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    Nitrogen-containing heterocyclic compound and pharmaceutical application thereof
    1.
    发明授权
    Nitrogen-containing heterocyclic compound and pharmaceutical application thereof 失效
    含氮杂环化合物及其药物应用

    公开(公告)号：US07968572B2

    公开(公告)日：2011-06-28

    申请号：US12089108

    申请日：2006-10-02

    申请人： Hisao Nakai ,  Shingo Yamamoto ,  Shingo Nakatani ,  Tomomi Hirosaki

    发明人： Hisao Nakai ,  Shingo Yamamoto ,  Shingo Nakatani ,  Tomomi Hirosaki

    IPC分类号： A61K31/4412 ,  A61K31/426 ,  A61K31/421 ,  C07D417/02

    CPC分类号： A61K31/00 ,  A61K31/4439 ,  A61K45/06 ,  C07D401/04 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/14

    摘要： It is intended to provide a compound represented by the formula (I): wherein all the symbols are as defined in the description; which has a p38 MAP kinase inhibitory activity, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. The compound of the invention is useful for preventing or treating a disease in which the abnormal production of a cytokine such as an inflammatory cytokine or a chemokine or overreaction to them is considered to be involved in the cause and aggravation of pathological conditions, in other words, an inflammatory disease, a respiratory disease, a cardiovascular disease, a central nervous system disease or the like, which is a cytokine-mediated disease.

    摘要翻译： 旨在提供由式（I）表示的化合物：其中所有符号如说明书中所定义; 其具有p38 MAP激酶抑制活性，其盐，其N-氧化物，其溶剂化物或其前药。 本发明的化合物可用于预防或治疗其中细胞因子如炎性细胞因子或趋化因子的异常产生或对其过度反应被认为参与病理状况的原因和加重的疾病，换句话说 ，炎性疾病，呼吸系统疾病，心血管疾病，中枢神经系统疾病等，其是细胞因子介导的疾病。

    Nitrogenous heterocyclic compound and pharmaceutical use thereof
    2.
    发明授权
    Nitrogenous heterocyclic compound and pharmaceutical use thereof 有权
    氮杂环化合物及其药物用途

    公开(公告)号：US07713998B2

    公开(公告)日：2010-05-11

    申请号：US11719058

    申请日：2005-11-09

    申请人： Hisao Nakai ,  Shingo Yamamoto ,  Shingo Nakatani ,  Tomomi Hirosaki

    发明人： Hisao Nakai ,  Shingo Yamamoto ,  Shingo Nakatani ,  Tomomi Hirosaki

    IPC分类号： A61K31/445 ,  C07D211/68

    CPC分类号： A61K45/06 ,  A61K31/00 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

    摘要： The present invention relates to a compound that has p38 MAP kinase inhibitory activity useful as drug medicine, represented by the general formula (I): wherein all the symbols are as defined in the description, or its salt, N-oxide or solvate, or a prodrug thereof. Further, there are provided a process for producing the same and usage thereof. The compound of the general formula (I) has a p38 MAP kinase inhibitory activity and is useful for the prevention and/or treatment of diseases in which an abnormal production of cytokine, such as inflammatory cytokine or chemokine, or an over-reaction thereto would be instrumental in the cause and aggravation of pathologic condition thereof, namely, cytokine-mediated diseases, for example, inflammatory diseases, respiratory diseases, circulatory diseases, central nervous diseases, etc.

    摘要翻译： 本发明涉及具有p38 MAP激酶抑制活性的化合物，其可用作药物药物，由通式（I）表示：其中所有符号如说明书中所定义，或其盐，N-氧化物或溶剂化物，或 其前药。 此外，提供了制造该方法和其用途的方法。 通式（I）的化合物具有p38 MAP激酶抑制活性，并且可用于预防和/或治疗细胞因子异常产生，例如炎性细胞因子或趋化因子或其过度反应的疾病 对其病理状况，即细胞因子介导的疾病，例如炎性疾病，呼吸系统疾病，循环系统疾病，中枢神经疾病等的病因和恶化有帮助。

    Nitrogenous Heterocyclic Compound and Pharmaceutical Use Thereof
    3.
    发明申请
    Nitrogenous Heterocyclic Compound and Pharmaceutical Use Thereof 有权
    氮杂环化合物及其药物用途

    公开(公告)号：US20070265308A1

    公开(公告)日：2007-11-15

    申请号：US11719058

    申请日：2005-11-09

    申请人： Hisao Nakai ,  Shingo Yamamoto ,  Shingo Nakatani ,  Tomomi Hirosaki

    发明人： Hisao Nakai ,  Shingo Yamamoto ,  Shingo Nakatani ,  Tomomi Hirosaki

    IPC分类号： A61K31/4523 ,  A61K31/44 ,  A61K31/4525 ,  A61K31/4535 ,  A61K31/454 ,  A61P11/00 ,  A61P19/00 ,  A61P9/00 ,  C07D401/04 ,  C07D413/04 ,  C07D419/04

    CPC分类号： A61K45/06 ,  A61K31/00 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14

    摘要： The present invention relates to a compound that has p38 MAP kinase inhibitory activity useful as drug medicine, represented by the general formula (I): wherein all the symbols are as defined in the description, or its salt, N-oxide or solvate, or a prodrug thereof. Further, there are provided a process for producing the same and usage thereof. The compound of the general formula (I) has a p38 MAP kinase inhibitory activity and is useful for the prevention and/or treatment of diseases in which an abnormal production of cytokine, such as inflammatory cytokine or chemokine, or an over-reaction thereto would be instrumental in the cause and aggravation of pathologic condition thereof, namely, cytokine-mediated diseases, for example, inflammatory diseases, respiratory diseases, circulatory diseases, central nervous diseases, etc.

    摘要翻译： 本发明涉及具有p38 MAP激酶抑制活性的化合物，其可用作药物药物，由通式（I）表示：其中所有符号如说明书中所定义，或其盐，N-氧化物或溶剂化物，或 其前药。 此外，提供了制造该方法和其用途的方法。 通式（I）的化合物具有p38 MAP激酶抑制活性，并且可用于预防和/或治疗细胞因子异常产生，例如炎性细胞因子或趋化因子或其过度反应的疾病 对其病理状况，即细胞因子介导的疾病，例如炎性疾病，呼吸系统疾病，循环系统疾病，中枢神经疾病等的病因和恶化有帮助。

    Purinone derivative
    6.
    发明授权
    Purinone derivative 有权
    嘌呤酮衍生物

    公开(公告)号：US08940725B2

    公开(公告)日：2015-01-27

    申请号：US13700774

    申请日：2011-05-30

    申请人： Shingo Yamamoto ,  Toshio Yoshizawa

    发明人： Shingo Yamamoto ,  Toshio Yoshizawa

    IPC分类号： A01N43/00 ,  A61K31/00 ,  A61K31/54 ,  A61K31/522 ,  C07D473/34

    CPC分类号： C07D473/34 ,  A61K31/522

    摘要： Compounds represented by general formula (I) (all of the symbols in the formula conform to the definitions in the Description) are compounds that, in addition to having a Btk-selective inhibitory activity, exhibit an excellent metabolic stability and can avoid hepatotoxicity or the like, and as a consequence can provide safe therapeutic agents for diseases in which B cells or mast cells participate.

    摘要翻译： 由通式（I）表示的化合物（式中的所有符号符合说明书中的定义）是除了具有Btk选择性抑制活性之外，表现出优异的代谢稳定性并且可以避免肝毒性或 因此，可以为B细胞或肥大细胞参与的疾病提供安全的治疗剂。

    Hopper and metering device comprising it
    7.
    发明申请
    Hopper and metering device comprising it 失效
    料斗和计量装置包括它

    公开(公告)号：US20050087372A1

    公开(公告)日：2005-04-28

    申请号：US10496396

    申请日：2003-06-23

    申请人： Yoshiharu Asai ,  Shizuo Minamino ,  Hiroshi Hattori ,  Shingo Yamamoto

    发明人： Yoshiharu Asai ,  Shizuo Minamino ,  Hiroshi Hattori ,  Shingo Yamamoto

    IPC分类号： G01G19/387 ,  B65G11/20 ,  B65G65/40 ,  G01G13/16 ,  G01G13/00 ,  G01L7/00

    CPC分类号： G01G13/16

    摘要： The object of the present invention is to provide a hopper having a simplified structure that can prevent fragments of component parts generated by vibrations and bolts, nuts, etc., that have fallen out of place from intermixing with the articles in the weighing hoppers or on the conveyor of a combination weighing apparatus. A link mechanism for opening and closing a gate is arranged on a plate provided on one side of the box-like body (20) of a pool hopper (7). A cover (25) that covers the entire link mechanism is provided and the cover (25) is configured such that it can be freely attached to and detached from the box-like body (20). An attachment/detachment mechanism (62) slides in the direction of arrows (O) and (P) inside a long hole (64) provided in a bulged part (63) of the cover main body (61). The attachment/detachment mechanism (62) is made up of a slide member (65), an attachment/detachment operating member (66) that is located on the outside of the cover main body (61) and coupled to the slide member (65), an engaging member (67) located on the inside of the cover main body, and nuts (69a, 69b) that are located on the plate side and serve to engage with the engaging member (67).

    摘要翻译： 本发明的目的是提供一种具有简化结构的料斗，其可以防止由振动产生的部件碎片和螺母，螺母等已经脱落的位置与物料在计量料斗中的混合或者 组合称重装置的输送机。 用于打开和关闭闸门的连杆机构设置在设置在储料斗（7）的盒状主体（20）一侧的板上。 提供覆盖整个连杆机构的盖（25），并且盖（25）被构造成使得其能够自由地附接到盒状主体（20）并从箱体（20）拆卸。 安装/拆卸机构（62）沿设置在盖主体（61）的凸出部（63）的长孔（64）内沿箭头（O）和（P）的方向滑动。 安装/拆卸机构（62）由位于盖主体（61）的外侧并与滑动构件（65）连接的滑动构件（65），安装/拆卸操作构件（66） ），位于盖主体内侧的接合件（67）和位于板侧的用于与接合件（67）接合的螺母（69a，69b）。

    POWER MODULE
    8.
    发明申请
    POWER MODULE 有权
    电源模块

    公开(公告)号：US20120127668A1

    公开(公告)日：2012-05-24

    申请号：US13376282

    申请日：2010-06-22

    申请人： Shingo Yamamoto ,  Akio Sumiya ,  Yasuo Matsuda ,  Naoto Inoue ,  Makoto Tami ,  Ryo Sugihara ,  Fumiaki Tanaka ,  Shintaro Hara ,  Shota Akinaga

    发明人： Shingo Yamamoto ,  Akio Sumiya ,  Yasuo Matsuda ,  Naoto Inoue ,  Makoto Tami ,  Ryo Sugihara ,  Fumiaki Tanaka ,  Shintaro Hara ,  Shota Akinaga

    IPC分类号： H05K7/20

    CPC分类号： H05K7/20509 ,  H01L21/565 ,  H01L23/3121 ,  H01L2924/00 ,  H01L2924/0002 ,  H05K7/20 ,  H05K7/20154 ,  H05K7/20254 ,  H05K7/20854 ,  H05K7/20863 ,  H05K7/209

    摘要： A power module can prevent damages due to cracking or breakage of an insulating substrate when molding even if a heat plate constituting a power module pre-product is made areally smaller than the insulating substrate, and can also sufficiently satisfy demand for minimization. Specifically, the power module pre-product is sealed by a molding resin layer in a state where externally exposed end portion on one end side in both external connecting terminals and the other surface side of a heat plate are each exposed to the outside. The power module substrate constituting a multilayer substrate body includes an aligning hole, into which an aligning pin is inserted, the pin being included in a lower molding die constituting a molding die with an upper molding die that molds a molding resin layer, so as to position the power module pre-product inside a cavity.

    摘要翻译： 即使构成电源模块预制品的加热板小于绝缘基板，功率模块也可以防止由于绝缘基板的开裂或断裂而造成的损坏，并且还可以充分满足最小化的要求。 具体地说，在两个外部连接端子中的一端侧的外露端部和加热板的另一表面侧的外露端部各自露出的状态下，通过模制树脂层密封功率模块预制品。 构成多层基板主体的功率模块基板包括：对准销插入其中的定位孔，该引脚包括在构成模具的下模具中，上模塑模具成型树脂层，以便 将电源模块预产品定位在腔内。

    Hopper and weighing apparatus equipped with the same
    9.
    发明授权
    Hopper and weighing apparatus equipped with the same 失效
    料斗和称重设备配备相同

    公开(公告)号：US07053317B2

    公开(公告)日：2006-05-30

    申请号：US10496396

    申请日：2003-06-23

    申请人： Yoshiharu Asai ,  Shizuo Minamino ,  Hiroshi Hattori ,  Shingo Yamamoto

    发明人： Yoshiharu Asai ,  Shizuo Minamino ,  Hiroshi Hattori ,  Shingo Yamamoto

    IPC分类号： G01G19/387 ,  A23L3/00

    CPC分类号： G01G13/16

    摘要： The object of the present invention is to provide a hopper having a simplified structure that can prevent fragments of component parts generated by vibrations and bolts, nuts, etc., that have fallen out of place from intermixing with the articles in the weighing hoppers or on the conveyor of a combination weighing apparatus. A link mechanism for opening and closing a gate is arranged on a plate provided on one side of the box-like body of a pool hopper. A cover that covers the entire link mechanism is provided and the cover is configured such that it can be freely attached to and detached from the box-like body. The cover can be attached to and detached from the box-like body by engaging and disengaging an engaging member of the cover with and from a nut coupled to the box-like body.

    摘要翻译： 本发明的目的是提供一种具有简化结构的料斗，其可以防止由振动产生的部件碎片和螺母，螺母等已经脱落的位置与物料在计量料斗中的混合或者 组合称重装置的输送机。 用于打开和关闭闸门的连杆机构设置在设置在储存料斗的盒状主体的一侧上的板上。 提供了覆盖整个连杆机构的盖子，并且盖被构造成使得其能够自由地附接到盒状体上并从盒状体脱离。 可以通过使盖子的接合构件与与盒状体连接的螺母接合和分离，从而将盖子附接到盒状体上并从盒体脱离。

    Allocating mechanism for a weighing apparatus
    10.
    发明授权
    Allocating mechanism for a weighing apparatus 失效

    公开(公告)号：US06607098B2

    公开(公告)日：2003-08-19

    申请号：US09904832

    申请日：2001-07-16

    申请人： Shingo Yamamoto

    发明人： Shingo Yamamoto

    IPC分类号： B67D508

    CPC分类号： G01G13/18

    摘要： An allocating mechanism of a weighing apparatus that temporarily stores objects and allocates the objects to a plurality of hoppers disposed below is provided to reduce the amount of objects that remain without being allocated. The allocating mechanism 21 is included in the weighing apparatus. The allocating mechanism 21 is a mechanism that temporarily stores objects, and allocates the objects to hoppers 24 and 25 disposed below. The allocating mechanism 21 includes a tubular member 61, a bottom plate 62, a driving motor, and a controller. The bottom plate 62 can, together with the tubular member 61, form a storage space S, in which the objects are stored. The driving motor rotates the tubular member 61 and the bottom plate 62. The controller controls the driving motor to rotate the tubular member 61 and the bottom plate 62, such that the objects are dropped in one of the hoppers 24 and 25.