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公开(公告)号：US20240393608A1
公开(公告)日：2024-11-28
申请号：US18670935
申请日：2024-05-22
Applicant: ILLUMINA, INC.
Inventor： Steven Boege , Stanley Hong
Abstract: An apparatus includes a sample stage region, an optical assembly, and a camera assembly. The optical assembly includes an objective element, a tube lens, a first dichroic element, and a compensating element. The objective element provides a field of view including the object plane. The tube lens is configured to receive light transmitted through the objective element. The optical assembly is configured to transmit light in at least a first color channel, a second color channel, a third color channel, and a fourth color channel from the tube lens toward the first dichroic element. The first dichroic element is configured to transmit light of the first and third color channels while reflecting light of the second and fourth color channels. The compensating element is configured to induce an astigmatism in the first and third color channels offsetting an astigmatism induced by the dichroic element.
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公开(公告)号：US20220308354A1
公开(公告)日：2022-09-29
申请号：US17704485
申请日：2022-03-25
Applicant: ILLUMINA, INC.
Inventor： Steven Boege , Simon Prince , Danilo Condello
Abstract: Apparatus and methods for transmitting light are disclosed. In an implementation, an apparatus includes a collimator at an input end positioned to receive an input beam from a fiber beam source and to produce a collimated beam. The apparatus further includes a beam shaping group having one or more optical elements and positioned to receive the collimated beam from the collimator and format the collimated beam into a shaped propagation beam having a substantially rectangular cross-section in a far field. The apparatus further includes an objective stage for optically probing a sample, such as a flow cell, using substantially rectangular cross-section sampling beam, where fluorescence from the sample is captured by a line sensor for detecting properties of the sample, such as chemical reactions therein.
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公开(公告)号：US20240369468A1
公开(公告)日：2024-11-07
申请号：US18572189
申请日：2022-12-27
Applicant: ILLUMINA, INC.
Inventor： Steven Boege , Danilo Condello , Simon Prince , Jason Bryant , Merek Siu
IPC: G01N15/1434 , G01N15/10 , G01N15/14
Abstract: Imaging systems and related methods are disclosed. In accordance with an implementation, a system includes a flow cell receptacle to receive a flow cell that receives a sample and an imaging system having a light source assembly, and an imaging device. The light source assembly to form a substantially collimated beam. The optical assembly including an asymmetric beam expander group that includes one or more asymmetric elements or anamorphic elements disposed along an optical axis. The optical assembly to receive the substantially collimated beam from the light source assembly, and transform the substantially collimated beam into a shaped sampling beam having an elongated cross section in a far field at or near a focal plane of the optical assembly to optically probe the sample. The imaging device to obtain image data associated with the sample in response to the optical probing of the sample with the sampling beam.
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Patent Agency Ranking
公开(公告)号：US20240348906A1
公开(公告)日：2024-10-17
申请号：US18750675
申请日：2024-06-21
Applicant: ILLUMINA, INC.
Inventor： Steven Boege , Simon Prince , Peter Newman , Matthew Hage , Geraint Evans
CPC classification number: H04N23/55 , G02B13/0095 , H04N23/54
Abstract: An apparatus and method for imaging includes an imaging system formed of a movable objective stage proximal to a sample and positioned for providing an excitation beam onto and for capturing an emission from the sample. The movable objective stage includes an optical lens apparatus and a turn reflector optically coupled to the imaging optics, where at least one of the optical lens apparatus and the turn reflector are movable relative to one another for scanning the sample, and wherein the movement is achieved while maintaining a substantially fixed optical path length between the optical lens apparatus and a fixed plane in a fixed imaging optics stage.
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公开(公告)号：US12063430B2
公开(公告)日：2024-08-13
申请号：US17957659
申请日：2022-09-30
Applicant: ILLUMINA, INC.
Inventor： Steven Boege , Simon Prince , Peter Newman , Matthew Hage , Geraint Evans
CPC classification number: H04N23/55 , G02B13/0095 , H04N23/54
Abstract: An apparatus and method for imaging includes an imaging system formed of a movable objective stage proximal to a sample and positioned for providing an excitation beam onto and for capturing an emission from the sample. The movable objective stage includes an optical lens apparatus and a turn reflector optically coupled to the imaging optics, where at least one of the optical lens apparatus and the turn reflector are movable relative to one another for scanning the sample, and wherein the movement is achieved while maintaining a substantially fixed optical path length between the optical lens apparatus and a fixed plane in a fixed imaging optics stage.
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公开(公告)号：US12287490B2
公开(公告)日：2025-04-29
申请号：US17981206
申请日：2022-11-04
Applicant: ILLUMINA, INC.
Inventor： Danilo Condello , Dakota Watson , Andrew Carson , Vincent Hsieh , Steven Boege , Changqin Ding , Stanley Hong
Abstract: Apparatus and methods for controlling heating of an objective in a linescanning sequencing system to improve resolution are disclosed. In accordance with a first implementation, an apparatus includes or comprises a beam source for providing input radiation and a beam shaping group including or comprising one or more optical elements positioned to receive the input radiation from the beam source, and to perform beam shaping on the input radiation to form a shaped beam. The apparatus further including or comprising an objective positioned to receive the shaped beam and to transform the shaped beam into a probe beam and configured to provide the probe beam to a focal plane of the objective for optically probing a sample. The beam shaping group is configured to adjust one or more properties of the shaped beam over time to generally uniformly heat the objective over a region of incidence for the shaped beam.
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公开(公告)号：US12276806B2
公开(公告)日：2025-04-15
申请号：US17704485
申请日：2022-03-25
Applicant: ILLUMINA, INC.
Inventor： Steven Boege , Simon Prince , Danilo Condello
Abstract: Apparatus and methods for transmitting light are disclosed. In an implementation, an apparatus includes a collimator at an input end positioned to receive an input beam from a fiber beam source and to produce a collimated beam. The apparatus further includes a beam shaping group having one or more optical elements and positioned to receive the collimated beam from the collimator and format the collimated beam into a shaped propagation beam having a substantially rectangular cross-section in a far field. The apparatus further includes an objective stage for optically probing a sample, such as a flow cell, using substantially rectangular cross-section sampling beam, where fluorescence from the sample is captured by a line sensor for detecting properties of the sample, such as chemical reactions therein.
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8.发明公开公开(公告)号：US20230143682A1
公开(公告)日：2023-05-11
申请号：US17981206
申请日：2022-11-04
Applicant: ILLUMINA, INC.
Inventor： Danilo Condello , Dakota Watson , Andrew Carson , Vincent Hsieh , Steven Boege , Changqin Ding , Stanley Hong
CPC classification number: G02B27/0927 , G02B26/101 , G02B27/0916 , G02B27/0955 , G02B27/0994 , G01N21/6428 , G01N21/6456 , G01N2021/6439
Abstract: Apparatus and methods for controlling heating of an objective in a linescanning sequencing system to improve resolution are disclosed. In accordance with a first implementation, an apparatus includes or comprises a beam source for providing input radiation and a beam shaping group including or comprising one or more optical elements positioned to receive the input radiation from the beam source, and to perform beam shaping on the input radiation to form a shaped beam. The apparatus further including or comprising an objective positioned to receive the shaped beam and to transform the shaped beam into a probe beam and configured to provide the probe beam to a focal plane of the objective for optically probing a sample. The beam shaping group is configured to adjust one or more properties of the shaped beam over time to generally uniformly heat the objective over a region of incidence for the shaped beam.
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