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    Triazole derivatives and salts thereof, and antifungal agent containing the same
    1.
    发明授权
    Triazole derivatives and salts thereof, and antifungal agent containing the same 失效
    三唑衍生物及其盐，以及含有它们的抗真菌剂

    公开(公告)号：US5605921A

    公开(公告)日：1997-02-25

    申请号：US261952

    申请日：1994-06-17

    申请人： Hiroyuki Imaizumi ,  Tetsuya Kajita ,  Kenichi Takashima ,  Minako Yotsuji ,  Keiko Takakura ,  Akira Yotsuji ,  Junichi Mitsuyama ,  Katsumi Shimizu ,  Hiroshi Sakai ,  Hirokazu Narita

    发明人： Hiroyuki Imaizumi ,  Tetsuya Kajita ,  Kenichi Takashima ,  Minako Yotsuji ,  Keiko Takakura ,  Akira Yotsuji ,  Junichi Mitsuyama ,  Katsumi Shimizu ,  Hiroshi Sakai ,  Hirokazu Narita

    IPC分类号： A61K31/41 ,  A61P31/04 ,  A61P31/10 ,  C07D249/08 ,  C07D401/12 ,  C07D417/06 ,  C07D521/00 ,  A01N43/653

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： The present invention relates to a compound represented by the general formula (1) or its salt, a process for producing the same, and an antifungal agent comprising the same as an effective component: ##STR1## wherein R.sup.1 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group bonded through a carbon atom in the ring to the main chain; R.sup.2 presents a hydrogen atom, a fluorine atom or a substituted or unsubstituted alkyl group; and R.sup.3 represents a cyano group, a thioamido group or a group represented by the formula ##STR2## in which R.sup.4 is a hydroxyl group or a group of the formula ##STR3## (R.sup.7 and R.sup.8, which may be the same or different, are hydrogen atoms or substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, amino, alkoxy, hydroxyl or heterocyclic groups, and may form a substituted or unsubstituted heterocyclic group together with the nitrogen atom to which R.sup.7 and R.sup.8 attach), R.sup.5 is a substituted or unsubstituted alkoxy group or a group of the formula ##STR4## (R.sup.7 and R.sup.8 are as defined above), and R.sup.6 is a hydrogen atom or a substituted or unsubstituted alkyl group.

    摘要翻译： 本发明涉及由通式（1）表示的化合物或其盐，其制备方法和含有该化合物的有效成分的抗真菌剂：有或无取代的芳基或取代或未取代的杂环基 通过环中的碳原子键合到主链上; R2表示氢原子，氟原子或取代或未取代的烷基; 并且R 3表示氰基，硫代酰氨基或由下式表示的基团：其中R 4是羟基或式（R 3和R 8）可以相同或不同， 氢原子或取代或未取代的烷基，烯基，炔基，环烷基，芳基，氨基，烷氧基，羟基或杂环基，并且可以与R7和R8连接的氮原子一起形成取代或未取代的杂环基），R5是 取代或未取代的烷氧基或式的基团（R 7和R 8如上定义），R 6为氢原子或取代或未取代的烷基。

    Triazole derivatives and salts thereof and antifungal agent containing the same
    2.
    发明授权
    Triazole derivatives and salts thereof and antifungal agent containing the same 失效
    三唑衍生物及其盐和含有它们的抗真菌剂

    公开(公告)号：US5366989A

    公开(公告)日：1994-11-22

    申请号：US986800

    申请日：1992-12-08

    申请人： Hiroyuki Imaizumi ,  Tetsuya Kajita ,  Kenichi Takashima ,  Minako Yotsuji ,  Keiko Takakura ,  Akira Yotsuji ,  Junichi Mitsuyama ,  Katsumi Shimizu ,  Hiroshi Sakai ,  Hirokazu Narita

    发明人： Hiroyuki Imaizumi ,  Tetsuya Kajita ,  Kenichi Takashima ,  Minako Yotsuji ,  Keiko Takakura ,  Akira Yotsuji ,  Junichi Mitsuyama ,  Katsumi Shimizu ,  Hiroshi Sakai ,  Hirokazu Narita

    IPC分类号： A61K31/41 ,  A61P31/04 ,  A61P31/10 ,  C07D249/08 ,  C07D401/12 ,  C07D417/06 ,  C07D521/00 ,  A01N43/653

    CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

    摘要： The present invention relates to a compound represented by the general formula (1) or its salt, a process for producing the same, and an antifungal agent comprising the same as an effective component: ##STR1## wherein R.sup.1 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group bonded through a carbon atom in the ring to the main chain; R.sup.2 presents a hydrogen atom, a fluorine atom or a substituted or unsubstituted alkyl group; and R.sup.3 represents a cyano group, a thioamido group or a group represented by the formula ##STR2## in which R.sup.4 is a hydroxyl group or a group of the formula ##STR3## (R.sup.7 and R.sup.8, which may be the same or different, are hydrogen atoms or substituted or unsubstituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, amino, alkoxy, hydroxyl or heterocyclic groups, and may form a substituted or unsubstituted heterocyclic group together with the nitrogen atom to which R.sup.7 and R.sup.8 attach), R.sup.5 is a substituted or unsubstituted alkoxy group or a group of the formula ##STR4## (R.sup.7 and R.sup.8 are as defined above), and R.sup.6 is a hydrogen atom or a substituted or unsubstituted alkyl group.

    摘要翻译： 本发明涉及由通式（1）表示的化合物或其盐，其制备方法和含有该化合物的有效成分的抗真菌剂：有或无取代的芳基或取代或未取代的杂环基 通过环中的碳原子键合到主链上; R2表示氢原子，氟原子或取代或未取代的烷基; 并且R 3表示氰基，硫代酰氨基或由下式表示的基团：其中R 4是羟基或式（R 3和R 8）可以相同或不同， 氢原子或取代或未取代的烷基，烯基，炔基，环烷基，芳基，氨基，烷氧基，羟基或杂环基，并且可以与R7和R8连接的氮原子一起形成取代或未取代的杂环基），R5是 取代或未取代的烷氧基或式6的基团是氢原子或取代或未取代的烷基。

    Cephalosporins
    4.
    发明授权
    Cephalosporins 失效
    头孢菌素

    公开(公告)号：US4489072A

    公开(公告)日：1984-12-18

    申请号：US304912

    申请日：1981-09-23

    申请人： Hiroshi Sadaki ,  Hirokazu Narita ,  Hiroyuki Imaizumi ,  Yoshinori Konishi ,  Takihiro Inaba ,  Tatsuo Hirakawa ,  Hideo Taki ,  Masaru Tai ,  Yasuo Watanabe ,  Isamu Saikawa

    发明人： Hiroshi Sadaki ,  Hirokazu Narita ,  Hiroyuki Imaizumi ,  Yoshinori Konishi ,  Takihiro Inaba ,  Tatsuo Hirakawa ,  Hideo Taki ,  Masaru Tai ,  Yasuo Watanabe ,  Isamu Saikawa

    IPC分类号： C07D501/24 ,  A61K31/545 ,  C07D20060101 ,  C07D501/04 ,  C07D501/18 ,  C07D501/20 ,  C07D501/38 ,  C07D501/40 ,  C07D501/46 ,  C07D501/56 ,  C07D501/57

    CPC分类号： C07D501/46 ,  A61K31/545 ,  C07D501/38 ,  C07D501/56 ,  C07D501/57

    摘要： Novel cephalosporins which has attached to the exomethylene group at the 3-position of the cephem ring a substituted or unsubstituted aryl, acylamino, aromatic heterocyclic, triazolyl or tetrazolyl group, said aromatic heterocyclic group being attached through a carbon-carbon bond and said triazolyl or tetrazolyl group being attached through a carbon-nitrogen bond, and has the following group attached to the amino group at the 7-position: ##STR1## wherein A represents a group of the formula, --CH.sub.2 -- or a group of the formula ##STR2## in which R.sup.5 represents a hydrogen atom or an alkyl group, and the bond represents syn or anti isomer or their mixture; R.sup.3 represents a hydrogen or halogen atom; and R.sup.4 represents a hydrogen atom or an amino group which may be protected or substituted. These cephalosporins have a broad antibacterial spectrum, are stable against .beta.-lactamase produced by bacteria, have a low toxicity, and are well absorbed when administered orally or parenterally.This invention relates to such novel cephalosporins, processes for producing said cephalosporins, intermediates for producing said cephalosporins, and a process for producing said intermediates.

    摘要翻译： 在头孢烯环的3位连接到外亚甲基的新型头孢菌素是取代或未取代的芳基，酰氨基，芳族杂环，三唑基或四唑基，所述芳族杂环基通过碳 - 碳键连接，所述三唑基或 四唑基通过碳 - 氮键连接，并且具有与7-位上的氨基连接的下列基团：其中A表示下式的基团：-CH 2 - 或式 其中R 5表示氢原子或烷基，并且该键表示顺式或反式异构体或其混合物; R3表示氢或卤素原子; R4表示氢原子或可被保护或取代的氨基。 这些头孢菌素具有广泛的抗菌谱，对细菌产生的β-内酰胺酶是稳定的，具有低毒性，并且当口服或肠胃外给药时被良好吸收。 本发明涉及这种新型头孢菌素，生产所述头孢菌素的方法，用于生产所述头孢菌素的中间体，以及生产所述中间体的方法。

    Insulation displacement stand and automatic insulation displacement machine including the same
    8.
    发明授权
    Insulation displacement stand and automatic insulation displacement machine including the same 失效
    绝缘位移架和自动绝缘排量机包括相同

    公开(公告)号：US06513215B2

    公开(公告)日：2003-02-04

    申请号：US09843863

    申请日：2001-04-30

    申请人： Hiroyuki Imaizumi

    发明人： Hiroyuki Imaizumi

    IPC分类号： B23P2304

    CPC分类号： H01R43/01 ,  Y10T29/49174 ,  Y10T29/5137 ,  Y10T29/5138 ,  Y10T29/514 ,  Y10T29/5145 ,  Y10T29/5193 ,  Y10T29/53209 ,  Y10T29/53213 ,  Y10T29/53235

    摘要： An insulation displacement stand includes: a fixed rack in which a first surface for receiving a pressure-receiving surface of a connector housing and a second surface escaping from a locking portion are formed with a difference in level in a heightwise direction; a movable rack in which a third surface for receiving a connection surface having contact connection portions opened in the connector housing and a fourth surface for receiving the surface having electric wire insertion holes opened in the connector housing are formed; and a braking unit provided in the fixed rack and pressing the connector housing against the third surface by pressing a surface of the connector housing from which electric wires are drawn out. In the insulation displacement stand, the movable rack is provided so that the movable rack can be apart from the fixed rack in the heightwise direction.

    摘要翻译： 绝缘位移支架包括：固定齿条，其中用于接收连接器壳体的受压面的第一表面和从锁定部分脱出的第二表面在高度方向上形成有水平差; 形成用于接收具有在连接器壳体中开口的接触连接部分的连接表面的第三表面和用于接收在连接器壳体中敞开的电线插入孔的表面的第四表面; 以及制动单元，其设置在所述固定齿条中，并且通过按压所述连接器壳体的从所述电线拉出的表面将所述连接器壳体压靠在所述第三表面上。 在绝缘位移支架中，可移动的支架设置成可移动的支架能够在高度方向上与固定支架分离。

    Pressurized gas introducing device, and injection molding method for moldings having hollow portion
    9.
    发明申请
    Pressurized gas introducing device, and injection molding method for moldings having hollow portion 有权
    加压气体引入装置和具有中空部分的模制品的注射成型方法

    公开(公告)号：US20050226954A1

    公开(公告)日：2005-10-13

    申请号：US10514315

    申请日：2003-07-02

    申请人： Yoshihiro Kayano ,  Akimasa Kaneishi ,  Hiroyuki Imaizumi

    发明人： Yoshihiro Kayano ,  Akimasa Kaneishi ,  Hiroyuki Imaizumi

    IPC分类号： B29C45/17 ,  B29D22/00

    CPC分类号： B29C45/1732

    摘要： An apparatus for introducing a pressurized gas comprises a pressurized-gas supply-source 10, a plurality of measuring tanks 20A, 20B and 20C, a first pressurized-gas supply-line 30, pressurized-gas supply valves 31A, 31B and 31C somewhere in the first pressurized-gas supply-line 30, second pressurized-gas supply-lines 32 and pressurized-gas discharge-control valves 33A, 33B and 33C disposed somewhere in the second pressurized-gas supply-lines 32, in which a combination of the measuring tanks 20A, 20B and 20C is determined on the basis of the amount of a pressurized gas required for forming a hollow portion in a molded article, and the pressurized-gas discharge-control valves 33A, 33B and 33C disposed in the second pressurized-gas supply-lines 32 are controlled on the basis of the above determination.

    摘要翻译： 用于引入加压气体的装置包括加压气体供应源10，多个测量罐20A，20B和20C，第一加压气体供应管线30，加压气体供应阀31A，31 在第一加压气体供给管线30的某处，第二加压气体供给管线32和设置在第二加压气体供给管线30的某处的第二加压气体供给管线32和加压气体排出控制阀33A，33B， 基于在成型品中形成中空部所需的加压气体的量来确定测量罐20A，20B和20C的组合的管线32，并且加压气体排出控制 基于上述判定来控制设置在第二加压气体供给管线32中的阀33A，33B，33C。

    Insulation displacement apparatus
    10.
    发明授权
    Insulation displacement apparatus 失效
    绝缘位移装置

    公开(公告)号：US06676437B2

    公开(公告)日：2004-01-13

    申请号：US10329374

    申请日：2002-12-27

    申请人： Hiroyuki Imaizumi

    发明人： Hiroyuki Imaizumi

    IPC分类号： H01R424

    CPC分类号： H01R43/01

    摘要： Insulation displacement type contacts (3) each having a receptacle portion (9) are individually held in compartments (4) that are formed in an insulated housing (2). A stationary die (21) temporarily holds an electric connector (1) having such contacts (3). A punch (22) facing and cooperating with this die (21) will reciprocate vertically to press wire ends (15) into the receptacle portions (9) so as to establish electric connection between each wire end (15) and each portion (9). In order to protect these portions (9) from being forcibly widened when an insulation displacement operation is done, a pair of upright guards (31,32) formed integral with a supporting plate (33) are disposed in the die (21). These guards (31,32) are spaced from one another a distance equal to the sideways width of the insulated housing (2), so that its end walls (6,6) are propped up by these guards from the outside. Thus, a means is provided to protect the receptacle portions (9) from being widened, at the same time enabling this apparatus to be composed from simple and cheap parts easy to replace with each other.

    摘要翻译： 每个具有容纳部分（9）的绝缘位移型触点（3）分别保持在形成在绝缘壳体（2）中的隔室（4）中。 固定模具（21）临时保持具有这种触点（3）的电连接器（1）。 与模具（21）相对并配合的冲头（22）将垂直往复运动，将压线端部（15）压入插座部分（9），以便在每个线端部（15）和每个部分（9）之间建立电连接， 。 为了保护这些部分（9）在进行绝缘移动操作时被强制加宽，在模具（21）中设置一对与支撑板（33）形成一体的直立保护件（31,32）。 这些防护件（31,32）彼此间隔开等于绝缘壳体（2）的侧向宽度的距离，使得其端壁（6,6）由这些防护件从外部支撑。 因此，提供了一种用于保护插座部分（9）不被加宽的装置，同时使得该装置能够由易于彼此替换的简单且便宜的部件组成。