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公开(公告)号：US20060165656A1
公开(公告)日：2006-07-27
申请号：US10530473
申请日：2003-10-29
申请人： Seiji Yamamoto , Hitoshi Kotani , Yasufumi Kaneda
发明人： Seiji Yamamoto , Hitoshi Kotani , Yasufumi Kaneda
IPC分类号： A61K48/00 , A61K38/14 , A61K38/08 , A61K31/704 , A61K31/4745 , A61K31/7072 , A61K31/337
CPC分类号： A61K9/5184
摘要： An apparatus and a method of remote control which can enable real time operation of a device in home from a terminal device at remote location through a network are provided. A first server communicates with a terminal device through the Internet and generates device control data for controlling the device. A second server communicates with the device in a predetermined manner to acquire and store a specific address of the device, generates transmission data for transmission of the received device control data from the first server to the device based on the specific address, and transmits the transmission data to the device. This allows real time control of the device from the terminal device through the network to be realized.
摘要翻译： 提供一种远程控制的装置和方法，其能够通过网络在远程位置从终端设备实现设备在家中的实时操作。 第一服务器通过因特网与终端设备通信，并产生用于控制设备的设备控制数据。 第二服务器以预定的方式与设备通信以获取和存储设备的特定地址，基于特定地址生成用于将接收到的设备控制数据从第一服务器发送到设备的传输数据，并且发送传输 数据到设备。 这允许通过网络实现来自终端设备的设备的实时控制。
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公开(公告)号：US07427395B2
公开(公告)日：2008-09-23
申请号：US10530473
申请日：2003-10-29
申请人： Seiji Yamamoto , Hitoshi Kotani , Yasufumi Kaneda
发明人： Seiji Yamamoto , Hitoshi Kotani , Yasufumi Kaneda
IPC分类号： A61K48/00
CPC分类号： A61K9/5184
摘要： An apparatus and a method of remote control which can enable real time operation of a device in home from a terminal device at remote location through a network are provided. A first server communicates with a terminal device through the Internet and generates device control data for controlling the device. A second server communicates with the device in a predetermined manner to acquire and store a specific address of the device, generates transmission data for transmission of the received device control data from the first server to the device based on the specific address, and transmits the transmission data to the device. This allows real time control of the device from the terminal device through the network to be realized.
摘要翻译： 提供一种远程控制的装置和方法，其能够通过网络在远程位置从终端设备实现设备在家中的实时操作。 第一服务器通过因特网与终端设备通信，并产生用于控制设备的设备控制数据。 第二服务器以预定的方式与设备通信以获取和存储设备的特定地址，基于特定地址生成用于将接收到的设备控制数据从第一服务器发送到设备的传输数据，并且发送传输 数据到设备。 这允许通过网络实现来自终端设备的设备的实时控制。
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公开(公告)号：US07871765B2
公开(公告)日：2011-01-18
申请号：US10594443
申请日：2005-03-31
IPC分类号： C12Q1/70
CPC分类号： A61K39/0011 , A61K9/5184 , A61K31/24 , A61K31/282 , A61K31/704 , A61K31/7064 , A61K2039/55561 , A61K2039/55572 , A61K2039/585 , A61K2039/6006 , C12N2760/18842
摘要： The present invention is intended to provide a pharmaceutical composition for delivering a chemotherapeutic, preferably an anticancer drug, into cells or into a living organism, using a viral envelope vector, and provides a pharmaceutical composition comprising a chemotherapeutic encapsulated in, or used in combination with, a viral envelope vector having an adjuvanticity as an active ingredient. Thereby it is possible to introduce an anticancer drug encapsulated in a viral envelope vector directly into a tumor, with coadministration of another anticancer drug so as to induce tumor cell-specific antitumor immunity also thanks to the adjuvant action of HVJ-E, and hence to regress the tumor. The present invention also provides a pharmaceutical composition comprising a viral envelope vector and a chemotherapeutic as active ingredients.
摘要翻译： 本发明旨在提供一种药物组合物，其用于使用病毒包膜载体将化疗药物，优选抗癌药物递送至细胞或生物体内，并提供药物组合物，所述药物组合物包含化学治疗剂包封或与 ，具有佐剂性作为活性成分的病毒包膜载体。 因此，通过共同施用另一种抗癌药物，可以将包封在病毒包膜载体中的抗癌药物直接引入肿瘤中，以便通过HVJ-E的辅助作用诱导肿瘤细胞特异性抗肿瘤免疫，因此可以 回归肿瘤。 本发明还提供了包含病毒包膜载体和作为活性成分的化学治疗剂的药物组合物。
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4.发明授权Method of treating skin ulcers with vectors encoding hepatocyte growth factor 有权用编码肝细胞生长因子的载体治疗皮肤溃疡的方法公开(公告)号：US07939504B2
公开(公告)日：2011-05-10
申请号：US11763361
申请日：2007-06-14
CPC分类号： A61K38/1709 , A61K38/1825 , A61K38/1833 , A61K38/1866 , A61K48/005
摘要： The present invention relates to a therapeutic preventive agent that includes an angiogenic factor gene (such as hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), fibroblast growth f actor (FGF), and hypoxia inducible factor (HIF)) as its active ingredient, and the administration of such an agent into the targeted skin diseases-affected area.
摘要翻译： 本发明涉及包含血管生成因子基因（例如肝细胞生长因子（HGF），血管内皮生长因子（VEGF），成纤维细胞生长因子（FGF）和缺氧诱导因子（HIF））的治疗性预防药物 其活性成分，以及将这种药物施用于目标皮肤疾病影响区域。
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5.发明申请METHOD OF TREATING SKIN WOUNDS WITH VECTORS ENCODING HEPATOCYTE GROWTH FACTOR 有权用编码肝细胞生长因子的向量处理皮肤伤口的方法公开(公告)号：US20070264321A1
公开(公告)日：2007-11-15
申请号：US11763361
申请日：2007-06-14
IPC分类号： A61K31/711 , A61K9/127 , A61P17/02 , C12N15/63
CPC分类号： A61K38/1709 , A61K38/1825 , A61K38/1833 , A61K38/1866 , A61K48/005
摘要： The present invention relates to a therapeutic preventive agent that includes an angiogenic factor gene (such as hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), fibroblast growth f actor (FGF), and hypoxia inducible factor (HIF)) as its active ingredient, and the administration of such an agent into the targeted skin diseases-affected area.
摘要翻译： 本发明涉及包含血管生成因子基因（例如肝细胞生长因子（HGF），血管内皮生长因子（VEGF），成纤维细胞生长因子（FGF）和缺氧诱导因子（HIF））的治疗性预防药物 其活性成分，以及将这种药物施用于目标皮肤疾病影响区域。
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6.发明授权Method of treating skin wounds with vectors encoding hepatocyte growth factor 有权用编码肝细胞生长因子的载体处理皮肤伤口的方法公开(公告)号：US07247620B2
公开(公告)日：2007-07-24
申请号：US10477166
申请日：2002-05-09
CPC分类号： A61K38/1709 , A61K38/1825 , A61K38/1833 , A61K38/1866 , A61K48/005
摘要： The present invention relates to a therapeutic preventive agent that includes an angiogenic factor gene (such as hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), and hypoxia inducible factor (HIF)) as its active ingredient, and the administration of such an agent into the targeted skin diseases-affected area.
摘要翻译： 本发明涉及包含血管生成因子基因（如肝细胞生长因子（HGF），血管内皮生长因子（VEGF）），成纤维细胞生长因子（FGF）和缺氧诱导因子（HIF））的治疗性预防药物 活性成分，以及将这种药剂施用于目标皮肤疾病影响区域。
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公开(公告)号：US20080226674A1
公开(公告)日：2008-09-18
申请号：US10594443
申请日：2005-03-31
IPC分类号： A61K39/21 , A61K39/12 , A61K39/275 , A61K39/245 , A61K39/235 , A61P37/04 , A61P35/00
CPC分类号： A61K39/0011 , A61K9/5184 , A61K31/24 , A61K31/282 , A61K31/704 , A61K31/7064 , A61K2039/55561 , A61K2039/55572 , A61K2039/585 , A61K2039/6006 , C12N2760/18842
摘要： The present invention is intended to provide a pharmaceutical composition for delivering a chemotherapeutic, preferably an anticancer drug, into cells or into a living organism, using a viral envelope vector, and provides a pharmaceutical composition comprising a chemotherapeutic encapsulated in, or used in combination with, a viral envelope vector having an adjuvanticity as an active ingredient. Thereby it is possible to introduce an anticancer drug encapsulated in a viral envelope vector directly into a tumor, with coadministration of another anticancer drug so as to induce tumor cell-specific antitumor immunity also thanks to the adjuvant action of HVJ-E, and hence to regress the tumor. The present invention also provides a pharmaceutical composition comprising a viral envelope vector and a chemotherapeutic as active ingredients.
摘要翻译： 本发明旨在提供一种药物组合物，其用于使用病毒包膜载体将化疗药物，优选抗癌药物递送至细胞或生物体内，并提供药物组合物，所述药物组合物包含化学治疗剂包封或与 ，具有佐剂性作为活性成分的病毒包膜载体。 因此，通过共同施用另一种抗癌药物，可以将包封在病毒包膜载体中的抗癌药物直接引入肿瘤中，以便通过HVJ-E的辅助作用诱导肿瘤细胞特异性抗肿瘤免疫，因此可以 回归肿瘤。 本发明还提供了包含病毒包膜载体和作为活性成分的化学治疗剂的药物组合物。
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公开(公告)号：US07259149B2
公开(公告)日：2007-08-21
申请号：US10536274
申请日：2003-12-02
CPC分类号： C07K14/475 , A61K48/0016 , A61K48/0083 , C07K14/4753 , C12N9/0073
摘要： A method for enhancing the transfection efficiency of naked plasmid DNA in treating and/or preventing angiogenesis-dependent symptoms is provided by the present inventions. According to the present method, a suitable naked plasmid DNA is subjected for intramuscular injection under increased pressure inside the muscle or hyperbaric oxygen. Angiogenesis-dependent symptoms, including wounds, inflammatory diseases, critical limb ischemia, ischemia heart diseases, cerebral infarction, diabetic neuropathy, spinal canal stenosis, etc., may be treated by the present methods.
摘要翻译： 本发明提供了一种提高裸小质粒DNA在治疗和/或预防血管生成依赖性症状中的转染效率的方法。 根据本方法，将合适的裸质粒DNA在肌肉或高压氧内加压肌内注射。 可以通过本发明的方法治疗血管发生依赖性症状，包括伤口，炎性疾病，临界肢体缺血，缺血性心脏病，脑梗塞，糖尿病性神经病变，椎管狭窄等。
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公开(公告)号：US20060135452A1
公开(公告)日：2006-06-22
申请号：US10536274
申请日：2003-12-02
IPC分类号： A61K48/00
CPC分类号： C07K14/475 , A61K48/0016 , A61K48/0083 , C07K14/4753 , C12N9/0073
摘要： A method for enhancing the transfection efficiency of naked plasmid DNA in treating and/or preventing angiogenesis-dependent symptoms is provided by the present inventions. According to the present method, a suitable naked plasmid DNA is subjected for intramuscular injection under increased pressure inside the muscle or hyperbaric oxygen. Angiogenesis-dependent symptoms, including wounds, inflammatory diseases, critical limb ischemia, ischemic heart diseases, cerebral infarction, diabetic neuropathy, spinal canal stenosis, etc., may be treated by the present methods.
摘要翻译： 本发明提供了一种提高裸小质粒DNA在治疗和/或预防血管生成依赖性症状中的转染效率的方法。 根据本方法，将合适的裸质粒DNA在肌肉或高压氧内加压肌内注射。 可以通过本发明的方法治疗血管发生依赖性症状，包括伤口，炎性疾病，临界肢体缺血，缺血性心脏病，脑梗塞，糖尿病性神经病变，椎管狭窄等。
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公开(公告)号：US09919010B2
公开(公告)日：2018-03-20
申请号：US12990086
申请日：2009-04-30
IPC分类号： A61K35/28 , C12N5/0775 , A61K35/12
CPC分类号： A61K35/28 , A61K2035/124 , C12N5/0663
摘要： Biologically low invasive vessels are filled with biological factors that have the activity of mobilizing specific functional cells in the body. The vessels are indwelled in the body. After specific functional cells are mobilized into the vessels, the vessels are removed from the body to collect functional cell populations mobilized to the vessels. Alternatively, the cells are directly collected from the vessels indwelled in the body.
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