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    Process for producing cephem compounds in an aqueous medium
    1.
    发明授权
    Process for producing cephem compounds in an aqueous medium 失效
    在水性介质中生产头孢烯化合物的方法

    公开(公告)号：US5998611A

    公开(公告)日：1999-12-07

    申请号：US936839

    申请日：1997-09-25

    申请人： Homare Shinohara ,  Masato Kodama ,  Kimio Hamamura ,  Hirofumi Kuroda

    发明人： Homare Shinohara ,  Masato Kodama ,  Kimio Hamamura ,  Hirofumi Kuroda

    IPC分类号： C07D501/00 ,  C07D501/06 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/44 ,  C07D501/46 ,  C07D501/59

    CPC分类号： C07D501/00

    摘要： An industrially excellent, novel process for producing cephem compounds which are useful as medicines, particularly, antibiotics and represented by the following formula (III): ##STR1## wherein R.sup.1 means either group represented by the following formula: ##STR2## R.sup.2 denotes a carboxyl group or a carboxyl anion, and R.sup.3 stands for a lower alkyl group, a halogen atom, a lower alkyl group substituted by an aliphatic acyloxy group having 1-6 carbon atoms, or any one of the groups represented by the following formulae: ##STR3## which comprises reacting in water a 3-cephem-4-carboxylate represented by the following formula (I): ##STR4## or a salt thereof with an acid chloride represented by the formula (II), R.sup.1 COCl.

    摘要翻译： 一种工业上优异的新型头孢烯化合物的制备方法，其可用作药物，特别是抗生素，由下式（III）表示：其中R1表示下式表示的基团：R2表示羧基或羧基阴离子， R3表示低级烷基，卤素原子，被1-6个碳原子的脂肪族酰氧基取代的低级烷基，或下述通式表示的基团中的任意一种： 由下式（I）表示的头孢烯-4-羧酸盐或其与式（II）表示的酰氯的盐，R1COCl。

    Tetrahydro-alkenyl-methanonaphthalene-5,8-dione derivatives
    2.
    发明授权
    Tetrahydro-alkenyl-methanonaphthalene-5,8-dione derivatives 失效
    四氢 - 烯基 - 甲烷基-5,8-二酮衍生物

    公开(公告)号：US5686635A

    公开(公告)日：1997-11-11

    申请号：US686484

    申请日：1996-07-26

    申请人： Kimio Hamamura ,  Tetsuo Iwama ,  Chiaki Seki ,  Masayuki Konishi

    发明人： Kimio Hamamura ,  Tetsuo Iwama ,  Chiaki Seki ,  Masayuki Konishi

    IPC分类号： B01J23/04 ,  B01J31/02 ,  C07B61/00 ,  C07C46/00 ,  C07C49/683 ,  C07C49/753 ,  C07C50/06 ,  C07C50/14 ,  C07C50/28 ,  C07C50/32 ,  C07C50/04

    CPC分类号： C07C50/14 ,  C07C46/00 ,  C07C49/683 ,  C07C49/753

    摘要： Disclosed herein are a quinone derivative represented by the following formula: ##STR1## wherein R.sup.1 and R.sup.2 are identical with or different from each other and mean individually a lower alkyl or lower alkoxy group, or may form an aromatic ring together, R.sup.3 denotes a lower alkyl group, n stands for 0 or an integer of 1-9, and a linkage --- is a single or double bond, such as a vitamin K derivative or coenzyme derivative; and a process for the preparation of the quinone derivative at a high yield without forming any geometric isomer; as well as a 1,4,4.sub.a,8.sub.a -tetrahydro-4.sub.a .alpha.-alkenyl-1.alpha.,4.alpha.-methanonaphthalene-5,8-dione derivative which is useful as an intermediate for the preparation of the quinone derivative.

    摘要翻译： 本文公开了由下式表示的醌衍生物：其中R 1和R 2彼此相同或不同，并且分别表示低级烷基或低级烷氧基，或者可以一起形成芳环，R 3表示低级 烷基，n表示0或1-9的整数，键+ E，uns --- + EE是单键或双键，例如维生素K衍生物或辅酶衍生物; 以及高产率制备醌衍生物而不形成任何几何异构体的方法; 以及可用作制备醌衍生物的中间体的1,4,4a，8a-四氢-4aα-烯基-1α，4α-甲基萘-5,8-二酮衍生物。

    Preparation process of naphthoquinone derivative and intermediate for the preparation thereof
    6.
    发明授权
    Preparation process of naphthoquinone derivative and intermediate for the preparation thereof 失效
    萘醌衍生物及其制备方法的制备方法

    公开(公告)号：US5412124A

    公开(公告)日：1995-05-02

    申请号：US280550

    申请日：1994-07-26

    申请人： Kimio Hamamura ,  Chiaki Seki ,  Masayuki Konishi

    发明人： Kimio Hamamura ,  Chiaki Seki ,  Masayuki Konishi

    IPC分类号： C07C46/00 ,  C07C49/617 ,  C07C49/653 ,  C07C50/10 ,  C07C50/14 ,  C07C50/00

    CPC分类号： C07C50/14 ,  C07C46/00 ,  C07C49/617 ,  C07C49/653 ,  C07C50/10

    摘要： Disclosed herein are a naphthoquinone derivative represented by the following formula: ##STR1## wherein R.sup.1 means a hydrogen atom or methyl group, R.sup.2 is a hydrogen atom or methyl group, n stands for 0 or an integer of 1-9, and a linkage is a single bond or double bond with the proviso that if n is an integer of 2-9, the linkages may be identical with or different optionally from each other, such as a vitamin K derivative; and a process for producing the naphthoquinone derivative at a high yield without forming any geometric isomer; as well as 1,4,4.sub.a,5,8,9.sub.a -hexahydro-4.sub.a .alpha.-alkenyl-1.alpha.,4.alpha.-methanoanthraquinone derivatives and 1,4,4.sub.a,5,8,9.sub.a -hexahydro-1.alpha.,4.alpha.-methanoanthraquinone derivatives which are useful as intermediates for the preparation of the naphthoquinone derivatives.

    摘要翻译： 本文公开的是由下式表示的萘醌衍生物：其中R 1表示氢原子或甲基，R 2表示氢原子或甲基，n表示0或1-9的整数， 连接是单键或双键，条件是如果n是2-9的整数，则连接可以彼此相同或不同，例如维生素K衍生物; 以及高产率生产萘醌衍生物而不形成几何异构体的方法; 以及1,4,4a，5,8,9a-六氢-4aα-烯基-1α，4α-甲基蒽醌衍生物和1,4,4a，5,8,9a-六氢-1α，4α - 甲基蒽醌衍生物，其可用作制备萘醌衍生物的中间体。

    Process for the preparation of quinone derivative
    9.
    发明授权
    Process for the preparation of quinone derivative 失效
    醌衍生物的制备方法

    公开(公告)号：US5677471A

    公开(公告)日：1997-10-14

    申请号：US686412

    申请日：1996-07-26

    申请人： Kimio Hamamura ,  Tetsuo Iwama ,  Chiaki Seki ,  Masayuki Konishi

    发明人： Kimio Hamamura ,  Tetsuo Iwama ,  Chiaki Seki ,  Masayuki Konishi

    IPC分类号： B01J23/04 ,  B01J31/02 ,  C07B61/00 ,  C07C46/00 ,  C07C49/683 ,  C07C49/753 ,  C07C50/06 ,  C07C50/14 ,  C07C50/28 ,  C07C50/32 ,  C07C50/12

    CPC分类号： C07C50/14 ,  C07C46/00 ,  C07C49/683 ,  C07C49/753

    摘要： Disclosed herein are a quinone derivative represented by the following formula: ##STR1## wherein R.sup.1 and R.sup.2 are identical with or different from each other and mean individually a lower alkyl or lower alkoxy group, or may form an aromatic ring together, R.sup.3 denotes a lower alkyl group, n stands for 0 or an integer of 1-9, and a linkage--is a single or double bond, such as a vitamin K derivative or coenzyme Q derivative; and a process for the preparation of the quinone derivative at a high yield without forming any geometric isomer; as well as a 1,4,4.sub.a,8.sub.a -tetrahydro-4.sub.a .alpha.-alkenyl-1.alpha.,4.alpha.-methanonaphthalene-5,8-dione derivative which is useful as an intermediate for the preparation of the quinone derivative.

    摘要翻译： 本文公开了由下式表示的醌衍生物：其中R 1和R 2彼此相同或不同，并且分别表示低级烷基或低级烷氧基，或者可以一起形成芳环，R 3表示低级 烷基，n表示0或1-9的整数，连接是单键或双键，例如维生素K衍生物或辅酶Q衍生物; 以及高产率制备醌衍生物而不形成任何几何异构体的方法; 以及可用作制备醌衍生物的中间体的1,4,4a，8a-四氢-4aα-烯基-1α，4α-甲基萘-5,8-二酮衍生物。