Probe for diagnosing infectious diseases which hybridizes with DNA from
candida albicans
    7.
    发明授权
    Probe for diagnosing infectious diseases which hybridizes with DNA from candida albicans 失效
    探测与来自白念珠菌的DNA杂交的传染病

    公开(公告)号:US5708159A

    公开(公告)日:1998-01-13

    申请号:US416831

    申请日:1995-06-19

    CPC分类号: C12Q1/6895

    摘要: The invention provides a probe useful for rapidly detecting and identifying fungi causative of infectious diseases by digesting completely a DNA extracted from a fungus, e.g., Candida albicans, with EcoRI, inserting the same into an appropriate cloning vector, and selecting a probe containing DNA fragments unique to each fungus. The invention also provides a standard sequence suitable for making reference to a genomic DNA contained in a clinical specimen by elucidating the base sequence of the probe thus selected.

    摘要翻译: PCT No.PCT / JP93 / 01555 Sec。 371日期:1995年6月19日 102(e)日期1995年6月19日PCT提交1993年10月25日PCT公布。 WO94 / 10341 PCT出版物 日期1994年5月11日本发明提供了一种用于快速检测和鉴定感染性疾病真菌的探针,通过用EcoRI完全消化从真菌例如白色念珠菌提取的DNA,将其插入合适的克隆载体中,并选择 探针含有每种真菌特有的DNA片段。 本发明还提供了通过阐明如此选择的探针的碱基序列,适于参考临床标本中所含的基因组DNA的标准序列。

    Anti-hiv agent
    8.
    发明申请
    Anti-hiv agent 审中-公开
    抗艾滋病毒药物

    公开(公告)号:US20050123899A1

    公开(公告)日:2005-06-09

    申请号:US10500774

    申请日:2003-06-30

    CPC分类号: A61K38/1709

    摘要: Disclosed are anti-HIV agents which comprise a mannose binding protein (MBP) as an active component and are useful for effectively inhibiting progress of diseases state in and useful in therapy for individuals infected with human immunodeficiency virus (HIV). Also disclosed are a method for evaluating an anti-HIV activity of MBP comprising the step of culturing HIV infected cells under the presence of MBP.

    摘要翻译: 公开了包含作为活性成分的甘露糖结合蛋白(MBP)的抗HIV剂,并且可有效地有效地抑制感染人类免疫缺陷病毒(HIV)的个体的疾病状态并用于治疗。 还公开了评估MBP的抗HIV活性的方法,包括在MBP存在下培养HIV感染细胞的步骤。

    METHODS OF PRODUCING PROTEINS HAVING TRIPLE-HELIX STRUCTURE
    9.
    发明申请
    METHODS OF PRODUCING PROTEINS HAVING TRIPLE-HELIX STRUCTURE 有权
    生产具有三螺旋结构的蛋白质的方法

    公开(公告)号:US20120172577A1

    公开(公告)日:2012-07-05

    申请号:US11909873

    申请日:2006-03-31

    CPC分类号: C12P21/02 C07K14/78

    摘要: An objective of the present invention is to provide methods of producing human collagen molecules that are easy to isolate and purify and that have a structure substantially equivalent to that of a natural collagen molecule, wherein host cells that are transduced with a collagen gene synthesize large amounts of human collagen protein derived from a gene introduced into a high exogenous gene expression vector. Another objective of the present invention is to provide collagen molecules produced by the production methods.The present inventors discovered that a large amount of human collagen hardly contaminated with host cell-derived collagen could be produced, by selecting from various mammalian cells a host cell that has low collagen expression and introducing a collagen gene construct into a vector capable of high exogenous gene expression.

    摘要翻译: 本发明的目的是提供生产易于分离和纯化的人胶原分子的方法,其具有与天然胶原分子基本上相同的结构,其中用胶原基因转导的宿主细胞合成大量 的衍生自引入高外源基因表达载体的基因的人胶原蛋白。 本发明的另一个目的是提供通过生产方法制备的胶原分子。 本发明人发现,通过从各种哺乳动物细胞中选择具有低胶原表达的宿主细胞并将胶原基因构建体导入能够高度外源的载体中,可以产生几乎不被宿主细胞衍生的胶原蛋白污染的大量人胶原 基因表达。

    Collectin
    10.
    发明授权
    Collectin 有权
    集体

    公开(公告)号:US07985833B2

    公开(公告)日:2011-07-26

    申请号:US12334052

    申请日:2008-12-12

    IPC分类号: C07K14/00 A61K38/00

    摘要: Provided are isolated collectin (CL-L2s) genes including a base sequence set out in SEQ ID NO: 1, 3, 5, 7, 9, 12, 36, 38 or 40 relating to a novel collectin which are expected to exhibit an antibacterial activity, an antiviral activity and the like particularly in a human body; and isolated collectin proteins including an amino acid sequence set out in SEQ ID NO: 2, 4, 6, 8, 10, 13, 37, 39 or 41 and derivatives and fragments thereof.

    摘要翻译: 提供了分离的集合蛋白(CL-L2)基因,其包括与预期显示抗细菌剂的新型聚集蛋白相关的SEQ ID NO:1,3,5,7,9,12,32,38或40所示的碱基序列 活动,抗病毒活性等,特别是在人体内; 和分离的集合蛋白,包括SEQ ID NO:2,4,6,8,10,13,37,39或41所示的氨基酸序列及其衍生物和片段。