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    B CELL-DERIVED IPS CELLS AND APPLICATION THEREOF
    1.
    发明申请
    B CELL-DERIVED IPS CELLS AND APPLICATION THEREOF 审中-公开
    B细胞衍生的IPS细胞及其应用

    公开(公告)号：US20110231944A1

    公开(公告)日：2011-09-22

    申请号：US13062439

    申请日：2009-09-04

    申请人： Hiroshi Watarai ,  Tomokatsu Ikawa ,  Fumihiko Ishikawa ,  Hiroshi Kawamoto ,  Haruhiko Koseki ,  Masaru Taniguchi

    发明人： Hiroshi Watarai ,  Tomokatsu Ikawa ,  Fumihiko Ishikawa ,  Hiroshi Kawamoto ,  Haruhiko Koseki ,  Masaru Taniguchi

    IPC分类号： A01K67/027 ,  C12N5/071 ,  C12N5/10 ,  C12P21/08 ,  C12N15/00

    CPC分类号： C12N5/0696 ,  A01K2267/01 ,  C12N15/8775 ,  C12N2501/2302 ,  C12N2501/235 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2506/11 ,  C12N2510/00

    摘要： Provided are a B cell-derived iPS cell generated using a convenient technique, a technology for providing a human antibody at low cost using the iPS cell, an immunologically humanized mouse prepared using cells differentiated from the iPS cell, and the like. Also provided are a cloned cell obtained by contacting a B cell with nuclear reprogramming factors excluding C/EBPα and Pax5 expression inhibiting substances, particularly nucleic acids that encode Oct3/4, Sox2, Klf4 and c-Myc, wherein the cloned cell has an immunoglobulin gene rearranged therein and possesses pluripotency and replication competence (B-iPS cell). Still also provided are a method of producing a monoclonal antibody against a specified antigen, comprising recovering an antibody from a culture of B cells obtained by differentiating a B-iPS cell derived from a B cell immunized with the specified antigen, and a method of generating an immunologically humanized mouse, comprising transplanting to an immunodeficient mouse a human immunohematological system cell obtained by differentiating a B-iPS cell.

    摘要翻译： 提供了使用方便的技术产生的B细胞衍生的iPS细胞，使用iPS细胞以低成本提供人抗体的技术，使用从iPS细胞分化的细胞制备的免疫人源化小鼠等的技术。 还提供了通过使B细胞与不包括C /EBPα和Pax5表达抑制物质，特别是编码Oct3 / 4，Sox2，Klf4和c-Myc的核酸的核重编程因子接触获得的克隆细胞，其中克隆的细胞具有免疫球蛋白 基因重排并具有多能性和复制能力（B-iPS细胞）。 还提供了针对特定抗原产生单克隆抗体的方法，包括从通过分化来源于用特定抗原免疫的B细胞的B-iPS细胞获得的B细胞的培养物中回收抗体，以及产生 一种免疫人源化的小鼠，包括将免疫缺陷小鼠移植到通过分化B-iPS细胞获得的人免疫血液学系统细胞中。

    Reverse-charge prevention apparatus
    2.
    发明授权
    Reverse-charge prevention apparatus 失效
    防反转装置

    公开(公告)号：US5646811A

    公开(公告)日：1997-07-08

    申请号：US211546

    申请日：1994-08-03

    申请人： Hiromasa Higasa ,  Fumihiko Ishikawa

    发明人： Hiromasa Higasa ,  Fumihiko Ishikawa

    IPC分类号： H02J3/38 ,  H02J5/00 ,  H02J7/00 ,  H02H3/00

    CPC分类号： H02J3/38 ,  H02J5/00

    摘要： In a reverse-charge prevention apparatus (24) including a 1st breaker (25) for connecting or disconnecting an electric power system (A) to or from a distributed electric power apparatus (11), in which the 1st breaker (25) is switched off when the distributed electric power apparatus (11) is disconnected from the electric power system (A) by switching off a 2nd breaker (F) disposed in the electric power system (A) so that reverse-charge from the distributed electric power apparatus (11) to the electric power system (A) is prevented, the reverse-charge prevention apparatus (24) further includes a disturbance generator (20) for slightly varying electric power outputted by the distributed electric power apparatus (11) regularly with a given period; a variable period extraction circuit and a filter (26, 27) for extracting a variable period same in period to the given period, the variable period existing in a period of an alternating-current voltage outputted by the distributed electric power apparatus (11); and a judgment circuit (28) for switching off the 1st breaker (25) when the extraction circuit and the filter (26, 27) regularly extract the variable period.

    摘要翻译： PCT No.PCT / JP92 / 01012 Sec。 371日期1994年8月3日 102（e）日期1994年8月3日PCT提交1992年8月7日PCT公布。 公开号WO94 / 03957 日期：1994年2月17日在包括用于将电力系统（A）连接或分配给分布式电力设备（11）的第一断路器（25）的反向充电防止装置（24）中，其中第一断路器 当分配式电力设备（11）通过关闭设置在电力系统（A）中的第二断路器（F）从电力系统（A）断开时，关闭电源（25），从而从 防止了分配式电力设备（11）到电力系统（A）的反向充电防止装置（24）还包括用于由分布式电力设备（11）输出的略微变化的电力的扰动发生器（20） 定期给定期间; 可变周期提取电路和滤波器（26,27），用于在给定周期内提取在分配电力设备（11）输出的交流电压的周期内存在的可变周期; 以及当所述提取电路和所述滤波器（26,27）有规律地提取所述可变周期时，关闭所述第一断路器（25）的判断电路（28）。

    Superconducting bearing
    3.
    发明授权
    Superconducting bearing 失效
    超导轴承

    公开(公告)号：US5525849A

    公开(公告)日：1996-06-11

    申请号：US284680

    申请日：1994-08-09

    申请人： Norio Ito ,  Tatsuya Shimoda ,  Hiroshi Imaizumi ,  Hiromasa Higasa ,  Fumihiko Ishikawa

    发明人： Norio Ito ,  Tatsuya Shimoda ,  Hiroshi Imaizumi ,  Hiromasa Higasa ,  Fumihiko Ishikawa

    IPC分类号： F16C39/06 ,  H02K7/09

    CPC分类号： F16C32/0438 ,  Y10S505/877

    摘要： A superconducting bearing comprises a rotating member A and a fixed member B, one of which is provided with a superconducting member (5) while the other is provided with a magnet (8). The superconducting member (5) includes a superconductor (4) for floating the magnet (8) and a support (3) for supporting the superconductor (4). The magnet (8) includes a ring-like magnet (11) which is coaxial with the axis of the rotary member A, and the ring-like magnet (11) and the superconductor member (5) are so disposed as to face each other with a gap between them. A magnetic flux diffusion member (13) is disposed on the surface of the ring-like magnet (11) opposed to the superconductor (5). The ring-like magnet (11) comprises two ring-like magnets (11A and 11B) having mutually different diameters, and the ring-like magnets (11A and 11B) are magnetized so that the directions of magnetic fluxes face slantingly with one another.

    摘要翻译： PCT No.PCT / JP93 / 00172 Sec。 371日期1994年8月9日 102（e）日期1994年8月9日PCT提交1993年2月10日PCT公布。 公开号WO93 / 16294 日期：1993年8月19日。超导轴承包括旋转构件A和固定构件B，其中一个具有超导构件（5），而另一个设置有磁体（8）。 超导构件（5）包括用于浮动磁体（8）的超导体（4）和用于支撑超导体（4）的支撑件（3）。 磁体（8）包括与旋转构件A的轴线同轴的环状磁体（11），并且环状磁体（11）和超导体构件（5）被设置成彼此面对 他们之间有差距。 在与超导体（5）相对的环状磁体（11）的表面上设置磁通扩散部件（13）。 环形磁体（11）包括具有相互不同直径的两个环状磁体（11A和11B），并且使环状磁体（11A和11B）磁化，使得磁通量的方向彼此倾斜。

    Image forming apparatus having toner recycling device with electrostatic conveyor
    6.
    发明授权
    Image forming apparatus having toner recycling device with electrostatic conveyor 失效
    具有带静电输送机的调色剂回收装置的图像形成装置

    公开(公告)号：US5555469A

    公开(公告)日：1996-09-10

    申请号：US323573

    申请日：1994-10-17

    申请人： Fumihiko Ishikawa ,  Seiji Oka ,  Tsukuru Kai

    发明人： Fumihiko Ishikawa ,  Seiji Oka ,  Tsukuru Kai

    IPC分类号： G03G15/08 ,  G03G21/10 ,  G03G21/00

    CPC分类号： G03G15/0822 ,  G03G21/105

    摘要： An image forming apparatus of the type collecting a toner remaining on the surface of an image carrier after image transfer and returning it to a developing unit to use it again. The apparatus separates the toner from paper dust and other impurities before returning the toner to the developing unit on the basis of differences in charge, weight and volume between the toner and the impurities. The toner is returned via an eletrostatic conveyor.

    摘要翻译： 该图像形成装置在图像转印之后收集残留在图像载体的表面上的调色剂并将其返回到显影单元以再次使用的图像形成装置。 该设备根据调色剂和杂质之间的电荷，重量和体积的差异将调色剂与纸屑和其它杂质分离，然后将调色剂返回到显影单元。 调色剂通过静电输送机返回。

    Inverter system for inputting alternating current and direct current in combination
    8.
    发明授权
    Inverter system for inputting alternating current and direct current in combination 失效
    用于组合输入交流电和直流电的逆变系统

    公开(公告)号：US4697136A

    公开(公告)日：1987-09-29

    申请号：US936596

    申请日：1986-12-01

    申请人： Fumihiko Ishikawa

    发明人： Fumihiko Ishikawa

    IPC分类号： G05F1/67 ,  H02J1/10 ,  H02J3/00 ,  H02J3/38 ,  H02J7/35 ,  H02M7/48 ,  G05F1/00

    CPC分类号： H02J7/35 ,  H02J1/10 ,  Y10S136/293 ,  Y10S323/906 ,  Y10T307/832

    摘要： An inverter system is disclosed for inputting an alternating current and a direct current in combination. This inverter system comprises an AC-DC converter to convert a received AC electric power from an AC electric power source to a DC electric power; a DC-AC converter to convert a thus converted DC electric power and a DC electric power from a DC electric power source to an AC electric power; a first switching means to open or close an electric circuit between an output side of the DC-AC converter and a first load; a second switching means to open or close an electric circuit between the AC electric power source to which a second load is connected and the output side of the DC-AC converter; and a controlling means for controlling opening and closing of the first and second switching means. When a electric power consumption of the first load is larger than an output of the DC electric power source, the controller closes the first switching means and opens the second switching means. When an operation of the first load is stopped, the controller opens the first switching means and closes the second switching means. When the electric power consumption of the first load is smaller than the output of the DC electric power source, the controller closes both the first and second switching means.

    摘要翻译： 公开了用于组合地输入交流电流和直流电的逆变器系统。 该逆变器系统包括AC-DC转换器，用于将接收到的AC电力从AC电源转换成DC电力; 将这样转换的直流电力和直流电力从直流电源转换为交流电力的直流 - 交流转换器; 用于在DC-AC转换器的输出侧和第一负载之间打开或关闭电路的第一开关装置; 第二开关装置，用于在连接有第二负载的AC电源和DC-AC转换器的输出侧之间打开或关闭电路; 以及用于控制第一和第二开关装置的打开和关闭的控制装置。 当第一负载的电力消耗大于直流电源的输出时，控制器关闭第一开关装置并打开第二开关装置。 当第一负载的操作停止时，控制器打开第一开关装置并关闭第二开关装置。 当第一负载的电力消耗小于直流电源的输出时，控制器关闭第一和第二开关装置。

    Process for producing human-origin immunocompetent cell
    9.
    发明申请
    Process for producing human-origin immunocompetent cell 有权
    生产人源免疫活性细胞的方法

    公开(公告)号：US20060161996A1

    公开(公告)日：2006-07-20

    申请号：US10560829

    申请日：2004-06-16

    申请人： Fumihiko Ishikawa ,  Mine Harada ,  Masaki Yasukawa

    发明人： Fumihiko Ishikawa ,  Mine Harada ,  Masaki Yasukawa

    IPC分类号： A01K67/027 ,  A61K39/395 ,  C07K16/44

    CPC分类号： C07K16/00 ,  C07K2317/21 ,  C07K2317/74

    摘要： It is an object of the present invention to provide an immunodeficient animal capable of generating human-derived lymphoid cells, a human-derived lymphoid cell, and a method for producing a human antigen-specific antibody. The means for solving the aforementioned object is: an immature immunodeficient mammal into which human-derived hematopoietic precursor cells have been transplanted, and which is able to generate said human-derived hematopoietic cells or immunocompetent cells; and a method for producing a human-derived antibody, which is characterized in that it comprises recovering immunocompetent cells from the above-described mammal, culturing the immunocompetent cells, and collecting a human-derived antibody from the obtained culture product.

    摘要翻译： 本发明的目的是提供能够产生人源性淋巴样细胞的免疫缺陷型动物，人源性淋巴样细胞，以及生产人抗原特异性抗体的方法。 用于解决上述目的的方法是：人源性造血前体细胞被移植到其中的未成熟免疫缺陷型哺乳动物，其能够产生所述人源造血细胞或免疫活性细胞; 以及人源性抗体的制造方法，其特征在于，包括从上述哺乳动物中回收免疫活性细胞，培养免疫活性细胞，从得到的培养物中收集人源性抗体。

    Method of designing a superconductivity employing apparatus and a superconductivity employing apparatus constructed by the method
    10.
    发明授权
    Method of designing a superconductivity employing apparatus and a superconductivity employing apparatus constructed by the method 失效
    利用该方法构造超导性设计方法和采用超导体的装置的方法

    公开(公告)号：US5719455A

    公开(公告)日：1998-02-17

    申请号：US759119

    申请日：1996-12-02

    申请人： Hiromasa Higasa ,  Fumihiko Ishikawa ,  Masanori Yamashita ,  Makoto Hirose

    发明人： Hiromasa Higasa ,  Fumihiko Ishikawa ,  Masanori Yamashita ,  Makoto Hirose

    IPC分类号： H02N15/04 ,  F16C39/06 ,  B60L13/04 ,  H02K7/09

    CPC分类号： F16C32/0438 ,  F16C37/005 ,  F16C2361/55 ,  Y10S505/876 ,  Y10S505/878

    摘要： A method of designing a superconductivity employing apparatus includes the steps of causing a magnetism generating disk-shaped floatable portion (4) to face a disk-shaped fixed portion (2) capable of exhibiting superconductivity with a gap (G) therebetween; initializing the fixed portion (2) to reach a superconducting state at a position where the floatable portion (4) is spaced away from the fixed portion (2) to such an extent that its magnetic field does not influence the fixed portion (2); and using properly first, second, and n-th approach characteristics (S1, S2, Sn) when a difference between an n-th approach characteristic (Sn) and the second characteristic (S2) is smaller than a difference between the first and second characteristics (S1, S2), where the first approach characteristic (S1) is a characteristic of a magnetic floating force obtained by allowing the floatable portion (4) to approach the fixed portion (2), the second approach characteristic (S2) is a characteristic of a magnetic floating force obtained by allowing the floatable portion (4) to approach the fixed portion (2) after the floatable portion (4) is allowed to recede from the fixed portion (2) to such an extent that its magnetic field does not influence the fixed portion (2), and the n-th approach characteristic is a characteristic of a magnetic floating force obtained by repeatedly carrying out the operations subsequent to the operation of the second approach characteristic (S2).

    摘要翻译： 设计使用超导体的装置的方法包括以下步骤：使磁性产生盘状可浮动部分（4）面对能够表现出超导性的盘形固定部分（2），其间具有间隙（G）; 初始化固定部分（2）以在可浮动部分（4）与固定部分（2）间隔开的位置处达到超导状态，使其磁场不影响固定部分（2）; 并且当第n个接近特性（Sn）和第二特征（S2）之间的差小于第一和第二接近特性（S2）之间的差时，适当地使用第一，第二和第n接近特性（S1，S2，Sn） 特征（S1，S2），其中第一接近特性（S1）是通过允许可浮动部分（4）接近固定部分（2）而获得的磁浮动力的特性，第二接近特性（S2）是 在可浮动部分（4）被允许从固定部分（2）后退到使得可浮动部分（4）到达固定部分（2）之后获得的磁悬浮力的特征为使其可变磁场 不影响固定部（2），第n接近特性是通过反复进行第二接近特性（S2）的动作后的动作而得到的磁悬浮力的特征。