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公开(公告)号：US06432913B1
公开(公告)日：2002-08-13
申请号：US09558340
申请日：2000-04-26
申请人： Hisao Tajima , Koichiro Kitagawa , Hiroyuki Ohno
发明人： Hisao Tajima , Koichiro Kitagawa , Hiroyuki Ohno
IPC分类号： A01N6100
摘要： The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the said polypeptide; vector derived the said DNA; host cells transformed the said vector; antibody of the said polypeptide; pharmaceutical composition containing the said peptide or antibody; method for the prevention and/or treatment of diabetes, which is characterized by tyrosine phosphorylation of the said protein p140; agent for the prevention and/or treatment for the currently said the prevention and/or treatment method; agent for the prevention and/or treatment of diabetes, which is characterized by containing a compound which can tyrosine phosphorylation of protein p140, as active ingredient and the screening methods of the said prevention and/or treatment agent. Tyrosine phosphorylation of protein p140 is an essential step in the induction of hypoglycemia by glucose uptake. Method and agent of prevention and/or treatment based on tyrosine phosphorylation of protein p140 in the present invention is not only improve the diabetes-derived hyperglycemic conditions but are also useful for the treatment and/or prevention of diabetes, especially non-insulin dependent diabetes mellitus (NIDDM).
摘要翻译： 本发明涉及胰岛素信号传递系统中涉及的关键蛋白质的新型蛋白质p140多肽， 制备方法 编码所述多肽的DNA; 载体衍生所述DNA; 宿主细胞转化所述载体; 所述多肽的抗体; 含有所述肽或抗体的药物组合物; 用于预防和/或治疗糖尿病的方法，其特征在于所述蛋白质p140的酪氨酸磷酸化; 用于预防和/或治疗目前所述的预防和/或治疗方法的药剂; 用于预防和/或治疗糖尿病的药物，其特征在于含有可以作为活性成分的蛋白质p140的酪氨酸磷酸化的化合物和所述预防和/或治疗剂的筛选方法。蛋白质p140的酪氨酸磷酸化是 通过葡萄糖摄取诱导低血糖的关键步骤。 本发明中基于蛋白质p140的酪氨酸磷酸化的预防和/或治疗方法和药剂不仅可以改善糖尿病来源的高血糖状况，而且可用于治疗和/或预防糖尿病，特别是非胰岛素依赖型糖尿病 （NIDDM）。
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公开(公告)号：US06303320B1
公开(公告)日：2001-10-16
申请号：US09192435
申请日：1998-01-08
申请人： Hisao Tajima , Koichiro Kitagawa , Hiroyuki Ohno
发明人： Hisao Tajima , Koichiro Kitagawa , Hiroyuki Ohno
IPC分类号： G01N3353
摘要： The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the polypeptide; vector derived with the DNA; host cells transformed with the vector; antibody of the polypeptide; pharmaceutical composition containing the peptide or antibody; method for the prevention and/or treatment of diabetes, which is characterized by tyrosine phosphorylation of the protein p140; agent for the prevention and/or treatment of diabetes, which is characterized by containing a compound which can tyrosine phosphorylate protein p140, as active ingredient and the screening methods of the prevention and/or treatment agent. Tyrosine phosphorylation of protein p140 is an essential step in the induction of hypoglycemia by glucose uptake. Method and agent of prevention and/or treatment based on tyrosine phosphorylation of protein p140 in the present invention not only improve the diabetes-derived hyperglycemic conditions but are also useful for the treatment and/or prevention of diabetes, especially non-insulin dependent diabetes mellitus (NIDDM).
摘要翻译： 本发明涉及胰岛素信号传递系统中涉及的关键蛋白质的新型蛋白质p140多肽， 制备方法 编码多肽的DNA; 用DNA衍生的载体; 宿主细胞用载体转化; 多肽的抗体; 含有肽或抗体的药物组合物; 用于预防和/或治疗糖尿病的方法，其特征在于蛋白质p140的酪氨酸磷酸化; 用于预防和/或治疗糖尿病的药物，其特征在于含有可以酪氨酸磷酸化蛋白质p140的化合物作为活性成分和预防和/或治疗剂的筛选方法。 蛋白质p140的酪氨酸磷酸化是通过葡萄糖摄取诱导低血糖的关键步骤。 本发明中基于蛋白质p140的酪氨酸磷酸化的预防和/或治疗方法和药剂不仅改善糖尿病衍生的高血糖病症，而且可用于治疗和/或预防糖尿病，特别是非胰岛素依赖性糖尿病 （NIDDM）。
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公开(公告)号：US5804411A
公开(公告)日：1998-09-08
申请号：US571785
申请日：1995-12-13
申请人： Hisao Tajima , Koichiro Kitagawa , Hiroyuki Ohno
发明人： Hisao Tajima , Koichiro Kitagawa , Hiroyuki Ohno
IPC分类号： A61K38/00 , C07K14/47 , C12N1/21 , C12N15/12 , C12P21/08 , C12P21/02 , C07H21/04 , C12N15/63
摘要： The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the said polypeptide; vector derived the said DNA; host cells transformed the said vector; antibody of the said polypeptide; pharmaceutical composition containing the said peptide or antibody; method for the prevention and/or treatment of diabetes, which is characterized by tyrosine phosphorylation of the said protein p140; agent for the prevention and/or treatment of diabetes, agent for the prevention and/or treatment of diabetes, which is characterized by containing a compound which can tyrosine phosphorylate of protein p140, as active ingredient and the screening methods of the said prevention and/or treatment agent. Tyrosine phosphorylation of protein p140 is an essential step in the induction of hypoglycemia by glucose uptake. Method and agent of prevention and/or treatment based on tyrosine phosphorylation of protein p140 in the present invention is not only to improve the diabetes-derived hypoglycemic conditions but are also useful for the treatment and/or prevention of diabetes, especially non-insulin dependent diabetes mellitus (NIDDM).
摘要翻译： 本发明涉及胰岛素信号传递系统中涉及的关键蛋白质的新型蛋白质p140多肽， 制备方法 编码所述多肽的DNA; 载体衍生所述DNA; 宿主细胞转化所述载体; 所述多肽的抗体; 含有所述肽或抗体的药物组合物; 用于预防和/或治疗糖尿病的方法，其特征在于所述蛋白质p140的酪氨酸磷酸化; 用于预防和/或治疗糖尿病的药剂，用于预防和/或治疗糖尿病的药剂，其特征在于含有可以将蛋白质p140的酪氨酸磷酸化的化合物作为活性成分，以及所述预防和/ 或治疗剂。 蛋白质p140的酪氨酸磷酸化是通过葡萄糖摄取诱导低血糖的关键步骤。 基于本发明的蛋白质p140的酪氨酸磷酸化的预防和/或治疗方法和药剂不仅可改善糖尿病衍生的低血糖状况，而且可用于治疗和/或预防糖尿病，特别是非胰岛素依赖性 糖尿病（NIDDM）。
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公开(公告)号：US5506205A
公开(公告)日：1996-04-09
申请号：US348143
申请日：1994-11-23
申请人： Hisao Tajima , Koichiro Kitagawa , Hiroyuki Ohno
发明人： Hisao Tajima , Koichiro Kitagawa , Hiroyuki Ohno
摘要： The present invention is related to a novel protein p140 polypeptide which is a key protein involved in the signal transmission system of insulin; method for preparation of it; DNA encoding the said polypeptide; vector comprising the DNA; host cells transformed with the vector; antibody against the polypeptide; pharmaceutical compositions containing the peptide or antibody; method for the prevention and/or treatment of diabetes, which is characterized by tyrosine phosphorylation of the said protein p140; agent for the prevention and/or treatment of diabetes, which is characterized by containing a compound which can tyrosine phosphorylate protein p140, as active ingredient and screening methods for the prevention and/or treatment agent.Tyrosine phosphorylation of protein p140 is an essential step in the induction of hypoglycemia by glucose uptake. Method and agent of prevention and/or treatment based on tyrosine phosphorylation of protein p140 in the present invention is not only to improves the diabetes-derived hyperglycemic conditions but are also useful for the treatment and/or prevention of diabetes, especially non-insulin dependent diabetes mellitus (NIDDM).
摘要翻译： 本发明涉及胰岛素信号传递系统中涉及的关键蛋白质的新型蛋白质p140多肽， 制备方法 编码所述多肽的DNA; 包含DNA的载体; 宿主细胞用载体转化; 抗多肽抗体; 含有肽或抗体的药物组合物; 用于预防和/或治疗糖尿病的方法，其特征在于所述蛋白质p140的酪氨酸磷酸化; 用于预防和/或治疗糖尿病的药物，其特征在于含有可将酪氨酸磷酸化蛋白质p140的化合物作为活性成分和预防和/或治疗剂的筛选方法。 蛋白质p140的酪氨酸磷酸化是通过葡萄糖摄取诱导低血糖的关键步骤。 基于本发明的蛋白质p140的酪氨酸磷酸化的预防和/或治疗方法和药剂不仅可改善糖尿病来源的高血糖病症，而且可用于治疗和/或预防糖尿病，特别是非胰岛素依赖性 糖尿病（NIDDM）。
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公开(公告)号：US20090228183A1
公开(公告)日：2009-09-10
申请号：US12074726
申请日：2008-03-05
申请人： Satoru Watabe , Hiroyuki Ohno
发明人： Satoru Watabe , Hiroyuki Ohno
IPC分类号： B60W40/12
CPC分类号： B60K28/16 , B60T8/1706 , B60T8/175 , B60W2510/0638 , B60W2510/0652 , B60W2510/1005 , B60W2520/10 , B60W2710/0616 , B60W2710/0666 , Y10T477/755
摘要： A slip detection system for a vehicle comprises an engine speed detector configured to detect an engine speed of an engine mounted in the vehicle, an engine speed increase rate detector configured to detect an increase rate in a predetermined time of the engine speed detected by the engine speed detector, and a slip determiner configured to integrate values of increase rates in respective predetermined times, from when the increase rate detected by the engine speed increase rate detector becomes larger than a first threshold until the increase rate becomes smaller than the first threshold, and to determine that a drive wheel of the vehicle is in a slip-state when an integrated value resulting from integration of the values of the increase rates becomes larger than a second threshold.
摘要翻译： 一种用于车辆的滑动检测系统包括：发动机速度检测器，被配置为检测安装在车辆中的发动机的发动机转速;发动机速度增加率检测器，被配置为检测在发动机检测到的发动机转速的预定时间内的增加率 速度检测器和滑动判定器，其被配置为在从发动机速度增加率检测器检测到的增加率变得大于第一阈值直到增加速率变得小于第一阈值时，在各个预定时间内积分增加率的值，以及 当由增加率的值的积分导致的积分值变得大于第二阈值时，确定车辆的驱动轮处于滑动状态。
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公开(公告)号：US07385035B2
公开(公告)日：2008-06-10
申请号：US10496384
申请日：2002-12-05
申请人： Hiroyuki Ohno , Hiromitsu Saisho , Hideki Tanzawa
发明人： Hiroyuki Ohno , Hiromitsu Saisho , Hideki Tanzawa
IPC分类号： C07K5/10
CPC分类号： C07K14/205 , A61K38/164 , C07K16/121 , C12P21/02 , G01N2333/205 , Y10S435/81
摘要： This invention relates to a new cytotoxic protein (M toxin, mucous layer devastating toxin) produced by Helicobacter pylori and the use.This invention provides a cytotoxic protein (M toxin) produced by Helicobacter pylori, a partial peptide, and an antitumor agent containing the cytotoxic protein. The protein is obtained by culturing a transformant which is transformed with a recombination vector containing DNA coding the cytotoxin protein. This invention provides further the use of the protein.
摘要翻译： 本发明涉及由幽门螺杆菌产生的新的细胞毒素蛋白（M毒素，粘液层破坏性毒素）及其用途。 本发明提供由幽门螺杆菌，部分肽和含有细胞毒性蛋白质的抗肿瘤剂产生的细胞毒性蛋白（M毒素）。 通过培养用含有编码细胞毒素蛋白的DNA的重组载体转化的转化体获得蛋白质。 本发明进一步提供了蛋白质的用途。
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公开(公告)号：US07176240B2
公开(公告)日：2007-02-13
申请号：US10194247
申请日：2002-07-15
IPC分类号： A01N37/00 , A61K31/20 , A61K31/19 , A61K31/231 , C07C63/04
CPC分类号： C07D213/75 , A61K31/19 , C07C53/21 , C07C69/612 , C07C69/63 , C07C69/708 , C07C233/05 , C07C233/11 , C07C233/25 , C07C233/47 , C07C233/54 , C07C323/52 , C07D295/185
摘要： The compound of the formula (I): wherein R1 is alkyl substituted by fluorine(s); R2 is hydroxy, alkoxy, alkoxy substituted by phenyl, NR3R4, in which R3, R4 is (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl substituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to R3 and R4, taken together a saturated heterocyclic ring or amino acid residues; and non-toxic salts thereof and acid addition salts thereof. The compounds of the present invention of the formula (I) and the compounds of the formula (X): wherein n is 0 or 1, R11 is hydrogen and chlorine, R5 is R7—CH2— or R8, or R5 and R11, taken together is alkylidene; R6 is hydroxy, alkoxy, alkoxy substituted by phenyl, NR9R10, in which R9, R10 is (i) hydrogen, (ii) alkyl, (iii) phenyl, (iv) phenyl substituted by alkoxy or carboxyl, (v) heterocyclic ring containing nitrogen atom, (vi) alkyl substituted by phenyl, phenyl-substituted by alkoxy or carboxyl, heterocyclic ring containing nitrogen atom, (vii) the nitrogen bonded to R9 and R10, taken together a saturated heterocyclic ring or amino acid residues, R7 is (i) F—(CH2)m— or F3C—CH2—, (ii) alkyl substituted by chlorine, (iii) alkyl substituted by alkoxy, cycloalkyl, phenyl, phenoxy; R8 is alkyl, alkenyl, alkoxy, alkylthio, cycloalkyl, phenyl, phenoxy; non-toxic salts and acid addition salts thereof are useful for prevention and/or treatment for neurodegenerarive disease (Alzheimer's disease etc.) and neuronal dysfunction by stroke or traumic injury (Multiple sclerosis etc.) etc.
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公开(公告)号：US20060210575A1
公开(公告)日：2006-09-21
申请号：US10496384
申请日：2002-12-05
申请人： Hiroyuki Ohno , Hiromitsu Saisho , Hideki Tanzawa
发明人： Hiroyuki Ohno , Hiromitsu Saisho , Hideki Tanzawa
IPC分类号： G01N33/53 , A61K39/395 , A61K39/00 , C07K14/47
CPC分类号： C07K14/205 , A61K38/164 , C07K16/121 , C12P21/02 , G01N2333/205 , Y10S435/81
摘要： This invention relates to a new cytotoxic protein (M toxin, mucous layer devastating toxin) produced by Helicobacter pylori and the use. This invention provides a cytotoxic protein (M toxin) produced by Helicobacter pylori, a partial peptide, and an antitumor agent containing the cytotoxic protein. The protein is obtained by culturing a transformant which is transformed with a recombination vector containing DNA coding the cytotoxin protein. This invention provides further the use of the protein.
摘要翻译： 本发明涉及由幽门螺杆菌产生的新的细胞毒素蛋白（M毒素，粘液层破坏性毒素）及其用途。 本发明提供由幽门螺杆菌，部分肽和含有细胞毒性蛋白质的抗肿瘤剂产生的细胞毒性蛋白（M毒素）。 通过培养用含有编码细胞毒素蛋白的DNA的重组载体转化的转化体获得蛋白质。 本发明进一步提供了蛋白质的用途。
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公开(公告)号：US6048639A
公开(公告)日：2000-04-11
申请号：US232655
申请日：1999-01-19
CPC分类号： H01M10/0436 , H01M2/021 , H01M2/0275 , H01M10/0525 , H01M2/0287
摘要： In a thin type sealed cell utilizing a cell case made of a laminated material, a storage life and reliability of the cell is increased by preventing a sectional surface at an end of the laminated material from being exposed in the cell case, and thereby a leakage of an electrolyte out of the cell and a short circuit in the cell are avoided. This is achieved by disposing a resin layer on the inner surface of the cell case composed of a sheet type laminated material, and covering the sectional surface existing inside the cell case with resin.
摘要翻译： 在使用由层压材料制成的电池壳体的薄型密封电池中，通过防止层叠材料的端部的截面被暴露在电池壳体中，从而提高电池的储存寿命和可靠性，从而泄漏 的电解液，并避免了电池中的短路。 这是通过在由片状层压材料构成的电池壳体的内表面上设置树脂层，并且用树脂覆盖存在于电池壳体内的截面来实现的。
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公开(公告)号：US5712391A
公开(公告)日：1998-01-27
申请号：US671001
申请日：1996-06-28
申请人： Hiroyuki Ohno , Natsue Kawahara , Isaburo Amano , Takanao Suzuki , Koji Chiba
发明人： Hiroyuki Ohno , Natsue Kawahara , Isaburo Amano , Takanao Suzuki , Koji Chiba
IPC分类号： A61K8/895 , A61K8/898 , A61K47/34 , A61Q1/00 , A61Q19/00 , C08G77/388 , C07D251/00 , C07D251/40 , C07D251/54 , C07F7/04
CPC分类号： A61K8/898 , A61K47/34 , A61Q19/00 , C08G77/388 , A61K2800/57
摘要： Disclosed are amino silicone derivatives having triazinyl groups or pyrimidinyl groups bound to amino groups of amino silicones, their production and use, said silicone derivatives being able to gel silicone oil or to increase the viscosity thereof stably and homogeneously, and therefore being useful as bases for cosmetics, pharmaceutical preparations and industrial materials.
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