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    CETP activity inhibitor
    3.
    发明授权
    CETP activity inhibitor 有权
    CETP活性抑制剂

    公开(公告)号：US06753346B2

    公开(公告)日：2004-06-22

    申请号：US10151813

    申请日：2002-05-22

    申请人： Hisashi Shinkai ,  Kimiya Maeda ,  Hiroshi Okamoto

    发明人： Hisashi Shinkai ,  Kimiya Maeda ,  Hiroshi Okamoto

    IPC分类号： A61K31255

    CPC分类号： C07D307/10 ,  A61K31/164 ,  A61K31/18 ,  A61K31/33 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/435 ,  A61K31/44 ,  C07C311/14 ,  C07C311/15 ,  C07C311/21 ,  C07C323/40 ,  C07C323/41 ,  C07C323/42 ,  C07C327/30 ,  C07C329/10 ,  C07C329/20 ,  C07C333/04 ,  C07C333/08 ,  C07C333/10 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/08 ,  C07C2602/22 ,  C07C2602/28 ,  C07C2603/74 ,  C07D211/34 ,  C07D213/80 ,  C07D213/81 ,  C07D307/68 ,  C07D333/38 ,  Y02P20/55

    摘要： The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I): wherein R represents a straight chain or branched alkyl group; a straight chain or branched alkenyl group; a lower haloalkyl group; a substituted or unsubstituted cycloalkyl group; a substituted or unsubstituted cycloalkenyl group; a substituted or unsubstituted cycloalkylalkyl group; a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclic group, X1, X2, X3, and X4 may be the same or different and each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower haloalkyl group; a lower alkoxy group; a cyano group; a nitro group; an acyl group; or an aryl group, Y represents —CO— or —SO2—, and Z represents a hydrogen atom or a mercapto-protecting group, or a prodrug compound, a pharmaceutically acceptable salt, or hydrate or solvate thereof. The compounds represented by the formula (I) can increase HDL and at the same time decrease LDL through selective inhibition of CETP activity and, therefore, is expected to be useful as a new type of a preventive or therapeutic agent for atherosclerosis or hyperlipidemia.

    摘要翻译： 本发明提供一种CETP活性抑制剂，其包含由式（I）表示的化合物作为活性成分：其中R表示直链或支链烷基; 直链或支链烯基; 低级卤代烷基; 取代或未取代的环烷基; 取代或未取代的环烯基; 取代或未取代的环烷基烷基; 取代或未取代的芳基或取代或未取代的杂环基，X 1，X 2，X 3和X 4可以相同或不同，各自表示氢原子，卤素原子，低级烷基，低级卤代烷基。 低级烷氧基; 氰基; 硝基; 酰基; 或芳基，Y表示-CO-或-SO 2 - ，Z表示氢原子或巯基保护基，或前药化合物，其药学上可接受的盐或水合物或溶剂化物。 由式（I）表示的化合物可以增加HDL，同时通过选择性抑制CETP活性降低LDL，因此预期可用作动脉粥样硬化或高脂血症的新型预防或治疗剂。

    CETP activity inhibitors
    6.
    发明授权
    CETP activity inhibitors 有权
    CETP活性抑制剂

    公开(公告)号：US06426365B1

    公开(公告)日：2002-07-30

    申请号：US09367299

    申请日：1999-12-23

    申请人： Hisashi Shinkai ,  Kimiya Maeda ,  Hiroshi Okamoto

    发明人： Hisashi Shinkai ,  Kimiya Maeda ,  Hiroshi Okamoto

    IPC分类号： A61K31165

    CPC分类号： C07D307/10 ,  A61K31/164 ,  A61K31/18 ,  A61K31/33 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/435 ,  A61K31/44 ,  C07C311/14 ,  C07C311/15 ,  C07C311/21 ,  C07C323/40 ,  C07C323/41 ,  C07C323/42 ,  C07C327/30 ,  C07C329/10 ,  C07C329/20 ,  C07C333/04 ,  C07C333/08 ,  C07C333/10 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/08 ,  C07C2602/22 ,  C07C2602/28 ,  C07C2603/74 ,  C07D211/34 ,  C07D213/80 ,  C07D213/81 ,  C07D307/68 ,  C07D333/38 ,  Y02P20/55

    摘要： The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I): wherein R represents a straight chain or branched alkyl group; a straight chain or branched alkenyl group; a lower haloalkyl group; a substituted or unsubstituted cycloalkyl group; a substituted or unsubstituted cycloalkenyl group; a substituted or unsubstituted cycloalkylalkyl group; a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclic group, X1, X2, X3, and X4 may be the same or different and each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower haloalkyl group; a lower alkoxy group; a cyano group; a nitro group; an acyl group; or an aryl group, Y represents —CO— or —SO2—, and Z represents a hydrogen atom or a mercapto-protecting group, or a prodrug compound, a pharmaceutically acceptable salt, or hydrate or solvate thereof. The compounds represented by the formula (I) can increase HDL and at the same time decrease LDL through selective inhibition of CETP activity and, therefore, is expected to be useful as a new type of a preventive or therapeutic agent for atherosclerosis or hyperlipidemia.

    摘要翻译： 本发明提供一种CETP活性抑制剂，其包含由式（I）表示的化合物作为活性成分：其中R表示直链或支链烷基; 直链或支链烯基; 低级卤代烷基; 取代或未取代的环烷基; 取代或未取代的环烯基; 取代或未取代的环烷基烷基; 取代或未取代的芳基或取代或未取代的杂环基，X 1，X 2，X 3和X 4可以相同或不同，各自表示氢原子，卤素原子，低级烷基，低级卤代烷基。 低级烷氧基; 氰基; 硝基; 酰基; 或芳基，Y表示-CO-或-SO 2 - ，Z表示氢原子或巯基保护基，或前药化合物，其药学上可接受的盐或水合物或溶剂化物。 由式（I）表示的化合物可以增加HDL，同时通过选择性抑制CETP活性降低LDL，因此预期可用作动脉粥样硬化或高脂血症的新型预防或治疗剂。

    CETP activity inhibitors
    8.
    发明授权
    CETP activity inhibitors 有权
    CETP活性抑制剂

    公开(公告)号：US07271196B2

    公开(公告)日：2007-09-18

    申请号：US10825531

    申请日：2004-04-15

    申请人： Hisashi Shinkai ,  Kimiya Maeda ,  Hiroshi Okamoto

    发明人： Hisashi Shinkai ,  Kimiya Maeda ,  Hiroshi Okamoto

    IPC分类号： A61K31/167 ,  C07C327/22

    CPC分类号： C07D307/10 ,  A61K31/164 ,  A61K31/18 ,  A61K31/33 ,  A61K31/341 ,  A61K31/381 ,  A61K31/40 ,  A61K31/435 ,  A61K31/44 ,  C07C311/14 ,  C07C311/15 ,  C07C311/21 ,  C07C323/40 ,  C07C323/41 ,  C07C323/42 ,  C07C327/30 ,  C07C329/10 ,  C07C329/20 ,  C07C333/04 ,  C07C333/08 ,  C07C333/10 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/08 ,  C07C2602/22 ,  C07C2602/28 ,  C07C2603/74 ,  C07D211/34 ,  C07D213/80 ,  C07D213/81 ,  C07D307/68 ,  C07D333/38 ,  Y02P20/55

    摘要： The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I): wherein R represents a straight chain or branched alkyl group; a straight chain or branched alkenyl group; a lower haloalkyl group; a substituted or unsubstituted cycloalkyl group; a substituted or unsubstituted cycloalkenyl group; a substituted or unsubstituted cycloalkylalkyl group; a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclic group, X1, X2, X3, and X4 may be the same or different and each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower haloalkyl group; a lower alkoxy group; a cyano group; a nitro group; an acyl group; or an aryl group, Y represents —CO— or —SO2—, and Z represents a hydrogen atom or a mercapto-protecting group, or a prodrug compound, a pharmaceutically acceptable salt, or hydrate or solvate thereof. The compounds represented by the formula (I) can increase HDL and at the same time decrease LDL through selective inhibition of CETP activity and, therefore, is expected to be useful as a new type of a preventive or therapeutic agent for atherosclerosis or hyperlipidemia.

    摘要翻译： 本发明提供一种CETP活性抑制剂，其包含由式（I）表示的化合物作为活性成分：其中R表示直链或支链烷基; 直链或支链烯基; 低级卤代烷基; 取代或未取代的环烷基; 取代或未取代的环烯基; 取代或未取代的环烷基烷基; 取代或未取代的芳基或取代或未取代的杂环基，X 1，X 2，X 3和X 3， 4可以相同或不同，各自表示氢原子，卤素原子，低级烷基，低级卤代烷基; 低级烷氧基; 氰基; 硝基; 酰基; 或芳基，Y表示-CO-或-SO 2 - ，Z表示氢原子或巯基保护基，或前药化合物，药学上可接受的盐或水合物或溶剂合物 其中。 由式（I）表示的化合物可以增加HDL，同时通过选择性抑制CETP活性降低LDL，因此预期可用作动脉粥样硬化或高脂血症的新型预防或治疗剂。

    ANTENNA
    10.
    发明申请
    ANTENNA 有权
    天线

    公开(公告)号：US20140168026A1

    公开(公告)日：2014-06-19

    申请号：US14234224

    申请日：2012-07-20

    申请人： Masaki Nakamura ,  Hiroshi Okamoto ,  Hirohiko Miki

    发明人： Masaki Nakamura ,  Hiroshi Okamoto ,  Hirohiko Miki

    IPC分类号： H01Q7/00

    CPC分类号： H01Q7/00 ,  H01F5/04 ,  H01Q1/40 ,  H01Q7/06

    摘要： An antenna comprising a coreless coil formed by winding a conductor wire, a relay member connected to the coil, and a magnetic plate member covering the coil and part of the relay member; the relay member comprising a substrate having a notch for lead wires of the coil, and a pair of terminal members formed on the substrate; each terminal member comprising an internal terminal portion connected to an end of each lead wire, an external terminal portion connected to an external circuit, and a line portion connecting the internal terminal portion to the external terminal portion; the coil and part of the relay member disposed on the magnetic member being fixed to a first adhesive layer on the non-transmission side of the coil; and the internal terminal portion being positioned in a region overlapping the magnetic member, or in a region surrounded by the notch of the magnetic member.

    摘要翻译： 一种天线，包括通过缠绕导线而形成的无芯线圈，连接到所述线圈的中继部件和覆盖所述线圈和所述中继部件的一部分的磁性板部件; 所述继电器构件包括具有用于所述线圈的引线的凹口的基板和形成在所述基板上的一对端子构件; 每个端子构件包括连接到每个引线的端部的内部端子部分，连接到外部电路的外部端子部分和将内部端子部分连接到外部端子部分的线路部分; 所述线圈和设置在所述磁性构件上的所述中继构件的一部分被固定到所述线圈的非透射侧上的第一粘合剂层; 并且内部端子部分位于与磁性构件重叠的区域中，或者位于由磁性构件的凹口包围的区域中。