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公开(公告)号：US20170145365A1
公开(公告)日：2017-05-25
申请号：US15319905
申请日：2014-07-29
Applicant: Hitachi, Ltd.
Inventor： Takayuki NOZAKI , Masaharu KIYAMA , Masakazu SUGAYA , Guangbin ZHOU , Taku NAKAMURA , Daisuke SUZUKI , Shizu TAKEDA , Yumiko IGARASHI , Koichi TERADA
Abstract: A culture which maintains an aseptic state at the time of culturing is achieved, the avoidance of damage to a closed-system culture vessel and of an influence to the cells due to impacts and oscillation is possible during transportation after being manufactured. The closed-system culture vessel 101 has culture vessels 201, 202 for maintaining the cells and/or the culture medium, and a culturing space which is closed by holding members 203, 204 for holding the culture vessels, and the holding member has a semi-open cavity 221 independent of the culturing space. Further, the holding member, by being provided with a lid fixing ring 220 surrounding a connector part 214, is not damaged even when impacts are applied during transportation.
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公开(公告)号：US20180362915A1
公开(公告)日：2018-12-20
申请号：US15896947
申请日：2018-02-14
Applicant: HITACHI, LTD.
Inventor： Hikaru SAITO , Masaharu KIYAMA , Midori KATO , Kunio OHYAMA , Guangbin ZHOU , Hiroko HANZAWA , Shizu TAKEDA
Abstract: A liquid delivery device includes a first and second container for a first and second liquid; a third container for receiving a first and second liquid; a fourth container into which a first and second liquid are discharged; a fifth container for a third liquid; a first liquid delivery tube for delivering a first liquid; a second liquid delivery tube for delivering a second liquid; a third liquid delivery tube connected to the first and second liquid delivery tube; a first liquid delivery pump on the third liquid delivery tube; a fourth liquid delivery tube for discharging a first liquid contained in the third container and delivering a third liquid to the third container; a fifth liquid delivery tube connected to the fourth liquid delivery tube; a sixth liquid delivery tube connected to the fourth liquid delivery tube; and a second liquid delivery pump on the fourth liquid delivery tube.
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公开(公告)号：US20220340847A1
公开(公告)日：2022-10-27
申请号：US17721233
申请日：2022-04-14
Applicant: Hitachi, Ltd.
Inventor： Takayuki NOZAKI , Kunio OHYAMA , Masaharu KIYAMA , Kakuro HIRAI
Abstract: The present invention relates to an automatic culture device using a single-use closed system flow path for culturing a cell or a tissue, and realizes reduction in manufacturing cost and high integration property of a device. A cell culture system including an automatic culture device and an information processing device. The automatic culture device includes a plurality of types of closed system flow paths possible to be installed and removed, and a plurality of culture devices. The information processing device includes: an input device configured to receive, as an input, at least one piece of data selected from a group consisting of data of an identifier of a patient, data related to a transplantation method, data related to a type of cell, data related to the required number of cells, and data related to a treatment plan; an arithmetic device configured to select, based on the input data, from options of a cell culture method, the culture devices, and the closed system flow paths, the cell culture method, the culture device, and the closed system flow path to be used; and an output device configured to output a number of the closed system flow path to be used and a number of the culture device to be used.
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公开(公告)号：US20210301248A1
公开(公告)日：2021-09-30
申请号：US16951244
申请日：2020-11-18
Applicant: Hitachi, Ltd.
Inventor： Hikaru SAITO , Midori KATO , Kakuro HIRAI , Masaharu KIYAMA , Kunio OHYAMA , Hiroko HANZAWA , Shizu TAKEDA
Abstract: Provided are an evaluator including an analysis unit that evaluates a differentiation level of a cultured cell on the basis of a content of a component in a culture supernatant of the cultured cell, and an automatic cell culture system including the evaluator and an automatic culture device.
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公开(公告)号：US20160017271A1
公开(公告)日：2016-01-21
申请号：US14770627
申请日：2013-03-25
Applicant: HITACHI, LTD.
Inventor： Takayuki NOZAKI , Guangbin ZHOU , Masaharu KIYAMA , Taku NAKAMURA , Shizu TAKEDA , Ryota NAKAJIMA , Masakazu SUGAYA , Koichi TERADA
Abstract: In culture vessels for producing biological samples, it is possible to prevent decrease in a temperature at the time of taking out the culture vessels from an automatic culture apparatus and during delivery of the culture vessels which have been taken out from the automatic culture apparatus. This invention includes a culture vessel 201 holding a biological sample therein, a heat storage portion 701 holding the culture vessel, and a heat insulation portion 601 surrounding the heat storage portion. The whole circumference or a part of 609, 610, and 611 of the heat insulation portion 601 is removable depending on an arrangement environment.
Abstract translation: 在用于制造生物样品的培养容器中，可以防止从自动培养装置取出培养容器时的温度降低，以及从自动培养装置取出的培养容器的输送期间的温度降低。 本发明包括保存生物样品的培养容器201，保持培养容器的储热部701和围绕蓄热部的隔热部601。 隔热部分601的整个圆周或609,610和611的一部分可根据排列环境而被去除。
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Patent Agency Ranking
公开(公告)号：US20210009935A1
公开(公告)日：2021-01-14
申请号：US16924955
申请日：2020-07-09
Applicant: Hitachi, Ltd.
Inventor： Hikaru SAITO , Kakuro HIRAI , Midori KATO , Masaharu KIYAMA , Kunio OHYAMA , Hiroko HANZAWA , Shizu TAKEDA
IPC: C12M1/34 , G01N33/543 , C12M1/36
Abstract: An object of the invention is to provide a cell culture monitoring device capable of monitoring the number of cells during culture and a cell culture system. The cell culture monitoring device for monitoring proliferation of cells includes: a detection unit configured to detect particles of exosomes in culture supernatant; and an analysis unit configured to calculate the number of cells based on an obtained detection result. The cell culture system includes the cell culture monitoring device and an automatic culture device.
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公开(公告)号：US20190300837A1
公开(公告)日：2019-10-03
申请号：US16316908
申请日：2017-02-24
Applicant: Hitachi, Ltd.
Inventor： Masaharu KIYAMA , Guangbin ZHOU , Daisuke SUZUKI , Midori KATO , Hikaru SAITO
Abstract: A liquid feed device that feeds a liquid medium and a cell suspension to target containers by respectively suited liquid feed methods is provided. A pump 6 is connected between a first liquid bottle 12 containing a liquid medium and a second liquid bottle 2 containing a cell suspension, and a receptacle 8 to be used as a culture container is connected downstream of a second liquid bottle 12. The liquid medium in the first liquid bottle is sent to the receptacle through the pump 6 and a branch point 20 by opening a first supply valve 17, and the cell suspension in the second liquid bottle is sent to the receptacle by opening a first gas introducing valve 10, a second gas introducing valve 15, and a second supply valve 19 and transferring, by pressure, a gas supplied from the first gas introducing valve 10 to the second liquid bottle through the pump 6 and a branch point 16.
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8.发明申请公开(公告)号：US20180171278A1
公开(公告)日：2018-06-21
申请号：US15575940
申请日：2016-05-09
Applicant: Hitachi, Ltd.
Inventor： Masaharu KIYAMA , Midori KATO , Shuhei HASHIBA , Yumiko IGARASHI
CPC classification number: C12M27/00 , B01L3/00 , B01L2400/0605 , B01L2400/0666 , C12M1/00 , C12M23/06 , C12M23/36 , C12M29/00 , C12M41/00 , C12M41/40
Abstract: The present invention is directed to provide cell concentration devices and cell concentration systems having a novel liquid flow-circulation chamber. It is a cell concentration device including a liquid flow-circulation chamber, the liquid flow-circulation chamber having a first tube and a second tube, the first tube and the second tube being connected with each other via a liquid delivery tube outside the liquid flow-circulation chamber, the liquid delivery tube including a liquid delivery pump and a cell concentration module, the liquid delivery pump being capable of feeding a liquid through the liquid delivery pump in both directions, the first tube and the second tube each having an open end in a liquid in the liquid flow-circulation chamber, the first tube having an opening in a gas in the liquid flow-circulation chamber, and the liquid being a suspension of cells.
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公开(公告)号：US20170355941A1
公开(公告)日：2017-12-14
申请号：US15536668
申请日：2015-01-30
Applicant: Hitachi, Ltd.
Inventor： Guangbin ZHOU , Masaharu KIYAMA , Yumiko IGARASHI
CPC classification number: C12M3/04 , C12M1/005 , C12M1/09 , C12M1/38 , C12M3/02 , C12M23/10 , C12M23/38 , C12M23/56 , C12M41/12 , C12M41/14 , C12M41/46 , G01B11/06 , G01N21/41
Abstract: The present invention provides a culture vessel and a measuring device for measuring a cell sheet thickness nondestructively during culturing. A culture vessel having a lid 4 has a float 8 installed in the interior and the float is structured so as to be uplifted by a culture medium in the culture vessel. Further, a cell sheet thickness measuring device having a sensor head 10 having a light-emitting element 10A and a light-receiving element 10B to detect a positional variation of the float in the vertical direction and a controller 11 to process a signal of the sensor head is configured.
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公开(公告)号：US20170198249A1
公开(公告)日：2017-07-13
申请号：US15323977
申请日：2014-07-23
Applicant: Hitachi, Ltd.
Inventor： Masaharu KIYAMA , Guangbin ZHOU , Takayuki NOZAKI , Ryota NAKAJIMA , Daisuke SUZUKI , Yumiko IGARASHI , Shizu TAKEDA , Taku NAKAMURA , Masakazu SUGAYA , Koichi TERADA
CPC classification number: C12M41/40 , C12M23/14 , C12M23/40 , C12M29/00 , C12M29/14 , C12M29/26 , C12M41/48
Abstract: There is the problem that a liquid culture medium fed by a pump has a high frequency of contact with a gas during movement in a tube, and the pH value of the liquid culture medium before and after feeding changes easily. In a liquid feeder and a cell culture apparatus provided therewith, a feed pipe 7 is connected with a gas bag 14, the liquid to be fed into the feed pipe 7 is fed so as to be sandwiched by a gas for suppressing the qualitative changes of the liquid. Furthermore, the gas bag is connected with a container 8 for holding a liquid, and holds the gas for suppressing qualitative changes of the liquid in a gas phase of the container.
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