公开(公告)号：US20040127698A1

公开(公告)日：2004-07-01

申请号：US10743835

申请日：2003-12-24

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Shiao-Wen Tsai ,  Chiung-Lin Yang ,  Jui-Hsiang Chen ,  Pei-Ching Chang ,  Li-Ting Su ,  Shu-Hua Jan

IPC: C08B037/00

CPC classification number: D01F9/00 ,  C08B37/0072 ,  D01F11/00

Abstract: A method for producing a double-crosslinked hyaluronate material. A hyaluronic acid or a salt thereof is sequentially reacted with an epoxide compound and a carbodiimide compound to produce a more biodegradation-resistant hyaluronate material.

Abstract translation: 一种双交联透明质酸盐材料的制造方法。 透明质酸或其盐依次与环氧化合物和碳二亚胺化合物反应，生成更耐生物降解的透明质酸盐物质。

公开(公告)号：US20030100739A1

公开(公告)日：2003-05-29

申请号：US10076288

申请日：2002-02-19

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Shiao-Wen Tsai ,  Jui-Hsiang Chen ,  Chiung-Lin Yang

IPC: A01N037/18 ,  A61K038/00 ,  C07K001/00 ,  C07K014/00 ,  C07K017/00 ,  C09H003/00 ,  C09H003/02 ,  A61K038/17

CPC classification number: A61L31/129 ,  A61L15/225 ,  A61L24/0094 ,  A61L26/0095 ,  A61L27/48 ,  C07K1/1077 ,  C07K14/78 ,  C08B37/0072 ,  C08H1/06 ,  C08L5/08 ,  C08L89/06 ,  C08L89/00 ,  C08L2666/02

Abstract: This invention is concerned with a new method for producing different types of cross-linked hyaluronic acidnullprotein bio-composites. In the process of manufacture, polysaccharide and protein solution are mixed under moderate pH values and salts, and the well mixed solution can be prepared to various types, such as membrane, sponge, fiber, tube or micro-granular and so on. After then, with the bio-compatibility, biodegradation, prolong enzymatic degradation and good physical of bio-composite is formed in the little acid of organic solution that with the cross-linked reagent.

Abstract translation: 本发明涉及用于生产不同类型的交联透明质酸 - 蛋白质生物复合材料的新方法。 在制造过程中，将多糖和蛋白质溶液在中等pH值和盐下混合，可以制备各种类型的良好混合溶液，如膜，海绵，纤维，管或微粒等。 之后，在与交联试剂有机溶液的少量酸形成生物相容性，生物降解，延长酶降解和生物复合物的良好物理性能。