摘要:
DC107 derivatives represented by formula (I) or pharmaceutically acceptable salts thereof which have antimicrobial activity and antitumor activity are provided: ##STR1## wherein R.sup.1 represents hydrogen, lower alkoxyalkyl, aralkyloxyalkyl, lower alkoxyalkoxyalkyl, lower alkoxyalkoxyalkoxyalkyl, aralkyl, tetrahydropyranyl, COR.sup.4, or the like; R.sup.2 represents hydrogen or COR.sup.6 ; R.sup.3 represents --CH.sub.2 OCOR.sup.7, phthalimidomethyl, or the like; and W represents oxygen or NR.sup.8 (wherein R.sup.8 represents hydroxy, lower alkoxy, lower alkenyloxy, aralkyloxy, substituted or unsubstituted arylsulfonylamino, or lower alkoxycarbonylamino).
摘要:
DC107 derivatives represented by formula (I) or pharmaceutically acceptable salts thereof which have antimicrobial activity and antitumor activity are provided: ##STR1## wherein R.sup.1 represents CO(CR.sup.4A R.sup.4B).sub.n1 (O(CH.sub.2).sub.p1).sub.n2 OR.sup.5 {wherein n1 represents an integer of 1 or 2; R.sup.4A and R.sup.4B are the same or different, and each represents hydrogen or lower alkyl; p1 and n2 each represents an integer of 1 to 10; and R.sup.5 represents hydrogen, lower alkyl, or the like), or ##STR2##
摘要:
Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are novel methods for assaying or screening for inhibitors of telomerase activity.
摘要:
Provided is a lithium-ion secondary battery that uses a non-carbonaceous negative electrode active material capable of exhibiting capacitance properties. The lithium-ion secondary battery includes a positive electrode, a negative electrode, and a non-aqueous electrolyte solution. The negative electrode includes a mica group mineral having at least one transition metal in its composition as a negative electrode active material.
摘要:
An objective of the present invention is to provide a cefditoren pivoxil pharmaceutical preparation which can safely be administered to a patient and not only improves wettability of cefditoren pivoxil, but also further improves absorbability through the intestinal tracts by maintaining amorphous particles having a high oral absorbability in a liquid for a long period of time. The present invention is a pharmaceutical composition comprising amorphous cefditoren pivoxil and a sucrose fatty acid ester, which is obtainable by mixing or wet-granulating particles containing amorphous cefditoren pivoxil with the sucrose fatty acid ester while amorphous cefditoren pivoxil maintains its particle state.
摘要:
An object of the invention is to provide an application method capable of facilitating the application of the soft contact lens without using any instrument, a liquid for contact lenses capable of being used for the application method, and a soft contact lens package. The present invention is a method for applying a soft contact lens, including a shrinkage step of shrinking a soft contact lens by contacting the soft contact lens with a liquid for contact lenses, the liquid for contact lenses being capable of shrinking the soft contact lens to a state of being more intensively shrunken than an equilibrium state thereof in a physiological saline; and an application step of applying the shrunken soft contact lens to the eye, in which after the application step, the size of the soft contact lens is restored.
摘要:
Assuming that N1 and N2 are the respective numbers of pinion rollers (23, 63); ρ1 is the ratio between the inner diameter of a ring roller (22) and the outer diameter of a sun roller (21); and ρ2 is the ratio between the inner diameter of a ring roller (62) and the outer diameter of a sun roller (61); and it holds that N1=3, and (ρ11)×(p21)≧24+16×20.5, in the case where N2=3, then it holds that ρ1≧0.102×(ρ1+1)×(ρ2+1)+1.196, and ρ1≦min[0.204×(ρ1+1)×(ρ2+1)+3.123, 7+4×30.5], and in the case where N2=4, then it holds that ρ1≧(2−20.5)×(ρ1+1)×(p2+1)/4−1, and ρ1≦min [0.185×(ρ1+1)×(ρ2+1)+1.320, 7+4×30.5].
摘要:
A virtual machine managing method includes: a dependence relation list generation step of detecting a dependence relation among virtual machines implemented on a physical machine and generating a dependence relation list, based on a detection result; a target management table generation step of reading, when a selection instruction for selecting a target virtual machine to be halted among the plurality of implemented virtual machines is detected; and a halted target presentation step of reading the virtual machine identification information on all of the virtual machines in dependence relation with the target virtual machine to be halted, and visually presenting the read virtual machine identification information on all of the target virtual machines to be halted.
摘要:
A secondary battery capable of improving the cycle characteristics is provided. The secondary battery includes a cathode and an anode oppositely arranged with a separator in between, and an electrolytic solution. At least one of the cathode, the anode, the separator, and the electrolytic solution contains a sulfone compound having a carbonate group and a sulfonyl group.
摘要:
A battery capable of obtaining the high energy density and obtaining the superior cycle characteristics is provided. In an anode, the thickness of a single face of an anode active material layer containing a carbon material as an anode active material is from 75 μm to 120 μm. An electrolytic solution contains difluoroethylene carbonate as a solvent. Thereby, the energy density of the anode is improved, and the diffusion and the acceptance of lithium ions in the anode are improved.