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公开(公告)号：US20240279733A1
公开(公告)日：2024-08-22
申请号：US18567989
申请日：2022-12-15
Applicant: Illumina, Inc.
Inventor： Fei Shen , Mathieu Lessard-Viger , Eric Brustad , Allison Meade , Esteban Armijo , Michael Howard , Jeffrey Fisher , Jonathan Boutell , Ramon Saracho , Olivia Ghazinejad , Seth McDonald , Lena Storms , Jeffrey Brodin
IPC: C12Q1/6874
CPC classification number: C12Q1/6874
Abstract: The present disclosure is directed to decoupling library capture (template seeding) from cluster generation to optimise both processes. This is achieved by introducing orthogonality between the seeding and clustering primer.
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公开(公告)号：US20230212534A1
公开(公告)日：2023-07-06
申请号：US18085674
申请日：2022-12-21
Applicant: ILLUMINA, INC. , ILLUMINA SINGAPORE PTE LTD
Inventor： Misha Golynskiy , Seth McDonald , Saurabh Nirantar , Matthew Kellinger , Michael Previte , Sergio Peisajovich , Molly He
CPC classification number: C12N9/1241 , C12N1/20
Abstract: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
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公开(公告)号：US20230047225A1
公开(公告)日：2023-02-16
申请号：US17829866
申请日：2022-06-01
Applicant: ILLUMINA, INC. , ILLUMINA CAMBRIDGE LIMITED , ILLUMINA SINGAPORE PTE. LTD.
Inventor： Misha Golynskiy , Mariko Matsuura , Saurabh Nirantar , Hamed Tabatabaei Ghomi , Seth McDonald , Ryan Craig , Sergio Peisajovich , Kyrie Johnson , Kay Klausing , Eric Murtfeldt , Alexandra Exner
IPC: C12N9/12 , C12Q1/6874
Abstract: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain low pre-phasing rates when using ambiently stored polymerases, as well as methods and kits using the same.
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公开(公告)号：US11634697B2
公开(公告)日：2023-04-25
申请号：US17226393
申请日：2021-04-09
Applicant: Illumina, Inc. , Illumina Cambridge Limited , Illumina Singapore Pte. Ltd.
Inventor： Kay Klausing , Hamed Tabatabaei Ghomi , Misha Golynskiy , Saurabh Nirantar , Seth McDonald , Sergio Peisajovich
IPC: C12N9/12
Abstract: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
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公开(公告)号：US20220162680A1
公开(公告)日：2022-05-26
申请号：US17507647
申请日：2021-10-21
Applicant: ILLUMINA, INC.
Inventor： Jeffrey Mandell , Sergio Peisajovich , Seth McDonald , Kaitlin Pugliese
IPC: C12Q1/6818 , C12Q1/6834
Abstract: A method is provided that includes adding, using a polymerase coupled to a substrate, nucleotides in a solution to a first polynucleotide using at least a sequence of a second polynucleotide. The method includes separating, using labels respectively coupled to the nucleotides, quenchers from respective fluorophores. The method includes then detecting a sequence in which the polymerase adds the nucleotides to the first polynucleotide using at least fluorescence from the respective fluorophores.
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Patent Agency Ranking
公开(公告)号：US20210348141A1
公开(公告)日：2021-11-11
申请号：US17226393
申请日：2021-04-09
Applicant: Illumina, Inc. , Illumina Cambridge Limited , Illumina Singapore Pte. Ltd.
Inventor： Kay Klausing , Hamed Tabatabaei Ghomi , Misha Golynskiy , Saurabh Nirantar , Seth McDonald , Sergio Peisajovich
IPC: C12N9/12
Abstract: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
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公开(公告)号：US12077789B2
公开(公告)日：2024-09-03
申请号：US17829866
申请日：2022-06-01
Applicant: ILLUMINA, INC.
Inventor： Misha Golynskiy , Mariko Matsuura , Saurabh Nirantar , Hamed Tabatabaei Ghomi , Seth McDonald , Ryan Craig , Sergio Peisajovich , Kyrie Johnson , Kay Klausing , Eric Murtfeldt , Alexandra Exner
IPC: C12N9/12 , C12Q1/6874
CPC classification number: C12N9/1252 , C12Q1/6874 , C12Y207/07007
Abstract: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain low pre-phasing rates when using ambiently stored polymerases, as well as methods and kits using the same.
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公开(公告)号：US11104888B2
公开(公告)日：2021-08-31
申请号：US16670876
申请日：2019-10-31
Applicant: Illumina, Inc. , Illumina Singapore Pte. Ltd.
Inventor： Misha Golynskiy , Seth McDonald , Saurabh Nirantar , Matthew Kellinger , Michael Previte , Sergio Peisajovich , Molly He
IPC: C12N9/12
Abstract: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
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公开(公告)号：US11001816B2
公开(公告)日：2021-05-11
申请号：US16703569
申请日：2019-12-04
Applicant: Illumina, Inc. , Illumina Cambridge Limited , Illumina Singapore Pte. Ltd.
Inventor： Kay Klausing , Hamed Tabatabaei Ghomi , Misha Golynskiy , Saurabh Nirantar , Seth McDonald , Sergio Peisajovich
IPC: C12N9/12
Abstract: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
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公开(公告)号：US20200181587A1
公开(公告)日：2020-06-11
申请号：US16703569
申请日：2019-12-04
Applicant: Illumina, Inc. , Illumina Cambridge Limited , Illumina Singapore Pte. Ltd.
Inventor： Kay Klausing , Hamed Tabatabael Ghomi , Misha Golynskiy , Saurabh Nirantar , Seth McDonald , Sergio Peisajovich
IPC: C12N9/12
Abstract: Presented herein are altered polymerase enzymes for improved incorporation of nucleotides and nucleotide analogues, in particular altered polymerases that maintain high fidelity under reduced incorporation times, as well as methods and kits using the same.
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