公开(公告)号：US20040127698A1

公开(公告)日：2004-07-01

申请号：US10743835

申请日：2003-12-24

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Shiao-Wen Tsai ,  Chiung-Lin Yang ,  Jui-Hsiang Chen ,  Pei-Ching Chang ,  Li-Ting Su ,  Shu-Hua Jan

IPC: C08B037/00

CPC classification number: D01F9/00 ,  C08B37/0072 ,  D01F11/00

Abstract: A method for producing a double-crosslinked hyaluronate material. A hyaluronic acid or a salt thereof is sequentially reacted with an epoxide compound and a carbodiimide compound to produce a more biodegradation-resistant hyaluronate material.

Abstract translation: 一种双交联透明质酸盐材料的制造方法。 透明质酸或其盐依次与环氧化合物和碳二亚胺化合物反应，生成更耐生物降解的透明质酸盐物质。

公开(公告)号：US20030146532A1

公开(公告)日：2003-08-07

申请号：US10038419

申请日：2002-01-02

Applicant: Industrial Technology Research Institute

Inventor： Jui-Hsiang Chen ,  Jean-Dean Yang ,  Bin-Hong Tsai ,  Mei-Jun Liu ,  Yu-Lin Hsieh

IPC: B29C067/20 ,  B29C071/00

CPC classification number: C08J9/28 ,  A61L27/18 ,  A61L27/56 ,  A61L27/58 ,  C08J2201/0542 ,  C08J2367/04 ,  C08L67/04

Abstract: The present invention provides a process for preparing a porous bioresorbable material having interconnected pores. A bioresorbable polymer and a low molecular weight oligomer are dissolved in an organic solvent to form a bioresorbable polymer solution. The bioresorbable polymer has a molecular weight greater than 20,000 and the oligomer has a molecular weight of 200 to 4000. The bioresorbable polymer solution is then contacted with a coagulant to form a porous bioresorbable material.

Abstract translation: 本发明提供一种制备具有互连孔的多孔生物可再吸收材料的方法。 将生物可再吸收聚合物和低分子量低聚物溶解在有机溶剂中以形成生物可再吸收的聚合物溶液。 生物再吸收聚合物的分子量大于20,000，低聚物的分子量为200至4000.然后将生物可再吸收的聚合物溶液与凝结剂接触以形成多孔生物可再吸收材料。

公开(公告)号：US20030100739A1

公开(公告)日：2003-05-29

申请号：US10076288

申请日：2002-02-19

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Shiao-Wen Tsai ,  Jui-Hsiang Chen ,  Chiung-Lin Yang

IPC: A01N037/18 ,  A61K038/00 ,  C07K001/00 ,  C07K014/00 ,  C07K017/00 ,  C09H003/00 ,  C09H003/02 ,  A61K038/17

CPC classification number: A61L31/129 ,  A61L15/225 ,  A61L24/0094 ,  A61L26/0095 ,  A61L27/48 ,  C07K1/1077 ,  C07K14/78 ,  C08B37/0072 ,  C08H1/06 ,  C08L5/08 ,  C08L89/06 ,  C08L89/00 ,  C08L2666/02

Abstract: This invention is concerned with a new method for producing different types of cross-linked hyaluronic acidnullprotein bio-composites. In the process of manufacture, polysaccharide and protein solution are mixed under moderate pH values and salts, and the well mixed solution can be prepared to various types, such as membrane, sponge, fiber, tube or micro-granular and so on. After then, with the bio-compatibility, biodegradation, prolong enzymatic degradation and good physical of bio-composite is formed in the little acid of organic solution that with the cross-linked reagent.

Abstract translation: 本发明涉及用于生产不同类型的交联透明质酸 - 蛋白质生物复合材料的新方法。 在制造过程中，将多糖和蛋白质溶液在中等pH值和盐下混合，可以制备各种类型的良好混合溶液，如膜，海绵，纤维，管或微粒等。 之后，在与交联试剂有机溶液的少量酸形成生物相容性，生物降解，延长酶降解和生物复合物的良好物理性能。

公开(公告)号：US20020022673A1

公开(公告)日：2002-02-21

申请号：US09870370

申请日：2001-05-30

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Chun-Jen Liao ,  Chin-Fu Chen ,  Jui-Hsiang Chen ,  Ken-Yuan Chang ,  Yure-Ru Lin ,  Shu-Fang Chiang

IPC: C08J009/26

CPC classification number: C08J9/26 ,  C08J2201/0444 ,  C08J2201/046 ,  C08J2201/0542

Abstract: The present invention provides a process for producing porous polymer materials. In the present invention, a polymer material and a soluble material are mixed in their solid states. The surface of the polymer material is partially dissolved and fused by introducing a solvent. The present invention makes use of a pressure difference while introducing a non-solvent into the polymer material to solidify and resolve the solved polymer material. Then, a substantial amount of water is used to wash the inside soluble material out. Therefore, the porous polymer materials with high porosity and interconnecting pores inside the materials are produced massively and rapidly.