the hyperacute rejection-occurring local cells and gene encoding human N-acetylglucosaminyltransferase III (GnT-III), or a nonhuman transgenic mammal carrying transgene comprising the regulatory genes and genes encoding GnT-III and the human complement inhibitor. Because of reduced α-Gal antigens in the hyperacute rejection-occurring local cells or because of both reduced α-Gal antigens and expression of the human complement inhibitor, the transgenic mammal of this invention can effectively inhibit the hyperacute rejection caused by discordant xenotransplantation. Consequently, this invention provides the transgenic mammal suitable for organ transplantation.
摘要翻译： 本发明提供了携带转基因的非人类转基因哺乳动物，其包含能够在超急性排斥反应发生的局部细胞中起作用的调节基因和编码人N-乙酰葡糖胺基转移酶III（GnT-III）的基因，或携带包含调节基因的转基因的非人转基因哺乳动物， 编码GnT-III和人补体抑制剂的基因。 由于超急性排斥反应发生的局部细胞中α-Gal抗原减少或由于α-Gal抗原减少和人补体抑制剂的表达均降低，本发明的转基因哺乳动物可有效抑制不协调异种移植引起的超急性排斥反应。 因此，本发明提供了适合于器官移植的转基因哺乳动物。
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2.发明授权Transgenic non-human mammals expressing the human complement inhibitor (DAF/CD55) 有权表达人补体抑制剂（DAF / CD55）的转基因非人哺乳动物公开(公告)号：US06825395B1
公开(公告)日：2004-11-30
申请号：US09462740
申请日：2000-04-05
IPC分类号： A01K67027
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2227/108 , A01K2267/025 , A01K2267/03 , C07K14/70596
摘要： This invention provides transgenic mammals other than man carrying the gene of the human complement inhibitor (DAF/CD55) and expressing the human complement inhibitor in their organs and tissues, particularly in their endothelial cells. This invention provides nonhuman transgenic mammals useful as laboratory animals in the medical and pharmacological fields and/or sources of organs, tissues, cells and the like for medical treatment of man.
摘要翻译： 本发明提供了携带人补体抑制剂（DAF / CD55）基因的人以外的转基因哺乳动物，并在其器官和组织，特别是其内皮细胞中表达人补体抑制剂。 本发明提供非人类转基因哺乳动物，其用作医疗和药理学领域的实验室动物和/或用于人类医疗的器官，组织，细胞等的来源。
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公开(公告)号：US06255474B1
公开(公告)日：2001-07-03
申请号：US09180939
申请日：1998-11-17
IPC分类号： C12N1509
CPC分类号： C12N15/8509 , A01K2217/05 , A01K2227/108 , A01K2267/025 , A01K2267/03 , A61K38/00 , A61K48/00 , C07K14/472
摘要： The present invention provides the base sequence defined as Sequence No. 1, DNA comprising a part of the sequence, or DNA containing the sequence, and relates to a promoter gene of the porcine complement inhibitor. In generating transgenic pigs transformed with human complement inhibitor and/or such thrombosis-inhibiting factors as thrombomudulin (collectively termed the complement inhibitor), DNA of the invention can effectively be used to express the complement inhibitor by integrating the gene into the upstream part of the human complement-inhibitor gene. Since hyperacute rejection, which occurs on transplanting a porcine organ or tissue to man, can be prevented, xenotransplantaion of the porcine organs and tissues to man will become possible. Therefore, the problem of the lack of donors for transplantation can be solved.
摘要翻译： 本发明提供了定义为序列号1的碱基序列，包含一部分序列的DNA或含有该序列的DNA，涉及猪补体抑制剂的启动子基因。 在产生用人补体抑制剂转化的转基因猪和/或血栓形成抑制因子（称为补体抑制剂）时，本发明的DNA可以有效地用于表达补体抑制剂，将该基因整合到上游部分 人补体抑制基因。 由于可以防止在将猪器官或组织移植到人时发生的超急性排斥，因此可以使猪器官和组织对人的异种转移成为可能。 因此，解决了移植供体缺乏的问题。
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公开(公告)号：US06270997B1
公开(公告)日：2001-08-07
申请号：US08981234
申请日：1998-04-13
IPC分类号： C07H2104
CPC分类号： C07K14/705
摘要： This invention is related to the DNA encoding the porcine complement inhibitor (pMCPcDNA), the porcine complement inhibitor expressed by the DNA, and a method for screening for the porcine complement inhibitor. pMCPcDNA can be obtained by preparing a cDNA library from porcine vascular endothelium and screening for cDNA encoding the porcine complement inhibitor. pMCPcDNA of this invention is useful for production of the porcine complement inhibitor by genetic recombination and for analysis for the promoter region of the porcine complement inhibitor.
摘要翻译： 本发明涉及编码猪补体抑制剂（pMCPcDNA）的DNA，由DNA表达的猪补体抑制剂以及用于筛选猪补体抑制剂的方法。 通过从猪血管内皮制备cDNA文库并筛选编码猪补体抑制剂的cDNA，可以获得pMCPcDNA。 本发明的pMCPcDNA可用于通过遗传重组产生猪补体抑制剂，并用于猪补体抑制剂启动子区的分析。
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5.发明申请Composition, Functional Food and Pharmaceutical Composition for Improvement in Obesity 审中-公开用于改善肥胖症的组合物，功能性食品和药物组合物公开(公告)号：US20090068281A1
公开(公告)日：2009-03-12
申请号：US11887239
申请日：2005-03-29
申请人： Koji Toyomura , Mikako Sato , Jun Ichikawa
发明人： Koji Toyomura , Mikako Sato , Jun Ichikawa
摘要： A composition for improving obesity is disclosed. The composition contains a natural ingredient free of side effects in daily intake as an active ingredient. The composition is capable of remarkably reducing body fat, as compared with a conventional ingredient which is derived from a natural ingredient as an active ingredient, and is capable of suppressing fat storage. The composition includes a meat extract or a fish meat extract, and a fat storage suppressive substance.
摘要翻译： 公开了一种用于改善肥胖症的组合物。 该组合物含有作为活性成分的每日摄取无副作用的天然成分。 与作为活性成分的天然成分的常规成分相比，能够显着降低体脂肪，能够抑制脂肪的储存。 该组合物包括肉提取物或鱼肉提取物和脂肪储存抑制物质。
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公开(公告)号：US20090087495A1
公开(公告)日：2009-04-02
申请号：US11920573
申请日：2005-05-19
申请人： Koji Toyomura , Mikako Sato , Jun Ichikawa
发明人： Koji Toyomura , Mikako Sato , Jun Ichikawa
CPC分类号： A23G3/44 , A23G3/36 , A23J1/002 , A23J1/02 , A23L13/30 , A23L13/42 , A23L13/424 , A23L13/50 , A23L33/10 , A23L33/17 , A23V2002/00 , A23V2250/204 , A23V2250/306
摘要： A food for improving motor function comprising as effective components carnosine and/or anserine and a material for improving motor performance (a material for motor energy source, a material for promoting conversion into energy and/or an antioxidant) is provided. In the invention, by synergistic effect of these components, the motor function or stamina can be improved and recovery from fatigue can be promoted in humans and mammals. Further, any of the effective components of the food for improving motor function of the invention is a naturally occurring component, therefore, the food has a characteristic of high safety.
摘要翻译： 提供了用于改善运动功能的食物，其包括作为有效成分的肌肽和/或丝氨酸和用于改善运动性能的材料（用于运动能源的材料，促进转化成能量的材料和/或抗氧化剂）。 在本发明中，通过这些成分的协同作用，可以改善运动功能或耐力，并可以在人和哺乳动物中促进疲劳恢复。 此外，用于改善本发明的运动功能的食品的任何有效成分是天然存在的成分，因此食品具有高安全性。
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