公开(公告)号：US06264989B1

公开(公告)日：2001-07-24

申请号：US09463327

申请日：2000-01-24

申请人： Hisayoshi Kato ,  Nagayoshi Myo ,  Ikuo Tanai ,  Yusuke Suzuki ,  Toshiro Fujii ,  Yoshitaka Tomoda

发明人： Hisayoshi Kato ,  Nagayoshi Myo ,  Ikuo Tanai ,  Yusuke Suzuki ,  Toshiro Fujii ,  Yoshitaka Tomoda

IPC分类号： A61K916

CPC分类号： B01J2/14 ,  A23L27/70 ,  A23L33/15 ,  A23P10/22 ,  A23V2002/00 ,  A61K9/1688 ,  B01J2/16 ,  A23V2250/708 ,  A23V2250/6422 ,  A23V2200/224 ,  A23V2250/204 ,  A23V2250/1614 ,  A23V2250/1582 ,  A23V2250/6418 ,  A23V2250/51086

摘要： The present invention relates to a process for producing a spherical particle comprising an aggregate of particles containing at least 95% of a water-soluble single substance having a viscosity of 10 mPa.s or less as determined in the form of a saturated aqueous solution, the process comprising: preparing moist spherical particles of the single substance by charging, as cores, crystalline particles or granulated particles of the single substance on a rotary disc in a processing vessel of a centrifugal tumbling granulating apparatus, wherein the granulated particles are prepared by granulating a powder of the single substance, and dispersing over the cores a powder of the single substance and simultaneously spraying on the cores a liquid such as water or the like while supplying slit air to provide a fluidized condition; and then fixation treating the moist spherical particles by drying them while spraying an aqueous solution of the single substance or the like on the spherical particles in a fluidized bed apparatus; to the spherical particle produced by the process; and to a pharmaceutical preparation and a food containing the spherical particle.

摘要翻译： 本发明涉及一种球形颗粒的制造方法，其包含以饱和水溶液的形式测定的含有至少95％的粘度为10mPa·s以下的水溶性单一物质的颗粒聚集体， 该方法包括：通过在离心转鼓造粒装置的处理容器中将旋转盘上的单一物质的核心，结晶颗粒或造粒颗粒作为核心，制备单一物质的湿球形颗粒，其中造粒颗粒通过造粒 将该单一物质的粉末分散在芯体上，并且同时在芯体上喷洒诸如水等的液体，同时在狭缝空气中提供流化条件; 然后在流化床装置中将单一物质等的水溶液喷雾在球形颗粒上的同时，通过干燥固定处理湿球形颗粒; 通过该方法生产的球形颗粒; 以及含有球形颗粒的药物制剂和食品。

公开(公告)号：US06171619B2

公开(公告)日：2001-01-09

申请号：US09254438

申请日：1999-03-09

申请人： Yasutoyo Fusejima ,  Yasuhiro Takemura ,  Nagayoshi Myo ,  Hisayoshi Kato

发明人： Yasutoyo Fusejima ,  Yasuhiro Takemura ,  Nagayoshi Myo ,  Hisayoshi Kato

IPC分类号： A61K914

CPC分类号： A61K9/1694 ,  A61J3/07 ,  A61J3/10 ,  A61K9/1676 ,  B01J2/14 ,  B01J2/16

摘要： The invention relates to spherical granules having a uniform grain size and a uniform density which are suitable for a controlled-release preparation, a process for producing the same, and a spherical granule preparation using the same. Specifically, the invention relates to a process for producing spherical granules comprising the steps of: wetting powder materials comprising one or more kinds of pharmaceutical substances and have a mean particle size of from 1 to 100 &mgr;m; charging the wet powder materials into a centrifugal fluidized granulating apparatus; spraying a liquid to the wet powder materials at a rate of less than 3% based on the plastic limit of the powder materials per min. while rotating the rotary disk of the centrifugal fluidized granulating apparatus until the liquid content of the powder materials reaches 75 to 120% based on the plastic limit of the powder materials, and drying the sprayed product to give spherical granules; spherical granules having a mean grain size of 100-1000 &mgr;m, in which at least 90% by weight of the total amount of the spherical granules has such a grain size distribution that the maximum grain size is not larger than 1.2 times the minimum grain size, and the difference in density between the individual spherical granules is less than 0.05 g/cm3; and a spherical granule preparation comprising the spherical granules.

摘要翻译： 本发明涉及适用于控释制剂的粒度均匀，密度均匀的球形颗粒，其制备方法和使用其的球形颗粒制剂。具体地说，本发明涉及一种 制备球形颗粒，其包括以下步骤：润湿包含一种或多种药物的粉末材料，并且具有1至100μm的平均粒度; 将湿粉末材料装入离心流化制粒装置中; 基于每分钟粉末材料的塑料极限，以低于3％的速率向湿粉末材料喷射液体。 同时旋转离心式流化造粒装置的旋转盘，直到粉末材料的液体含量基于粉末材料的塑料极限达到75〜120％，并干燥喷射产物得到球形颗粒; 平均粒径为100-1000μm的球形颗粒，其中至少90重量％的球形颗粒的总量具有最大晶粒尺寸不大于最小晶粒尺寸的1.2倍的粒度分布 ，各球形颗粒之间的密度差小于0.05g / cm 3; 和包含球形颗粒的球形颗粒制剂。

公开(公告)号：US5792507A

公开(公告)日：1998-08-11

申请号：US788588

申请日：1997-01-24

申请人： Hisayoshi Kato ,  Nagayoshi Myo

发明人： Hisayoshi Kato ,  Nagayoshi Myo

IPC分类号： C07H3/04 ,  A61K9/16 ,  A61K9/50 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  B01J2/00 ,  B01J2/14 ,  C13K5/00 ,  B05D1/38 ,  B05D1/02 ,  B05D1/40

CPC分类号： C13K5/00 ,  A61K9/1676 ,  A61K9/5078

摘要： To provide spherical particles made substantially from lactose and having high surface smoothness with low abrasiveness, and a process for their production. A process for producing spherical particles containing at least 95 wt % lactose, characterized by comprising a step of producing lactose spherical particles by charging crystalline lactose and/or lactose granules onto a rotary disk in the treatment vessel of a centrifugal tumbling apparatus, dispersing powdered lactose to the lactose granules and/or crystalline lactose as the rotary disk is rotated while providing slit air into the vessel, while also spraying water, an aqueous lactose solution or a dilute aqueous solution of a water-soluble polymer, and a fixation treatment step of drying the obtained spherical particles in a fluidized bed apparatus while spraying an aqueous lactose solution and/or a dilute solution of a water-soluble polymer.

摘要翻译： 提供基本上由乳糖制备并具有高磨损性的高表面平滑度的球形颗粒及其生产方法。 一种生产含有至少95重量％乳糖的球形颗粒的方法，其特征在于包括通过将结晶乳糖和/或乳糖颗粒装入离心翻转装置的处理容器中的旋转盘上产生乳糖球形颗粒的步骤，将粉末状乳糖 在旋转盘旋转同时向容器中提供狭缝空气的同时还喷洒水，乳糖水溶液或水溶性聚合物的稀水溶液的乳糖颗粒和/或结晶乳糖，以及固定处理步骤 在流化床设备中干燥得到的球形颗粒，同时喷洒乳糖水溶液和/或水溶性聚合物的稀溶液。

公开(公告)号：US5618562A

公开(公告)日：1997-04-08

申请号：US544061

申请日：1995-10-17

申请人： Hiroshi Saito ,  Toshio Mikami ,  Nagayoshi Myo

发明人： Hiroshi Saito ,  Toshio Mikami ,  Nagayoshi Myo

IPC分类号： A23L1/00 ,  A23P1/02 ,  A23P1/04 ,  A61K9/16 ,  A61K9/50 ,  A61K9/52 ,  B01J2/14 ,  B01J2/16 ,  B01J2/28 ,  C13K5/00 ,  A61K9/14

CPC分类号： A61K9/1676 ,  A23P10/22 ,  A23P10/28 ,  A23P10/30 ,  A61K9/5078 ,  B01J2/16 ,  C13K5/00

摘要： The spherical granules useful as a precipient for medicines and foods, and a production method thereof. A spherical granule comprises 95% by weight or more of lactose, and has a long diameter/short diameter ratio of 1.2 or less, and, when aggregated, a bulk density of 0.7 g/ml or more and an angle of repose of 35.degree. or less. The spherical granule is produced by feeding lactose particles into a granulating and coating apparatus equipped with a horizontal rotary disk having a smooth surface to contact with the granules, and by spraying lactose solution while the above-mentioned rotary disk is rotated.

摘要翻译： 用作药物和食品的沉淀物的球形颗粒及其制备方法。 球形颗粒包含95重量％以上的乳糖，长直径/短径比为1.2以下，聚集时的堆积密度为0.7g / ml以上，休止角为35° 或更少。 球形颗粒通过将乳糖颗粒喂入配备有具有光滑表面的水平旋转盘与颗粒接触并在旋转上述旋转盘的同时喷洒乳糖溶液的造粒和涂布设备来制备。

公开(公告)号：US06745960B1

公开(公告)日：2004-06-08

申请号：US10009299

申请日：2001-12-04

申请人： Nagayoshi Myo ,  Akira Iwasaki ,  Hiroshi Okada ,  Kuniaki Yamanaka ,  Koji Nagaoka ,  Mamoru Shiratori

发明人： Nagayoshi Myo ,  Akira Iwasaki ,  Hiroshi Okada ,  Kuniaki Yamanaka ,  Koji Nagaoka ,  Mamoru Shiratori

IPC分类号： B02C2324

CPC分类号： C04B41/009 ,  B01J2/14 ,  C04B41/52 ,  F27D1/0009 ,  F27D1/1652 ,  C04B41/4539 ,  C04B41/5031 ,  C04B41/5035 ,  C04B41/4527 ,  C04B41/5029 ,  C04B41/522 ,  C04B14/4625 ,  C04B30/02 ,  C04B14/4631

摘要： A centrifugal tumbling granulating apparatus 1 comprises a fixed wall 7 having a grain contact portion 7a which is in contact with powder grains 2 and of which a horizontal section is formed in a circular shape, and a rotating disk 5 provided a clearance 12 away from an inner side of the fixed wall 7 and rotating in a horizontal direction by a motor 13, wherein an air supply device 21 for supplying drying air 22 to an upper surface side of the rotating disk 5 is provided above the rotating disk 5. The air supply device 21 has a cylindrical straight tube portion 25, and an air supply port 23 formed in a cone shape, and is disposed in a centrifugal tumbling chamber 6 to be movable in an up-and-down direction. During a granulating step, the air supply device 21 stops to supply the dry air 22 and waits at an upper position H. After the granulation processing, the air supply device is lowered at a lower position L and supplies the dry air 22 onto the rotating disk 5 to dry granulated substances. As a result, the granulating apparatus capable of efficiently obtaining, in a single apparatus, spherical particles of which each particle size is small and which exist within a narrow range of particle size distribution and of which deviation from spherical form is small is provided.

摘要翻译： 离心式翻滚造粒装置1包括固定壁7，该固定壁7具有与粉末颗粒2接触并且水平部分形成为圆形的颗粒接触部分7a，以及设置有远离 固定壁7的内侧并通过马达13在水平方向上旋转，其中，在旋转盘5的上方设置有用于将干燥空气22供给到旋转盘5的上表面侧的供气装置21。 装置21具有圆柱形直管部分25和形成为锥形的空气供给口23，并且设置在离心翻转室6中以能够沿上下方向移动。 在制粒步骤期间，空气供给装置21停止供给干燥空气22并在上部位置H等待。在造粒处理之后，供气装置在下部位置L下降，并将干燥空气22供给到旋转 盘5干燥造粒物质。 结果，能够在单个装置中有效地获得颗粒尺寸小的并且存在于窄的粒度分布范围内并且与球形的偏离小的球形颗粒的造粒装置。

公开(公告)号：US06274174B1

公开(公告)日：2001-08-14

申请号：US09341052

申请日：1999-06-30

申请人： Takeshi Hom-ma ,  Nagayoshi Myo ,  Takaya Sato ,  Hironobu Nanbu

发明人： Takeshi Hom-ma ,  Nagayoshi Myo ,  Takaya Sato ,  Hironobu Nanbu

IPC分类号： A61K926

CPC分类号： C08L5/04 ,  A61K9/146 ,  A61K9/1652 ,  C08B37/0084

摘要： The present inventors have made studies for the purpose of establishing a process for preparing controlled-release preparations which can rapidly release 99% or more of a slightly soluble medicament (which has by itself shows a slow dissolution rate) in the upper part of the small intestine. As a result, the inventors have succeeded in establishing a process comprising carrying a slightly soluble medicament which has a slow intestinal dissolution rate on aggregates of the spherical microparticles of a multivalent metal alginate, in which each of the secondary particles (i.e., the aggregates) has a specific surface area ranging from 1 to 280 m2/g. This success leads to the accomplishment of the present invention.

摘要翻译： 本发明人为了建立控制释放制剂的方法进行了研究，所述控释制剂可以在小部分的上部快速释放99％以上的微溶药物（其本身显示缓慢的溶解速度） 肠。 结果，本发明人成功地建立了一种方法，其包括携带微溶性药物，其在多价金属藻酸盐的球形微粒的聚集体上具有缓慢的肠溶解速率，其中每个次级颗粒（即聚集体） 具有1至280m 2 / g的比表面积。 这成功地实现了本发明的完成。

公开(公告)号：US5507871A

公开(公告)日：1996-04-16

申请号：US201553

申请日：1994-02-24

申请人： Jiro Morino ,  Nagayoshi Myo ,  Kaoru Kurita ,  Isaku Shichijo

发明人： Jiro Morino ,  Nagayoshi Myo ,  Kaoru Kurita ,  Isaku Shichijo

IPC分类号： B01J2/00 ,  B01J2/14 ,  B01J2/16 ,  G05D5/06 ,  B05C11/00

CPC分类号： B01J2/14 ,  B01J2/003 ,  B01J2/16 ,  G05D5/06

摘要： An apparatus for granulation and coating, wherein a rotary disk 2 provided at a bottom portion of a granulating vessel 1 is rotated for particles to centrifugally tumble on the rotary disk 2, while a powder material and a binder liquid are supplied into the granulating vessel 1. A position of a surface of a particle layer M in the granulating vessel 1 is detected by a sensor 18, to automatically adjust a position of a binder liquid supply port of a spray nozzle 13 in accordance with the detection signal informing of a change in the surface of the particle layer M.

摘要翻译： 一种造粒和涂布装置，其中设置在造粒容器1的底部的旋转盘2旋转以使颗粒在旋转盘2上离心滚筒，同时将粉末材料和粘合剂液体供应到造粒容器1中 通过传感器18检测造粒容器1中的颗粒层M的表面的位置，根据检测信号自动调整喷嘴13的粘合剂液体供给口的位置， 颗粒层M的表面。

公开(公告)号：US4592302A

公开(公告)日：1986-06-03

申请号：US669264

申请日：1984-11-07

申请人： Shimesu Motoyama ,  Shizuka Sakashita ,  Nagayoshi Myo ,  Hirotsune Yasumi ,  Hiroaki Ogishima

发明人： Shimesu Motoyama ,  Shizuka Sakashita ,  Nagayoshi Myo ,  Hirotsune Yasumi ,  Hiroaki Ogishima

IPC分类号： B01J2/00 ,  B05B7/00

CPC分类号： B01J2/006

摘要： Coating method and apparatus, in which jet streams of a high-pressure fluid are ejected in the opposed directions into a pulverization zone in a pulverizer to hit a raw material conveyed by one of the jet streams on the other and thereby pulverize the same, the surfaces of particles of the resultant raw material are coated at the same time that the pulverization is done. The raw material to be pulverized is fed into the pulverization zone with a jet stream or by a mechanical means to be then accelerated by a jet stream therein. A coating material is fed in the same direction in which a jet stream flows, or directly into the pulverization zone.

摘要翻译： 喷射方法和装置，其中将高压流体的喷射流沿相反的方向喷射到粉碎机中的粉碎区域中，以将由一个喷射流输送的原料撞击在另一个上，从而将其粉碎， 在进行粉碎的同时涂布所得原料的颗粒的表面。 待粉碎的原料用喷射流或机械装置送入粉碎区，然后通过喷射流加速。 涂料以与喷射流流动相同的方向进料，或直接进入粉碎区。