公开(公告)号：US09681844B2

公开(公告)日：2017-06-20

申请号：US14315520

申请日：2014-06-26

Applicant: IMEC VZW ,  Stichting IMEC Nederland

Inventor： Jiawei Xu ,  Refet Firat Yazicioglu

IPC: A61B5/00 ,  A61B5/04 ,  A61B5/0402 ,  A61B5/0428 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0496 ,  A61B5/0408 ,  A61B5/0478 ,  A61B5/0492

CPC classification number: A61B5/7207 ,  A61B5/04004 ,  A61B5/0402 ,  A61B5/0408 ,  A61B5/0428 ,  A61B5/0476 ,  A61B5/0478 ,  A61B5/0488 ,  A61B5/0492 ,  A61B5/0496 ,  A61B2562/0209

Abstract: A biopotential signal acquisition system, comprising: a first active electrode including an integrated pre-amplifier and an analogue to digital converter; a second active electrode including an integrated pre-amplifier and an analogue to digital converter, wherein the second active electrode has variable gain; a test signal generator for generating a test signal at a test frequency and coupling the test signal to the first and/or second active electrodes; and a digital signal processor configured to: process the digital outputs of the first and second active electrodes to derive a gain control signal based on a difference between the first and second active electrode outputs at the test frequency, and apply the gain control signal to the second active electrode. The disclosure also relates to an electronic circuit or device and a biopotential signal acquisition method.

公开(公告)号：US20150119747A1

公开(公告)日：2015-04-30

申请号：US14528931

申请日：2014-10-30

Applicant: IMEC VZW

Inventor： Tom Torfs ,  Refet Firat Yazicioglu

IPC: A61B5/053 ,  A61B5/00

CPC classification number: A61B5/053 ,  A61B5/04004 ,  A61B5/04012 ,  A61B5/04284 ,  A61B5/7207 ,  A61B5/7278

Abstract: A system for the acquisition of biopotential signals, comprising at least a first electrode configured for detecting a biopotential signal within a signal bandwidth of interest and being connected to an impedance detection module that provides a first electrode voltage. The impedance detection module comprises a current generation circuit connected in parallel to an amplifier. The current generation circuit comprises an AC current generator configured to generate a first current signal through the first electrode. The first current signal has a frequency outside of the signal bandwidth of interest. The current generation circuit also comprising a capacitor connected between the input of the amplifier and the AC current generator so as to isolate the AC current generator from the amplifier input at the signal bandwidth of interest. The system also including a signal processor configured to calculate a component value of a first and a second electrode-tissue impedance based on a difference between the first electrode voltage and a second electrode voltage.

Abstract translation: 一种用于获取生物电位信号的系统，包括至少第一电极，其被配置用于检测感兴趣的信号带宽内的生物电位信号，并连接到提供第一电极电压的阻抗检测模块。 阻抗检测模块包括与放大器并联连接的电流产生电路。 电流产生电路包括配置成通过第一电极产生第一电流信号的AC电流发生器。 第一电流信号具有在感兴趣的信号带宽以外的频率。 电流产生电路还包括连接在放大器的输入端和交流电流发生器之间的电容器，以便在感兴趣的信号带宽上将交流电流发生器与放大器输入隔离。 该系统还包括被配置为基于第一电极电压和第二电极电压之间的差来计算第一和第二电极组织阻抗的分量值的信号处理器。

公开(公告)号：US09375182B2

公开(公告)日：2016-06-28

申请号：US14573714

申请日：2014-12-17

Applicant: IMEC VZW

Inventor： Hyejung Kim ,  Nick Van Helleputte ,  Refet Firat Yazicioglu

IPC: A61B5/04 ,  A61B5/00 ,  A61B5/0428 ,  A61B5/0402

CPC classification number: A61B5/7207 ,  A61B5/04017 ,  A61B5/0402 ,  A61B5/0428 ,  A61B5/7214 ,  A61B5/7246

Abstract: A biopotential signal acquisition system including an analog readout unit configured to receive an analog biopotential signal, which may be acquired from at least one electrode attached to a body; and to extract an analog measured biopotential signal and an analog reference signal. The system also includes an ADC unit configured to provide a digital version of the analog measured biopotential signal and the analog reference signal, a digital filter unit configured to calculate a digital motion artifact estimate based on the digital version of the measured biopotential signal and the reference signal. The system further comprises a reference signal processing unit configured to convert the reference signal into a new reference signal being provided to the digital filter unit based on the correlation between the measured biopotential signal and the reference signal.

Abstract translation: 生物电位信号采集系统，包括被配置为接收模拟生物电位信号的模拟读出单元，模拟生物电位信号可以从附着于身体的至少一个电极获取; 并提取模拟测量的生物电位信号和模拟参考信号。 该系统还包括被配置为提供模拟测量生物电位信号和模拟参考信号的数字版本的ADC单元，数字滤波器单元，被配置为基于测量的生物电位信号和参考的数字版本来计算数字运动伪影估计 信号。 该系统还包括参考信号处理单元，其被配置为基于所测量的生物电位信号和参考信号之间的相关性将参考信号转换为提供给数字滤波器单元的新参考信号。

公开(公告)号：US20150216481A1

公开(公告)日：2015-08-06

申请号：US14615150

申请日：2015-02-05

Applicant: IMEC VZW

Inventor： Hyejung Kim ,  Nick Van Helleputte ,  Refet Firat Yazicioglu

IPC: A61B5/00 ,  A61B5/0488 ,  A61B5/0476 ,  A61B5/0402 ,  A61B5/04

CPC classification number: A61B5/7207 ,  A61B5/04012 ,  A61B5/04017 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/7214

Abstract: A biopotential signal acquisition system comprising an analogue readout unit configured to receive an analogue biopotential signal and to extract an analogue measured biopotential signal and an analogue reference signal, and an ADC unit configured to provide a digital version of the analogue measured biopotential signal and the analogue reference signal. The system also includes a first digital filter unit comprising a cascaded integrator-comb filter configured to provide a first digital filtered version of the digital measured biopotential signal and the reference signal, and a second digital filter unit configured to calculate a digital motion artifact estimate based on the first digital filtered version signals.

Abstract translation: 生物电位信号采集系统，包括模拟读出单元，其被配置为接收模拟生物电位信号并提取模拟测量的生物电位信号和模拟参考信号，以及ADC单元，被配置为提供所述模拟测量生物电位信号和模拟 参考信号。 该系统还包括第一数字滤波器单元，其包括级联的积分器梳状滤波器，其被配置为提供数字测量的生物电位信号和参考信号的第一数字滤波版本，以及第二数字滤波器单元，被配置为基于数字滤波器单元 在第一个数字滤波版本信号上。

公开(公告)号：US20170000368A1

公开(公告)日：2017-01-05

申请号：US15197778

申请日：2016-06-30

Applicant: IMEC VZW ,  Katholieke Universiteit Leuven, KU LEUVEN R&D

Inventor： Bogdan Raducanu ,  Srinjoy Mitra ,  Refet Firat Yazicioglu

IPC: A61B5/0478 ,  A61B5/00 ,  A61B5/04

CPC classification number: A61B5/6868 ,  A61B5/04001 ,  A61B5/4076 ,  A61B5/7225 ,  A61B2562/043 ,  A61N1/0529 ,  A61N1/0551

Abstract: Devices and systems described herein relate to a sensing device that includes an output area and an electrode area. The output area includes an output circuit comprising an integrator adapted to integrate a received current so as to generate an output voltage corresponding to the received current. The electrode area includes an electrode comprising an exposed, electrically conductive, surface area and electrode circuitry connected to the exposed surface area. The electrode circuitry comprises a voltage-to-current transducer adapted to produce a wire current corresponding to a voltage present at the exposed surface area. The sensing device also includes a connecting wire electrically connecting the electrode circuitry to the output circuit, wherein the current received by the output circuit is the wire current.

Abstract translation: 本文所述的装置和系统涉及包括输出区域和电极区域的感测装置。 输出区域包括输出电路，该输出电路包括积分器，该积分器适于积分接收的电流，以产生对应于所接收的电流的输出电压。 电极区域包括包括暴露的导电表面区域和连接到暴露表面区域的电极电路的电极。 电极电路包括适于产生对应于暴露表面区域处存在的电压的线电流的电压 - 电流换能器。 感测装置还包括将电极电路电连接到输出电路的连接线，其中由输出电路接收的电流是线电流。

公开(公告)号：US20150005585A1

公开(公告)日：2015-01-01

申请号：US14315520

申请日：2014-06-26

Applicant: IMEC VZW ,  Stichting IMEC Nederland

Inventor： Jiawei Xu ,  Refet Firat Yazicioglu

IPC: A61B5/00 ,  A61B5/0476 ,  A61B5/04 ,  A61B5/0496 ,  A61B5/0428 ,  A61B5/0402 ,  A61B5/0488

CPC classification number: A61B5/7207 ,  A61B5/04004 ,  A61B5/0402 ,  A61B5/0408 ,  A61B5/0428 ,  A61B5/0476 ,  A61B5/0478 ,  A61B5/0488 ,  A61B5/0492 ,  A61B5/0496 ,  A61B2562/0209

Abstract: A biopotential signal acquisition system, comprising: a first active electrode including an integrated pre-amplifier and an analogue to digital converter; a second active electrode including an integrated pre-amplifier and an analogue to digital converter, wherein the second active electrode has variable gain; a test signal generator for generating a test signal at a test frequency and coupling the test signal to the first and/or second active electrodes; and a digital signal processor configured to: process the digital outputs of the first and second active electrodes to derive a gain control signal based on a difference between the first and second active electrode outputs at the test frequency, and apply the gain control signal to the second active electrode. The disclosure also relates to an electronic circuit or device and a biopotential signal acquisition method.

Abstract translation: 一种生物电势信号采集系统，包括：第一有源电极，包括集成前置放大器和模数转换器; 包括集成前置放大器和模数转换器的第二有源电极，其中所述第二有源电极具有可变增益; 测试信号发生器，用于产生测试频率的测试信号，并将测试信号耦合到第一和/或第二有源电极; 以及数字信号处理器，被配置为：处理第一和第二有源电极的数字输出，以基于在测试频率处的第一和第二有源电极输出之间的差异导出增益控制信号，并将增益控制信号施加到 第二活性电极。 本公开还涉及电子电路或装置以及生物电势信号采集方法。

公开(公告)号：US09326733B2

公开(公告)日：2016-05-03

申请号：US14615150

申请日：2015-02-05

Applicant: IMEC VZW

Inventor： Hyejung Kim ,  Nick Van Helleputte ,  Refet Firat Yazicioglu

IPC: A61B5/04 ,  A61B5/00 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0488

CPC classification number: A61B5/7207 ,  A61B5/04012 ,  A61B5/04017 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/7214

Abstract: A biopotential signal acquisition system comprising an analog readout unit configured to receive an analog biopotential signal and to extract an analog measured biopotential signal and an analog reference signal, and an ADC unit configured to provide a digital version of the analog measured biopotential signal and the analog reference signal. The system also includes a first digital filter unit comprising a cascaded integrator-comb filter configured to provide a first digital filtered version of the digital measured biopotential signal and the reference signal, and a second digital filter unit configured to calculate a digital motion artifact estimate based on the first digital filtered version signals.

Abstract translation: 生物电位信号采集系统，包括模拟读出单元，其被配置为接收模拟生物电位信号并提取模拟测量的生物电位信号和模拟参考信号;以及ADC单元，被配置为提供模拟测量的生物电位信号的数字版本和模拟 参考信号。 该系统还包括第一数字滤波器单元，其包括级联的积分器梳状滤波器，其被配置为提供数字测量的生物电位信号和参考信号的第一数字滤波版本，以及第二数字滤波器单元，被配置为基于数字滤波器单元 在第一个数字滤波版本信号。

公开(公告)号：US09294048B2

公开(公告)日：2016-03-22

申请号：US14315478

申请日：2014-06-26

Applicant: IMEC VZW

Inventor： Nick Van Helleputte ,  Refet Firat Yazicioglu

IPC: H03F3/45 ,  H03F1/34 ,  H03F3/68

CPC classification number: H03F1/34 ,  H03F3/45 ,  H03F3/45932 ,  H03F3/45941 ,  H03F3/68 ,  H03F2200/261 ,  H03F2203/45084 ,  H03F2203/45114 ,  H03F2203/45116

Abstract: An instrumentation amplifier includes a first amplifier having one input connected to a first input of the instrumentation amplifier, a second amplifier having one input connected to a second input of the instrumentation amplifier, and a feedback network. The feedback network including an active filter having a first low pass filter characteristic with a first cut-off frequency in respect of differential mode signals at the first and second inputs of the instrumentation amplifier, and a second low pass filter characteristic with a second cut-off frequency in respect of common mode signals at the first and second inputs of the instrumentation amplifier. The disclosure also relates to a device for acquiring biopotential signals and a signal amplification method.

Abstract translation: 仪表放大器包括具有连接到仪表放大器的第一输入的一个输入的第一放大器，具有连接到仪表放大器的第二输入的一个输入的第二放大器和反馈网络。 所述反馈网络包括有源滤波器，所述有源滤波器具有关于所述仪表放大器的第一和第二输入处的差模信号的具有第一截止频率的第一低通滤波器特性，以及具有第二截止频率的第二低通滤波器特性， 关于仪表放大器的第一和第二输入处的共模信号的截止频率。 本公开还涉及用于获取生物电位信号的装置和信号放大方法。

公开(公告)号：US20150173683A1

公开(公告)日：2015-06-25

申请号：US14573714

申请日：2014-12-17

Applicant: IMEC VZW

Inventor： Hyejung Kim ,  Nick Van Helleputte ,  Refet Firat Yazicioglu

IPC: A61B5/00 ,  A61B5/0402 ,  A61B5/04

CPC classification number: A61B5/7207 ,  A61B5/04017 ,  A61B5/0402 ,  A61B5/0428 ,  A61B5/7214 ,  A61B5/7246

Abstract: A biopotential signal acquisition system including an analogue readout unit configured to receive an analogue biopotential signal, which may be acquired from at least one electrode attached to a body; and to extract an analogue measured biopotential signal and an analogue reference signal. The system also includes an ADC unit configured to provide a digital version of the analogue measured biopotential signal and the analogue reference signal, a digital filter unit configured to calculate a digital motion artifact estimate based on the digital version of the measured biopotential signal and the reference signal. The system further comprises a reference signal processing unit configured to convert the reference signal into a new reference signal being provided to the digital filter unit based on the correlation between the measured biopotential signal and the reference signal.

Abstract translation: 生物电位信号采集系统，包括被配置为接收模拟生物电位信号的模拟读出单元，模拟生物电位信号可以从附着于身体的至少一个电极获取; 并提取模拟测量的生物电位信号和模拟参考信号。 该系统还包括被配置为提供模拟测量生物电位信号和模拟参考信号的数字版本的ADC单元，被配置为基于所测量的生物电位信号和参考的数字版本来计算数字运动伪像估计的数字滤波器单元 信号。 该系统还包括参考信号处理单元，其被配置为基于所测量的生物电位信号和参考信号之间的相关性将参考信号转换为提供给数字滤波器单元的新参考信号。

公开(公告)号：US20150002221A1

公开(公告)日：2015-01-01

申请号：US14315478

申请日：2014-06-26

Applicant: IMEC VZW

Inventor： Nick Van Helleputte ,  Refet Firat Yazicioglu

IPC: H03F1/34 ,  H03F3/68 ,  H03F3/45

CPC classification number: H03F1/34 ,  H03F3/45 ,  H03F3/45932 ,  H03F3/45941 ,  H03F3/68 ,  H03F2200/261 ,  H03F2203/45084 ,  H03F2203/45114 ,  H03F2203/45116

Abstract: An instrumentation amplifier includes a first amplifier having one input connected to a first input of the instrumentation amplifier, a second amplifier having one input connected to a second input of the instrumentation amplifier, and a feedback network. The feedback network including an active filter having a first low pass filter characteristic with a first cut-off frequency in respect of differential mode signals at the first and second inputs of the instrumentation amplifier, and a second low pass filter characteristic with a second cut-off frequency in respect of common mode signals at the first and second inputs of the instrumentation amplifier. The disclosure also relates to a device for acquiring biopotential signals and a signal amplification method.

Abstract translation: 仪表放大器包括具有连接到仪表放大器的第一输入的一个输入的第一放大器，具有连接到仪表放大器的第二输入的一个输入的第二放大器和反馈网络。 所述反馈网络包括有源滤波器，所述有源滤波器具有关于所述仪表放大器的第一和第二输入处的差模信号的具有第一截止频率的第一低通滤波器特性，以及具有第二截止频率的第二低通滤波器特性， 关于仪表放大器的第一和第二输入处的共模信号的截止频率。 本公开还涉及用于获取生物电位信号的装置和信号放大方法。