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公开(公告)号：US20080226674A1
公开(公告)日：2008-09-18
申请号：US10594443
申请日：2005-03-31
IPC分类号： A61K39/21 , A61K39/12 , A61K39/275 , A61K39/245 , A61K39/235 , A61P37/04 , A61P35/00
CPC分类号： A61K39/0011 , A61K9/5184 , A61K31/24 , A61K31/282 , A61K31/704 , A61K31/7064 , A61K2039/55561 , A61K2039/55572 , A61K2039/585 , A61K2039/6006 , C12N2760/18842
摘要： The present invention is intended to provide a pharmaceutical composition for delivering a chemotherapeutic, preferably an anticancer drug, into cells or into a living organism, using a viral envelope vector, and provides a pharmaceutical composition comprising a chemotherapeutic encapsulated in, or used in combination with, a viral envelope vector having an adjuvanticity as an active ingredient. Thereby it is possible to introduce an anticancer drug encapsulated in a viral envelope vector directly into a tumor, with coadministration of another anticancer drug so as to induce tumor cell-specific antitumor immunity also thanks to the adjuvant action of HVJ-E, and hence to regress the tumor. The present invention also provides a pharmaceutical composition comprising a viral envelope vector and a chemotherapeutic as active ingredients.
摘要翻译： 本发明旨在提供一种药物组合物，其用于使用病毒包膜载体将化疗药物，优选抗癌药物递送至细胞或生物体内，并提供药物组合物，所述药物组合物包含化学治疗剂包封或与 ，具有佐剂性作为活性成分的病毒包膜载体。 因此，通过共同施用另一种抗癌药物，可以将包封在病毒包膜载体中的抗癌药物直接引入肿瘤中，以便通过HVJ-E的辅助作用诱导肿瘤细胞特异性抗肿瘤免疫，因此可以 回归肿瘤。 本发明还提供了包含病毒包膜载体和作为活性成分的化学治疗剂的药物组合物。
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公开(公告)号：US07871765B2
公开(公告)日：2011-01-18
申请号：US10594443
申请日：2005-03-31
IPC分类号： C12Q1/70
CPC分类号： A61K39/0011 , A61K9/5184 , A61K31/24 , A61K31/282 , A61K31/704 , A61K31/7064 , A61K2039/55561 , A61K2039/55572 , A61K2039/585 , A61K2039/6006 , C12N2760/18842
摘要： The present invention is intended to provide a pharmaceutical composition for delivering a chemotherapeutic, preferably an anticancer drug, into cells or into a living organism, using a viral envelope vector, and provides a pharmaceutical composition comprising a chemotherapeutic encapsulated in, or used in combination with, a viral envelope vector having an adjuvanticity as an active ingredient. Thereby it is possible to introduce an anticancer drug encapsulated in a viral envelope vector directly into a tumor, with coadministration of another anticancer drug so as to induce tumor cell-specific antitumor immunity also thanks to the adjuvant action of HVJ-E, and hence to regress the tumor. The present invention also provides a pharmaceutical composition comprising a viral envelope vector and a chemotherapeutic as active ingredients.
摘要翻译： 本发明旨在提供一种药物组合物，其用于使用病毒包膜载体将化疗药物，优选抗癌药物递送至细胞或生物体内，并提供药物组合物，所述药物组合物包含化学治疗剂包封或与 ，具有佐剂性作为活性成分的病毒包膜载体。 因此，通过共同施用另一种抗癌药物，可以将包封在病毒包膜载体中的抗癌药物直接引入肿瘤中，以便通过HVJ-E的辅助作用诱导肿瘤细胞特异性抗肿瘤免疫，因此可以 回归肿瘤。 本发明还提供了包含病毒包膜载体和作为活性成分的化学治疗剂的药物组合物。
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3.发明授权Method of treating skin ulcers with vectors encoding hepatocyte growth factor 有权用编码肝细胞生长因子的载体治疗皮肤溃疡的方法公开(公告)号：US07939504B2
公开(公告)日：2011-05-10
申请号：US11763361
申请日：2007-06-14
CPC分类号： A61K38/1709 , A61K38/1825 , A61K38/1833 , A61K38/1866 , A61K48/005
摘要： The present invention relates to a therapeutic preventive agent that includes an angiogenic factor gene (such as hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), fibroblast growth f actor (FGF), and hypoxia inducible factor (HIF)) as its active ingredient, and the administration of such an agent into the targeted skin diseases-affected area.
摘要翻译： 本发明涉及包含血管生成因子基因（例如肝细胞生长因子（HGF），血管内皮生长因子（VEGF），成纤维细胞生长因子（FGF）和缺氧诱导因子（HIF））的治疗性预防药物 其活性成分，以及将这种药物施用于目标皮肤疾病影响区域。
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4.发明申请METHOD OF TREATING SKIN WOUNDS WITH VECTORS ENCODING HEPATOCYTE GROWTH FACTOR 有权用编码肝细胞生长因子的向量处理皮肤伤口的方法公开(公告)号：US20070264321A1
公开(公告)日：2007-11-15
申请号：US11763361
申请日：2007-06-14
IPC分类号： A61K31/711 , A61K9/127 , A61P17/02 , C12N15/63
CPC分类号： A61K38/1709 , A61K38/1825 , A61K38/1833 , A61K38/1866 , A61K48/005
摘要： The present invention relates to a therapeutic preventive agent that includes an angiogenic factor gene (such as hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), fibroblast growth f actor (FGF), and hypoxia inducible factor (HIF)) as its active ingredient, and the administration of such an agent into the targeted skin diseases-affected area.
摘要翻译： 本发明涉及包含血管生成因子基因（例如肝细胞生长因子（HGF），血管内皮生长因子（VEGF），成纤维细胞生长因子（FGF）和缺氧诱导因子（HIF））的治疗性预防药物 其活性成分，以及将这种药物施用于目标皮肤疾病影响区域。
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5.发明授权Method of treating skin wounds with vectors encoding hepatocyte growth factor 有权用编码肝细胞生长因子的载体处理皮肤伤口的方法公开(公告)号：US07247620B2
公开(公告)日：2007-07-24
申请号：US10477166
申请日：2002-05-09
CPC分类号： A61K38/1709 , A61K38/1825 , A61K38/1833 , A61K38/1866 , A61K48/005
摘要： The present invention relates to a therapeutic preventive agent that includes an angiogenic factor gene (such as hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and hypoxia inducible factor (HIF)) as its active ingredient, and the administration of such an agent into the targeted skin diseases-affected area.
摘要翻译： 本发明涉及包含血管生成因子基因（如肝细胞生长因子（HGF），血管内皮生长因子（VEGF）），成纤维细胞生长因子（FGF）和缺氧诱导因子（HIF））的治疗性预防药物 活性成分，以及将这种药剂施用于目标皮肤疾病影响区域。
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公开(公告)号：US20060165656A1
公开(公告)日：2006-07-27
申请号：US10530473
申请日：2003-10-29
申请人： Seiji Yamamoto , Hitoshi Kotani , Yasufumi Kaneda
发明人： Seiji Yamamoto , Hitoshi Kotani , Yasufumi Kaneda
IPC分类号： A61K48/00 , A61K38/14 , A61K38/08 , A61K31/704 , A61K31/4745 , A61K31/7072 , A61K31/337
CPC分类号： A61K9/5184
摘要： An apparatus and a method of remote control which can enable real time operation of a device in home from a terminal device at remote location through a network are provided. A first server communicates with a terminal device through the Internet and generates device control data for controlling the device. A second server communicates with the device in a predetermined manner to acquire and store a specific address of the device, generates transmission data for transmission of the received device control data from the first server to the device based on the specific address, and transmits the transmission data to the device. This allows real time control of the device from the terminal device through the network to be realized.
摘要翻译： 提供一种远程控制的装置和方法，其能够通过网络在远程位置从终端设备实现设备在家中的实时操作。 第一服务器通过因特网与终端设备通信，并产生用于控制设备的设备控制数据。 第二服务器以预定的方式与设备通信以获取和存储设备的特定地址，基于特定地址生成用于将接收到的设备控制数据从第一服务器发送到设备的传输数据，并且发送传输 数据到设备。 这允许通过网络实现来自终端设备的设备的实时控制。
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公开(公告)号：US07427395B2
公开(公告)日：2008-09-23
申请号：US10530473
申请日：2003-10-29
申请人： Seiji Yamamoto , Hitoshi Kotani , Yasufumi Kaneda
发明人： Seiji Yamamoto , Hitoshi Kotani , Yasufumi Kaneda
IPC分类号： A61K48/00
CPC分类号： A61K9/5184
摘要： An apparatus and a method of remote control which can enable real time operation of a device in home from a terminal device at remote location through a network are provided. A first server communicates with a terminal device through the Internet and generates device control data for controlling the device. A second server communicates with the device in a predetermined manner to acquire and store a specific address of the device, generates transmission data for transmission of the received device control data from the first server to the device based on the specific address, and transmits the transmission data to the device. This allows real time control of the device from the terminal device through the network to be realized.
摘要翻译： 提供一种远程控制的装置和方法，其能够通过网络在远程位置从终端设备实现设备在家中的实时操作。 第一服务器通过因特网与终端设备通信，并产生用于控制设备的设备控制数据。 第二服务器以预定的方式与设备通信以获取和存储设备的特定地址，基于特定地址生成用于将接收到的设备控制数据从第一服务器发送到设备的传输数据，并且发送传输 数据到设备。 这允许通过网络实现来自终端设备的设备的实时控制。
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公开(公告)号：US09919010B2
公开(公告)日：2018-03-20
申请号：US12990086
申请日：2009-04-30
IPC分类号： A61K35/28 , C12N5/0775 , A61K35/12
CPC分类号： A61K35/28 , A61K2035/124 , C12N5/0663
摘要： Biologically low invasive vessels are filled with biological factors that have the activity of mobilizing specific functional cells in the body. The vessels are indwelled in the body. After specific functional cells are mobilized into the vessels, the vessels are removed from the body to collect functional cell populations mobilized to the vessels. Alternatively, the cells are directly collected from the vessels indwelled in the body.
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公开(公告)号：US09012417B2
公开(公告)日：2015-04-21
申请号：US10468717
申请日：2002-02-06
IPC分类号： A61K48/00 , A61K31/711 , A61K38/17 , C12N15/113
CPC分类号： A61K31/711 , A61K38/1709 , C12N15/113 , C12N2310/13
摘要： A pharmaceutical composition for performing treatment against a skin disease, the pharmaceutical composition comprising at least one decoy and a pharmaceutically acceptable carrier. The at least one decoy may be selected from the group consisting of an NF-κB decoy, a STAT-1 decoy, a GATA-3 decoy, a STAT-6 decoy, an AP-1 decoy and an Ets decoy. The at least one decoy may be an oligonucleotide including at least two decoys bonded to each other, the at least two decoys being selected from the group consisting of an NF-κB decoy, a STAT-1 decoy, a GATA-3 decoy, a STAT-6 decoy, an AP-1 decoy and an Ets decoy. The skin disease may be atopic dermatitis, psoriasis vulgaris, contact dermatitis, keloid, bedsore, ulcerative colitis, or Crohn's disease.
摘要翻译： 一种用于对皮肤病进行治疗的药物组合物，所述药物组合物包含至少一种诱饵和药学上可接受的载体。 所述至少一个诱饵可以选自NF-和kgr B诱饵，STAT-1诱饵，GATA-3诱饵，STAT-6诱饵，AP-1诱饵和Ets诱饵。 所述至少一个诱饵可以是包含至少两个彼此键合的诱饵的寡核苷酸，所述至少两个诱饵选自由NF-和κB诱饵，STAT-1诱饵，GATA-3诱饵 ，STAT-6诱饵，AP-1诱饵和Ets诱饵。 皮肤病可能是特应性皮炎，寻常型牛皮癣，接触性皮炎，瘢痕疙瘩，褥疮，溃疡性结肠炎或克罗恩病。
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公开(公告)号：US08691212B2
公开(公告)日：2014-04-08
申请号：US13119148
申请日：2009-09-16
CPC分类号： C07K14/005 , A61K9/0019 , A61K9/19 , A61K31/76 , A61K35/768 , A61K45/06 , C12N2760/18833 , A61K2300/00
摘要： Provided are a novel therapeutic agent and therapeutic method for prostatic cancers. More specifically, a prostatic cancer therapeutic/prophylactic agent having a viral envelope vector, particularly a Sendai viral envelope vector, as an active ingredient, the therapeutic/prophylactic agent which is an apoptosis induction promoter, the therapeutic/prophylactic agent used for prostatic cancers whose androgen susceptibility has been partially or completely reduced, and a melanoma therapeutic/prophylactic agent containing a Sendai viral envelope vector as the only active ingredient, and the like are provided.
摘要翻译： 提供前列腺癌的新型治疗剂和治疗方法。 更具体地，具有病毒包膜载体，特别是仙台病毒包膜载体作为活性成分的前列腺癌治疗/预防剂，作为凋亡诱导启动子的治疗/预防剂，用于前列腺癌的治疗/预防剂，其用于前列腺癌 已经部分地或完全地降低了雄激素敏感性，并且提供了含有仙台病毒包膜载体作为唯一活性成分的黑素瘤治疗/预防剂等。
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