公开(公告)号：US20050181146A1

公开(公告)日：2005-08-18

申请号：US11058652

申请日：2005-02-16

申请人： Hiroyuki Yoneyama ,  Yukihiko Kanazawa

发明人： Hiroyuki Yoneyama ,  Yukihiko Kanazawa

IPC分类号： G02B1/10 ,  B32B7/02 ,  C09K19/00 ,  G02B1/11 ,  G02B1/111 ,  G02B1/14 ,  G02B1/16 ,  G02B1/18 ,  G02B5/30 ,  G02F1/1335 ,  G02F1/13363

CPC分类号： G02B1/111 ,  Y10T428/1041 ,  Y10T428/1045 ,  Y10T428/31667

摘要： An antireflective film comprising a transparent substrate and a low refractive index layer formed by coating a low refractive index layer-forming composition, wherein the low refractive index layer-forming composition contains at least one of a hydrolysate of an organosilyl compound represented by the following formula (1) and a partial condensation product of the hydrolysate, and an outermost face of the antireflective film has a centerline surface roughness Ra of from 0.005 to 0.30 μm: R11mSi(X11)n  (1) wherein X11 represents —OH, a halogen atom, —OR12 or —OCOR12 in which R12 represents an alkyl group; R11 represents an alkyl group, an alkenyl group or an aryl group; and m and n are each a positive integer provided that m+n is 4.

摘要翻译： 一种抗反射膜，包括透明基材和通过涂覆低折射率层形成组合物形成的低折射率层，其中所述低折射率层形成组合物含有由下式表示的有机甲硅烷基化合物的水解产物中的至少一种： （1）和水解产物的部分缩合产物，并且防反射膜的最外表面的中心线表面粗糙度Ra为0.005-0.30μm：<？in-line-formula description =“In-line formula”end = “铅”？（1）（1） -formulae description =“In-line Formulas”end =“tail”？>其中X 11表示-OH，卤素原子，-OR 12或-OCOR ^{12，其中R 12表示烷基; R 11表示烷基，烯基或芳基; 并且m和n各自为正整数，条件是m + n为4。}

公开(公告)号：US07695781B2

公开(公告)日：2010-04-13

申请号：US11058652

申请日：2005-02-16

申请人： Hiroyuki Yoneyama ,  Yukihiko Kanazawa

发明人： Hiroyuki Yoneyama ,  Yukihiko Kanazawa

IPC分类号： G02F1/1335

CPC分类号： G02B1/111 ,  Y10T428/1041 ,  Y10T428/1045 ,  Y10T428/31667

摘要： An antireflective film comprising a transparent substrate and a low refractive index layer formed by coating a low refractive index layer-forming composition, wherein the low refractive index layer-forming composition contains at least one of a hydrolysate of an organosilyl compound represented by the following formula (1) and a partial condensation product of the hydrolysate, and an outermost face of the antireflective film has a centerline surface roughness Ra of from 0.005 to 0.20 μm: R11mSi(X11)n  (1) wherein X11 represents —OH, a halogen atom, —OR12 or —OCOR12 in which R12 represents an alkyl group; R11 represents an alkyl group, an alkenyl group or an aryl group; and m and n are each a positive integer provided that m+n is 4.

摘要翻译： 一种抗反射膜，包括透明基材和通过涂覆低折射率层形成组合物形成的低折射率层，其中所述低折射率层形成组合物含有由下式表示的有机甲硅烷基化合物的水解产物中的至少一种： （1）和水解产物的部分缩合产物，防反射膜的最外表面的中心线表面粗糙度Ra为0.005〜0.20μm：R11mSi（X11）n（1）其中X11表示-OH，卤素原子 ，-OR12或-OCOR12，其中R12表示烷基; R11表示烷基，烯基或芳基; 并且m和n各自为正整数，条件是m + n为4。

公开(公告)号：US08705174B2

公开(公告)日：2014-04-22

申请号：US12512608

申请日：2009-07-30

申请人： Shuntaro Ibuki ,  Kenichi Fukuda ,  Hiroyuki Yoneyama ,  Tokuju Oikawa

发明人： Shuntaro Ibuki ,  Kenichi Fukuda ,  Hiroyuki Yoneyama ,  Tokuju Oikawa

IPC分类号： G02B5/30 ,  G02B5/02 ,  G02B1/11 ,  G02F1/1335

CPC分类号： G02B5/0294 ,  G02B1/105 ,  G02B1/14 ,  G02B5/0226 ,  Y10T428/25 ,  Y10T428/252 ,  Y10T428/254 ,  Y10T428/26

摘要： An antiglare film is provided, the antiglare film including a transparent plastic film substrate; an antiglare layer having fine recesses and projections on the surface thereof; and an abrasion resistant layer provided at an uppermost surface of the antiglare film, the abrasion resistant layer having an average film thickness of from 0.03 to 0.4 μm, wherein the abrasion resistant layer is formed from a curable composition containing at least following components (A), (B), and (C): (A) an inorganic fine particle containing silicon oxide as a main component and having an average particle size of from 1 to 300 nm; (B) an ionizing radiation-curable resin; and (C) a polymer thickener.

摘要翻译： 提供防眩膜，防眩膜包括透明塑料膜基材; 防眩层，其表面上具有细小的凹凸; 以及设置在所述防眩膜的最上表面的耐磨层，所述耐磨层的平均膜厚度为0.03〜0.4μm，其中，所述耐磨层由至少含有以下成分（A）的固化性组合物形成， ，（B）和（C）：（A）以氧化硅为主要成分，平均粒径为1〜300nm的无机细粒; （B）电离辐射固化树脂; 和（C）聚合物增稠剂。

公开(公告)号：US08330895B2

公开(公告)日：2012-12-11

申请号：US12749916

申请日：2010-03-30

申请人： Jun Watanabe ,  Hiroyuki Yoneyama ,  Takato Suzuki

发明人： Jun Watanabe ,  Hiroyuki Yoneyama ,  Takato Suzuki

IPC分类号： G02F1/1335 ,  G02B5/02 ,  G02B1/08 ,  G02B27/00 ,  B05D5/06 ,  B05D3/02

CPC分类号： G02B5/02 ,  G02F1/133502

摘要： In a method for making an antiglare film including the casting, the releasing, the drying, the applying and the curing as defined herein, the transparent particles have an average primary particle size of greater than 2.5 μm and not greater than 12 μm, the transparent base has on at least one side thereof flat portions substantially parallel to a film-forming plane and rounded protrusions arising from the transparent particles, the protrusions having a maximum height Rt from the flat portions of from 1 to 15 μm, and the cured layer has an average thickness of from 1 to 15.0 μm and a surface profile with an arithmetic average roughness Ra, a mean spacing between peaks Sm, and an average slope θa, all as measured in accordance with JIS B0601, satisfying the relationships (1) to (3) as defined herein.

摘要翻译： 在制造包括如本文所定义的浇铸，脱模，干燥，施加和固化的防眩膜的方法中，透明颗粒的平均一次粒径大于2.5μm且不大于12μm，透明 基底的至少一侧的平坦部分基本上平行于成膜平面和由透明颗粒产生的圆形突起，突起具有从1至15μm的平坦部分的最大高度Rt，并且固化层具有 平均厚度为1至15.0μm，具有算术平均粗糙度Ra，平均间距Sm和平均斜率等的表面轮廓; a，根据JIS B0601测量的全部满足关系式（1） 至（3）。

公开(公告)号：US08208197B2

公开(公告)日：2012-06-26

申请号：US12032389

申请日：2008-02-15

申请人： Tetsuya Asakura ,  Hiroyuki Yoneyama ,  Naohiro Matsunaga

发明人： Tetsuya Asakura ,  Hiroyuki Yoneyama ,  Naohiro Matsunaga

IPC分类号： G02B5/20 ,  F21V9/06

CPC分类号： G02B5/208 ,  G02B1/111 ,  G02B5/3025 ,  G02F1/133528

摘要： An optical film includes a filmy support that includes a polymer having all alicyclic structure; an ultraviolet absorbing layer; and a hardcoat layer, wherein the ultraviolet absorbing layer has a beam transmittance of 5% or less in a wavelength region of 200 to 340 nm and includes at least one ultraviolet absorbent selected from the group consisting of a metal oxide fine particle and a polymer particle.

摘要翻译： 光学膜包括膜状载体，其包括具有所有脂环结构的聚合物; 紫外线吸收层; 以及硬涂层，其中所述紫外线吸收层的波长范围为200〜340nm的波长透射率为5％以下，并且包括选自金属氧化物微粒和聚合物粒子中的至少一种紫外线吸收剂 。

公开(公告)号：US20120117671A1

公开(公告)日：2012-05-10

申请号：US13319851

申请日：2009-07-31

申请人： Hiroyuki Yoneyama ,  Masato Fujii

发明人： Hiroyuki Yoneyama ,  Masato Fujii

IPC分类号： A01K67/027 ,  G01N33/566 ,  C12Q1/02 ,  A61K49/00 ,  A61K31/7008

CPC分类号： A01K67/027 ,  A01K2207/20 ,  A01K2207/25 ,  A01K2227/10 ,  A01K2267/0331

摘要： Fatty liver was induced by administering agents for inducing organ inflammation to experimental animals to evoke insulin resistance and by rearing them with high-fat diets. As a result, steatohepatitis was successfully induced in the animals. The animals show pathological findings similar to those of humans. By using these model animals, substances for treating or preventing diseases can be efficiently screened and the efficacy of medicinal substances can be effectively evaluated.

摘要翻译： 通过给实验动物诱导器官炎症的给药剂引起脂肪肝，以诱发胰岛素抵抗，并通过用高脂饮食饲养它们。 结果，在动物中成功诱导了脂肪性肝炎。 动物显示类似于人类的病理学发现。 通过使用这些模型动物，可以有效地筛选用于治疗或预防疾病的物质，并且可以有效地评价药物的功效。

公开(公告)号：US07968181B2

公开(公告)日：2011-06-28

申请号：US12801441

申请日：2010-06-09

申请人： Hiroyuki Yoneyama ,  Yasuhiro Okamoto

发明人： Hiroyuki Yoneyama ,  Yasuhiro Okamoto

IPC分类号： B32B27/20

CPC分类号： G02B1/111 ,  B32B17/10018 ,  B32B17/10174 ,  G02B5/3033 ,  Y10T428/249953 ,  Y10T428/249971 ,  Y10T428/249986 ,  Y10T428/249991 ,  Y10T428/249992 ,  Y10T428/249993 ,  Y10T428/25

摘要： An antireflection film comprises: at least one layer containing fine pores; and an antistatic layer, wherein the antistatic layer and one of said at least one layer containing fine pores are the same or different; and wherein, when a surface of the antireflection film is brought into contact with water for 15 minutes, a wiped portion of the surface shows a chromaticity change, ΔE, of 0.45 or less in the CIE 1976 L*a*b* color space measured under a standard illuminant D65.

摘要翻译： 防反射膜包括：至少一层含有细孔的层; 和抗静电层，其中所述抗静电层和所述至少一层含有细孔的层之一相同或不同; 并且其中，当防反射膜的表面与水接触15分钟时，表面的擦拭部分在CIE 1976 L * a * b *颜色中显示色度变化，Dgr; E为0.45以下 在标准光源D65下测量的空间。

公开(公告)号：US20110026121A1

公开(公告)日：2011-02-03

申请号：US12805442

申请日：2010-07-30

申请人： Masaaki Suzuki ,  Hiroyuki Yoneyama ,  Katsuyuki Takada

发明人： Masaaki Suzuki ,  Hiroyuki Yoneyama ,  Katsuyuki Takada

IPC分类号： G02B1/11 ,  B32B27/06 ,  B32B5/00 ,  G02B1/04

CPC分类号： G02B1/111 ,  G02B1/04 ,  G02B2207/121 ,  G02F1/133502 ,  G02F1/133528 ,  G02F2201/50 ,  G02F2202/22 ,  G02F2202/28 ,  H01J2211/444 ,  H01J2229/8913 ,  H01J2329/892 ,  Y10T428/269 ,  Y10T428/31971 ,  C08L27/12 ,  C08L101/12

摘要： A laminate includes a support and a layer formed from a composition containing at least (A) an organic conductive compound and (B) a fluorine-containing curable compound, a common logarithm value (log SR) of surface resistivity SR (Ω/sq) of a surface of the laminate on the layer side is 13.0 or less, and a lower part uneven distribution ratio of the organic conductive compound (A) in the layer defined by the formula as defined herein is from 55 to 100 percent.

摘要翻译： 层压体包括载体和由至少包含（A）有机导电化合物和（B）含氟可固化化合物的组合物形成的层，表面电阻率SR（＆amp; OHgr / sq）的通常对数值（log SR） 层叠层的表面的面积为13.0以下，由本发明定义的层中的有机导电性化合物（A）的下部不均匀分布比例为55〜100％。

公开(公告)号：US20100172913A1

公开(公告)日：2010-07-08

申请号：US12663420

申请日：2008-06-06

申请人： Hiroyuki Yoneyama

发明人： Hiroyuki Yoneyama

IPC分类号： A61K39/395 ,  C07K16/18

CPC分类号： C07K16/18 ,  A61K2039/505 ,  G01N2800/00 ,  G01N2800/042 ,  G01N2800/062 ,  G01N2800/085 ,  G01N2800/12 ,  G01N2800/2835 ,  G01N2800/325

摘要： An objective of the present invention is to provide methods for treating or preventing fibrotic diseases, which are based on the novel finding that fibrosis is suppressed by administering ER-TR7 to a subject.

摘要翻译： 本发明的目的是提供治疗或预防纤维化疾病的方法，其基于通过向受试者施用ER-TR7来抑制纤维化的新发现。

公开(公告)号：US20100021442A1

公开(公告)日：2010-01-28

申请号：US12554676

申请日：2009-09-04

申请人： Kouji MATSUSHIMA ,  Hiroyuki Yoneyama ,  Yuang Zhang ,  Shiro Kanegasaki ,  Teruo Akuta

发明人： Kouji MATSUSHIMA ,  Hiroyuki Yoneyama ,  Yuang Zhang ,  Shiro Kanegasaki ,  Teruo Akuta

IPC分类号： A61K35/12 ,  A61P37/00

CPC分类号： A61K38/195

摘要： Although the fields of therapeutic applications of dendritic cells are now expanding, dendritic cell precursors exist only in a small amount in the peripheral blood and, therefore, it is still difficult to obtain them in a therapeutically useful amount even though they are proliferated in vitro. Therefore, it is a key point in performing a therapy with the use of dendritic cells in practice to elevate dendritic cell precursor level in the peripheral blood of a patient. The present invention provides an agent for elevating dendritic cell precursor level in the blood which comprises an agonist to a receptor expressed in immature dendritic cells or a functional derivative thereof as the active ingredient.

摘要翻译： 尽管树突状细胞的治疗应用领域现在正在扩大，但是树突状细胞前体在外周血中仅存在少量，因此即使体外增殖，仍然难以以治疗有用的量获得它们。 因此，在实践中使用树突状细胞进行治疗是关键点，以提高患者外周血中的树突状细胞前体水平。 本发明提供了一种用于提高血液中树突状细胞前体水平的试剂，其包含对未成熟树突状细胞中表达的受体的激动剂或其功能性衍生物作为活性成分。