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111 条记录 (耗时 0.063 秒)

    Imidazopyridines as cyclin dependent kinase inhibitors
    9.
    发明授权
    Imidazopyridines as cyclin dependent kinase inhibitors 有权
    咪唑并吡啶类作为细胞周期蛋白依赖性激酶抑制剂

    公开(公告)号：US07452902B2

    公开(公告)日：2008-11-18

    申请号：US11238597

    申请日：2005-09-29

    申请人： Michael P. Dwyer ,  Timothy J. Guzi ,  Kamil Paruch ,  Ronald J. Doll ,  Kartik M. Keertikar ,  Viyyoor M. Girijavallabhan

    发明人： Michael P. Dwyer ,  Timothy J. Guzi ,  Kamil Paruch ,  Ronald J. Doll ,  Kartik M. Keertikar ,  Viyyoor M. Girijavallabhan

    IPC分类号： A01N43/42 ,  A61K31/44

    CPC分类号： C07D471/04

    摘要： In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyridine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.

    摘要翻译： 在其许多实施方案中，本发明提供了一类新颖的咪唑并[1,2-a]吡啶化合物作为细胞周期蛋白依赖性激酶的抑制剂，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备药物制剂的方法 包括一种或多种这样的化合物，以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。

    Adjustable guard for protecting coupling connection between rotating shafts
    10.
    发明授权
    Adjustable guard for protecting coupling connection between rotating shafts 有权
    可调节防护罩，用于保护旋转轴之间的联接连接

    公开(公告)号：US07275995B2

    公开(公告)日：2007-10-02

    申请号：US10430963

    申请日：2003-05-06

    申请人： Ronald J. Doll

    发明人： Ronald J. Doll

    IPC分类号： F16D3/84

    CPC分类号： F16P1/02

    摘要： An injection molded plastic guard is used to enclose a coupling connection between a prime mover input shaft and a driven output shaft. The guard is comprised of two halves that are hinged together with a stainless steel pin at one end. The coupling is centered within the guard with the hinge being positioned above the coupling. The halves extend from the hinge to distal ends that are pivoted about the pin to surround and enclose the coupling. The distal ends meet underneath the coupling area and are mounted to a non-rotating base. Sleeves extend outwardly from opposing ends of the guard to surround the input and output shafts and abut against the prime mover and output device equipment. The sleeves have a vertically, elongated opening so that one guard can be used to cover many different base-to-shaft heights. Further, the length of the sleeves can be adjusted to accommodate different centerline-of-guard to equipment face distances. End caps are used when these distances are too great or if the equipment face is such that it does not abut appropriately against the respective sleeve. A shaft opening is cut into the end caps at the appropriate base-to-shaft height.

    摘要翻译： 使用注射成型的塑料防护罩封装原动机输入轴和从动输出轴之间的联接连接。 防护罩由两端铰接在一起的不锈钢销钉组成。 联轴器在防护罩内居中，铰链位于联轴器上方。 一半从铰链延伸到远端，围绕销枢转以围绕并包围联接器。 远端在耦合区域下方相遇，并安装在非旋转底座上。 套管从护罩的相对端向外延伸，以围绕输入和输出轴并抵靠原动机和输出装置设备。 袖子有一个垂直细长的开口，所以一个防护罩可以用来覆盖许多不同的底座到轴的高度。 此外，袖子的长度可以被调节以适应不同的中心线到设备面距离。 当这些距离太大或者设备面不能适当地抵靠相应的套筒时，使用端盖。 在适当的基轴至轴高度处，将轴孔切割成端盖。