利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

104 条记录 (耗时 0.033 秒)

    Substituted phenylpropionic acid derivatives
    1.
    发明授权
    Substituted phenylpropionic acid derivatives 失效
    取代苯基丙酸衍生物

    公开(公告)号：US07049342B2

    公开(公告)日：2006-05-23

    申请号：US10296206

    申请日：2001-05-25

    申请人： Hiroyuki Miyachi ,  Masahiro Nomura ,  Yukie Takahashi ,  Takahiro Tanase ,  Kouji Murakami ,  Masahiro Suzuki

    发明人： Hiroyuki Miyachi ,  Masahiro Nomura ,  Yukie Takahashi ,  Takahiro Tanase ,  Kouji Murakami ,  Masahiro Suzuki

    IPC分类号： A61K31/195 ,  C07C235/52

    CPC分类号： C07C229/34 ,  C07B2200/07 ,  C07C69/734 ,  C07C69/738 ,  C07C233/55 ,  C07C235/38

    摘要： The invention provides novel substituted phenylpropionic acid derivatives that bind to the receptor as ligands of human peroxisome proliferator-activated receptor α (PPARα) to activate and exhibit potent lipid-decreasing action, and processes for preparing them.It relates to substituted phenylpropionic acid derivatives represented by a general formula (1) [wherein R1 denotes a lower alkyl group with carbon atoms of 1 to 4, lower alkoxy group with carbon atoms of 1 to 3, trifluoromethyl group, trifluoromethoxy group, phenyl group which is unsubstituted or may have substituents, phenoxy group which is unsubstituted or may have substituents or benzyloxy group which is unsubstituted or may have substituents, R2 denotes a hydrogen atom, lower alkyl group with carbon atoms of 1 to 4 or lower alkoxy group with carbon atoms of 1 to 3, R3 denotes a lower alkoxy group with carbon atoms of 1 to 3, and the binding mode of A portion denotes —CH2CONH—, —NHCOCH2—, —CH2CH2CO—, —CH2CH2CH2—, —CH2CH2O—, —CONHCH2—, —CH2NHCH2—, —COCH2O—, —OCH2CO—, —COCH2NH— or —CHCH2CO—], their pharmaceutically acceptable salts and their hydrates, and processes for preparing them.

    摘要翻译： 本发明提供新的取代的苯基丙酸衍生物，其结合受体作为人类过氧化物酶体增殖物激活受体α（PPARα）的配体，以活化并显示出有力的降脂作用，以及制备它们的方法。 它涉及由通式（1）表示的取代的苯基丙酸衍生物[其中R 1表示碳原子数为1〜4的低级烷基，碳原子数1〜3的低级烷氧基， 三氟甲基，三氟甲氧基，未取代或可具有取代基的苯基，未取代或可具有取代基的苯氧基或未取代或可具有取代基的苄氧基，R 2表示氢原子， 碳原子数为1〜3的碳原子数为1〜4的低级烷基，碳原子数1〜3的低级烷氧基，碳原子数为1〜3的低级烷氧基，A 部分表示-CH 2 CO 2，-NHCOCH 2 - ， - CH 2 CH 2 CO-， - CH 2 CH 2 CH 2 - ， - CH 2 CH 2 - O-（CH 2）2 CH 2 - ，-CONHCH 2 - ， - CH 2 NHCH 2 - ， - COCH 2 O - ， - OCH 2 - CO - ， - COCH 2 NH-或-CHCH 2 - CO-]，它们的药学上可接受的盐和它们的水合物，以及它们的制备方法。

    Substituted benzylthiazolidine-2, 4-dione derivatives
    3.
    发明授权
    Substituted benzylthiazolidine-2, 4-dione derivatives 失效
    取代的苄基噻唑烷-2,4-二酮衍生物

    公开(公告)号：US06734199B1

    公开(公告)日：2004-05-11

    申请号：US10049904

    申请日：2002-02-20

    申请人： Hiroyuki Miyachi ,  Masahiro Nomura ,  Takahiro Tanase ,  Koji Murakami ,  Masaki Tsunoda

    发明人： Hiroyuki Miyachi ,  Masahiro Nomura ,  Takahiro Tanase ,  Koji Murakami ,  Masaki Tsunoda

    IPC分类号： A61K31426

    CPC分类号： C07D277/34

    摘要： The invention provides novel substituted benzylthiazolidine-2,4-dione derivatives which increase the transactivation action of receptor as a ligand of human peroxisome proliferator-activated receptor (PPAR) and exhibit the blood glucose-decreasing action and lipid-decreasing action, and a process for preparing them. The invention relates to substituted benzylthiazolidine-2,4-dione derivatives represented by the general formula (1) [wherein A denotes a phenyl group which is unsubstituted or may have substituents, phenoxy group which is unsubstituted or may have substituents or benzyloxy group which is unsubstituted or may have substituents], their medicinally acceptable salts, their hydrates and a process for preparing them.

    摘要翻译： 本发明提供新的取代的苄基噻唑烷-2,4-二酮衍生物，其增加受体作为人过氧化物酶体增殖物激活受体（PPAR）的配体的反式激活作用，并显示出降血糖作用和降脂作用， 本发明涉及由通式（1）表示的取代的苄基噻唑烷-2,4-二酮衍生物[其中A表示未取代或可具有取代基的苯基，未取代或可具有取代基的苯氧基或 未取代或可具有取代基的苄氧基，其药学上可接受的盐，它们的水合物及其制备方法。

    Substituted benzylthiazolidine-2, 4-dione derivatives
    4.
    发明授权
    Substituted benzylthiazolidine-2, 4-dione derivatives 失效
    取代的苄基噻唑烷-2,4-二酮衍生物

    公开(公告)号：US06730687B1

    公开(公告)日：2004-05-04

    申请号：US10049645

    申请日：2002-02-25

    申请人： Hiroyuki Miyachi ,  Masahiro Nomura ,  Takahiro Tanase ,  Koji Murakami ,  Masaki Tsunoda

    发明人： Hiroyuki Miyachi ,  Masahiro Nomura ,  Takahiro Tanase ,  Koji Murakami ,  Masaki Tsunoda

    IPC分类号： A61K31426

    CPC分类号： C07D277/34

    摘要： The invention provides novel substituted benzylthiazolidine-2,4-dione derivatives that bind to receptor to activate as ligands of human peroxisome proliferator-activated receptor (PPAR) and exhibit blood glucose-decreasing action and lipid-decreasing action, and processes for preparing them. It relates to substituted benzylthiazolidine-2,4-dione derivatives represented by the general formula (1) [wherein the bond mode of A denotes —CH2CONH—, —NHCONH—, —CH2CH2CO— or —NHCOCH2—, and B denotes a lower alkyl group with carbon atoms of 1 to 4, lower alkoxy group with carbon atoms of 1 to 3, halogen atom, trifluoromethyl group, trifluoromethoxy group, phenyl group which is unsubstituted or may have substituents, phenoxy group which is unsubstituted or may have substituents or benzyloxy group which is unsubstituted or may have substituents], their medicinally acceptable salts, their hydrates and processes for preparing them.

    摘要翻译： 本发明提供了新的取代的苄基噻唑烷-2,4-二酮衍生物，其结合受体以作为人类过氧化物酶体增殖物激活受体（PPAR）的配体活化并显示出血糖降低作用和降脂作用，以及制备它们的方法。 它涉及由通式（1）表示的取代的苄基噻唑烷-2,4-二酮衍生物[其中A的键合模式表示-CH 2 CONH-，-NHCONH-，-CH 2 CH 2 CO-或-NHCOCH 2 - ，B表示低级烷基 具有1至4个碳原子的烷基，具有1至3个碳原子的低级烷氧基，卤素原子，三氟甲基，三氟甲氧基，未取代或可具有取代基的苯基，未被取代或可具有取代基的苯氧基或可具有取代基的苯氧基 未取代或可具有取代基的基团]，它们的药学上可接受的盐，它们的水合物及其制备方法。

    Semiconductor integrated circuit device
    8.
    发明授权
    Semiconductor integrated circuit device 有权
    半导体集成电路器件

    公开(公告)号：US07659772B2

    公开(公告)日：2010-02-09

    申请号：US11813502

    申请日：2006-01-06

    申请人： Masahiro Nomura ,  Koichi Takeda

    发明人： Masahiro Nomura ,  Koichi Takeda

    IPC分类号： G05F1/10

    CPC分类号： H03K19/0008

    摘要： A semiconductor integrated circuit device includes: a switching current observer for observing a switching current; a leakage current observer for observing a leakage current; a comparator which compares the switching current and the leakage current with each other; a threshold voltage controller for controlling a substrate bias voltage in order to make a ratio of the switching current and the leakage current constant; a delay observer for observing a delay amount; and a power supply voltage controller for controlling a power supply voltage in order to keep the delay amount in a predetermined range. In the semiconductor integrated circuit device, a process which enables the minimization of an operation power is carried out by controlling the threshold voltage to make the ratio of the switching current and the leakage current constant at a given clock frequency and controlling the power supply voltage to guarantee the operating speed.

    摘要翻译： 一种半导体集成电路器件，包括：用于观察开关电流的开关电流观察器; 用于观察泄漏电流的漏电流观测器; 将开关电流和漏电流进行比较的比较器; 用于控制衬底偏置电压以使开关电流和漏电流的比率恒定的阈值电压控制器; 用于观察延迟量的延迟观察器; 以及用于控制电源电压以便将延迟量保持在预定范围内的电源电压控制器。 在半导体集成电路器件中，通过控制阈值电压来实现能够最小化操作功率的处理，以使给定时钟频率下的开关电流和漏电流的比率恒定，并将电源电压控制为 保证运行速度。

    PRECISION ALLOY
    9.
    发明申请
    PRECISION ALLOY 审中-公开
    精密合金

    公开(公告)号：US20090274575A1

    公开(公告)日：2009-11-05

    申请号：US12439940

    申请日：2007-09-20

    申请人： Masahiro Nomura

    发明人： Masahiro Nomura

    IPC分类号： C22C18/04 ,  C22C30/02

    CPC分类号： C22C18/04 ,  C22C30/02 ,  C22C30/06 ,  C22F1/00 ,  C22F1/10

    摘要： A precision alloy for die-casting contains aluminum, silicon and zinc, wherein on the basis of the overall mass, the content of aluminum is 40% by mass or more and 45% by mass or less, and the content of silicon is 2% by mass or more and 8% by mass or less. Also other solving means will be described.

    摘要翻译： 用于压铸的精密合金包含铝，硅和锌，其中基于总质量，铝的含量为40质量％以上且45质量％以下，硅的含量为2质量％ 以上且8质量％以下。 还将描述其他解决方案。