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1.发明授权Tricyclic pyridine derivatives, medicaments containing such compounds, their use and process for their preparation 有权三环吡啶衍生物，含有此类化合物的药物，其用途及其制备方法公开(公告)号：US09029544B2
公开(公告)日：2015-05-12
申请号：US13029697
申请日：2011-02-17
申请人： Holger Wagner , Daniela Berta , Klaus Fuchs , Riccardo Giovannini , Dieter Wolfgang Hamprecht , Ingo Konetzki , Ruediger Streicher , Thomas Trieselmann
发明人： Holger Wagner , Daniela Berta , Klaus Fuchs , Riccardo Giovannini , Dieter Wolfgang Hamprecht , Ingo Konetzki , Ruediger Streicher , Thomas Trieselmann
IPC分类号： C07D491/20 , A61K31/506 , C07D491/048 , C07D491/04 , C07D215/56
CPC分类号： C07D491/04 , A61K31/506 , C07D215/56 , C07D491/20
摘要： The present invention relates to compounds defined by formula I wherein the variables R1-R8 are defined as in the description, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of cholesterol ester transfer protein (CETP) and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme.
摘要翻译： 本发明涉及由式I定义的化合物，其中变量R1-R8如描述中所定义，具有有价值的药理学活性。 特别地，化合物是胆固醇酯转移蛋白（CETP）的抑制剂，因此适用于治疗和预防可受该酶抑制影响的疾病。
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2.发明申请公开(公告)号：US20130053404A1
公开(公告)日：2013-02-28
申请号：US13397855
申请日：2012-02-16
申请人： Holger Wagner , Daniela Berta , Klaus Fuchs , Riccardo Giovannini , Dieter Wolfgang Hamprecht , Ingo Konetzki , Ruediger Streicher , Thomas Trieselmann
发明人： Holger Wagner , Daniela Berta , Klaus Fuchs , Riccardo Giovannini , Dieter Wolfgang Hamprecht , Ingo Konetzki , Ruediger Streicher , Thomas Trieselmann
IPC分类号： C07D491/048 , A61K31/4747 , A61K31/506 , C07D491/20 , A61P9/10 , C07D221/20 , A61P9/00 , A61P3/00 , A61P3/06 , A61K31/4741 , C07D215/56
CPC分类号： C07D491/048 , C07D491/107 , C07D491/18
摘要： The present invention relates to compounds defined by formula I wherein the variables R1-R8 are defined as in the description, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of cholesterol ester transfer protein (CETP) and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme.
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公开(公告)号：US20050014810A1
公开(公告)日：2005-01-20
申请号：US10744830
申请日：2003-12-23
申请人： Ruediger Streicher , Juergen Mack , Rainer Walter , Ingo Konetzki , Thomas Trieselmann , Volkhard Austel
发明人： Ruediger Streicher , Juergen Mack , Rainer Walter , Ingo Konetzki , Thomas Trieselmann , Volkhard Austel
IPC分类号： A61K31/4184
CPC分类号： A61K31/4184
摘要： The present invention relates to the use of a substituted 2-phenylbenzimidazole of formula I wherein R1, R2, R3, R4, R5 and m have the meanings given in the claims, for the preparation of a medicament for the treatment or prevention of diseases involving glucagon receptors, as well as new compounds of formula I wherein R1 is a group of formula
摘要翻译： 本发明涉及式I的取代的2-苯基苯并咪唑的用途，其中R 1，R 2，R 3，R 4，R 5和m具有权利要求书中给出的含义 ，用于制备用于治疗或预防涉及胰高血糖素受体的疾病的药物，以及新的式I化合物，其中R 1是式
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4.发明授权Indol-containing beta-agonists, methods for the preparation thereof and their use as pharmaceutical compositions 有权含吲哚的β-激动剂，其制备方法及其作为药物组合物的用途公开(公告)号：US07754756B2
公开(公告)日：2010-07-13
申请号：US11550830
申请日：2006-10-19
申请人： Rainer Walter , Bradford S. Hamilton , Thomas Trieselmann , Matthew R. Netherton , Marco Santagostino , Ingo Konetzki
发明人： Rainer Walter , Bradford S. Hamilton , Thomas Trieselmann , Matthew R. Netherton , Marco Santagostino , Ingo Konetzki
IPC分类号： A61K31/4045 , A61K31/404 , C07D209/24 , C07D209/18 , C07D413/02
CPC分类号： C07D209/08 , C07D209/18 , C07D209/42 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12
摘要： The present invention relates to new beta-agonists of general formula (I) wherein the groups R1 and R2 have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers, solvates, hydrates, mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, methods of preparing these compounds and their use as pharmaceutical compositions.
摘要翻译： 本发明涉及通式（I）的新β-激动剂，其中基团R 1和R 2具有权利要求和说明书中给出的含义，互变异构体，外消旋体，对映异构体，非对映异构体，溶剂合物，水合物，其混合物，其前药 其盐，特别是其与无机或有机酸或碱的生理学上可接受的盐，制备这些化合物的方法及其作为药物组合物的用途。
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5.发明申请Indol-containing beta-agonists, methods for the preparation thereof and their use as pharmaceutical compositions 有权含吲哚的β-激动剂，其制备方法及其作为药物组合物的用途公开(公告)号：US20070105906A1
公开(公告)日：2007-05-10
申请号：US11550830
申请日：2006-10-19
申请人： Rainer Walter , Bradford Hamilton , Thomas Trieselmann , Matthew Netherton , Marco Santagostino , Ingo Konetzki
发明人： Rainer Walter , Bradford Hamilton , Thomas Trieselmann , Matthew Netherton , Marco Santagostino , Ingo Konetzki
IPC分类号： A61K31/4439 , A61K31/433 , A61K31/41 , A61K31/405 , C07D413/02 , C07D409/02 , C07D403/02
CPC分类号： C07D209/08 , C07D209/18 , C07D209/42 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/12
摘要： The present invention relates to new beta-agonists of general formula (I) wherein the groups R1 and R2 have the meanings given in the claims and specification, the tautomers, racemates, enantiomers, diastereomers, solvates, hydrates, mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, methods of preparing these compounds and their use as pharmaceutical compositions.
摘要翻译： 本发明涉及通式（I）的新的β-激动剂，其中基团R 1和R 2 2具有权利要求书和说明书中给出的含义，互变异构体， 其外消旋物，对映异构体，非对映异构体，溶剂合物，水合物，其混合物，其前药及其盐，特别是其与无机或有机酸或碱的生理上可接受的盐，制备这些化合物的方法及其作为药物组合物的用途。
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公开(公告)号：US08372838B2
公开(公告)日：2013-02-12
申请号：US13031895
申请日：2011-02-22
申请人： Norbert Hauel , Angelo Ceci , Henri Doods , Ingo Konetzki , Juergen Mack , Henning Priepke , Annette Schuler-Metz , Rainer Walter , Dieter Wiedenmayer
发明人： Norbert Hauel , Angelo Ceci , Henri Doods , Ingo Konetzki , Juergen Mack , Henning Priepke , Annette Schuler-Metz , Rainer Walter , Dieter Wiedenmayer
IPC分类号： A61K31/50 , A61K31/501
CPC分类号： C07D405/12 , C07C237/24 , C07C2601/02 , C07D207/277 , C07D211/62 , C07D213/81 , C07D233/90 , C07D239/28 , C07D239/557 , C07D261/18 , C07D271/10 , C07D401/12
摘要： Compounds of the formula I wherein n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and X are defined as described in the specification, which are bradykinin B1 antagonists, and their use as medicaments.
摘要翻译： 其中n，R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11和X如说明书中所描述的缓激肽B1拮抗剂及其作为药物的用途的式I化合物 。
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公开(公告)号：US20110077231A1
公开(公告)日：2011-03-31
申请号：US12672465
申请日：2008-08-12
申请人： Norbert Hauel , Angelo Ceci , Henri Doods , Iris Kauffmann-Hefner , Ingo Konetzki , Annette Schuler-Metz , Walter Rainer
发明人： Norbert Hauel , Angelo Ceci , Henri Doods , Iris Kauffmann-Hefner , Ingo Konetzki , Annette Schuler-Metz , Walter Rainer
IPC分类号： A61K31/397 , C07C271/24 , A61K31/27 , C07D207/08 , A61K31/40 , C07C311/29 , A61K31/18 , C07D205/04 , A61P29/00
CPC分类号： C07D295/088 , C07C311/29 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07D205/04 , C07D207/06 , C07D243/08 , C07D295/155
摘要： Novel compounds, with the following being exemplary:
摘要翻译： 新型化合物，具体如下：
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8.发明申请公开(公告)号：US20090155185A1
公开(公告)日：2009-06-18
申请号：US12349907
申请日：2009-01-07
IPC分类号： A61K31/4353 , A61K9/12 , A61P11/00
CPC分类号： A61K9/0075 , A61K9/008 , A61K31/4704 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical composition comprising an anticholinergic and a betamimetic of formula 2 optionally together with a pharmaceutically acceptable excipient, the anticholinergic and the betamimetic optionally in the form of their enantiomers, mixtures of their enantiomers, their racemates, their solvates, or their hydrates, processes for preparing them, and their use in the treatment of asthma, COPD, or other inflammatory or obstructive respiratory complaints.
摘要翻译： 一种药物组合物，其包含式2的抗胆碱能药物和β-受体激动剂，任选与药学上可接受的赋形剂，抗胆碱能药物和β-模拟物任选以其对映体形式，其对映异构体的混合物，其外消旋物，其溶剂化物或其水合物， 准备他们，并用于治疗哮喘，COPD或其他炎症或阻塞性呼吸道疾病。
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9.发明授权3-hydroxymethyl-4-hydroxy-phenyl-derivatives for the treatment of respiratory diseases 有权3-羟甲基-4-羟基 - 苯基 - 衍生物，用于治疗呼吸系统疾病公开(公告)号：US07511067B2
公开(公告)日：2009-03-31
申请号：US11028264
申请日：2005-01-03
申请人： Thierry Bouyssou , Frank Buettner , Ingo Konetzki , Sabine Pestel , Andreas Schnapp , Hermann Schollenberger , Kurt Schromm , Claudia Heine
发明人： Thierry Bouyssou , Frank Buettner , Ingo Konetzki , Sabine Pestel , Andreas Schnapp , Hermann Schollenberger , Kurt Schromm , Claudia Heine
IPC分类号： A61K31/415 , C07D233/00
CPC分类号： C07D249/08 , C07D233/64
摘要： The present invention relates to the use of the compounds of general formula 1 wherein the groups R1, X and Y may have the meanings given in the claims and in the specification, for preparing a pharmaceutical composition for the treatment of COPD (chronic obstructive pulmonary disease), as well as new compounds of general formula 1 and processes for preparing them.
摘要翻译： 本发明涉及通式1化合物的用途，其中R1，X和Y基团可以具有权利要求书和说明书中给出的含义，用于制备治疗COPD的药物组合物（慢性阻塞性肺疾病 ），以及通式1的新化合物及其制备方法。
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10.发明授权Enantiomerically pure beta agonists, process for the manufacture thereof, and use thereof as medicaments 有权对映体纯的β激动剂，其制造方法及其作为药物的用途公开(公告)号：US07491719B2
公开(公告)日：2009-02-17
申请号：US11543168
申请日：2006-10-04
IPC分类号： C07D265/36 , A61K31/538 , A61P11/00
CPC分类号： C07D265/36 , C07D413/04
摘要： Enantiomerically pure compounds of general formula 1 wherein the groups R1, R2, R3, R4, and X− may have the meanings given in the claims and in the specification, processes for preparing them and the use thereof as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.
摘要翻译： 对映体纯的通式1的化合物，其中基团R 1，R 2，R 3，R 4和X可以具有权利要求书和说明书中给出的含义，其制备方法及其作为药物组合物的用途，特别是作为药物组合物 用于治疗呼吸道疾病。
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